Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2892 | 0.63 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1767 | 0.3848 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2635 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3289 | 0.3289 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0048 | 0.0048 |
Brugia malayi | RNA binding protein | 0.0064 | 0.4591 | 0.4591 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2635 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.091 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2635 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.091 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.4591 | 0.4591 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2892 | 0.63 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2635 | 0.2635 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2635 | 0.5738 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4591 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.4591 | 0.4591 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2892 | 0.63 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2892 | 0.63 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.2892 | 0.63 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2635 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1767 | 0.1767 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.4591 | 0.4591 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.091 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.4591 | 0.4591 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.091 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.091 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.3289 | 0.3289 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.091 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2635 | 0.5738 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.091 | 0.091 |
Brugia malayi | hypothetical protein | 0.0025 | 0.091 | 0.091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.2892 | 0.63 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.2892 | 0.2892 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.3289 | 0.3289 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.091 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2635 | 0.5738 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.2892 | 0.63 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1767 | 0.1767 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.2892 | 0.2892 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4591 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.4591 | 0.4591 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4591 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2635 | 0.5738 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.7278 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.