Detailed information for compound 587731

Basic information

Technical information
  • TDR Targets ID: 587731
  • Name: (6R,6aS,8S)-3,8-dihydroxy-2,6-dimethoxy-5,6,6 a,7,8,9-hexahydropyrrolo[2,1-c][1,4]benzodiaz epin-11-one
  • MW: 294.303 | Formula: C14H18N2O5
  • H donors: 3 H acceptors: 3 LogP: 0.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1Nc2cc(O)c(cc2C(=O)N2[C@H]1C[C@@H](C2)O)OC
  • InChi: 1S/C14H18N2O5/c1-20-12-4-8-9(5-11(12)18)15-13(21-2)10-3-7(17)6-16(10)14(8)19/h4-5,7,10,13,15,17-18H,3,6H2,1-2H3/t7-,10-,13+/m0/s1
  • InChiKey: FDZKMDGYTVIWIB-LCWDIZFYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • chicamycin A
  • 89675-37-6
  • 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 1,2,3,10,11,11a-hexahydro-2,8-dihydroxy-7,11-dimethoxy-, (2S-(2-alpha,11-alpha,11b-beta))-
  • BRN 5763463

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein patched 0.0043 0.0355 0.0355
Schistosoma mansoni adenoreceptor 0.0024 0.0118 0.0139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0118 0.0118
Loa Loa (eye worm) inositol-1 0.0038 0.0295 0.0339
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0347 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0118 0.0139
Schistosoma mansoni nuclear hormone receptor 0.002 0.0071 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0118 0.0136
Mycobacterium leprae Probable pyruvate kinase PykA 0.0068 0.0662 0.075
Brugia malayi steroid hormone receptor 0.0043 0.0347 0.0398
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0283 0.0283
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0321
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0568 0.067
Brugia malayi G protein-coupled receptor 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis serotonin receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0118 0.0118
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0347 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0737 0.8835 1
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Schistosoma mansoni patched 1 0.0043 0.0355 0.0419
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0136
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0028 0.0173 0.0303
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.042 0.0476
Onchocerca volvulus 0.0148 0.1639 0.2866
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0355 0.0408
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0031 0.0208 0.0236
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0295 0.0846
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.042 0.0476
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0284 0.0321
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0118 0.0118
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0347 0.0398
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.108 0.1273
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0118 0.0118
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0031 0.0208 0.0236
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0118 0.0118
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0118 0.0136
Brugia malayi AKH receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0283 0.0325
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0347 0.0409
Echinococcus multilocularis somatostatin receptor 0.0024 0.0118 0.0118
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Brugia malayi Dopamine receptor protein 1 0.0024 0.0118 0.0136
Echinococcus granulosus pyruvate kinase 0.0035 0.0255 0.0292
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0347 0.0347
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.042 0.0476
Echinococcus granulosus lamin dm0 0.0028 0.0173 0.0198
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2753 0.3116
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0402 0.0474
Trichomonas vaginalis esterase, putative 0.0037 0.0284 0.0496
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.042 0.6344
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0068 0.0662 0.075
Brugia malayi putative neuropeptide receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.042 0.0476
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0118 0.0118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0295 0.0517
Schistosoma mansoni opsin-like receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0071 0.0071
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0118 0.0136
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0118 0.0136
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0355 0.0408
Brugia malayi AMP-binding enzyme family protein 0.0049 0.042 0.0482
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0071 0.0082
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0284 0.0325
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0284 0.0321
Echinococcus granulosus g protein coupled receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Onchocerca volvulus 0.0024 0.0118 0.0207
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3493 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni nuclear hormone receptor 0.002 0.0071 0.0084
Schistosoma mansoni hypothetical protein 0.0148 0.1639 0.1932
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0071 0.0084
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0071 0.0082
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0118 0.0118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0402 0.0461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0402 0.0474
Mycobacterium ulcerans pyruvate kinase 0.0068 0.0662 0.075
Onchocerca volvulus 0.0024 0.0118 0.0207
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.042 0.0476
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0662 0.1158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0129 0.1405 0.1612
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0118 0.0136
Schistosoma mansoni intermediate filament proteins 0.0028 0.0173 0.0204
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0118 0.0118
Echinococcus multilocularis lamin 0.0028 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) MBCTL1 0.0056 0.0507 0.0581
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0101 0.0116
Onchocerca volvulus 0.0028 0.0173 0.0303
Onchocerca volvulus 0.0037 0.0284 0.0496
