Detailed information for compound 589247

Basic information

Technical information
  • TDR Targets ID: 589247
  • Name: 5-[(E)-1-hydroxybut-2-enyl]-4-methoxy-6-methy l-pyran-2-one
  • MW: 210.226 | Formula: C11H14O4
  • H donors: 1 H acceptors: 2 LogP: 0.59 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/C(c1c(OC)cc(=O)oc1C)O
  • InChi: 1S/C11H14O4/c1-4-5-8(12)11-7(2)15-10(13)6-9(11)14-3/h4-6,8,12H,1-3H3/b5-4+
  • InChiKey: XQPQKPDEDMGAPV-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(E)-1-hydroxybut-2-enyl]-4-methoxy-6-methyl-2-pyranone
  • 5-[(E)-1-hydroxybut-2-enyl]-4-methoxy-6-methylpyran-2-one
  • pyrenocine C
  • 94474-69-8
  • 2H-Pyran-2-one, 5-(1-hydroxy-2-butenyl)-4-methoxy-6-methyl-, (E)-(+)-
  • Pyrenocin C

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0287 0.4093 0.5619
Schistosoma mansoni bromodomain containing protein 0.0062 0.0685 0.094
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0913 0.1254
Schistosoma mansoni tar DNA-binding protein 0.0436 0.6342 0.8706
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0319 0.0931
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0512 0.0199
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.1552 1
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1352 0.4077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0195 0.0267
Onchocerca volvulus 0.0235 0.3297 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0013 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0062 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0447 0.0614
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0222 0.0329
Echinococcus granulosus dna polymerase kappa 0.0038 0.0319 0.0438
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1352 0.4077
Trichomonas vaginalis esterase, putative 0.0106 0.1352 0.4077
Brugia malayi Bromodomain containing protein 0.0038 0.0315 0.0476
Toxoplasma gondii hypothetical protein 0.0047 0.0464 0.2927
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Trypanosoma brucei unspecified product 0.0026 0.0142 0.0307
Brugia malayi TAR-binding protein 0.0436 0.6342 1
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1352 0.3206
Echinococcus multilocularis geminin 0.0498 0.7284 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0222 0.0304
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.1352 0.1067
Mycobacterium tuberculosis Conserved protein 0.0106 0.1352 0.1067
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0561 0.077
Mycobacterium ulcerans beta-lactamase 0.0106 0.1352 0.5843
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.1352 0.1067
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.1352 0.1856
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0632 0.0867
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0319 0.0438
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 1
Brugia malayi mbt repeat family protein 0.0047 0.0462 0.0709
Echinococcus granulosus GPCR family 2 0.0031 0.0222 0.0304
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0913 0.6353
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0113 0.0155
Onchocerca volvulus 0.0106 0.1352 0.3731
Brugia malayi beta-lactamase family protein 0.0106 0.1352 0.2116
Schistosoma mansoni tar DNA-binding protein 0.0436 0.6342 0.8706
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0447 0.0614
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0447 0.0614
Giardia lamblia DINP protein human, muc B family 0.0038 0.0319 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0462 0.0635
Echinococcus granulosus dna polymerase eta 0.0038 0.0319 0.0438
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1247 0.1949
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1352 0.3206
Loa Loa (eye worm) hypothetical protein 0.0106 0.1352 0.2121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1552 0.6974
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0222 0.0336
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0113 0.0646
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0222 0.0304
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0013 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0436 0.6342 0.8706
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.1552 0.3685
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.1552 0.1274
Schistosoma mansoni tar DNA-binding protein 0.0436 0.6342 0.8706
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0372 0.0859
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0913 0.1254
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1352 0.4077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0419 0.064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0113 0.0157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1352 0.1856
Echinococcus multilocularis tar DNA binding protein 0.0436 0.6342 0.8706
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.4189 1
Loa Loa (eye worm) RNA binding protein 0.0436 0.6342 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0419 0.0647
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0319 0.0931
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.1552 0.2131
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0319 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0222 0.0304
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0013 0.0018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.1352 0.1067
Loa Loa (eye worm) hypothetical protein 0.0054 0.0561 0.0872
Brugia malayi mbt repeat family protein 0.0047 0.0462 0.0709
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0081 0.0112
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0372 0.0859
Echinococcus multilocularis zinc finger protein 0.0019 0.0037 0.0051
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0014 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Loa Loa (eye worm) hypothetical protein 0.0149 0.2001 0.3145
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0319 0.0732
Brugia malayi Pre-SET motif family protein 0.0206 0.2866 0.4508
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0178 0.0245
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0913 0.1254
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0462 0.0635
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1352 0.4077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0113 0.0303
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0304
Mycobacterium tuberculosis Conserved protein 0.0106 0.1352 0.1067
Mycobacterium leprae conserved hypothetical protein 0.0106 0.1352 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0195 0.0267
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0772 0.1199
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0913 0.5849
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0561 0.0866
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0195 0.1178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1552 0.6974
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0222 0.0329
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0419 0.0575
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.1552 0.2131
Leishmania major DNA polymerase eta, putative 0.0038 0.0319 0.0732
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0018
Brugia malayi Pre-SET motif family protein 0.003 0.0195 0.0287
Leishmania major DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Brugia malayi Bromodomain containing protein 0.0073 0.0858 0.1335
Onchocerca volvulus 0.0047 0.0462 0.0862
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0509 0.1186
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0142 0.0307
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0512 0.3014
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0319 0.0732
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.1352 0.1067
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.1352 0.1856
Loa Loa (eye worm) hypothetical protein 0.0106 0.1352 0.2121
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 0.3361
Plasmodium vivax SET domain protein, putative 0.003 0.0195 0.0379
Brugia malayi beta-lactamase 0.0106 0.1352 0.2116
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0113 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0447 0.0692
Plasmodium vivax hypothetical protein, conserved 0.0106 0.1352 1
Trypanosoma brucei unspecified product 0.0038 0.0319 0.0732
