Detailed information for compound 587482

Basic information

Technical information
  • TDR Targets ID: 587482
  • Name: 6-bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-9H-pyr ido[3,4-b]indole
  • MW: 314.18 | Formula: C15H12BrN3
  • H donors: 1 H acceptors: 1 LogP: 3.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)c1ccnc(c1[nH]2)C1=NCCC1
  • InChi: 1S/C15H12BrN3/c16-9-3-4-12-11(8-9)10-5-7-18-15(14(10)19-12)13-2-1-6-17-13/h3-5,7-8,19H,1-2,6H2
  • InChiKey: BJVWSKGRRKQZGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-bromo-1-(1-pyrrolin-2-yl)-9H-$b-carboline
  • eudistomin H
  • 6-bromo-1-(4,5-dihydro-3H-pyrrol-2-yl)-9H-pyrido[3,4-b]indole
  • 88704-44-3
  • NCI60_006770
  • NSC622807
  • 9H-Pyrido(3,4-b)indole, 6-bromo-1-(3,4-dihydro-2H-pyrrol-5-yl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0418 0.113
Entamoeba histolytica Ran family GTPase 0.0043 0.0526 0.8795
Plasmodium vivax SET domain protein, putative 0.003 0.0323 0.3085
Brugia malayi nuclear hormone receptor 0.002 0.018 0.0215
Schistosoma mansoni thyroid hormone receptor 0.002 0.018 0.018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0343 0.0343
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0022 0.0022
Brugia malayi hypothetical protein 0.0009 0.0022 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0433 0.1177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.018 0.018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.018 0.0215
Echinococcus granulosus excitatory amino acid transporter 2 0.0507 0.7461 0.7461
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0943 0.1181
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.018 0.0215
Loa Loa (eye worm) hypothetical protein 0.0071 0.0943 0.0999
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0071 0.015
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0592 0.1662
Loa Loa (eye worm) hypothetical protein 0.0071 0.0943 0.0999
Echinococcus granulosus importin subunit beta 1 0.0059 0.0758 0.0758
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0943 0.2732
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1237 0.1237
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0022 0.0002
Schistosoma mansoni cpg binding protein 0.0028 0.0298 0.0298
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1237 0.1237
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.018 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1343 0.1777
Schistosoma mansoni microtubule-associated protein tau 0.0677 1 1
Brugia malayi steroid hormone receptor 0.002 0.018 0.0215
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.5821 0.5821
Brugia malayi Pre-SET motif family protein 0.003 0.0323 0.0407
Brugia malayi nuclear receptor NHR-88 0.002 0.018 0.0215
Brugia malayi tailless protein 0.0009 0.0022 0.0002
Schistosoma mansoni ap endonuclease 0.0037 0.0433 0.0433
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.018 0.0215
Brugia malayi nuclear receptor RXR 0.0009 0.0022 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0418 0.0418
Brugia malayi RNA, U transporter 1 0.0167 0.2376 0.3165
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0343 0.0343
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.018 0.018
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0943 0.1181
Entamoeba histolytica hypothetical protein 0.0048 0.0592 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0022 0.0002
Plasmodium falciparum importin beta, putative 0.0059 0.0758 1
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1671 0.1671
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0418 0.0418
Schistosoma mansoni cpg binding protein 0.0029 0.0321 0.0321
Brugia malayi kap beta 3 protein 0.0011 0.0046 0.0035
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0071 0.015
Schistosoma mansoni hypothetical protein 0.0626 0.9248 0.9248
Plasmodium falciparum glutathione reductase 0.0013 0.0071 0.0343
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0526 0.535
Brugia malayi hypothetical protein 0.0011 0.0039 0.0025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0626 0.9248 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0943 0.0943
Brugia malayi Muscleblind-like protein 0.0159 0.2257 0.3005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0418 0.2284
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0418 0.0534
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1343 0.1432
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0025 0.0025
Trichomonas vaginalis set domain proteins, putative 0.0231 0.333 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0225 0.324 0.324
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0943 0.2732
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0433 0.0433
Schistosoma mansoni ran 0.0043 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0059 0.0758 0.0798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.018 0.018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0433 0.7082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0022 0.0022
Toxoplasma gondii thioredoxin reductase 0.0037 0.043 0.236
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0071 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0025
Onchocerca volvulus 0.0071 0.0943 0.1239
Brugia malayi ecdysteroid receptor 0.002 0.018 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.018 0.018
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0067 0.088 0.093
Trichomonas vaginalis ran, putative 0.0043 0.0526 0.1461
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0418 0.0418
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0071 0.0343
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0433 0.4148
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0526 0.522
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0071 0.0272
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0225 0.324 0.324
Schistosoma mansoni cpg binding protein 0.0029 0.0321 0.0321
Onchocerca volvulus 0.0071 0.0943 0.1239
Echinococcus multilocularis cpg binding protein 0.0029 0.0321 0.0321
Echinococcus granulosus cpg binding protein 0.0029 0.0321 0.0321
Echinococcus granulosus dnaJ subfamily B 0.0397 0.5821 0.5821
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0943 0.0943
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.088 0.1155
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0433 0.2261
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0437 0.0437
Echinococcus granulosus geminin 0.0166 0.2365 0.2365
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0071 0.0943 0.0999
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.6671 0.8931