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0347 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Onchocerca volvulus 0.002 0.0071 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0568 0.8576
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0118 0.0139
Schistosoma mansoni inositol monophosphatase 0.0038 0.0295 0.0348
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1591 0.1824
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.1639 0.188
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0212 0.0243
Leishmania major hypothetical protein, conserved 0.0037 0.0284 0.4282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1048 0.1202
Loa Loa (eye worm) hypothetical protein 0.0187 0.2113 0.2423
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0347 0.0347
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0496
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus granulosus neuropeptide receptor A26 0.0509 0.6051 0.694
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0101 0.0119
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0496
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0347 0.0398
Brugia malayi hypothetical protein 0.0023 0.0101 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0049 0.042 0.0482
Loa Loa (eye worm) hypothetical protein 0.0061 0.0568 0.0652
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0284 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0118 0.0136
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.042 0.6344
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0284 0.4282
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0118 0.0139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0347 0.0398
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.027 0.2214
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0101 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0587 0.0665
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0255 0.2091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1405 0.1612
Echinococcus multilocularis pyruvate kinase 0.0035 0.0255 0.0255
Brugia malayi larval opioid receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0347 0.0398
Echinococcus granulosus S formylglutathione hydrolase 0.0031 0.0208 0.0239
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0424 0.05
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0071 0.0071
Brugia malayi Inositol-1 0.0038 0.0295 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0587 0.0665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0568 0.067
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0246 0.0279
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0053 0.0475 0.0544
Echinococcus multilocularis protein dispatched 1 0.0049 0.043 0.043
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0424 0.0424
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0118 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0355 0.0408
Brugia malayi hypothetical protein 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0048 0.0409 0.0469
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1048 0.1202
Loa Loa (eye worm) hypothetical protein 0.0049 0.042 0.0482
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0031 0.0208 0.0236
Schistosoma mansoni nuclear receptor 0.002 0.0071 0.0084
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0726 0.8704 0.9983
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0118
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi Serotonin receptor 0.0024 0.0118 0.0136
Brugia malayi tailless protein 0.002 0.0071 0.0082
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.5004 0.5739
Echinococcus granulosus allatostatin A receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0212 0.0243
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0118 0.0136
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.042 0.0476
Echinococcus multilocularis serotonin receptor 0.0024 0.0118 0.0118
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0662 1
Brugia malayi sulfakinin receptor protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1617 0.183
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0284 0.0325
Onchocerca volvulus Huntingtin homolog 0.0129 0.1405 0.2457
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.027 0.2214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi neuropeptide F receptor 0.0024 0.0118 0.0136
Brugia malayi beta-lactamase 0.0037 0.0284 0.0325
Trypanosoma brucei pyruvate kinase 1, putative 0.0068 0.0662 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0424 0.0486
Onchocerca volvulus 0.002 0.0071 0.0125
Brugia malayi CHE-14 protein 0.0043 0.0355 0.0408
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0118 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0101 0.0116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3493 1
Brugia malayi hypothetical protein 0.0155 0.1721 0.1974
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.3493 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0347 0.0347
Trypanosoma brucei pyruvate kinase 1 0.0068 0.0662 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Schistosoma mansoni pyruvate kinase 0.0035 0.0255 0.0301
Onchocerca volvulus 0.0024 0.0118 0.0207
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi nuclear receptor NHR-67 0.002 0.0071 0.0082
Schistosoma mansoni biogenic amine receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0101 0.0116
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0283 0.0334
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0587 0.0692
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0402 0.0461
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0049 0.042 0.0482
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0347 0.0409
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi hypothetical protein 0.0727 0.8719 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0071 0.0082
Echinococcus multilocularis lamin dm0 0.0028 0.0173 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0402 0.0474
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0347 0.0398
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0347 0.0606
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0071 0.0084
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0031 0.0208 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0402 0.0461