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Mycobacterium ulcerans lipase LipD 0.0106 0.1352 0.5843
Brugia malayi RNA binding protein 0.0436 0.6342 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0379 0.0584
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2866 0.4512
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0304
Mycobacterium tuberculosis Conserved protein 0.0106 0.1352 0.1067
Schistosoma mansoni zinc finger protein 0.0019 0.0037 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1552 0.6974
Schistosoma mansoni hypothetical protein 0.0068 0.0772 0.106
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0462 0.0716
Trypanosoma brucei unspecified product 0.0026 0.0142 0.0307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0436 0.6342 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0319 0.0438
Loa Loa (eye worm) hypothetical protein 0.0047 0.0462 0.0716
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0372 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Mycobacterium ulcerans hypothetical protein 0.0106 0.1352 0.5843
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0106 0.1352 0.2121
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.4189 1
Schistosoma mansoni tar DNA-binding protein 0.0436 0.6342 0.8706
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0319 0.0732
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1352 0.4077
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0462 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0419 0.0575
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1552 0.2131
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0113 0.0155
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0462 0.0635
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1247 0.1949
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.185 0.4397
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0447 0.0614
Onchocerca volvulus 0.0106 0.1352 0.3731
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 0.3361
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0319 0.0732
Entamoeba histolytica hypothetical protein 0.0024 0.0113 0.3249
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0462 0.0635
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.1352 0.5843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0419 0.0575
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0081 0.0112
Mycobacterium leprae Probable lipase LipE 0.0106 0.1352 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0561 0.077
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2087 0.1826
Brugia malayi beta-lactamase family protein 0.0106 0.1352 0.2116
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0069
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0106 0.1352 0.2121
Loa Loa (eye worm) hypothetical protein 0.0099 0.1247 0.1954
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0014 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1552 0.2131
Loa Loa (eye worm) hypothetical protein 0.0106 0.1352 0.2121
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.028 0.0384
Schistosoma mansoni hypothetical protein 0.0498 0.7284 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0195 0.0267
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.1352 0.1067
Echinococcus multilocularis dna polymerase eta 0.0038 0.0319 0.0438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0419 0.0575
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0319 0.0483
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0319 0.049
Onchocerca volvulus 0.0106 0.1352 0.3731
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0319 0.0438
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1352 0.3206
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0372 0.0859
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0561 0.077
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0319 0.0732
Schistosoma mansoni hypothetical protein 0.0498 0.7284 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.185 0.4397
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0561 0.077
Onchocerca volvulus 0.0149 0.2001 0.5821
Echinococcus multilocularis GPCR, family 2 0.0031 0.0222 0.0304
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 0.5
Toxoplasma gondii hypothetical protein 0.0027 0.0149 0.0882
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1352 0.1856
Loa Loa (eye worm) MBCTL1 0.0054 0.0561 0.0872
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0013 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.1352 0.1067
Toxoplasma gondii ABC1 family protein 0.0106 0.1352 0.87
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.1352 0.2121
Mycobacterium ulcerans hypothetical protein 0.0155 0.2087 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0561 0.077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0632 0.0867
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1247 0.1954
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.1352 0.1067
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0913 0.6353
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0462 0.0635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0419 0.0575
Echinococcus granulosus zinc finger protein 0.0019 0.0037 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0222 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0419 0.0575
Trichomonas vaginalis set domain proteins, putative 0.0235 0.3297 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0419 0.0575
Leishmania major hypothetical protein, conserved 0.0106 0.1352 0.3206
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.2564 0.352
Brugia malayi RNA recognition motif domain containing protein 0.0436 0.6342 1
Loa Loa (eye worm) TAR-binding protein 0.0436 0.6342 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0316 0.0484
Echinococcus granulosus tar DNA binding protein 0.0436 0.6342 0.8706
Loa Loa (eye worm) hypothetical protein 0.0106 0.1352 0.2121
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0462 0.0635
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.1352 0.2116
Schistosoma mansoni DNA polymerase eta 0.0038 0.0319 0.0438
Loa Loa (eye worm) hypothetical protein 0.0077 0.0913 0.1428
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0319 0.0438
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0512 0.0703
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0462 0.0862
Brugia malayi PHD-finger family protein 0.0024 0.0116 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0142 0.0307
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0319 0.0438
Loa Loa (eye worm) hypothetical protein 0.0069 0.0795 0.1241
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0113 0.0238
Echinococcus granulosus geminin 0.0498 0.7284 1
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.4189 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0113 0.0238
Loa Loa (eye worm) hypothetical protein 0.0068 0.0772 0.1205
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0913 0.5
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0512 0.0703
Brugia malayi hypothetical protein 0.0149 0.2001 0.314
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.4189 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0319 0.0732
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0142 0.0307
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.028 0.0384
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0913 0.5849
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0081 0.0112
Loa Loa (eye worm) hypothetical protein 0.004 0.0351 0.054
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0512 0.0199
Loa Loa (eye worm) beta-lactamase 0.0106 0.1352 0.2121
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.1352 0.5843
Loa Loa (eye worm) hypothetical protein 0.0031 0.0222 0.0336
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0013 0.0007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0319 0.0732
Loa Loa (eye worm) hypothetical protein 0.0038 0.0319 0.049
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.2564 0.352
Loa Loa (eye worm) hypothetical protein 0.0021 0.0062 0.0083
Brugia malayi Probable ClpP-like protease 0.0077 0.0913 0.1422
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.185 0.4397
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0319 0.0483

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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