Detailed information for compound 587909

Basic information

Technical information
  • TDR Targets ID: 587909
  • Name: myricanol-15-glucoside
  • MW: 520.569 | Formula: C27H36O10
  • H donors: 6 H acceptors: 6 LogP: 2.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](Oc2c3CCCC[C@@H](O)CCc4cc(c(c3)c(c2OC)OC)c(O)cc4)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C27H36O10/c1-34-25-18-12-15(5-3-4-6-16(29)9-7-14-8-10-19(30)17(18)11-14)24(26(25)35-2)37-27-23(33)22(32)21(31)20(13-28)36-27/h8,10-12,16,20-23,27-33H,3-7,9,13H2,1-2H3/t16-,20-,21-,22+,23-,27+/m1/s1
  • InChiKey: NPSYWDNXSMBWKP-LMNFFIPXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 90052-02-1
  • beta-D-Glucopyranoside, 3,9-dihydroxy-16,17-dimethoxytricyclo(12.3.1.1(2,6))nonadeca-1(18),2,4,6(19),14,16-hexaen-15-yl, (R)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0013 0.0134 0.0157
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Giardia lamblia Replication factor C, subunit 1 0.001 0.0086 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0551 0.3699
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0395 0.0856
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0422 0.2795
Onchocerca volvulus 0.001 0.0078 0.0394
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0048 0.0036
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0078 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0086 0.0449
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0213 0.4378 0.6091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0259 0.0545
Mycobacterium leprae Probable lipase LipE 0.0075 0.1453 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0259 0.0332
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1004 0.2255
Echinococcus granulosus nAChR subunit 0.0019 0.0259 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0213 0.4378 0.6091
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.1453 1
Echinococcus multilocularis nAChR subunit 0.0019 0.0259 0.0332
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0259 0.0545
Echinococcus multilocularis tar DNA binding protein 0.0213 0.4378 0.6091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.1453 0.2001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0261 0.0335
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0875 0.1194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Echinococcus granulosus importin subunit beta 1 0.0032 0.0551 0.074
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0008 0.0036 0.0032
Schistosoma mansoni hypothetical protein 0.0345 0.7174 1
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0375 0.0494
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0261 0.1674
Schistosoma mansoni ferritin 0.0009 0.0055 0.0047
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0259 0.0332
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.1453 0.1453
Loa Loa (eye worm) glutamate receptor 0.0019 0.0277 0.0357
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0259 0.0332
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0086 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0875 0.1194
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.1453 0.1453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0875 0.1194
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0395 0.2607
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0078 0.0129
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0395 0.9328
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0024 0.0375 0.0494
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0086 0.0449
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.1453 0.2001
Onchocerca volvulus 0.0009 0.0048 0.0181
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0259 0.0332
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0022 0.0022
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0395 0.2607
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0395 0.2607
Mycobacterium ulcerans hypothetical protein 0.0075 0.1453 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.1453 0.3285
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0875 0.1194
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1004 0.1373
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Leishmania major hypothetical protein, conserved 0.0075 0.1453 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0048 0.006
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0086 0.0449
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0226 0.0286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0395 0.0395
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0078 0.0079
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0259 0.0332
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0395 0.0395
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0259 0.0332
Mycobacterium ulcerans lipase LipD 0.0075 0.1453 1
Brugia malayi DKFZp564C0469 protein 0.001 0.0086 0.0147
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0259 0.0332
Schistosoma mansoni topbp1 0.001 0.0086 0.009
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0259 0.0332
Schistosoma mansoni nAChR subunit 0.0009 0.0048 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0226 0.0286
Brugia malayi beta-lactamase family protein 0.0075 0.1453 0.3285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0048 0.0036
Schistosoma mansoni hypothetical protein 0.0008 0.0036 0.002
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0226 0.047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0395 0.9328
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0259 0.0545
Echinococcus multilocularis snurportin 1 0.0345 0.7174 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.024 0.024
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0086 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.024 0.024
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0078 0.0079
Echinococcus granulosus geminin 0.0174 0.3557 0.4943
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0086 0.0147
Echinococcus granulosus metabotropic glutamate receptor 5 0.0024 0.0375 0.0494
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0395 0.2607
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Echinococcus multilocularis GPCR, family 2 0.0017 0.0226 0.0286
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.009
Onchocerca volvulus 0.0019 0.0259 0.1659
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0259 0.0545
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0048 0.006
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0086 0.0449
Loa Loa (eye worm) hypothetical protein 0.0024 0.0375 0.0494
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.1453 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0395 0.2607
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0395 0.9328
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Schistosoma mansoni hypothetical protein 0.0174 0.3557 0.4943
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0086 0.1214
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0019 0.0277 0.0357
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0022
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0551 0.3699
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0259 0.0332
Onchocerca volvulus 0.0019 0.0259 0.1659
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0422 0.2795
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Loa Loa (eye worm) TAR-binding protein 0.0213 0.4378 0.6091
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0259 0.0332