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis neuropeptide receptor A26 0.0509 0.6051 0.6051
Echinococcus granulosus g protein coupled receptor 0.0024 0.0118 0.0136
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0662 0.1158
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0424 0.0741
Schistosoma mansoni myosin xvIII 0.0024 0.0118 0.0139
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0347 0.0409
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi follicle stimulating hormone receptor 0.0726 0.8704 0.9983
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0136
Echinococcus multilocularis musashi 0.0028 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0056 0.0507 0.0581
Onchocerca volvulus 0.0037 0.0284 0.0496
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.027 0.0305
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0071 0.0082
Brugia malayi hypothetical protein 0.0037 0.0283 0.0325
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0118 0.0136
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.1061 0.1216
Onchocerca volvulus 0.0024 0.0118 0.0207
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0284 0.0321
Schistosoma mansoni biogenic amine receptor 0.0024 0.0118 0.0139
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0295 0.0517
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0118 0.0118
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.042 0.1203
Brugia malayi Melatonin receptor type 1A 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0118 0.0118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0101 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Mycobacterium ulcerans hypothetical protein 0.0037 0.0284 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0424 0.0424
Brugia malayi RE15519p 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0727 0.8719 1
Schistosoma mansoni hypothetical protein 0.0068 0.0661 0.078
Echinococcus granulosus neuropeptide s receptor 0.0509 0.6051 0.694
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0118 0.0136
Schistosoma mansoni hypothetical protein 0.0347 0.4073 0.48
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0118 0.0118
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0118 0.0139
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0284 0.0496
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0321
Echinococcus granulosus somatostatin receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Onchocerca volvulus 0.0024 0.0118 0.0207
Echinococcus granulosus sex peptide receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2184 0.2184
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0071 0.0071
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0662 0.1158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0118 0.0139
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0284 0.4282
Brugia malayi intermediate filament protein 0.0028 0.0173 0.0198
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0284 0.0321
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0118 0.0136
Onchocerca volvulus 0.0024 0.0118 0.0207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Echinococcus granulosus pyruvate kinase 0.0068 0.0662 0.076
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.8484 0.8484
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Echinococcus granulosus serotonin receptor 0.0024 0.0118 0.0136
Schistosoma mansoni coup transcription factor 0.0043 0.0347 0.0409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0295 0.4461
Brugia malayi conserved hypotetical protein 0.002 0.0071 0.0082
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0118 0.0139
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0118 0.0136
Chlamydia trachomatis pyruvate kinase 0.0068 0.0662 1
Brugia malayi nuclear hormone receptor 0.002 0.0071 0.0082
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0118 0.0118
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0071 0.0082
Onchocerca volvulus 0.0024 0.0118 0.0207
Loa Loa (eye worm) DR-78 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Trichomonas vaginalis set domain proteins, putative 0.0482 0.5719 1
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0347 0.0409
Echinococcus granulosus intermediate filament protein 0.0028 0.0173 0.0198
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0347 0.0409
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0347 0.0409
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0284 0.0496
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Schistosoma mansoni nuclear receptor 0.002 0.0071 0.0084
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0101 0.1061 0.1216
Schistosoma mansoni hypothetical protein 0.0347 0.4073 0.48
Schistosoma mansoni hypothetical protein 0.0037 0.0283 0.0334
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0355 0.0408
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0507 0.0581
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0002 0.0002
Brugia malayi nuclear receptor NHR-88 0.0043 0.0347 0.0398
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0118 0.0136
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0347 0.0606
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0118 0.0136
Brugia malayi MH2 domain containing protein 0.0126 0.1365 0.1565
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Echinococcus granulosus neuropeptide receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0246 0.0278
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0284 0.2326
Schistosoma mansoni opsin-like receptor 0.0024 0.0118 0.0139
Brugia malayi neuropeptide F receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0347 0.0398
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0118 0.0136
Brugia malayi nuclear receptor RXR 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi Pyruvate kinase, muscle isozyme 0.0068 0.0662 0.076
Onchocerca volvulus 0.0024 0.0118 0.0207
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi hypothetical protein 0.0129 0.1405 0.1612
Brugia malayi mbt repeat family protein 0.0049 0.0424 0.0486
Brugia malayi beta-lactamase family protein 0.0037 0.0284 0.0325
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Brugia malayi Dopamine receptor protein 2 0.0024 0.0118 0.0136
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0071 0.0082
