Detailed information for compound 587795

Basic information

Technical information
  • TDR Targets ID: 587795
  • Name: 5H-chromeno[5,6-c]cinnoline-2,11-dione
  • MW: 264.236 | Formula: C15H8N2O3
  • H donors: 1 H acceptors: 2 LogP: 1.13 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)cc(=O)c1c2[nH]nc2c1cccc2
  • InChi: 1S/C15H8N2O3/c18-11-7-12-9(5-6-13(19)20-12)15-14(11)8-3-1-2-4-10(8)16-17-15/h1-7,17H
  • InChiKey: RFAMHHRPKMRQBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5H-[1]benzopyrano[5,6-c]cinnoline-2,11-dione
  • 5H-chromeno[5,6-c]cinnoline-2,11-quinone
  • necatorin
  • 89915-35-5
  • 2H-Benzo(c)pyrano(2,3-h)cinnolin-2-one, 11-hydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.3055 0.3055
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Schistosoma mansoni kinase 0.005 0.0777 0.0777
Mycobacterium tuberculosis Probable reductase 0.0116 0.235 0.8837
Loa Loa (eye worm) hypothetical protein 0.0124 0.2522 0.4931
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.1469 0.624
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0829 0.305
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0758 0.1482
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0303 0.0593
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0042 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0348 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0348 0.068
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0539 0.0633
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.257 0.257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0758 0.1482
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0448 0.0448
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.1469 0.1469
Brugia malayi follicle stimulating hormone receptor 0.0234 0.5114 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0449 0.0449
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0348 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0348 0.068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0348 0.068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.2338 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0448 0.2274
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0348 0.0348
Echinococcus granulosus geminin 0.0166 0.3511 0.3511
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0539 0.3552
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0348 0.0348
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.2602 0.2602
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0623 0.2582
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0529 0.1034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Brugia malayi PHD-finger family protein 0.0029 0.0303 0.0593
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0529 0.0529
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0448 0.2274
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0812 0.5443
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0829 0.0829
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.3339 0.3339
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0539 0.2763
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0303 0.1918
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.3055 0.5973
Giardia lamblia PHD finger protein 15 0.0029 0.0303 0.1492
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2958 0.2958
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0448 0.2274
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.188 0.188
Loa Loa (eye worm) hypothetical protein 0.005 0.0798 0.1561
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0623 0.3218
Loa Loa (eye worm) hypothetical protein 0.0124 0.2522 0.4931
Giardia lamblia Kinase, PLK 0.0097 0.1881 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.1469 1
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0348 0.0348
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0348 0.0348
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.235 0.8837
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0448 0.2274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0348 0.0348
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0348 0.068
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0348 0.0348
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0348 0.0348
Schistosoma mansoni cpg binding protein 0.0063 0.1085 0.1085
Loa Loa (eye worm) glutathione reductase 0.0051 0.0812 0.1587
Trypanosoma brucei trypanothione reductase 0.0051 0.0812 0.4234
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0623 0.4137
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0348 0.0348
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.1469 0.1469
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0042 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.235 0.8837
Loa Loa (eye worm) hypothetical protein 0.0033 0.0395 0.0772
Echinococcus granulosus cyclin dependent kinase 6 0.0196 0.4232 0.4232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0348 0.068
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0448 0.2274
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0812 0.4234
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.1006 0.1966
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.2656 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0448 0.2274
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0348 0.068
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0348 0.0348
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0348 0.0348
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0251 0.1553
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0529 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0348 0.068
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0812 0.2985
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0812 0.1587
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0524 0.0524
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0448 0.2274
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.1881 0.3677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0348 0.068
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0348 0.0348
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0303 0.1197
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0348 0.068
Schistosoma mansoni hypothetical protein 0.0166 0.3511 0.3511
Schistosoma mansoni thyroid hormone receptor 0.0159 0.3339 0.3339
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.188 0.188
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0348 0.068
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0348 0.0159
Leishmania major trypanothione reductase 0.0051 0.0812 0.4234
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0448 0.2274
Loa Loa (eye worm) hypothetical protein 0.0049 0.0758 0.1482
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0348 0.068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0348 0.0159
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.3386 0.3386
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.3055 0.3055
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0524 0.0524
Onchocerca volvulus 0.0031 0.0348 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0348 0.068
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0348 0.068
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0623 0.3218
Brugia malayi nuclear hormone receptor 0.0031 0.0348 0.068
Entamoeba histolytica hypothetical protein 0.0039 0.0524 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0348 0.068
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0348 0.0348
Onchocerca volvulus 0.0059 0.1006 0.2521
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0829 0.0829
Schistosoma mansoni cpg binding protein 0.0063 0.1085 0.1085
Echinococcus multilocularis dnaJ subfamily B 0.0442 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0448 0.0448
Brugia malayi hypothetical protein 0.0148 0.3089 0.604
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0027 0.0027
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0758 0.1482
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.5114 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0812 0.0812
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0348 0.068
Echinococcus granulosus cpg binding protein 0.0063 0.1085 0.1085
Brugia malayi CXXC zinc finger family protein 0.0059 0.1006 0.1966
