Detailed information for compound 587529

Basic information

Technical information
  • TDR Targets ID: 587529
  • Name: 6-[(1R,2S,4aR)-2-methyl-1,2,4a,5,6,7,8,8a-oct ahydronaphthalen-1-yl]-3-(hydroxymethyl)-4-me thoxy-pyran-2-one
  • MW: 304.381 | Formula: C18H24O4
  • H donors: 1 H acceptors: 2 LogP: 3.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(oc(=O)c1CO)[C@@H]1[C@@H](C)C=C[C@@H]2C1CCCC2
  • InChi: 1S/C18H24O4/c1-11-7-8-12-5-3-4-6-13(12)17(11)16-9-15(21-2)14(10-19)18(20)22-16/h7-9,11-13,17,19H,3-6,10H2,1-2H3/t11-,12+,13?,17+/m0/s1
  • InChiKey: YJHFAFJKTXEFDR-PLKHDWLOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[(1R,2S,4aR)-2-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3-(hydroxymethyl)-4-methoxy-2-pyranone
  • 6-[(1R,2S,4aR)-2-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-4-methoxy-3-methylol-pyran-2-one
  • 6-[(1R,2S,4aR)-2-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3-(hydroxymethyl)-4-methoxypyran-2-one
  • solanapyrone B
  • 88899-60-9
  • 2H-Pyran-2-one, 3-(hydroxymethyl)-4-methoxy-6-((1R,2S,4aR,8aR)-1,2,4a,5,6,7,8,8a-octahydro-2-methyl-1-naphthalenyl)-
  • Solanapyrone E

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0397 0.1529
Onchocerca volvulus 0.0052 0.0307 0.507
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.0684 0.265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0689
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0488 0.416
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0088 0.0084
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0333 0.257 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0356 0.0352
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0088 0.0084
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0016 0.0246
Trichomonas vaginalis glutaminase, putative 0.0268 0.2042 0.838
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0088 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0488 0.7557
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0128 0.0481
Brugia malayi nuclear receptor NHR-88 0.0024 0.0088 0.0325
Loa Loa (eye worm) TAR-binding protein 0.0333 0.257 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0049 0.0689
Echinococcus granulosus tar DNA binding protein 0.0333 0.257 0.2566
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0307 0.0303
Brugia malayi jmjC domain containing protein 0.0015 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Schistosoma mansoni DNA polymerase eta 0.0045 0.0255 0.0251
Echinococcus granulosus expressed protein 0.0017 0.0028 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0307 0.1181
Entamoeba histolytica protein kinase, putative 0.0094 0.0645 0.2633
Brugia malayi ecdysteroid receptor 0.0052 0.0307 0.1181
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Brugia malayi Cytochrome P450 family protein 0.0029 0.0124 0.0464
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0166 0.1314
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0128 0.0481
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.011 0.0747
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0051 0.019
Mycobacterium ulcerans glutaminase 0.0268 0.2042 1
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0166 0.2581
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.011 0.5355
Schistosoma mansoni ferritin 0.0017 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0074 0.0488 0.1886
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0056 0.0052
Schistosoma mansoni ap endonuclease 0.002 0.0051 0.0046
Schistosoma mansoni heat shock protein 0.0034 0.0166 0.0162
Brugia malayi nuclear receptor NHR-88 0.0052 0.0307 0.1181
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0016 0.0092
Loa Loa (eye worm) glutaminase 2 0.0268 0.2042 0.7942
Brugia malayi intermediate filament protein 0.0055 0.0332 0.1278
Schistosoma mansoni coup transcription factor 0.0052 0.0307 0.0303
Plasmodium vivax JmjC domain containing protein 0.0015 0.0016 0.0235
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.1135 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0043 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0307 0.1181
Treponema pallidum heat shock protein 90 0.0027 0.011 0.0343
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0051 0.0721
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0307 0.1181
Loa Loa (eye worm) hypothetical protein 0.0074 0.0488 0.1886
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0488 0.7557
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0043 0.0604
Echinococcus granulosus heat shock protein 0.0034 0.0166 0.0162
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0111 0.0417
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0054 0.0773
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0049 0.0182
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Brugia malayi Latrophilin receptor protein 2 0.0099 0.0684 0.265
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0049 0.0056
Echinococcus multilocularis dual specificity 0.0094 0.0645 0.064
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Schistosoma mansoni hypothetical protein 0.0099 0.0684 0.068
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0307 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0488 0.199
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0754
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0016 0.0011
Plasmodium falciparum heat shock protein 90 0.0034 0.0166 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Brugia malayi nuclear hormone receptor 0.0052 0.0307 0.1181
Echinococcus granulosus dna polymerase kappa 0.0019 0.0049 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0417
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Schistosoma mansoni ferritin light chain 0.0017 0.0028 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0124 0.0464
Echinococcus granulosus GPCR family 2 0.0099 0.0684 0.068
Echinococcus granulosus heat shock protein 90 0.0027 0.011 0.0106
Brugia malayi RNA recognition motif domain containing protein 0.0333 0.257 1
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0016 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1404 0.14
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0899 0.3486
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0112 0.0107
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0307 0.0303
Entamoeba histolytica protein kinase, putative 0.0094 0.0645 0.2633
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Schistosoma mansoni hypothetical protein 0.1259 1 1
Brugia malayi nuclear hormone receptor 0.0024 0.0088 0.0325
Onchocerca volvulus 0.0024 0.0088 0.1398
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0417
Plasmodium falciparum endoplasmin, putative 0.0021 0.006 0.345
