Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0794 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.8433 | 0.8433 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0081 | 0.516 | 0.5143 |
Schistosoma mansoni | lamin | 0.0026 | 0.1056 | 0.0748 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1056 | 0.1056 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.0794 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.0794 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1056 | 0.0928 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1056 | 0.1056 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.8433 | 0.8433 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.8433 | 0.8433 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1765 | 0.1736 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1056 | 0.1023 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.8433 | 0.8427 |
Schistosoma mansoni | lamin | 0.0026 | 0.1056 | 0.0748 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.8433 | 0.8411 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.0794 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0081 | 0.516 | 0.5895 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.0794 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0459 | 0.5 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0081 | 0.516 | 0.5091 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.102 | 0.102 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.516 | 0.516 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0794 | 0.256 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0459 | 0.0323 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1765 | 0.1736 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0081 | 0.516 | 0.5143 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1765 | 0.1638 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0141 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1056 | 0.1056 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.0794 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.8433 | 0.8427 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1056 | 0.0748 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0459 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0459 | 0.0459 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.0794 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0794 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0459 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1056 | 0.0928 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0459 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.8433 | 0.8411 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0459 | 0.0425 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1056 | 0.1023 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1765 | 0.1638 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0459 | 0.0425 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0794 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1056 | 0.1023 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0794 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.8433 | 1 |
Onchocerca volvulus | 0.0081 | 0.516 | 1 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0459 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1765 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.1056 | 0.1023 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1056 | 0.1023 |
Brugia malayi | RNA binding protein | 0.0125 | 0.8433 | 0.8411 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1765 | 0.1648 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.0794 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1056 | 0.1023 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.0794 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.