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1591 0.1591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.01 0.1048 0.1202
Echinococcus granulosus microtubule associated protein 2 0.0708 0.8484 0.973
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis geminin 0.0347 0.4073 0.4073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0347 0.0398
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0424 0.0486
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0212 0.0243
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0118 0.0136
Echinococcus granulosus orexin receptor type 2 0.0024 0.0118 0.0136
Plasmodium vivax vivapain-1 0.0114 0.1219 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2184 0.2505
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0587 0.8864
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0079 0.009
Brugia malayi pyruvate kinase 0.0014 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni amine GPCR 0.0024 0.0118 0.0139
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0118 0.0136
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.042 0.0476
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0173 0.0198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0212 0.0212
Onchocerca volvulus 0.0024 0.0118 0.0207
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.0409 0.0469
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.8484 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0347 0.0398
Onchocerca volvulus 0.0049 0.0424 0.0741
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0587 0.0673
Brugia malayi AMP-binding enzyme family protein 0.0049 0.042 0.0482
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0568 0.067
Echinococcus granulosus expressed conserved protein 0.0095 0.0986 0.1131
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0118 0.0118
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus GPCR family 2 0.0032 0.0212 0.0243
Schistosoma mansoni histamine h1 receptor 0.0024 0.0118 0.0139
Brugia malayi beta-lactamase family protein 0.0037 0.0284 0.0325
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0246 0.0279
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0118 0.0136
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.0325
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.1061 0.1216
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0662 0.1158
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0347 0.0398
Echinococcus granulosus fmrfamide receptor 0.0024 0.0118 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0662 0.076
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.042 0.1203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis survival motor neuron protein 1 0.0727 0.8719 0.8719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Echinococcus multilocularis pyruvate kinase 0.0035 0.0255 0.0255
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0071 0.0082
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1617 0.183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0347 0.0347
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0662 1
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0737 0.8835 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0424 0.0486
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0118 0.0136
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Schistosoma mansoni biogenic amine receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis GPCR, family 2 0.0032 0.0212 0.0212
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.1061 0.3037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0118 0.0139
Onchocerca volvulus 0.0061 0.0568 0.0993
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.205 0.3584
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0118 0.0136
Echinococcus multilocularis S formylglutathione hydrolase 0.0031 0.0208 0.0208
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.042 0.1203
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.027 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus granulosus pyruvate kinase 0.0035 0.0255 0.0292
Onchocerca volvulus 0.0037 0.0284 0.0496
Schistosoma mansoni zinc finger protein 0.002 0.0071 0.0084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0507 0.0597
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.042 0.0476
Echinococcus granulosus g protein coupled receptor 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor E75 0.002 0.0071 0.0082
Onchocerca volvulus 0.0043 0.0347 0.0606
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.042 0.0476
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0118 0.0139
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0071 0.0071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0118 0.0118
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0118 0.0118
Leishmania major pyruvate kinase 0.0068 0.0662 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0155 0.1721 0.1974
Brugia malayi nuclear hormone receptor 0.0043 0.0347 0.0398
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi ecdysteroid receptor 0.0043 0.0347 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0347 0.0398
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0507 0.0581
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0587 0.0665
Mycobacterium tuberculosis Conserved protein 0.0031 0.0208 0.0236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0284 0.0321
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi nuclear receptor RXR 0.0023 0.0101 0.0116
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0295 0.0295
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0662 0.076
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0284 0.0321
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0347 0.0347
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0118 0.0136
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0507 0.0581
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0173 0.0198
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0507 0.0507
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0071 0.0082
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi hypothetical protein 0.002 0.0071 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0071 0.0082
Toxoplasma gondii pyruvate kinase PyK1 0.0068 0.0662 1