Trypanosoma brucei unspecified product 0.0019 0.0049 0.0754
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0088 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1404 0.14
Echinococcus multilocularis lamin dm0 0.0055 0.0332 0.0328
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0488 0.1886
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0049 0.0044
Schistosoma mansoni hypothetical protein 0.0099 0.0684 0.068
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0166 0.2529
Brugia malayi tailless protein 0.0024 0.0088 0.0325
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0182 0.0766
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0088 0.0325
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.0645 0.2633
Brugia malayi beta-lactamase family protein 0.0074 0.0488 0.1886
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0016 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0307 0.0303
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0488 0.199
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0044
Brugia malayi CXXC zinc finger family protein 0.0088 0.0602 0.2328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0307 0.0303
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0182 0.2777
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0088 0.0084
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0307 0.0303
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0068 0.0064
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0049 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0333 0.257 0.2566
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0088 0.0084
Mycobacterium ulcerans heat shock protein 90 0.0027 0.011 0.041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0044
Schistosoma mansoni hypothetical protein 0.0099 0.0684 0.068
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.011 0.0106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0053 0.0199
Brugia malayi jmjC domain containing protein 0.0058 0.0356 0.1371
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0053 0.0199
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.3701 1
Schistosoma mansoni intermediate filament proteins 0.0055 0.0332 0.0328
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Loa Loa (eye worm) hypothetical protein 0.0093 0.0641 0.248
Schistosoma mansoni lamin 0.0055 0.0332 0.0328
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0166 0.0666
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0049 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0074 0.0488 0.1886
Brugia malayi Protein kinase domain containing protein 0.0094 0.0645 0.2495
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.1135 0.5495
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0182 0.0178
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.0645 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0049 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0307 0.1181
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0366 0.1679
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0088 0.0084
Brugia malayi hypothetical protein 0.0024 0.0088 0.0325
Schistosoma mansoni cpg binding protein 0.0093 0.0642 0.0638
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.3496 0.3493
Echinococcus multilocularis GPCR, family 2 0.0099 0.0684 0.068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0307 0.0303
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.1404 0.5456
Echinococcus multilocularis tar DNA binding protein 0.0333 0.257 0.2566
Loa Loa (eye worm) hypothetical protein 0.0054 0.0324 0.1247
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0366 0.0362
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.0684 0.068
Schistosoma mansoni tar DNA-binding protein 0.0333 0.257 0.2566
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0088 0.0325
Treponema pallidum fructose-bisphosphate aldolase 0.0317 0.2436 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0366 0.2935
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0016 0.0703
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0307 0.0303
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Schistosoma mansoni apoferritin-2 0.0017 0.0028 0.0023
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0307 0.1181
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0307 0.0303
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0488 0.0484
Echinococcus multilocularis dnaJ subfamily B 0.1259 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0488 0.1253
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Echinococcus multilocularis musashi 0.0055 0.0332 0.0328
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0166 0.0666
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0307 0.1181
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Mycobacterium ulcerans beta-lactamase 0.0074 0.0488 0.2286
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0488 0.1886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Brugia malayi nuclear receptor NHR-67 0.0024 0.0088 0.0325
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0051 0.018
Brugia malayi hypothetical protein 0.0027 0.0111 0.0417
Loa Loa (eye worm) hypothetical protein 0.0026 0.0105 0.039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.0684 0.068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0488 0.1253
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0074 0.0488 0.1886
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0312 0.2395 0.9321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0051 0.0721
Onchocerca volvulus 0.0055 0.0332 0.549
Mycobacterium ulcerans hypothetical protein 0.0074 0.0488 0.2286
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Schistosoma mansoni lamin 0.0055 0.0332 0.0328
Trichomonas vaginalis helicase, putative 0.002 0.0053 0.0199
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0051 0.0095
Trichomonas vaginalis heat shock protein, putative 0.0027 0.011 0.0436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0307 0.507
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0307 0.1181
Leishmania major DNA polymerase eta, putative 0.0045 0.0255 0.3917
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0332 0.1278
Schistosoma mansoni hypothetical protein 0.0099 0.0684 0.068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0049 0.0056
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0004 0.0069
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0105 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0307 0.0303
Echinococcus multilocularis expressed protein 0.0017 0.0028 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0397 0.0392
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.0645 0.2495
