Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.03 | 0.03 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0402 | 0.0402 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0447 | 0.0655 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.03 | 0.03 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0377 | 0.058 |
Onchocerca volvulus | 0.0048 | 0.03 | 0.2769 | |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.03 | 0.03 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0139 | 0.1706 | 0.2627 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.012 | 0.0185 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.2 | 0.406 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0675 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0149 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0675 | 0.0675 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0677 | 1 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0675 | 0.0675 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0334 | 0.4709 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0675 | 0.1039 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 0.4709 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0139 | 0.1706 | 0.2627 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0377 | 0.058 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.0462 | 0.0712 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.03 | 0.2769 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0091 | 0.0091 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0402 | 0.0619 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.03 | 0.0463 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.017 | 0.2192 | 0.2192 |
Onchocerca volvulus | 0.0072 | 0.0675 | 0.6219 | |
Brugia malayi | RNA binding protein | 0.0449 | 0.6492 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0289 | 0.0308 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0149 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.2 | 0.406 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.4697 | 0.4697 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0149 | 0.0229 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.017 | 0.2192 | 0.2192 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.017 | 0.2192 | 0.3376 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0092 | 0.0988 | 0.0988 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0402 | 0.0619 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.012 | 0.012 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0091 | 0.0091 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0289 | 0.0308 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0091 | 0.0091 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0675 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0449 | 0.6492 | 0.6492 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.403 | 0.403 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0402 | 0.0619 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.017 | 0.017 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0675 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.0988 | 0.1521 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.2 | 0.406 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.1706 | 0.1706 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.1706 | 0.1706 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.03 | 0.0463 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0377 | 0.058 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0091 | 0.0141 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0675 | 0.1039 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0188 | 0.246 | 0.246 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0675 | 0.0675 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0677 | 1 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.03 | 0.0463 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0149 | 0.0149 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0675 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.1706 | 0.1706 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.03 | 0.03 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0675 | 0.1039 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0675 | 0.1039 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.03 | 0.03 |
Onchocerca volvulus | 0.0072 | 0.0675 | 0.6219 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.017 | 0.2192 | 0.2192 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0091 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.4697 | 0.4697 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0675 | 0.1039 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.1826 | 0.1826 |
Echinococcus multilocularis | geminin | 0.0333 | 0.4697 | 0.4697 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0149 | 0.0149 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.017 | 0.017 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.031 | 0.0478 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0675 | 0.1039 |
Echinococcus granulosus | geminin | 0.0333 | 0.4697 | 0.4697 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0449 | 0.6492 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0675 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0377 | 0.058 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0675 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0675 | 0.1039 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0675 | 0.1039 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0402 | 0.0402 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0449 | 0.6492 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0449 | 0.6492 | 0.6492 |
Echinococcus granulosus | tar DNA binding protein | 0.0449 | 0.6492 | 0.6492 |
Schistosoma mansoni | tar DNA-binding protein | 0.0449 | 0.6492 | 0.6492 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 0.4709 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.03 | 0.03 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0149 | 0.0149 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0091 | 0.0091 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0395 | 0.5863 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0675 | 0.1153 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.03 | 0.03 |
Onchocerca volvulus | 0.0099 | 0.1085 | 1 | |
Brugia malayi | TAR-binding protein | 0.0449 | 0.6492 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.012 | 0.0185 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0675 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0402 | 0.0402 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.1706 | 0.1706 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.1706 | 0.1706 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0188 | 0.246 | 0.246 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0675 | 0.1039 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.1706 | 0.1706 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0675 | 0.1153 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0675 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.0675 | 0.1153 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.2275 | 0.2679 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.03 | 0.0463 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0334 | 0.4709 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0675 | 0.1039 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0675 | 0.1153 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.0675 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0675 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.017 | 0.2192 | 0.3376 |
Loa Loa (eye worm) | TAR-binding protein | 0.0449 | 0.6492 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.2275 | 1 |
Onchocerca volvulus | 0.0072 | 0.0675 | 0.6219 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.046 | 0.6648 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0449 | 0.6492 | 0.6492 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0149 | 0.2204 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0047 | 0.0289 | 0.0308 |
Loa Loa (eye worm) | RNA binding protein | 0.0449 | 0.6492 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0675 | 0.1039 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0149 | 0.0229 |
Schistosoma mansoni | tar DNA-binding protein | 0.0449 | 0.6492 | 0.6492 |
Schistosoma mansoni | jumonji domain containing protein | 0.0073 | 0.0695 | 0.0695 |
Schistosoma mansoni | alpha-glucosidase | 0.0147 | 0.1826 | 0.1826 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0675 | 0.1039 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0092 | 0.0988 | 0.0988 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0047 | 0.0289 | 0.0308 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.1706 | 0.1706 |
Schistosoma mansoni | tar DNA-binding protein | 0.0449 | 0.6492 | 0.6492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.