Detailed information for compound 587747

Basic information

Technical information
  • TDR Targets ID: 587747
  • Name: 2-[4-[(E)-2-(1-naphthyl)vinyl]pyridin-1-ium-1 -yl]acetic acid
  • MW: 290.336 | Formula: C19H16NO2+
  • H donors: 1 H acceptors: 2 LogP: 4.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[n+]1ccc(cc1)/C=C/c1cccc2c1cccc2
  • InChi: 1S/C19H15NO2/c21-19(22)14-20-12-10-15(11-13-20)8-9-17-6-3-5-16-4-1-2-7-18(16)17/h1-13H,14H2/p+1/b9-8+
  • InChiKey: COJVTPTZQDOKNQ-CMDGGOBGSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-[(E)-2-(1-naphthalenyl)vinyl]-1-pyridin-1-iumyl]acetic acid
  • 2-[4-[(E)-2-naphthalen-1-ylethenyl]pyridin-1-ium-1-yl]ethanoic acid
  • 2-[4-[(E)-2-naphthalen-1-ylethenyl]pyridin-1-ium-1-yl]acetic acid
  • N-(carboxymethyl)-4-(beta-1-naphthylvinyl)pyridinium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0419 0.0425
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0586 0.0595
Onchocerca volvulus 0.003 0.0459 0.0696
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0099 0.0091
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0202 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Schistosoma mansoni hypothetical protein 0.0063 0.1151 0.1242
Schistosoma mansoni cpg binding protein 0.0031 0.0479 0.0472
Mycobacterium leprae Possible regulatory protein 0.0016 0.016 0.5
Echinococcus granulosus cpg binding protein 0.0031 0.0479 0.0472
Brugia malayi hypothetical protein 0.0038 0.0627 0.0637
Schistosoma mansoni ap endonuclease 0.0018 0.0202 0.0154
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0099 0.01
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0099 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Echinococcus multilocularis GPCR, family 2 0.0063 0.1151 0.1144
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0974 0.099
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0099 0.01
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0038 0.0621 0.0631
Loa Loa (eye worm) hypothetical protein 0.0081 0.1549 0.1574
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0202 0.0983
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0586 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0202 0.0983
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.1859 0.1888
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0586 0.0578
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0099 0.01
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0202 0.0194
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0099 0.01
Onchocerca volvulus 0.0028 0.0419 0.0619
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0419 0.0619
Schistosoma mansoni hypothetical protein 0.0096 0.1859 0.2053
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0151 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Loa Loa (eye worm) Smad1 0.0016 0.0151 0.0154
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0166 0.0158
Brugia malayi GoLoco motif family protein 0.0012 0.0067 0.0068
Schistosoma mansoni smad 0.0016 0.0151 0.0096
Entamoeba histolytica hypothetical protein 0.0147 0.2953 1
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0419 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0419 0.0425
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0202 0.0454
Loa Loa (eye worm) hypothetical protein 0.0038 0.0619 0.0629
Brugia malayi hypothetical protein 0.0013 0.0099 0.01
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.2953 0.2947
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0419 0.0425
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0166 0.0158
Echinococcus multilocularis aryl hydrocarbon receptor 0.0054 0.0974 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0419 0.0425
Onchocerca volvulus 0.0081 0.1549 0.2803
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0443 0.0451
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0099 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0133 0.0135
Brugia malayi follicle stimulating hormone receptor 0.0235 0.4848 0.4925
Loa Loa (eye worm) hypothetical protein 0.0015 0.0133 0.0135
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0419 0.0425
Schistosoma mansoni intermediate filament proteins 0.0081 0.1549 0.1698
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0419 0.0411
Echinococcus multilocularis Smad4 0.0016 0.0151 0.0143
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0099 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1151 0.1144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0621 0.0631
Echinococcus multilocularis lamin 0.0081 0.1549 0.1542
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0008 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0419 0.0411
Brugia malayi hypothetical protein 0.0469 0.9844 1
Brugia malayi MH2 domain containing protein 0.0232 0.4777 0.4853
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0419 0.0425
Echinococcus granulosus lamin 0.0081 0.1549 0.1542
Brugia malayi hypothetical protein 0.0255 0.5272 0.5356
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0419 0.0425
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0419 0.0425
Brugia malayi hypothetical protein 0.003 0.0459 0.0466
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0586 0.0595
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1151 0.1144