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0166 0.2529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0307 0.1181
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0488 0.2286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1404 0.14
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0307 0.0303
Schistosoma mansoni ap endonuclease 0.002 0.0051 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0307 0.0303
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0016 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.2436 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.0645 1
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0088 0.0325
Schistosoma mansoni zinc finger protein 0.0024 0.0088 0.0084
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0182 0.0731
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0307 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0333 0.257 0.2566
Schistosoma mansoni cpg binding protein 0.0093 0.0642 0.0638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0051 0.0785
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0488 0.1253
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.011 0.0259
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0051 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.1404 0.14
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0488 0.1253
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0366 0.0362
Brugia malayi Inositol-1 0.0036 0.0182 0.0693
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0088 0.0084
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.3496 0.3493
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0182 0.2827
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0307 0.0303
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0488 0.1253
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0645 1
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0053 0.0199
Echinococcus multilocularis cpg binding protein 0.0093 0.0642 0.0638
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0049 0.0172
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0088 0.0084
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0307 0.1181
Echinococcus granulosus heat shock protein 90 0.0034 0.0166 0.0162
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.1135 0.3013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0053 0.0199
Schistosoma mansoni inositol monophosphatase 0.0036 0.0182 0.0178
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.011 0.1657
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.0684 0.265
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0049 0.0172
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0307 0.0303
Brugia malayi jmjC domain containing protein 0.0015 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0417
Loa Loa (eye worm) hypothetical protein 0.0074 0.0488 0.1886
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0307 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0307 0.1181
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0645 0.064
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Brugia malayi conserved hypotetical protein 0.0024 0.0088 0.0325
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0088 0.0325
Echinococcus granulosus cpg binding protein 0.0093 0.0642 0.0638
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0255 0.3917
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0111 0.0107
Loa Loa (eye worm) hypothetical protein 0.0213 0.1603 0.6233
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0899 0.3486
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0307 0.507
Echinococcus granulosus dual specificity 0.0094 0.0645 0.064
Brugia malayi heat shock protein 90 0.0034 0.0166 0.0631
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0111 0.0417
Schistosoma mansoni hypothetical protein 0.0173 0.1283 0.1279
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0016 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0049 0.0103
Schistosoma mansoni inositol monophosphatase 0.0036 0.0182 0.0178
Schistosoma mansoni ferritin light chain 0.0017 0.0028 0.0023
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0182 0.2777
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0016 0.0044
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0016 0.0011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0053 0.0199
Toxoplasma gondii ABC1 family protein 0.0074 0.0488 0.3926
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0255 0.3959
Echinococcus granulosus geminin 0.0173 0.1283 0.1279
Loa Loa (eye worm) endoplasmin 0.0034 0.0166 0.0631
Echinococcus granulosus ferritin 0.0017 0.0028 0.0023
Echinococcus granulosus endoplasmin 0.0027 0.011 0.0106
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0307 0.0303
Echinococcus granulosus neuropeptide s receptor 0.0449 0.3496 0.3493
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0366 0.0362
Loa Loa (eye worm) glutaminase 0.0268 0.2042 0.7942
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0307 0.0303
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0689
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0307 0.0303
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0307 0.0303
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0356 0.0352
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0051 0.0046
Echinococcus granulosus dna polymerase eta 0.0045 0.0255 0.0251
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0147 0.2231
Brugia malayi hypothetical protein 0.0027 0.0111 0.0417
Schistosoma mansoni ferritin 0.0017 0.0028 0.0023
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0049 0.0182
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0307 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1404 0.14
Mycobacterium tuberculosis Conserved protein 0.0074 0.0488 0.1253
Mycobacterium leprae Probable lipase LipE 0.0074 0.0488 0.416
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0112 0.0418
Schistosoma mansoni apoferritin-2 0.0017 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 0.2436 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Loa Loa (eye worm) hypothetical protein 0.0074 0.0488 0.1886
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0088 0.1398
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0488 0.0484
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.1404 0.5456
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0307 0.1181
Echinococcus multilocularis dna polymerase eta 0.0045 0.0255 0.0251
Leishmania major cytochrome p450-like protein 0.0019 0.0043 0.0604
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0016 0.0178
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0016 0.0178
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0366 0.0921
