Detailed information for compound 588038

Basic information

Technical information
  • TDR Targets ID: 588038
  • Name: ferrous 2-methyl-1-[1-[3,7,18-trimethyl-17-[1 -(2-methyl-3-oxo-pentyl)sulfanylethyl]-8,12-b is(3-oxobutyl)porphyrin-21,23-diid-2-yl]ethyl sulfanyl]pentan-3-one
  • MW: 862.963 | Formula: C47H58FeN4O4S2
  • H donors: 2 H acceptors: 6 LogP: 5.77 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC(=O)C(CSC(C1=C(C)C2=Cc3[n-]c(c(c3C(SCC(C(=O)CC)C)C)C)C=C3N=C(C=c4[n-]c(=CC1=N2)cc4CCC(=O)C)C(=C3C)CCC(=O)C)C)C.[Fe+2]
  • InChi: 1S/C47H58N4O4S2.Fe/c1-12-44(54)25(3)23-56-32(10)46-31(9)39-21-43-47(33(11)57-24-26(4)45(55)13-2)30(8)38(51-43)20-37-29(7)36(17-15-28(6)53)41(49-37)22-40-34(16-14-27(5)52)18-35(48-40)19-42(46)50-39;/h18-22,25-26,32-33H,12-17,23-24H2,1-11H3;/q-2;+2/b35-19-,37-20-,38-20-,39-21-,40-22-,41-22-,42-19-,43-21-;
  • InChiKey: DSSJNBBTFMOAOZ-FSXLTZBASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ferrous 2-methyl-1-[1-[3,7,18-trimethyl-17-[1-[(2-methyl-3-oxopentyl)thio]ethyl]-8,12-bis(3-oxobutyl)-2-porphyrin-21,23-diidyl]ethylthio]-3-pentanone
  • iron(2+); 2-methyl-1-[1-[3,7,18-trimethyl-17-[1-(2-methyl-3-oxo-pentyl)sulfanylethyl]-8,12-bis(3-oxobutyl)porphyrin-21,23-diid-2-yl]ethylsulfanyl]pentan-3-one
  • ferrous 1-[1-[8,12-bis(3-ketobutyl)-17-[1-[(3-keto-2-methyl-pentyl)thio]ethyl]-3,7,18-trimethyl-porphine-21,23-diid-2-yl]ethylthio]-2-methyl-pentan-3-one
  • iron(2+); 2-methyl-1-[1-[3,7,18-trimethyl-17-[1-(2-methyl-3-oxopentyl)sulfanylethyl]-8,12-bis(3-oxobutyl)porphyrin-21,23-diid-2-yl]ethylsulfanyl]pentan-3-one
  • Cytochromes c1

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0012 0.0046 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Schistosoma mansoni hypothetical protein 0.0085 0.092 0.2371
Schistosoma mansoni DNA polymerase eta 0.002 0.0145 0.0374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0672
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.002 0.004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0145 0.0294
Brugia malayi ecdysone receptor 0.001 0.0024 0.0049
Schistosoma mansoni cpg binding protein 0.0031 0.0282 0.0728
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0653 0.1682
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0188
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.4832 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0277 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0156 0.0323
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.018 0.1315
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Leishmania major hypothetical protein, conserved 0.0026 0.0219 0.5478
Loa Loa (eye worm) hypothetical protein 0.0079 0.0852 0.1764
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0015 0.0091 0.0801
Echinococcus multilocularis dna polymerase eta 0.002 0.0145 0.0145
Schistosoma mansoni cpg binding protein 0.0031 0.0282 0.0728
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0688 0.1773
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.018 0.3832
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.018 0.3832
Leishmania major hypothetical protein, conserved 0.0035 0.0325 1
Schistosoma mansoni hypothetical protein 0.0331 0.3879 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.108 0.2235
Mycobacterium leprae Probable lipase LipE 0.0035 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0708 0.1466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0038 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0139 0.2048
Brugia malayi beta-lactamase family protein 0.0035 0.0325 0.0672
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1296 0.2683
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0139 0.0139
Echinococcus multilocularis musashi 0.0079 0.0852 0.0852
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0139 0.0287
Onchocerca volvulus 0.0079 0.0852 0.151
Plasmodium vivax SET domain protein, putative 0.0059 0.0619 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0325 1
Schistosoma mansoni lamin 0.0079 0.0852 0.2197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0078
Loa Loa (eye worm) beta-lactamase 0.0035 0.0325 0.0672
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0714
Brugia malayi nuclear receptor RXR 0.0011 0.0038 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0188
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0156 0.0323
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0156 0.0323
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0139 0.2048
Onchocerca volvulus 0.0015 0.0091 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0325 0.0937
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.018 0.3832
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0042 0.0042
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0015 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0145 0.231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0619 0.1595
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0046 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0139 0.2048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Echinococcus multilocularis lamin 0.0079 0.0852 0.0852
Echinococcus granulosus cpg binding protein 0.0031 0.0282 0.0572
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0156 0.0323
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0219 0.5841
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0024 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0156 0.0156
Brugia malayi ecdysteroid receptor 0.0021 0.0156 0.0323
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0619 0.1254
Toxoplasma gondii ABC1 family protein 0.0035 0.0325 0.4432
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0024 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0672
Brugia malayi hypothetical protein 0.0015 0.0091 0.0188