Schistosoma mansoni smad1 5 8 and 0.0016 0.0151 0.0096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0419 0.0411
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0099 0.0091
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0722 0.0715
Echinococcus granulosus dnaJ subfamily B 0.042 0.8793 0.8792
Echinococcus granulosus G protein signaling modulator 2 0.0012 0.0067 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0419 0.0425
Brugia malayi CXXC zinc finger family protein 0.0029 0.0443 0.0451
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0099 0.0091
Loa Loa (eye worm) hypothetical protein 0.003 0.0459 0.0466
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0419 0.0411
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0133 0.0135
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0419 0.0403
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Brugia malayi conserved hypotetical protein 0.0013 0.0099 0.01
Brugia malayi MH1 domain containing protein 0.0016 0.0151 0.0154
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0202 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0651 0.0643
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1082 0.1163
Schistosoma mansoni hypothetical protein 0.0063 0.1151 0.1242
Schistosoma mansoni hypothetical protein 0.0024 0.0323 0.0294
Brugia malayi intermediate filament protein 0.0081 0.1549 0.1574
Schistosoma mansoni hypothetical protein 0.042 0.8793 1
Loa Loa (eye worm) intermediate filament protein 0.0081 0.1549 0.1574
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0151 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0133 0.0075
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0586 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1082 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0099 0.01
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.1549 0.1574
Loa Loa (eye worm) hypothetical protein 0.008 0.1517 0.1541
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0419 0.0411
Echinococcus multilocularis caspase 2 0.003 0.0459 0.0451
Brugia malayi hypothetical protein 0.0013 0.0099 0.01
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0038 0.0627 0.0642
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0419 0.0403
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0586 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0419 0.0411
Brugia malayi hypothetical protein 0.0038 0.0621 0.0631
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0133 0.0075
Loa Loa (eye worm) hypothetical protein 0.0054 0.0968 0.0984
Loa Loa (eye worm) hypothetical protein 0.0038 0.0621 0.0631
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0151 0.0143
Echinococcus multilocularis lamin dm0 0.0081 0.1549 0.1542
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1151 0.1144
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0419 0.0403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0419 0.0411
Echinococcus granulosus caspase 2 0.003 0.0459 0.0451
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0099 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1082 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0202 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.4848 0.4925
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0419 0.0403
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0743 0.0755
Echinococcus multilocularis neuropeptide s receptor 0.0476 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1151 0.1144
Brugia malayi steroid hormone receptor 0.0028 0.0419 0.0425
Loa Loa (eye worm) hypothetical protein 0.0255 0.5272 0.5356
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0419 0.0403
Echinococcus multilocularis cpg binding protein 0.0031 0.0479 0.0472
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.4042 0.4106
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0099 0.0091
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0586 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0038 0.0627 0.0637
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0099 0.0091
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0099 0.0091
Schistosoma mansoni survival motor neuron protein 0.0096 0.1859 0.2053
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1151 0.1169
Loa Loa (eye worm) DR-78 0.0013 0.0099 0.01
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0202 0.0194
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.4042 0.4106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0419 0.0425
Schistosoma mansoni nuclear receptor 0.0013 0.0099 0.0036
Brugia malayi PAS domain containing protein 0.0016 0.016 0.0162
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0133 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0419 0.0425
Brugia malayi nuclear receptor NHR-67 0.0013 0.0099 0.01
Schistosoma mansoni ap endonuclease 0.0018 0.0202 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0419 0.0425
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0621 0.0631
Echinococcus granulosus Smad4 0.0016 0.0151 0.0143
Brugia malayi nuclear receptor RXR 0.0013 0.0099 0.01
Schistosoma mansoni hypothetical protein 0.0063 0.1151 0.1242
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.115 0.1241
Schistosoma mansoni cpg binding protein 0.0031 0.0479 0.0472