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1237 0.1237
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0592 0.1662
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Echinococcus multilocularis muscleblind protein 0.0159 0.2257 0.2257
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0343 0.0343
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.018 0.0215
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0343 0.0434
Loa Loa (eye worm) steroid hormone receptor 0.002 0.018 0.0172
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Mycobacterium tuberculosis Conserved protein 0.0071 0.0943 0.1181
Brugia malayi nuclear receptor NHR-67 0.0009 0.0022 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0943 0.2732
Brugia malayi Importin beta-1 subunit 0.0059 0.0758 0.0991
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.018 0.018
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0022 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1237 0.1237
Echinococcus multilocularis FTZ F1 alpha 0.002 0.018 0.018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0526 0.0526
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0433 0.4148
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0943 0.1181
Schistosoma mansoni importin beta-1 0.0059 0.0758 0.0758
Mycobacterium ulcerans beta-lactamase 0.0071 0.0943 0.5451
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0022 0.0022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1134 0.5765
Schistosoma mansoni coup transcription factor 0.002 0.018 0.018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1134 0.1438
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0298 0.0299
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0071 0.0272
Schistosoma mansoni nuclear hormone receptor 0.002 0.018 0.018
Schistosoma mansoni nuclear receptor 0.0009 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0166 0.2365 0.2365
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.018 0.018
Echinococcus multilocularis muscleblind protein 1 0.0159 0.2257 0.2257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0343 0.0348
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0418 0.113
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0225 0.324 0.324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1237 0.1237
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0323 0.0323
Schistosoma mansoni hypothetical protein 0.0397 0.5821 0.5821
Onchocerca volvulus 0.0028 0.0298 0.0371
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.018 0.018
Echinococcus multilocularis neutral amino acid transporter A 0.0507 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Leishmania major importin beta-1 subunit, putative 0.0048 0.0592 0.3357
Chlamydia trachomatis neutral amino acid transporter 0.0225 0.324 0.4289
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.018 0.0215
Brugia malayi beta-lactamase family protein 0.0071 0.0943 0.124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0526 0.522
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0022 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.018 0.018
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0071 0.015
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0024 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0943 0.2732
Trypanosoma brucei trypanothione reductase 0.0037 0.043 0.4275
Schistosoma mansoni importin-beta 2 0.0011 0.0046 0.0046
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0022 0.0002
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0159 0.2257 0.2422
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0025
Brugia malayi beta-lactamase family protein 0.0071 0.0943 0.124
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0758 0.7933
Schistosoma mansoni nuclear receptor 0.0009 0.0022 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0323 0.0323
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0022 0.0022
Brugia malayi hypothetical protein 0.0011 0.0039 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0418 0.113
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.1671 1
Echinococcus granulosus neutral amino acid transporter A 0.0507 0.7461 0.7461
Onchocerca volvulus 0.002 0.018 0.0213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0022 0.0022
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0071 0.0068
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0433 0.1142
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0071 0.0943 0.0999
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0507 0.7461 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0943 0.5451
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0039 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0323 0.1703
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.018 0.018
Leishmania major hypothetical protein, conserved 0.0071 0.0943 0.5519
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.018 0.018
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0046 0.0027
Plasmodium vivax importin-beta 2, putative 0.0059 0.0758 0.7933
Echinococcus multilocularis importin 5 0.0011 0.0046 0.0046
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0433 0.0554
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0418 0.3974
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0943 0.1181
Brugia malayi glutathione reductase 0.0037 0.043 0.055
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0225 0.324 0.324
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0433 0.1177
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0343 0.0434
Brugia malayi CXXC zinc finger family protein 0.0028 0.0298 0.0373
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1273 0.1627
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0022 0.0022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0687 0.394
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0526 0.068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.018 0.0172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0343 0.0343
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.018 0.018
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0507 0.7461 0.7461
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0507 0.7461 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0507 0.7461 0.7461
Brugia malayi nuclear receptor RXR 0.0011 0.0039 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0943 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.043 0.0486
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0526 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.018 0.0215