Brugia malayi Serotonin receptor 0.0024 0.0118 0.0136
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0347 0.0606
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0424 0.05
Brugia malayi hypothetical protein 0.0023 0.0101 0.0116
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Brugia malayi Pyruvate kinase, M2 isozyme 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0568 0.0652
Loa Loa (eye worm) hypothetical protein 0.0068 0.0661 0.0759
Loa Loa (eye worm) hypothetical protein 0.0068 0.0662 0.076
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor E75 0.002 0.0071 0.0082
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0284 0.0496
Brugia malayi Esterase D 0.0031 0.0208 0.0239
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0118 0.0136
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0118 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0347 0.0398
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0347 0.0409
Mycobacterium tuberculosis Probable conserved exported protein 0.0031 0.0208 0.0236
Onchocerca volvulus 0.0155 0.1721 0.301
Plasmodium vivax SET domain protein, putative 0.0061 0.0568 0.466
Echinococcus multilocularis sex peptide receptor 0.0024 0.0118 0.0118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0295 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0031 0.0208 0.0236
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0118 0.0118
Onchocerca volvulus 0.0024 0.0118 0.0207
Brugia malayi G-protein coupled receptor 0.0024 0.0118 0.0136
Brugia malayi ORL1-like opioid receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0118 0.0136
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0347 0.0347
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1365 0.1565
Mycobacterium ulcerans hypothetical protein 0.0031 0.0208 0.0236
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0071 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Plasmodium falciparum cysteine proteinase falcipain 1 0.0114 0.1219 1
Onchocerca volvulus 0.0482 0.5719 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0402 0.0402
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0031 0.0208 0.0596
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0118 0.0136
Brugia malayi Pre-SET motif family protein 0.0061 0.0568 0.0652
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0347 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0347 0.0398
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0071 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0118 0.0136
Schistosoma mansoni opsin-like receptor 0.0024 0.0118 0.0139
Brugia malayi Dopamine receptor 0.0024 0.0118 0.0136
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0002 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0662 0.1158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0347 0.0398
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0187 0.2113 0.2423
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0118 0.0118
Onchocerca volvulus 0.0049 0.042 0.0735
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0118 0.0118
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0347 0.0409
Brugia malayi G-protein coupled receptor 0.0024 0.0118 0.0136
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.3493 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Loa Loa (eye worm) beta-lactamase 0.0037 0.0284 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Brugia malayi nuclear receptor NHR-88 0.002 0.0071 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0347 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Onchocerca volvulus 0.0024 0.0118 0.0207
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0118 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0212 0.0243
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0355 0.0355
Mycobacterium ulcerans hypothetical protein 0.0049 0.042 0.0476
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0295 0.0334
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0118 0.0118
Echinococcus granulosus pyruvate kinase 0.0068 0.0662 0.076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0402 0.0461
Onchocerca volvulus 0.0024 0.0118 0.0207
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0295 0.4461
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0118 0.0118
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0284 0.4282
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0118 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0347 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0347 0.0398
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0118 0.0136
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0198
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0118 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.027 0.031
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.1061 0.1061
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1617 0.183
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1365 0.1565
Schistosoma mansoni survival motor neuron protein 0.0148 0.1639 0.1932
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0541 0.062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0347 0.0347
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0118 0.0207
Plasmodium falciparum pyruvate kinase 0.0068 0.0662 0.5434
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Schistosoma mansoni pyruvate kinase 0.0068 0.0662 0.0781
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0347 0.0398
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Plasmodium vivax unspecified product 0.0114 0.1219 1
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0031 0.0208 0.0236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0118 0.0139
Echinococcus granulosus neuropeptide receptor 0.0024 0.0118 0.0136
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0118 0.0136
Plasmodium vivax pyruvate kinase, putative 0.0068 0.0662 0.5434
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0662 0.076
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0173 0.0198
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0737 0.8835 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1048 0.1202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0347 0.0398
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0071 0.0082