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0139 0.0281
Onchocerca volvulus 0.0035 0.0325 0.0549
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.018 0.1315
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0038 0.0077
Schistosoma mansoni zinc phosphodiesterase 0.0015 0.0091 0.0234
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0156 0.0242
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0325 0.0325
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0277 0.0561
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0325 0.0431
Loa Loa (eye worm) hypothetical protein 0.0038 0.0362 0.075
Echinococcus granulosus alkaline phosphatase 0.016 0.1827 0.3704
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0653 0.1682
Brugia malayi beta-lactamase family protein 0.0035 0.0325 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.1171 0.2423
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0156 0.0323
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0105 0.1171 0.2423
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0653 0.0653
Echinococcus multilocularis cpg binding protein 0.0031 0.0282 0.0282
Trichomonas vaginalis esterase, putative 0.0035 0.0325 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0325 1
Echinococcus granulosus lamin dm0 0.0079 0.0852 0.1728
Loa Loa (eye worm) intermediate filament protein 0.0079 0.0852 0.1764
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0325 0.4432
Brugia malayi nuclear receptor RXR 0.001 0.0024 0.0049
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0325 1
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0015 0.0091 0.0091
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0038 0.0098
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0145 0.2926
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0325 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0145 0.231
Schistosoma mansoni hypothetical protein 0.0031 0.0277 0.0714
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0188
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0156 0.0403
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0046 0.0093
Schistosoma mansoni hypothetical protein 0.0015 0.0091 0.0234
Schistosoma mansoni ap endonuclease 0.0019 0.0139 0.0358
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0024 0.0024
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0024 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0156 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0156 0.0323
Schistosoma mansoni zinc phosphodiesterase 0.0015 0.0091 0.0234
Trypanosoma brucei unspecified product 0.002 0.0145 0.2926
Echinococcus multilocularis geminin 0.0331 0.3879 0.3879
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.016 0.1827 0.1827
Brugia malayi hypothetical protein 0.0017 0.0108 0.0223
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0015 0.0091 0.0188
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.018 0.3832
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0653 0.1351
Loa Loa (eye worm) hypothetical protein 0.0023 0.018 0.0374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0672
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.002 0.004
Echinococcus multilocularis GPCR, family 2 0.0031 0.0277 0.0277
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.018 0.1315
Mycobacterium ulcerans beta-lactamase 0.0035 0.0325 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0156 0.0323
Onchocerca volvulus 0.0059 0.0619 0.1084
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0145 0.0145
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0139 0.3739
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0156 0.0317
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0139 0.2048
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0156 0.0156
Echinococcus multilocularis lamin dm0 0.0079 0.0852 0.0852
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0262 0.0542
Brugia malayi Pre-SET motif family protein 0.0411 0.4832 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.018 0.0374
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0277 0.0277
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0325 0.0837
Schistosoma mansoni hypothetical protein 0.0031 0.0277 0.0714
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0529 0.1363
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0105 0.1171 0.2373
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0156 0.0403
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0024 0.0049
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0015 0.0091 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0145 0.2926
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.018 0.0359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0219 0.0453
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.004 0.0083
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0156 0.0242
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0145 0.231
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0277 0.0573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.023
Schistosoma mansoni coup transcription factor 0.0021 0.0156 0.0403
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0015 0.0091 0.0801
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0672
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0015 0.0091 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0325 0.0431
Echinococcus granulosus FTZ F1 alpha 0.0419 0.4933 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0607 0.9779
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.018 0.0359
Onchocerca volvulus 0.0052 0.0529 0.0921
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0024 0.0061
Brugia malayi CXXC zinc finger family protein 0.003 0.0262 0.0542
Brugia malayi metallo-beta-lactamase superfamily protein 0.0015 0.0091 0.0188
