Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | musashi | 0.0028 | 0.6552 | 0.6552 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.5305 | 0.5 |
Echinococcus granulosus | lamin | 0.0028 | 0.6552 | 0.6552 |
Echinococcus multilocularis | lamin | 0.0028 | 0.6552 | 0.6552 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.3012 | 1 |
Onchocerca volvulus | 0.0025 | 0.5305 | 0.8097 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3012 | 0.4596 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.6552 | 0.6552 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.5305 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 0.6552 | 0.6552 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.5305 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.6552 | 0.6552 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.5305 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5305 | 0.8097 |
Onchocerca volvulus | 0.0028 | 0.6552 | 1 | |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.3012 | 0.139 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3012 | 0.4596 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.1761 | 0.1761 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5305 | 0.8097 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.5305 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1213 | 0.1213 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.5305 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.6552 | 0.6552 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.6552 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.5305 | 0.5305 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.6552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3012 | 0.4596 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.6363 | 0.9712 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.6552 | 1 | |
Schistosoma mansoni | lamin | 0.0028 | 0.6552 | 0.6552 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.5305 | 0.5305 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.3012 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.6552 | 0.6552 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.5305 | 0.5305 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3012 | 0.4596 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.3012 | 0.4596 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.5305 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.5305 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.5305 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.3012 | 0.5677 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.6552 | 0.6552 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.5305 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.3012 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.5305 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.5305 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.6552 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1213 | 0.1851 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 1 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.5305 | 0.5305 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.5305 | 0.5305 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1213 | 0.1213 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1761 | 0.2687 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.5305 | 0.5305 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1024 | 0.1563 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.5305 | 0.8097 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1024 | 0.1563 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.5305 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.5305 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.6552 | 0.6552 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.5305 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.