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0086 0.1606
Brugia malayi hypothetical protein 0.001 0.0086 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.0261 0.0335
Onchocerca volvulus 0.0019 0.0259 0.1659
Toxoplasma gondii ABC1 family protein 0.0075 0.1453 1
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.1453 0.1453
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0086 0.0449
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0048 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0213 0.4378 0.6091
Schistosoma mansoni hypothetical protein 0.0174 0.3557 0.4943
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.1453 0.2001
Schistosoma mansoni apoferritin-2 0.0009 0.0055 0.0047
Loa Loa (eye worm) RNA binding protein 0.0213 0.4378 0.6091
Loa Loa (eye worm) hypothetical protein 0.0054 0.1004 0.1373
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0226 0.0286
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0048 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0875 0.1194
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0008 0.0036 0.002
Echinococcus multilocularis ferritin 0.0009 0.0055 0.0047
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0259 0.0545
Brugia malayi beta-lactamase 0.0075 0.1453 0.3285
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0259 0.0545
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1453 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.0522
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0013 0.0134 0.0157
Onchocerca volvulus 0.0009 0.0048 0.0181
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0259 0.0332
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0055 0.0055
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0048 0.0036
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0086 0.0147
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1453 1
Schistosoma mansoni hypothetical protein 0.0017 0.0226 0.0286
Mycobacterium ulcerans beta-lactamase 0.0075 0.1453 1
Brugia malayi hypothetical protein 0.0009 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.0522
Echinococcus granulosus nibrin 0.001 0.0086 0.009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0075 0.1453 0.2001
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0086 0.0449
Echinococcus granulosus GPCR family 3 C terminal 0.0008 0.0036 0.002
Onchocerca volvulus 0.001 0.0078 0.0394
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0022 0.0022
Schistosoma mansoni ferritin 0.0009 0.0055 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0551 0.3699
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0086 0.0449
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0259 0.0545
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.7174 1
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0037 0.0644 0.087
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0134 0.0257
Mycobacterium tuberculosis Conserved protein 0.0075 0.1453 0.1453
Trichomonas vaginalis esterase, putative 0.0075 0.1453 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Loa Loa (eye worm) glutamate receptor 0.0013 0.0134 0.0157
Plasmodium falciparum importin beta, putative 0.0032 0.0551 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0422 0.2795
Schistosoma mansoni hypothetical protein 0.0037 0.0644 0.087
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Onchocerca volvulus Putative nachr subunit 0.0019 0.0259 0.1659
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0022 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0226 0.0286
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0259 0.0545
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0075 0.1453 0.2001
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0017 0.0226 0.0286
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0261 0.0261
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0022 0.0022
Loa Loa (eye worm) beta-lactamase 0.0075 0.1453 0.2001
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0551 0.074
Echinococcus multilocularis nibrin 0.001 0.0086 0.009
Echinococcus granulosus GPCR family 2 0.0017 0.0226 0.0286
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0086 0.0449
Schistosoma mansoni ferritin light chain 0.0009 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0259 0.0332
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.1453 0.1453
Echinococcus granulosus nAChR subunit 0.001 0.0078 0.0079
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0259 0.0332
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0875 0.1194
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Brugia malayi hypothetical protein 0.0009 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1453 1
Echinococcus granulosus ferritin 0.0009 0.0055 0.0047
Schistosoma mansoni hypothetical protein 0.0017 0.0226 0.0286
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0013 0.0134 0.0157
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0078 0.0129
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0259 0.0332
Echinococcus granulosus replication factor c subunit 1 0.001 0.0086 0.009
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0259 0.0332
Schistosoma mansoni ferritin light chain 0.0009 0.0055 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1453 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0259 0.0545
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0644 0.1429
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0226 0.047
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0048 0.0036
Echinococcus multilocularis GPCR, family 3, C terminal 0.0008 0.0036 0.002
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.1453 0.1453
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0259 0.0332
Onchocerca volvulus 0.0009 0.0048 0.0181
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0086 0.0449
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0395 0.2607
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0259 0.0545
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1453 1
Schistosoma mansoni apoferritin-2 0.0009 0.0055 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0395 0.2607
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.1453 0.1453
Brugia malayi topoisomerase 0.001 0.0086 0.0147
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0075 0.1453 0.2001
Onchocerca volvulus Poor gastrulation protein homolog 0.0008 0.0036 0.0099
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0086 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0259 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0213 0.4378 0.6091
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0086 0.0449
Brugia malayi beta-lactamase family protein 0.0075 0.1453 0.3285
Brugia malayi Metabotropic glutamate receptor precursor. 0.0013 0.0134 0.0257
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0375 0.081
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0261 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0261 0.1674
Brugia malayi RNA recognition motif domain containing protein 0.0213 0.4378 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1453 1
Brugia malayi Cation transporter family protein 0.0019 0.0259 0.0545
Schistosoma mansoni tar DNA-binding protein 0.0213 0.4378 0.6091
Echinococcus multilocularis geminin 0.0174 0.3557 0.4943
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0259 0.0545
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0048 0.006