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0488 0.7574
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0088 0.0325
Brugia malayi beta-lactamase 0.0074 0.0488 0.1886
Echinococcus multilocularis heat shock protein 0.0034 0.0166 0.0162
Brugia malayi jmjC domain containing protein 0.0015 0.0016 0.0044
Echinococcus multilocularis endoplasmin 0.0027 0.011 0.0106
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0112 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0307 0.1181
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0166 0.2581
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0602 0.2328
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0166 0.3347
Leishmania major hypothetical protein, conserved 0.0015 0.0016 0.0178
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0166 0.2581
Brugia malayi glutaminase DH11.1 0.0268 0.2042 0.7942
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0051 0.2852
Schistosoma mansoni endoplasmin 0.0034 0.0166 0.0162
Loa Loa (eye worm) RNA binding protein 0.0333 0.257 1
Leishmania major hypothetical protein, conserved 0.0074 0.0488 0.7557
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0053 0.0199
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0088 0.0084
Schistosoma mansoni heat shock protein 0.0034 0.0166 0.0162
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0016 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0488 0.0484
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0307 0.0303
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0182 0.2777
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0397 0.0392
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0307 0.1181
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0307 0.507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0027 0.0111 0.0417
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0166 0.1314
Brugia malayi steroid hormone receptor 0.0052 0.0307 0.1181
Loa Loa (eye worm) DR-78 0.0024 0.0088 0.0325
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0332 0.1278
Schistosoma mansoni ferritin 0.0017 0.0028 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0488 0.0484
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0053 0.0199
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0307 0.1181
Schistosoma mansoni hypothetical protein 0.0173 0.1283 0.1279
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0051 0.0046
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.011 0.1657
Echinococcus multilocularis geminin 0.0173 0.1283 0.1279
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0088 0.0325
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0043 0.0668
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0051 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0689
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0088 0.0325
Trichomonas vaginalis heat shock protein, putative 0.0027 0.011 0.0436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0307 0.1181
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0088 0.0325
Mycobacterium tuberculosis Conserved protein 0.0074 0.0488 0.1253
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Schistosoma mansoni cpg binding protein 0.0088 0.0602 0.0598
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0016 0.0011
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.011 0.1657
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0488 0.1253
Echinococcus multilocularis lamin 0.0055 0.0332 0.0328
Plasmodium vivax endoplasmin, putative 0.0034 0.0166 0.3347
Brugia malayi ecdysone receptor 0.0024 0.0088 0.0325
Brugia malayi Cytochrome P450 family protein 0.0019 0.0043 0.0151
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0166 0.0493
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0051 0.0721
Entamoeba histolytica hypothetical protein 0.0094 0.0645 0.2633
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Schistosoma mansoni tar DNA-binding protein 0.0333 0.257 0.2566
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0152 0.0337
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0397 0.0392
Brugia malayi jmjC domain containing protein 0.0063 0.0397 0.1529
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0166 0.2529
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.1603 0.6233
Loa Loa (eye worm) hypothetical protein 0.0045 0.0255 0.0978
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0182 0.0731
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0307 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0307 0.1181
Loa Loa (eye worm) hypothetical protein 0.0093 0.0641 0.248
Loa Loa (eye worm) hypothetical protein 0.0099 0.0684 0.265
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0307 0.1181
Schistosoma mansoni hypothetical protein 0.0213 0.1603 0.16
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0111 0.0417
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.0684 0.068
Echinococcus granulosus intermediate filament protein 0.0055 0.0332 0.0328
Trichomonas vaginalis heat shock protein, putative 0.0027 0.011 0.0436
Mycobacterium ulcerans lipase LipD 0.0074 0.0488 0.2286
Trichomonas vaginalis heat shock protein, putative 0.0021 0.006 0.023
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0088 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0366 0.1679
Loa Loa (eye worm) hypothetical protein 0.0055 0.0332 0.1278
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0332 0.1278
Leishmania major DNA polymerase eta, putative 0.0032 0.0147 0.2231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0166 0.0631
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0488 0.199
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0488 0.199
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0016 0.0011
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0182 1
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.0684 0.068
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0182 0.1443
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0152 0.112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.2395 0.9321
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0488 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.2395 0.9321
Trichomonas vaginalis esterase, putative 0.0074 0.0488 0.199
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0307 0.0303
Onchocerca volvulus 0.0074 0.0488 0.8099
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0255 0.0978
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0068 0.0064
Schistosoma mansoni nuclear receptor 0.0024 0.0088 0.0084
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0182 0.0178
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0645 1
Loa Loa (eye worm) beta-lactamase 0.0074 0.0488 0.1886
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0307 0.1181
