Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.1504 | 0.2314 | 0.2314 |
Echinococcus multilocularis | thymidylate synthase | 0.1504 | 0.2314 | 0.1528 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4498 | 0.7319 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.023 | 0.0184 | 0.0184 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4498 | 0.7319 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0675 | 0.0929 | 0.0699 |
Onchocerca volvulus | 0.1504 | 0.2314 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1504 | 0.2314 | 0.212 |
Echinococcus multilocularis | dihydrofolate reductase | 0.6101 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6101 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.023 | 0.0184 | 0.0184 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4498 | 0.7319 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.6101 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4498 | 0.7319 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0268 | 0.0247 | 0.0247 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1504 | 0.2314 | 0.1464 |
Echinococcus granulosus | thymidylate synthase | 0.1504 | 0.2314 | 0.1528 |
Echinococcus granulosus | dihydrofolate reductase | 0.6101 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 0.0247 | 0.0247 |
Brugia malayi | hypothetical protein | 0.0716 | 0.0996 | 0.0996 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4498 | 0.7319 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4498 | 0.7319 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0716 | 0.0996 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6101 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 0.0247 | 0.0247 |
Schistosoma mansoni | dihydrofolate reductase | 0.6101 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.1504 | 0.2314 | 0.2314 |
Mycobacterium ulcerans | thymidylate synthase | 0.1504 | 0.2314 | 0.212 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6101 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6101 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6101 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.