Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | Curated by TDR Targets | References |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 165 aa | 143 aa | 34.3 % |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 159 aa | 140 aa | 37.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0521 | 0.08 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.345 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3664 | 0.3573 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0442 | 0.0678 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0279 | 0.6519 | 0.6469 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.1263 | 0.1937 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.1263 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2744 | 0.264 |
Onchocerca volvulus | 0.0052 | 0.0714 | 0.1971 | |
Trichomonas vaginalis | glutaminase, putative | 0.0279 | 0.6519 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.3664 | 0.3573 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.0521 | 0.08 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.0789 | 0.0657 |
Loa Loa (eye worm) | glutaminase | 0.0279 | 0.6519 | 0.6469 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0442 | 0.0305 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0136 | 0.0209 |
Echinococcus multilocularis | tumor protein p63 | 0.0353 | 0.8408 | 0.8386 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.1263 | 0.1138 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0059 | 0.089 | 0.258 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.0181 |
Brugia malayi | hypothetical protein | 0.0131 | 0.2744 | 0.264 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.0181 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0442 | 0.0678 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.1517 | 0.1396 |
Brugia malayi | glutaminase DH11.1 | 0.0279 | 0.6519 | 0.6469 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.3664 | 0.3573 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.1055 | 0.0927 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0216 | 0.0076 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.1263 | 0.1138 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.1055 | 0.3058 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.345 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.2744 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0312 | 0.7363 | 0.7325 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0714 | 0.0581 |
Schistosoma mansoni | hypothetical protein | 0.0312 | 0.7363 | 0.7325 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.345 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.1263 | 0.1138 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0059 | 0.089 | 0.0759 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.089 | 0.0759 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.345 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0279 | 0.6519 | 0.6179 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.0181 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.0927 |
Onchocerca volvulus | Huntingtin homolog | 0.0131 | 0.2744 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0442 | 0.0895 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.2762 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0442 | 0.0305 |
Echinococcus granulosus | geminin | 0.0167 | 0.3664 | 0.3573 |
Echinococcus granulosus | tumor protein p63 | 0.0353 | 0.8408 | 0.8386 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.345 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.1263 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2744 | 0.264 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.1263 | 0.1138 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0059 | 0.089 | 0.0759 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0521 | 0.1209 |
Schistosoma mansoni | glutaminase | 0.0279 | 0.6519 | 0.6469 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0312 | 0.7363 | 0.7325 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.345 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0312 | 0.7363 | 0.7325 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0136 | 0.0209 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.1263 | 0.1138 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.0181 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.1263 | 0.1138 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0059 | 0.089 | 0.0759 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.1055 | 0.0927 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0714 | 0.0581 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.1055 | 0.0927 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.1263 | 0.1937 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium avium | 256134 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-28 | References: | 17017990 17552508 17569517 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium avium | 5868 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-28 | References: | 17017990 17552508 17569517 |
3 literature references were collected for this gene.