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0419 0.0619
Entamoeba histolytica hypothetical protein 0.0147 0.2953 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0419 0.0425
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0016 0.016 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0419 0.0425
Brugia malayi MH1 domain containing protein 0.0016 0.0151 0.0154
Schistosoma mansoni hypothetical protein 0.0135 0.2704 0.3022
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0419 0.0411
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0586 0.0595
Schistosoma mansoni hypothetical protein 0.003 0.0459 0.0449
Brugia malayi nuclear hormone receptor 0.0013 0.0099 0.01
Schistosoma mansoni Smad4 0.0016 0.0151 0.0096
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0099 0.0091
Onchocerca volvulus Protein cycle homolog 0.0038 0.0627 0.1021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0419 0.0403
Brugia malayi nuclear receptor NHR-88 0.0013 0.0099 0.01
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0586 0.4619
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.4777 0.4853
Brugia malayi MH2 domain containing protein 0.0016 0.0151 0.0154
Schistosoma mansoni zinc finger protein 0.0013 0.0099 0.0036
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0099 0.0091
Brugia malayi MH2 domain containing protein 0.0016 0.0151 0.0154
Echinococcus multilocularis neuropeptide receptor A26 0.0476 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0586 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0419 0.0425
Loa Loa (eye worm) hypothetical protein 0.0016 0.016 0.0162
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0099 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.4777 0.4853
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0419 0.0425
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0586 0.0578
Loa Loa (eye worm) hypothetical protein 0.0038 0.0621 0.0631
Brugia malayi hypothetical protein 0.0147 0.2953 0.3
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0586 0.0578
Brugia malayi nuclear receptor RXR 0.0015 0.0133 0.0135
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0068
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0202 0.0205
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0419 0.0411
Loa Loa (eye worm) hypothetical protein 0.0015 0.0133 0.0135
Loa Loa (eye worm) hypothetical protein 0.0039 0.0651 0.0661
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0038 0.0627 0.0637
Brugia malayi Raf kinase 0.0042 0.0722 0.0734
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Onchocerca volvulus 0.0029 0.0443 0.0666
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Brugia malayi Smad1 0.0016 0.0151 0.0154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0419 0.0411
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1082 0.1075
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0419 0.0403
Schistosoma mansoni hypothetical protein 0.0147 0.2953 0.3307
Onchocerca volvulus Huntingtin homolog 0.0255 0.5272 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0202 0.0205
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.4042 0.4106
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1082 0.1163
Loa Loa (eye worm) hypothetical protein 0.0469 0.9844 1
Schistosoma mansoni coup transcription factor 0.0028 0.0419 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0419 0.0425
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0459 0.0696
Schistosoma mansoni lamin 0.0081 0.1549 0.1698
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0419 0.0425
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0255 0.5272 0.5356
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0419 0.0425
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0099 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0419 0.0411
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0099 0.0091
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0419 0.0425
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0419 0.0403
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1151 0.1169
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0099 0.0091
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0419 0.0411
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0586 1
Echinococcus granulosus neuropeptide receptor A26 0.0476 1 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0722 0.0715
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1082 1
Brugia malayi hypothetical protein 0.0015 0.0133 0.0135
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.2704 0.2747
Entamoeba histolytica hypothetical protein 0.0147 0.2953 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0586 0.0578
Loa Loa (eye worm) hypothetical protein 0.0038 0.0619 0.0629
Brugia malayi nuclear hormone receptor 0.0028 0.0419 0.0425
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0202 0.5
Brugia malayi GoLoco motif family protein 0.0012 0.0067 0.0068
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0099 0.0036
Entamoeba histolytica hypothetical protein 0.0147 0.2953 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0586 0.1396
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0586 0.0578
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0586 0.0578