Onchocerca volvulus 0.0074 0.0488 0.8099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0307 0.0303
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0166 0.2529
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0016 0.0011
Brugia malayi Endoplasmin precursor 0.0034 0.0166 0.0631
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0307 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0016 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0307 0.1181
Brugia malayi nuclear receptor RXR 0.0024 0.0088 0.0325
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0088 0.0084
Brugia malayi TAR-binding protein 0.0333 0.257 1
Schistosoma mansoni ferritin 0.0017 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0307 0.1181
Giardia lamblia Grp94/Hsp90 0.0027 0.011 0.0259
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0051 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0068 0.0064
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0488 0.2286
Brugia malayi beta-lactamase family protein 0.0074 0.0488 0.1886
Trichomonas vaginalis endoplasmin, putative 0.0021 0.006 0.023
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0182 0.0731
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0307 0.0303
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0088 0.1398
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0016 0.0044
Schistosoma mansoni nuclear receptor 0.0024 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.0359
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0051 0.1476
Brugia malayi RNA binding protein 0.0333 0.257 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0307 0.0303
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0043 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0488 0.199
Echinococcus multilocularis ferritin 0.0017 0.0028 0.0023
Schistosoma mansoni endoplasmin 0.0034 0.0166 0.0162
Brugia malayi MH2 domain containing protein 0.0125 0.0899 0.3486
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0049 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0088 0.0084
Leishmania major DNA polymerase kappa, putative 0.0019 0.0049 0.0689
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0356 0.0352
Echinococcus multilocularis heat shock protein 90 0.0034 0.0166 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0088 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0307 0.1181
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0068 0.0064
Echinococcus granulosus lamin 0.0055 0.0332 0.0328
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0166 0.0666
Brugia malayi Cytochrome P450 family protein 0.0019 0.0043 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0333 0.257 0.2566
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.1237 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0088 0.0325
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0088 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0053 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0307 0.1181
Brugia malayi jmjC domain containing protein 0.0015 0.0016 0.0044
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0147 0.1159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.1404 0.14
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0016 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0111 0.0107
Loa Loa (eye worm) inositol-1 0.0036 0.0182 0.0693
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0111 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0754
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0049 0.0754
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0366 0.0362
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0049 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0049 0.0689
Echinococcus granulosus phd:f box containing protein 0.0015 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.0359
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0366 0.5649
Echinococcus granulosus lamin dm0 0.0055 0.0332 0.0328
Onchocerca volvulus 0.0074 0.0488 0.8099
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0307 0.1181
Echinococcus multilocularis heat shock protein 90 0.0027 0.011 0.0106
Trypanosoma brucei heat shock protein, putative 0.0034 0.0166 0.2581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 0.2436 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.011 0.0225
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0049 0.0044
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0051 0.019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.1397 0.1394
Trichomonas vaginalis ferritin, putative 0.0017 0.0028 0.0096
Toxoplasma gondii exonuclease III APE 0.002 0.0051 0.0375
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0043 0.0604
Brugia malayi hypothetical protein 0.0024 0.0088 0.0325
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0307 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Onchocerca volvulus 0.0024 0.0088 0.1398
Leishmania major heat shock protein 83-1 0.0034 0.0166 0.2529
Onchocerca volvulus 0.0088 0.0602 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0199
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.2395 0.9321
Mycobacterium tuberculosis Conserved protein 0.0074 0.0488 0.1253
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0307 0.1181
Schistosoma mansoni glutaminase 0.0268 0.2042 0.2038
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0111 0.0107
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0068 0.0064
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0056 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0356 0.0352
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0366 0.1679
Brugia malayi nuclear receptor RXR 0.0027 0.0111 0.0417
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0051 0.0955
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0307 0.1181
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0488 0.1253
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0051 0.018
Onchocerca volvulus 0.0055 0.0332 0.549
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0049 0.0754
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0182 0.0731
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0051 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.1404 0.14
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0105 0.01
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 0.2436 1
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.3496 0.3493
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0043 0.0151
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0109 0.0407
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0043 0.0151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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