Brugia malayi nuclear receptor NHR-88 0.001 0.0024 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0145 0.231
Entamoeba histolytica hypothetical protein 0.0072 0.0772 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0139 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0672
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0024 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0619 0.0619
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0139 0.0088
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0156 0.0403
Brugia malayi hypothetical protein 0.0011 0.0038 0.0078
Echinococcus granulosus intestinal type alkaline phosphatase 0.016 0.1827 0.3704
Echinococcus granulosus geminin 0.0331 0.3879 0.7864
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0672
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Entamoeba histolytica hypothetical protein 0.0072 0.0772 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0139 0.0908
Echinococcus multilocularis ETHE1 protein 0.0015 0.0091 0.0091
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2586 1
Brugia malayi hypothetical protein 0.001 0.0024 0.0049
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.018 0.3832
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1296 0.2683
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0325 1
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0015 0.0091 0.0188
Brugia malayi AMP-binding enzyme family protein 0.0023 0.018 0.0374
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Mycobacterium ulcerans hypothetical protein 0.0023 0.018 0.3832
Brugia malayi AMP-binding enzyme family protein 0.0023 0.018 0.0374
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0325 0.0937
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0325 0.0937
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0156 0.0317
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Loa Loa (eye worm) hypothetical protein 0.0052 0.0529 0.1094
Mycobacterium ulcerans lipase LipD 0.0035 0.0325 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0619 0.1595
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Onchocerca volvulus 0.0467 0.5512 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.01 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0024 0.0024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0024 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0024 0.0048
Onchocerca volvulus 0.003 0.0262 0.0434
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0156 0.0403
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.016 0.1827 0.3704
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0219 0.5478
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0653 0.1682
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0111 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0145 0.2926
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0024 0.0024
Brugia malayi nuclear receptor NHR-67 0.001 0.0024 0.0049
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0111 0.0379
Brugia malayi MH2 domain containing protein 0.0116 0.1296 0.2683
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.1171 0.2423
Schistosoma mansoni cpg binding protein 0.003 0.0262 0.0675
Loa Loa (eye worm) RNA binding protein 0.0062 0.0653 0.1351
Echinococcus granulosus tar DNA binding protein 0.0062 0.0653 0.1323
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0024 0.0049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0325 0.0672
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0024 0.0048
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0015 0.0091 0.0184
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0139 0.0908
Schistosoma mansoni hypothetical protein 0.0331 0.3879 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.018 0.3832
Schistosoma mansoni nuclear receptor 0.001 0.0024 0.0061
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0156 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Echinococcus granulosus lamin 0.0079 0.0852 0.1728
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0188
Leishmania major DNA polymerase eta, putative 0.002 0.0145 0.231
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0145 0.03
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0277 0.0561
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0042 0.0413 0.0854
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0156 0.0323
Brugia malayi hypothetical protein 0.0072 0.0772 0.1598
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.0078
Echinococcus multilocularis dna polymerase kappa 0.002 0.0145 0.0145
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0219 0.2428
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0038 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0156 0.0323
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0362 0.0735
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0038 0.0078
Entamoeba histolytica hypothetical protein 0.0072 0.0772 1
Brugia malayi cytoplasmic intermediate filament protein 0.0042 0.0413 0.0854
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0219 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0325 0.0937
Brugia malayi ethe1-prov protein 0.0015 0.0091 0.0188
Onchocerca volvulus 0.0015 0.0091 0.0123
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0156 0.0323
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0653 0.1682
Onchocerca volvulus 0.0035 0.0325 0.0549
Schistosoma mansoni hypothetical protein 0.0067 0.0708 0.1826
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0105 0.1171 0.3018
Schistosoma mansoni nuclear hormone receptor 0.001 0.0024 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Brugia malayi Pre-SET motif family protein 0.0059 0.0619 0.128
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Schistosoma mansoni alkaline phosphatase 0.016 0.1827 0.471