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0048 0.006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0086 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0048 0.0036
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0259 0.0332
Mycobacterium tuberculosis Conserved protein 0.0075 0.1453 0.1453
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0259 0.0545
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Trichomonas vaginalis ferritin, putative 0.0009 0.0055 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0086 0.0449
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0259 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0395 0.0856
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0259 0.0332
Schistosoma mansoni ferritin 0.0009 0.0055 0.0047
Schistosoma mansoni nAChR subunit 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.0551 0.074
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0078 0.0079
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1004 0.2255
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.009
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0259 0.0545
Entamoeba histolytica hypothetical protein 0.0026 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0395 0.0522
Mycobacterium leprae conserved hypothetical protein 0.0075 0.1453 1
Brugia malayi hypothetical protein 0.0009 0.0048 0.006
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0048 0.0036
Brugia malayi Cation transporter family protein 0.0019 0.0259 0.0545
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0395 0.0856
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Plasmodium vivax hypothetical protein, conserved 0.0075 0.1453 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0395 0.2607
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0055 0.0236
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.001 0.0086 0.1606
Brugia malayi hypothetical protein 0.001 0.0086 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1453 0.2001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0261 0.0335
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0259 0.0332
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0086 0.0449
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0259 0.0332
Echinococcus granulosus tar DNA binding protein 0.0213 0.4378 0.6091
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0259 0.0332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0875 0.1194
Echinococcus granulosus expressed protein 0.0009 0.0055 0.0047
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0086 0.009
Onchocerca volvulus 0.0019 0.0259 0.1659
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Onchocerca volvulus 0.0075 0.1453 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0075 0.1453 0.2001
Schistosoma mansoni nAChR subunit 0.0019 0.0259 0.0332
Echinococcus granulosus snurportin 1 0.0345 0.7174 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.1453 0.1453
Brugia malayi Cation transporter family protein 0.0019 0.0259 0.0545
Schistosoma mansoni importin beta-1 0.0032 0.0551 0.074
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0008 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0048 0.006
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0086 0.0449
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1453 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1453 0.2001
Treponema pallidum DNA ligase (lig) 0.001 0.0086 1
Onchocerca volvulus 0.001 0.0086 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0395 0.2607
Onchocerca volvulus 0.0025 0.0395 0.2607
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Brugia malayi RNA, U transporter 1 0.0092 0.1813 0.4112
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0259 0.0332
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0259 0.0545
Brugia malayi RNA binding protein 0.0213 0.4378 1
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0008 0.0036 0.0099
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0261 0.4525
Entamoeba histolytica hypothetical protein 0.001 0.0078 0.1409
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0226 0.0286
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0259 0.0332
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0078 0.0129
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0086 0.0449
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0259 0.0332
Brugia malayi hypothetical protein 0.0009 0.0048 0.006
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0075 0.1453 0.2001
Schistosoma mansoni ferritin 0.0009 0.0055 0.0047
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0259 0.0545
Echinococcus multilocularis expressed protein 0.0009 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0086 0.0449
Loa Loa (eye worm) hypothetical protein 0.0019 0.0261 0.0335
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0086 0.0449
Loa Loa (eye worm) hypothetical protein 0.0019 0.0261 0.0335
Onchocerca volvulus 0.0019 0.0259 0.1659
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0086 0.0449
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0019 0.0259 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0213 0.4378 0.6091
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0048 0.0036
Brugia malayi Importin beta-1 subunit 0.0032 0.0551 0.1215
Schistosoma mansoni DNA ligase IV 0.001 0.0086 0.009
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0259 0.0545
Loa Loa (eye worm) hypothetical protein 0.001 0.0078 0.0079
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0078 0.0129
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0022 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1453 0.2001
Brugia malayi TAR-binding protein 0.0213 0.4378 1
Brugia malayi hypothetical protein 0.0009 0.0048 0.006
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0048 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1453 1
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.1453 0.1453
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0259 0.0545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0875 0.1194
Leishmania major importin beta-1 subunit, putative 0.0026 0.0422 0.2795
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0055 0.0236
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0259 0.0332
Schistosoma mansoni hypothetical protein 0.0017 0.0226 0.0286
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0259 0.0332
Onchocerca volvulus 0.0075 0.1453 1
Onchocerca volvulus 0.0075 0.1453 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0875 0.196
Echinococcus multilocularis nAChR subunit 0.001 0.0078 0.0079
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0395 0.2607
Schistosoma mansoni hypothetical protein 0.0017 0.0226 0.0286
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0395 0.2607
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0055 0.0236
Plasmodium vivax importin-beta 2, putative 0.0032 0.0551 0.3699
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0086 0.0449
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0395 0.2607
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.0036
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0259 0.0332
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0395 0.2607
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0422 0.2795
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0259 0.0332
Schistosoma mansoni topbp1 0.001 0.0086 0.009
Onchocerca volvulus 0.0019 0.0259 0.1659

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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