Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0154 | 0.5144 | 0.5118 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.3458 | 0.3423 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0513 | 0.0462 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.07 | 0.078 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0406 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0011 | 0.0179 | 0.0152 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.07 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.15 | 0.1455 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0246 | 0.8342 | 1 |
Onchocerca volvulus | 0.005 | 0.1553 | 1 | |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0179 | 0.4422 |
Echinococcus multilocularis | GPCR, family 2 | 0.0049 | 0.15 | 0.1746 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.5144 | 0.5118 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.07 | 0.078 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.15 | 0.1746 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0179 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.15 | 0.1455 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.15 | 0.1746 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0125 | 0.4149 | 0.4118 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0011 | 0.0179 | 0.0152 |
Echinococcus multilocularis | serotonin receptor | 0.0125 | 0.4149 | 0.4941 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.8757 | 0.875 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0246 | 0.8342 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.6068 | 0.6047 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.07 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0179 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0179 | 0.0127 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.07 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.4274 | 0.4243 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0049 | 0.15 | 0.1455 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0049 | 0.15 | 0.1746 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.0179 | 0.0127 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.6068 | 0.6047 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0011 | 0.0179 | 0.0152 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.07 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0179 | 0.4422 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0287 | 0.5 |
Echinococcus multilocularis | geminin | 0.018 | 0.6068 | 0.7257 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0049 | 0.15 | 0.1746 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 0.5144 | 0.5118 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0049 | 0.15 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3458 | 0.3423 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.1553 | 0.1508 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0287 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.4149 | 0.4118 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0413 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.3458 | 0.3423 |
Echinococcus multilocularis | serotonin receptor | 0.0125 | 0.4149 | 0.4941 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0179 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.1553 | 0.1508 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0179 | 0.0127 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0179 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1553 | 0.1508 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0125 | 0.4149 | 0.4941 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0592 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.15 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.8342 | 0.8333 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0293 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0287 | 0.5 |
Brugia malayi | hypothetical protein | 0.0246 | 0.8342 | 0.8333 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 1 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0287 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.15 | 0.1455 |
Echinococcus granulosus | GPCR family 2 | 0.0049 | 0.15 | 0.1746 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.4149 | 0.4118 |
Echinococcus granulosus | geminin | 0.018 | 0.6068 | 0.7257 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 0.5144 | 0.5118 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.15 | 0.1455 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0049 | 0.15 | 0.1455 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0011 | 0.0179 | 0.0152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.