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0448 0.2274
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1881 1
Plasmodium falciparum thioredoxin reductase 0.0051 0.0812 0.5443
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0251 0.1553
Echinococcus multilocularis geminin 0.0166 0.3511 0.3511
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.3386 0.3386
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0747 0.3886
Trypanosoma brucei polo-like protein kinase 0.0097 0.1881 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0303 0.0593
Brugia malayi Cytochrome P450 family protein 0.0053 0.085 0.1661
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.1881 0.3677
Schistosoma mansoni cpg binding protein 0.0059 0.1006 0.1006
Echinococcus granulosus peregrin 0.0033 0.0388 0.0388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0623 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0348 0.068
Schistosoma mansoni hypothetical protein 0.0039 0.0524 0.0524
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Toxoplasma gondii hypothetical protein 0.0027 0.0251 0.0969
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.286 0.286
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1413 0.1413
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.3386 0.6621
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0524 0.0524
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.235 0.8729
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0263 0.0515
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0812 0.0812
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0184 0.0184
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0348 0.0159
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0348 0.0348
Brugia malayi jmjC domain containing protein 0.0096 0.188 0.3675
Loa Loa (eye worm) acetyltransferase 0.0146 0.3055 0.5973
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0448 0.1824
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.2656 1
Onchocerca volvulus 0.0093 0.1794 0.5352
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.1469 0.1469
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0529 0.0529
Schistosoma mansoni hypothetical protein 0.0166 0.3511 0.3511
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0348 0.068
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0348 0.0348
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.235 0.8837
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0448 0.2274
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.085 0.1661
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1881 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0348 0.068
Schistosoma mansoni hypothetical protein 0.0127 0.2602 0.2602
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0348 0.0348
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.1881 0.1881
Echinococcus multilocularis peregrin 0.0033 0.0388 0.0388
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0027 0.0053
Brugia malayi Probable ClpP-like protease 0.0079 0.1469 0.2872
Schistosoma mansoni alpha glucosidase 0.0036 0.0448 0.0448
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0829 0.305
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.1881 0.5662
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0348 0.068
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.2656 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0348 0.0348
Echinococcus multilocularis cyclin dependent kinase 6 0.0196 0.4232 0.4232
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0348 0.0348
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0251 0.1553
Plasmodium falciparum phd finger protein, putative 0.0029 0.0303 0.1918
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0448 0.0877
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.4232 0.4232
Schistosoma mansoni hypothetical protein 0.0029 0.0303 0.0303
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0303 0.0303
Brugia malayi nuclear receptor NHR-88 0.0031 0.0348 0.068
Entamoeba histolytica hypothetical protein 0.0039 0.0524 0.0531
Plasmodium vivax glutathione reductase, putative 0.0051 0.0812 0.5443
Brugia malayi hypothetical protein 0.0124 0.2522 0.4931
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0348 0.068
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.235 0.8837
Echinococcus multilocularis cpg binding protein 0.0063 0.1085 0.1085
Brugia malayi jmjC domain containing protein 0.0039 0.0529 0.1034
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.3386 0.6621
Brugia malayi glutathione reductase 0.0051 0.0812 0.1587
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Brugia malayi Thioredoxin reductase 0.0051 0.0812 0.1587
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0303 0.1197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0348 0.068
Schistosoma mansoni hypothetical protein 0.0033 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0448 0.0877
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0575 0.0575
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.1881 0.1881
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.2602 0.2602
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0079 0.1469 0.2872
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0623 0.2582
Schistosoma mansoni thyroid hormone receptor 0.0159 0.3339 0.3339
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0395 0.0772
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.1469 0.5064
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0348 0.0348
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0042 0.0042
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0303 0.0303
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.1881 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1041 0.2036
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.2656 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.235 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Brugia malayi steroid hormone receptor 0.0031 0.0348 0.068
Onchocerca volvulus Huntingtin homolog 0.0124 0.2522 0.7964
Brugia malayi hypothetical protein 0.0039 0.0524 0.1026
Plasmodium falciparum glutathione reductase 0.0051 0.0812 0.5443
Brugia malayi ecdysteroid receptor 0.0031 0.0348 0.068
Schistosoma mansoni alpha-glucosidase 0.0138 0.286 0.286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0348 0.0348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0348 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1881 0.1881
Trypanosoma brucei glucosidase, putative 0.0036 0.0448 0.2274
Loa Loa (eye worm) hypothetical protein 0.0148 0.3089 0.604
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0829 0.2402
Brugia malayi Bromodomain containing protein 0.0033 0.0388 0.0758
Schistosoma mansoni coup transcription factor 0.0031 0.0348 0.0348
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0448 0.2274
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1881 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0348 0.0348
Entamoeba histolytica hypothetical protein 0.0039 0.0524 0.0531
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.1469 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0348 0.068
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0575 0.0575
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.1881 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0303 0.0303
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0348 0.068
Toxoplasma gondii thioredoxin reductase 0.0051 0.0812 0.3396
Schistosoma mansoni hypothetical protein 0.0442 1 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0348 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0747 0.3886
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0348 0.0348
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0348 0.0348
Entamoeba histolytica hypothetical protein 0.0039 0.0524 0.0531
Onchocerca volvulus 0.0148 0.3089 1
Onchocerca volvulus Huntingtin homolog 0.0124 0.2522 0.7964
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0348 0.0348
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0348 0.0348
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.1469 0.624
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0448 0.2274

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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