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0015 0.0091 0.0123
Mycobacterium tuberculosis Conserved protein 0.0035 0.0325 0.0937
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0079 0.0852 0.1764
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0015 0.0091 0.0801
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0024 0.0049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0325 0.0672
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0156 0.0323
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0156 0.0317
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0156 0.0323
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0145 0.0793
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0156 0.0242
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0156 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Schistosoma mansoni nuclear hormone receptor 0.001 0.0024 0.0061
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0156 0.0403
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0111 0.0856
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0277 0.0277
Echinococcus multilocularis tumor protein p63 0.0355 0.4166 0.4166
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0024 0.0049
Brugia malayi steroid hormone receptor 0.0021 0.0156 0.0323
Mycobacterium tuberculosis Conserved protein 0.0035 0.0325 0.0937
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0156 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.018 0.3832
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0111 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0325 0.0431
Schistosoma mansoni intermediate filament proteins 0.0079 0.0852 0.2197
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Loa Loa (eye worm) hypothetical protein 0.0023 0.018 0.0374
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0145 0.03
Brugia malayi Intermediate filament tail domain containing protein 0.0079 0.0852 0.1764
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0042 0.0086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0619 0.0619
Mycobacterium tuberculosis Conserved protein 0.0035 0.0325 0.0937
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.108 0.2235
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0024 0.0048
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.016 0.1827 0.1827
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0156 0.0323
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0156 0.0403
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0145 0.231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0156 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0219 1
Schistosoma mansoni lamin 0.0079 0.0852 0.2197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.01 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0619 1
Schistosoma mansoni hypothetical protein 0.0031 0.0277 0.0714
Schistosoma mansoni ap endonuclease 0.0019 0.0139 0.0358
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0015 0.0091 0.0184
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0145 0.0374
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0024 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0345 0.0714
Entamoeba histolytica hypothetical protein 0.0072 0.0772 1
Schistosoma mansoni hypothetical protein 0.0015 0.0091 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0156 0.0323
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0139 0.0192
Echinococcus multilocularis FTZ F1 alpha 0.0105 0.1171 0.1171
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0156 0.0403
Echinococcus granulosus tumor protein p63 0.0355 0.4166 0.8445
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0619 0.1595
Brugia malayi conserved hypotetical protein 0.001 0.0024 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.01 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0156 0.0317
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0653 0.1351
Schistosoma mansoni nuclear receptor 0.001 0.0024 0.0061
Brugia malayi RNA binding protein 0.0062 0.0653 0.1351
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0042 0.0084
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0024 0.0061
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0325 0.0937
Trypanosoma brucei glyoxalase II 0.0015 0.0091 0.0801
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0139 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0219 0.5478
Echinococcus multilocularis alkaline phosphatase 0.016 0.1827 0.1827
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0653 0.1351
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.018 0.3832
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0145 0.03
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0139 0.2686
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0156 0.0323
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0156 0.0403
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0145 0.0374
Brugia malayi TAR-binding protein 0.0062 0.0653 0.1351
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0585 0.1186
Echinococcus multilocularis zinc phosphodiesterase 0.0015 0.0091 0.0091
Onchocerca volvulus Putative hydrolase PNKD 0.0015 0.0091 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.108 0.2235
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Echinococcus granulosus intermediate filament protein 0.0079 0.0852 0.1728
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0708 0.1466
Brugia malayi intermediate filament protein 0.0079 0.0852 0.1764
Schistosoma mansoni alkaline phosphatase 0.016 0.1827 0.471
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.01 0.0035
Echinococcus granulosus zinc phosphodiesterase 0.0015 0.0091 0.0184
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0325 0.0658
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0325 0.0431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0156 0.0323
