Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Bos taurus | Protein kinase C alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Protein kinase C alpha | 672 aa | 647 aa | 66.0 % | |
Schistosoma mansoni | atypical protein kinase C | Protein kinase C alpha | 672 aa | 580 aa | 36.9 % |
Echinococcus multilocularis | protein kinase c epsilon type | Protein kinase C alpha | 672 aa | 661 aa | 44.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0095 | 0.6622 | 0.6609 |
Brugia malayi | Protein kinase c protein 2 | 0.0113 | 0.8217 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0099 | 0.6929 | 0.8753 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.791 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0119 | 0.8712 | 0.8707 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0134 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0119 | 0.8712 | 0.8707 |
Schistosoma mansoni | atypical protein kinase C | 0.0035 | 0.1328 | 0.1293 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0021 | 0.0039 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0021 | 0.0039 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0134 | 1 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0095 | 0.6622 | 0.6609 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.6622 | 0.8363 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0038 | 0.1595 | 0.1562 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0038 | 0.1595 | 0.1562 |
Toxoplasma gondii | AGC kinase | 0.0021 | 0.0039 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0095 | 0.6622 | 0.6609 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0134 | 1 | 1 |
Brugia malayi | protein kinase C II. | 0.0038 | 0.1595 | 0.1903 |
Entamoeba histolytica | protein kinase, putative | 0.0021 | 0.0039 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0035 | 0.1328 | 0.1293 |
Echinococcus granulosus | protein kinase c iota type | 0.0035 | 0.1328 | 0.1293 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0021 | 0.0039 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0038 | 0.1595 | 0.1562 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0038 | 0.1595 | 0.1977 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0021 | 0.0039 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0021 | 0.0039 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 39.9 nM | Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alpha | ChEMBL. | 12699375 |
Ki (binding) | = 39.9 nM | Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserine | ChEMBL. | 11384235 |
Ki (binding) | = 39.9 nM | Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alpha | ChEMBL. | 12699375 |
Ki (binding) | = 39.9 nM | Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserine | ChEMBL. | 11384235 |
logP (ADMET) | = 3.88 | Partition coefficient (logP) | ChEMBL. | 11384235 |
logP (ADMET) | = 3.9 | Partition coefficient (logP) | ChEMBL. | 12699375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.