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0255 0.2091
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.042 0.0476
Echinococcus multilocularis pyruvate kinase 0.0068 0.0662 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0355 0.0621
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0347 0.0409
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0255 0.3849
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0118 0.0118
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0347 0.0409
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.042 0.6344
Loa Loa (eye worm) hypothetical protein 0.0028 0.0167 0.0191
Schistosoma mansoni hypothetical protein 0.0024 0.0118 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3493 0.6107
Echinococcus multilocularis expressed conserved protein 0.0095 0.0986 0.0986
Onchocerca volvulus Huntingtin homolog 0.0129 0.1405 0.2457
Entamoeba histolytica hypothetical protein 0.0037 0.0283 0.0811
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0347 0.0398
Toxoplasma gondii ABC1 family protein 0.0037 0.0284 0.4282
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0347 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Mycobacterium tuberculosis Possible conserved membrane protein 0.0031 0.0208 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0284 0.0334
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni inositol monophosphatase 0.0038 0.0295 0.0348
Schistosoma mansoni lamin 0.0028 0.0173 0.0204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0284 0.0321
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0118 0.0136
Brugia malayi ecdysone receptor 0.002 0.0071 0.0082
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0347 0.0398
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0101 0.0116
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0071 0.0125
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0347 0.0398
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.042 0.0476
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0295 0.0339
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0587 0.0665
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0212 0.0212
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0118 0.0139
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0424 0.05
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.0409 0.1171
Echinococcus multilocularis pyruvate kinase 0.0068 0.0662 0.0662
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0118 0.0118
Leishmania major pyruvate kinase 0.0068 0.0662 1
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0031 0.0208 0.0236
Echinococcus multilocularis pyruvate kinase 0.0054 0.0486 0.0486
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0587 0.8864
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0661 0.0759
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0284 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0118 0.0139
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0295 0.5
Loa Loa (eye worm) esterase D 0.0031 0.0208 0.0239
Schistosoma mansoni pyruvate kinase 0.0068 0.0662 0.0781
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0031 0.0208 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0347 0.0409
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0118 0.0118
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0568 0.0568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Mycobacterium leprae Probable lipase LipE 0.0037 0.0284 0.0321
Brugia malayi Pre-SET motif family protein 0.0423 0.5004 0.5739
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0284 0.0321
Schistosoma mansoni hypothetical protein 0.0032 0.0212 0.025
Echinococcus granulosus lamin 0.0028 0.0173 0.0198
Echinococcus granulosus pyruvate kinase 0.0035 0.0255 0.0292
Schistosoma mansoni lamin 0.0028 0.0173 0.0204
Mycobacterium tuberculosis Conserved protein 0.0037 0.0284 0.0321
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0347 0.0398
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0031 0.0208 0.0236
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0082
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0118 0.0136
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0284 0.0321
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0071 0.0125
Echinococcus granulosus geminin 0.0347 0.4073 0.4671
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0347 0.0347
Brugia malayi mbt repeat family protein 0.0049 0.0424 0.0486
Mycobacterium ulcerans lipase LipD 0.0037 0.0284 0.0321
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0284 0.0321
Plasmodium vivax unspecified product 0.0106 0.1127 0.924
Loa Loa (eye worm) hypothetical protein 0.0043 0.0347 0.0398
Loa Loa (eye worm) hypothetical protein 0.0049 0.042 0.0482
Loa Loa (eye worm) hypothetical protein 0.0023 0.0101 0.0116
Brugia malayi GnHR receptor homolog 0.0024 0.0118 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0049 0.0424 0.0486
Brugia malayi hypothetical protein 0.0024 0.0118 0.0136
Schistosoma mansoni hypothetical protein 0.0297 0.3464 0.4083
Echinococcus multilocularis pyruvate kinase 0.0035 0.0255 0.0255
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0347 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0347 0.0398
Echinococcus granulosus survival motor neuron protein 1 0.0727 0.8719 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0118 0.0139
Echinococcus multilocularis neuropeptide s receptor 0.0509 0.6051 0.6051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0136
Giardia lamblia Pyruvate kinase 0.0068 0.0662 0.1259
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0042 0.0336 0.0396
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0118 0.0139
Schistosoma mansoni neuropeptide receptor 0.0024 0.0118 0.0139
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0347 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0118 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0568 0.067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0212 0.0243
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0071 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0587 0.0692
Mycobacterium ulcerans beta-lactamase 0.0037 0.0284 0.0321

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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