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0145 0.01
Loa Loa (eye worm) DR-78 0.001 0.0024 0.0049
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0111 0.1563
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0156 0.0403
Onchocerca volvulus 0.0021 0.0156 0.0242
Echinococcus granulosus ETHE1 protein 0.0015 0.0091 0.0184
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0156 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0038 0.0078
Brugia malayi hypothetical protein 0.0026 0.0219 0.0453
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0015 0.0091 0.0091
Brugia malayi tailless protein 0.001 0.0024 0.0049
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0015 0.0091 0.0184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Giardia lamblia DINP protein human, muc B family 0.002 0.0145 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0277 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0653 0.1682
Brugia malayi metallo-beta-lactamase superfamily protein 0.0015 0.0091 0.0188
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0325 0.0937
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0772 0.1566
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.108 0.2235
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0145 0.231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0156 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0024 0.0024
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0145 0.01
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0325 0.0937
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0139 0.0088
Brugia malayi nuclear hormone receptor 0.001 0.0024 0.0049
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0139 0.0287
Loa Loa (eye worm) hypothetical protein 0.0077 0.0835 0.1728
Leishmania major DNA polymerase kappa, putative 0.002 0.0145 0.231
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0156 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Echinococcus granulosus dna polymerase eta 0.002 0.0145 0.0294
Brugia malayi nuclear hormone receptor 0.0021 0.0156 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0325 0.0431
Trichomonas vaginalis set domain proteins, putative 0.0467 0.5512 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0156 0.0317
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.018 0.3832
Echinococcus granulosus dna polymerase kappa 0.002 0.0145 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0325 0.0837
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.018 0.3832
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0156 0.0403
Loa Loa (eye worm) hypothetical protein 0.002 0.0145 0.03
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0024 0.0049
Schistosoma mansoni zinc finger protein 0.001 0.0024 0.0061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.023
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.002 0.002
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.016 0.1827 0.3704
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0139 0.8869
Brugia malayi hypothetical protein 0.001 0.0024 0.0049
Schistosoma mansoni hypothetical protein 0.0083 0.0904 0.233
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0145 0.0217
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0145 0.2926
Loa Loa (eye worm) hypothetical protein 0.0023 0.018 0.0374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0156 0.0323
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0015 0.0091 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0619 0.1595
Echinococcus granulosus GPCR family 2 0.0031 0.0277 0.0561
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.018 0.3832
Brugia malayi beta-lactamase 0.0035 0.0325 0.0672
Onchocerca volvulus 0.0079 0.0852 0.151
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0325 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0145 0.231
Onchocerca volvulus 0.0023 0.018 0.0286
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0024 0.0048
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0105 0.1171 0.1171
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0139 0.0703
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0145 0.0217
Schistosoma mansoni hypothetical protein 0.0015 0.0091 0.0234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0156 0.0323
Schistosoma mansoni hypothetical protein 0.0072 0.0772 0.1991
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0156 0.0317
Schistosoma mansoni hypothetical protein 0.0031 0.0277 0.0714
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.002 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Echinococcus multilocularis intestinal type alkaline phosphatase 0.016 0.1827 0.1827
Brugia malayi Nuclear hormone receptor E75 0.001 0.0024 0.0049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0362 0.0362
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0145 0.231
Brugia malayi Nuclear hormone receptor E75 0.001 0.0024 0.0049
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0219 0.2428
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0156 0.0403
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0277 0.0573
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.018 0.3832
Brugia malayi hypothetical protein 0.0011 0.0038 0.0078
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0024 0.0049
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0772 0.1991
Brugia malayi nuclear receptor NHR-88 0.0021 0.0156 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0145 0.2926
Onchocerca volvulus 0.0035 0.0325 0.0549
Loa Loa (eye worm) hypothetical protein 0.0059 0.0619 0.128
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0024 0.0049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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