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1671 1
Schistosoma mansoni hypothetical protein 0.0166 0.2365 0.2365
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0071
Echinococcus granulosus transportin 1 0.0011 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0022 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0592 0.1662
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.018 0.0215
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1237 0.1317
Toxoplasma gondii exonuclease III APE 0.0037 0.0433 0.2377
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0418 0.4138
Echinococcus granulosus neutral amino acid transporter A 0.0507 0.7461 0.7461
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0943 0.124
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.018 0.018
Echinococcus granulosus excitatory amino acid transporter 3 0.0507 0.7461 0.7461
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2912 0.3133
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.018 0.018
Plasmodium vivax glutathione reductase, putative 0.0037 0.043 0.4275
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1134 0.1438
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0039 0.0018
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0323 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.018 0.0215
Onchocerca volvulus 0.003 0.0323 0.0405
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.018 0.018
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0507 0.7461 0.7461
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0022 0.0022
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0943 0.5451
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.015
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0433 0.049
Echinococcus multilocularis geminin 0.0166 0.2365 0.2365
Loa Loa (eye worm) hypothetical protein 0.0071 0.0943 0.0999
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1343 0.1777
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0039 0.0039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0592 0.5973
Plasmodium falciparum glutathione reductase 0.0037 0.043 0.5389
Brugia malayi Pre-SET motif family protein 0.0203 0.2912 0.3887
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.018 0.0172
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.1671 0.1671
Echinococcus multilocularis excitatory amino acid transporter 3 0.0507 0.7461 0.7461
Loa Loa (eye worm) glutathione reductase 0.0037 0.043 0.0442
Echinococcus granulosus GPCR family 2 0.0031 0.0343 0.0343
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0298 0.0298
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0437 0.0437
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0943 0.0943
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1134 0.1438
Brugia malayi Excitatory amino acid transporter 0.0507 0.7461 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0943 0.0999
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0433 0.0445
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.018 0.018
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Conserved protein 0.0071 0.0943 0.1181
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0526 0.6744
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0943 0.1181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0323 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0323 0.0323
Echinococcus multilocularis Excitatory amino acid transporter 0.0507 0.7461 0.7461
Schistosoma mansoni zinc finger protein 0.0009 0.0022 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1671 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0039 0.0039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.018 0.018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0781 0.0781
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.0677 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1134 0.1438
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0071 0.015
Brugia malayi ecdysone receptor 0.0009 0.0022 0.0002
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1134 0.1438
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1273 0.1627
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1273 1
Echinococcus multilocularis translational activator gcn1 0.0011 0.0046 0.0046
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Mycobacterium tuberculosis Conserved protein 0.0071 0.0943 0.1181
Schistosoma mansoni ran 0.0043 0.0526 0.0526
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0758 0.7933
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.018 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.018 0.0215
Echinococcus granulosus translational activator gcn1 0.0011 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0323 0.0327
Loa Loa (eye worm) hypothetical protein 0.0036 0.0418 0.0429
Echinococcus multilocularis snurportin 1 0.0626 0.9248 0.9248
Leishmania major trypanothione reductase 0.0037 0.043 0.236
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0758 0.4378
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0071
Echinococcus granulosus neutral amino acid transporter 0.0507 0.7461 0.7461
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0526 0.535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1237 0.1237
Echinococcus multilocularis GPCR, family 2 0.0031 0.0343 0.0343
Echinococcus multilocularis excitatory amino acid transporter 2 0.0507 0.7461 0.7461
Echinococcus granulosus Excitatory amino acid transporter 0.0507 0.7461 0.7461
Echinococcus granulosus excitatory amino acid transporter 2 0.0507 0.7461 0.7461
Echinococcus granulosus muscleblind protein 0.0159 0.2257 0.2257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1237 0.1237
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.018 0.0215
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.018 0.018
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0022 0.0022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0071 0.0272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0272
Schistosoma mansoni thyroid hormone receptor 0.002 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.018 0.0172
Treponema pallidum glutamate transporter 0.0225 0.324 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.018 0.0213
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0418 0.0418
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0943 0.2732
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0071 0.0343
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.018 0.0215