Loa Loa (eye worm) hypothetical protein 0.0015 0.0133 0.0135
Echinococcus granulosus smad 0.0016 0.0151 0.0143
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1151 0.1169
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1082 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1082 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0133 0.0135
Schistosoma mansoni nuclear receptor 0.0013 0.0099 0.0036
Onchocerca volvulus 0.0081 0.1549 0.2803
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0099 0.01
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0586 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.2953 0.2947
Schistosoma mansoni single-minded 0.0016 0.016 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0722 0.0751
Schistosoma mansoni smad1 5 8 and 0.0016 0.0151 0.0096
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.1549 0.1574
Echinococcus granulosus GPCR family 2 0.0063 0.1151 0.1144
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0151 0.0096
Echinococcus granulosus aryl hydrocarbon receptor 0.0054 0.0974 0.0967
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0419 0.0403
Echinococcus granulosus survival motor neuron protein 1 0.0469 0.9844 0.9844
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0202 0.0983
Onchocerca volvulus 0.0054 0.0968 0.1681
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0099 0.0091
Loa Loa (eye worm) raf kinase 0.0042 0.0722 0.0734
Brugia malayi ecdysone receptor 0.0013 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0135 0.2704 0.2747
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0419 0.0411
Schistosoma mansoni smad1 5 8 and 0.0016 0.0151 0.0096
Onchocerca volvulus 0.0096 0.1859 0.3402
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0459 0.0449
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0419 0.0425
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0151 0.0143
Schistosoma mansoni cpg binding protein 0.0029 0.0443 0.0431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Brugia malayi hypothetical protein 0.0054 0.0968 0.0984
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0038 0.0627 0.0637
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0459 0.0451
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1082 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0419 0.0425
Brugia malayi tailless protein 0.0013 0.0099 0.01
Loa Loa (eye worm) hypothetical protein 0.0063 0.1151 0.1169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0419 0.0425
Brugia malayi hypothetical protein 0.0015 0.0133 0.0135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0419 0.0411
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0151 0.0154
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0651 0.0643
Onchocerca volvulus Huntingtin homolog 0.0255 0.5272 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0419 0.0411
Loa Loa (eye worm) hypothetical protein 0.003 0.0459 0.0466
Brugia malayi Cell death protein 3 precursor 0.003 0.0459 0.0466
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0202 0.0983
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0743 0.0755
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0133 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0419 0.0403
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0419 0.0619
Loa Loa (eye worm) hypothetical protein 0.0198 0.4042 0.4106
Echinococcus multilocularis survival motor neuron protein 1 0.0469 0.9844 0.9844
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0151 0.0143
Echinococcus multilocularis musashi 0.0081 0.1549 0.1542
Echinococcus granulosus lamin dm0 0.0081 0.1549 0.1542
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0459 0.0451
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0419 0.0411
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0133 0.0125
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0099 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0419 0.0411
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0419 0.0425
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1008 0.9152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0099 0.01
Echinococcus multilocularis smad 0.0016 0.0151 0.0143
Brugia malayi ecdysteroid receptor 0.0028 0.0419 0.0425
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1082 0.1075
Echinococcus multilocularis dnaJ subfamily B 0.042 0.8793 0.8792
Schistosoma mansoni hypothetical protein 0.0063 0.1151 0.1242
Brugia malayi nuclear receptor NHR-88 0.0028 0.0419 0.0425
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0133 0.0135
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.2953 0.3307
Echinococcus multilocularis G protein signaling modulator 2 0.0012 0.0067 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0419 0.0411
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0166 0.0113
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0012 0.0067 0.0068
Echinococcus granulosus intermediate filament protein 0.0081 0.1549 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0586 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0419 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0419 0.0425
Schistosoma mansoni lamin 0.0081 0.1549 0.1698

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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