Detailed information for compound 588375

Basic information

Technical information
  • TDR Targets ID: 588375
  • Name: technetium-99; 1,3,3-triphosphonopropylphosph onic acid
  • MW: 462.921 | Formula: C3H12O12P4Tc
  • H donors: 8 H acceptors: 12 LogP: -6.4 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: OP(=O)(C(P(=O)(O)O)CC(P(=O)(O)O)P(=O)(O)O)O.[99Tc]
  • InChi: 1S/C3H12O12P4.Tc/c4-16(5,6)2(17(7,8)9)1-3(18(10,11)12)19(13,14)15;/h2-3H,1H2,(H2,4,5,6)(H2,7,8,9)(H2,10,11,12)(H2,13,14,15);/i;1+1
  • InChiKey: YJNUDNCCDNTNID-IEOVAKBOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • technetium Tc 99m propanetetraphosphonate
  • technetium; 1,3,3-triphosphonopropylphosphonic acid
  • 91481-35-5
  • Phosphonic acid, 1,3-propanediylidenetetrakis-, technetium-99Tc salt
  • Tc-99m-Propanetetraphosphonate
  • Tc-99m-Ptp
  • Technetium propanetetraphosphonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0459 0.0425
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.1056 0.1056
Brugia malayi hypothetical protein 0.0039 0.177 0.1652
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.516 0.5143
Echinococcus multilocularis muscleblind protein 0.0158 1 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0794 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.516 0.589
Loa Loa (eye worm) hypothetical protein 0.0028 0.1056 0.1056
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0794 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.102 0.102
Echinococcus granulosus intermediate filament protein 0.0028 0.1056 0.1023
Echinococcus multilocularis lamin 0.0028 0.1056 0.1023
Schistosoma mansoni intermediate filament proteins 0.0028 0.1056 0.0747
Loa Loa (eye worm) hypothetical protein 0.0158 1 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.8441 1
Echinococcus multilocularis lamin dm0 0.0028 0.1056 0.1023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0459 0.5
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0459 0.0323
Schistosoma mansoni lamin 0.0028 0.1056 0.0747
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0459 0.5
Entamoeba histolytica hypothetical protein 0.0039 0.177 1
Brugia malayi intermediate filament protein 0.0028 0.1056 0.0928
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0459 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0025 0.0794 0.2552
Schistosoma mansoni tar DNA-binding protein 0.0135 0.8441 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.177 0.174
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0794 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0794 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0794 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0794 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.177 0.174
Echinococcus granulosus lamin dm0 0.0028 0.1056 0.1023
Schistosoma mansoni lamin 0.0028 0.1056 0.0747
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.8441 0.8419
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.177 0.1642
Echinococcus multilocularis musashi 0.0028 0.1056 0.1023
Schistosoma mansoni tar DNA-binding protein 0.0135 0.8441 1
Loa Loa (eye worm) hypothetical protein 0.0158 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.177 1
Onchocerca volvulus 0.0088 0.516 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0794 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.1056 0.1056
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0794 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0459 0.0459
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0459 0.5
Echinococcus granulosus muscleblind protein 0.0158 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.8441 0.8441
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0459 0.0425
Loa Loa (eye worm) hypothetical protein 0.0088 0.516 0.516
Echinococcus granulosus lamin 0.0028 0.1056 0.1023
Schistosoma mansoni tar DNA-binding protein 0.0135 0.8441 1
Echinococcus multilocularis tar DNA binding protein 0.0135 0.8441 0.8435
Echinococcus multilocularis muscleblind protein 1 0.0158 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0794 1
Brugia malayi RNA binding protein 0.0135 0.8441 0.8419
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0794 1
Loa Loa (eye worm) RNA binding protein 0.0135 0.8441 0.8441
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0794 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0794 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.516 0.5143
Entamoeba histolytica hypothetical protein 0.0039 0.177 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0794 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.8441 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.516 0.5091
Brugia malayi TAR-binding protein 0.0135 0.8441 0.8419
Entamoeba histolytica hypothetical protein 0.0039 0.177 1
Echinococcus granulosus tar DNA binding protein 0.0135 0.8441 0.8435
Schistosoma mansoni hypothetical protein 0.0039 0.177 0.1642
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0459 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.1056 0.0928
Loa Loa (eye worm) TAR-binding protein 0.0135 0.8441 0.8441

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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