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0022 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.018 0.0215
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.043 0.0442
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0433 0.4307
Loa Loa (eye worm) histone methyltransferase 0.001 0.0025 0.0004
Onchocerca volvulus 0.0071 0.0943 0.1239
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.018 0.0215
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0433 0.0433
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0022 0.0002
Echinococcus granulosus Excitatory amino acid transporter 0.0507 0.7461 0.7461
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0018
Brugia malayi Thioredoxin reductase 0.0037 0.043 0.055
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0418 0.7613
Leishmania major GTP-binding protein, putative 0.0043 0.0526 0.2953
Plasmodium falciparum thioredoxin reductase 0.0013 0.0071 0.0343
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0758 0.0758
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0022 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0943 0.1181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.018 0.018
Toxoplasma gondii ABC1 family protein 0.0071 0.0943 0.5519
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0943 0.0999
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0943 0.1181
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0433 0.4307
Brugia malayi nuclear receptor NHR-88 0.0009 0.0022 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.018 0.018
Plasmodium falciparum thioredoxin reductase 0.0037 0.043 0.5389
Echinococcus multilocularis excitatory amino acid transporter 2 0.0507 0.7461 0.7461
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0507 0.7461 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.018 0.0213
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172
Echinococcus multilocularis neutral amino acid transporter A 0.0507 0.7461 0.7461
Loa Loa (eye worm) hypothetical protein 0.0098 0.1343 0.1432
Brugia malayi nuclear hormone receptor 0.0009 0.0022 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0943 1
Brugia malayi conserved hypotetical protein 0.0009 0.0022 0.0002
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Schistosoma mansoni hypothetical protein 0.0067 0.088 0.088
Schistosoma mansoni ap endonuclease 0.0037 0.0433 0.0433
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.018 0.018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0323 0.0323
Loa Loa (eye worm) excitatory amino acid transporter 0.0507 0.7461 0.8063
Echinococcus granulosus FTZ F1 alpha 0.002 0.018 0.018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0943 0.5451
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0025 0.0025
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.018 0.018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0433 0.543
Echinococcus granulosus importin 5 0.0011 0.0046 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.1671 0.2166
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0418 0.0418
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0418 0.6803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0071 0.0272
Brugia malayi hypothetical protein 0.0009 0.0022 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0031 0.0343 0.0343
Echinococcus multilocularis transportin 1 0.0011 0.0046 0.0046
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0071 0.0074
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0433 0.049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1237 0.1635
Echinococcus granulosus sodium:dicarboxylate symporter 0.0507 0.7461 0.7461
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.018 0.0213
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.018 0.0215
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.1671 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0418 0.0418
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0071 0.015
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0071 0.0272
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.043 0.4115
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0418 0.3974
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0526 0.2953
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0526 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0433 0.7947
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0433 0.2377
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1671 1
Onchocerca volvulus 0.0231 0.333 0.4447
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0418 0.0418
Brugia malayi Steroid receptor seven-up type 2 0.002 0.018 0.0215
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0418 0.0418
Echinococcus granulosus snurportin 1 0.0626 0.9248 0.9248
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.018 0.0172
Loa Loa (eye worm) hypothetical protein 0.0159 0.2257 0.2422
Echinococcus multilocularis neutral amino acid transporter A 0.0507 0.7461 0.7461
Echinococcus multilocularis Excitatory amino acid transporter 0.0507 0.7461 0.7461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.018 0.0172
Trichomonas vaginalis esterase, putative 0.0071 0.0943 0.2732
Mycobacterium tuberculosis Probable reductase 0.0084 0.1134 0.1438
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1273 0.1627
Loa Loa (eye worm) hypothetical protein 0.0031 0.0343 0.0348
Brugia malayi beta-lactamase 0.0071 0.0943 0.124
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.043 0.4275
Chlamydia trachomatis glutamate symporter 0.0507 0.7461 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.018 0.0172
Treponema pallidum glutamate/aspartate transporter 0.0225 0.324 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.1671 0.1671
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0046 0.0027
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0071 0.0943 0.5451
Loa Loa (eye worm) beta-lactamase 0.0071 0.0943 0.0999
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0172

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.72 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.237 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.072 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.022 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.021 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.831 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.72 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.605 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.57 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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