Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0014 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.4 uM | The ability of a compound to stimulate dopamine-sensitive rat caudate adenylate cyclase or to antagonise the stimulant of dopamine was used as measure of D1 efficacy | ChEMBL. | 2875183 |
ED50 (functional) | = 1.4 uM | The ability of a compound to stimulate dopamine-sensitive rat caudate adenylate cyclase or to antagonise the stimulant of dopamine was used as measure of D1 efficacy | ChEMBL. | 2875183 |
ED50 (functional) | = 536 uM | The D2 efficacy was evaluated in isolated perfused rabbit ear artery test | ChEMBL. | 2875183 |
K Bind (binding) | = 0.043 uM | Affinity for Dopamine receptor D1 binding sites was evaluated in a test involving displacement of [3H]- fenoldopam in rat striatum | ChEMBL. | 2875183 |
K Bind (binding) | = 0.043 uM | Affinity for Dopamine receptor D1 binding sites was evaluated in a test involving displacement of [3H]- fenoldopam in rat striatum | ChEMBL. | 2875183 |
K Bind (binding) | = 3.16 uM | Affinity for Dopamine receptor D2 was evaluated from the ability of the compound to displace [3H]-spiroperidol from homogenized bovine pituitary | ChEMBL. | 2875183 |
K Bind (binding) | = 3.16 uM | Affinity for Dopamine receptor D2 was evaluated from the ability of the compound to displace [3H]-spiroperidol from homogenized bovine pituitary | ChEMBL. | 2875183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.