Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4194 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4194 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.4149 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4194 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.4149 | 0 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.4149 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.4149 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.4149 | 0 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4149 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4194 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4194 | 1 | 0.5 |
Onchocerca volvulus | 0.4149 | 0 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.4149 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.4149 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | < 100 ng ml-1 | In vitro antitumor activity against A204 rhabdomyosarcoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | < 100 ng ml-1 | In vitro antitumor activity against A204 rhabdomyosarcoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 180 ng ml-1 | In vitro antitumor activity against WiDr colon carcinoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 180 ng ml-1 | In vitro antitumor activity against WiDr colon carcinoma tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 942 ng ml-1 | In vitro antitumor activity against L1210 lymphocytic leukiemia tumor cell line was determined | ChEMBL. | 2500528 |
ID50 (functional) | = 942 ng ml-1 | In vitro antitumor activity against L1210 lymphocytic leukiemia tumor cell line was determined | ChEMBL. | 2500528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.