Detailed information for compound 589633

Basic information

Technical information
  • TDR Targets ID: 589633
  • Name: dihydrodinoreburnameninol
  • MW: 268.354 | Formula: C17H20N2O
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1C[C@H]2CCCN3[C@H]2c2n1c1ccccc1c2CC3
  • InChi: 1S/C17H20N2O/c20-15-10-11-4-3-8-18-9-7-13-12-5-1-2-6-14(12)19(15)17(13)16(11)18/h1-2,5-6,11,15-16,20H,3-4,7-10H2/t11-,15?,16-/m1/s1
  • InChiKey: KOIGYXJOGRVNIS-HAIWGOBWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 95909-85-6
  • 14,15-Dihydro-20,21-dinoreburnamenin-14-ol
  • 20,21-Dinoreburnamenin-14-ol, 14,15-dihydro-
  • DHDNE

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1122 0.3116
Plasmodium falciparum thioredoxin reductase 0.0014 0.0064 0.1548
Schistosoma mansoni hypothetical protein 0.0357 0.4094 0.4094
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.014 0.3359
Plasmodium falciparum glutathione reductase 0.0014 0.0064 0.1548
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.002 0.002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.1122 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0004 0.0007
Onchocerca volvulus 0.0015 0.0066 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Onchocerca volvulus 0.001 0.0012 0.0022
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.002 0.0055
Brugia malayi Ets-domain containing protein 0.0011 0.0026 0.0046
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0456 0.0827
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0133 0.037
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0066 0.0505
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0026 0.0026
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0066 0.0359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0456 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0019 0.0034
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0019 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0479 0.2591
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0066 0.012
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0212 0.0712
Echinococcus granulosus zinc finger protein 0.0044 0.0417 0.0417
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0004 0.0007
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0004 0.0007
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0066 0.0359
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.1122 0.3116
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0036
Schistosoma mansoni myst-related protein 0.0011 0.0026 0.0026
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0026 0.0026
Schistosoma mansoni ets 0.0011 0.0026 0.0026
Trichomonas vaginalis set domain proteins, putative 0.0262 0.2973 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0019 0.0034
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0066 0.0359
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0064 0.0574
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.0066 0.0584
Schistosoma mansoni coup transcription factor 0.0011 0.0019 0.0019
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0795 0.1441
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.014 0.0253
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0019 0.0034
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.014 0.0253
Loa Loa (eye worm) hypothetical protein 0.005 0.0479 0.0867
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0128 0.1405 0.1405
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0066 0.1593
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1649 0.4579
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0479 0.2591
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0019 0.0034
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0066 0.0584
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.014 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0019 0.0019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0456 0.0456
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0416 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0479 0.4266
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0026 0.0026
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.002 0.0055
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0066 0.0359
Loa Loa (eye worm) hypothetical protein 0.0188 0.211 0.3823
Leishmania major DNA polymerase kappa, putative 0.002 0.0133 0.037
Echinococcus multilocularis protein C ets 2 0.0011 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.1122 0.1122
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0004 0.0004
Brugia malayi hypothetical protein 0.0478 0.5519 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0066 0.012
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0059 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0187
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0416 0.1155
Trypanosoma brucei polo-like protein kinase 0.0104 0.1122 0.3116
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.049 0.049
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.039 0.039
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0479 0.1329
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0416 0.1155
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Onchocerca volvulus 0.0015 0.0066 0.012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0133 0.0133
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.211 0.3823
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0505 0.1699
Brugia malayi PHD-finger family protein 0.0056 0.0549 0.0994
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0019 0.0019
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1649 0.4579
Brugia malayi Bromodomain containing protein 0.016 0.1782 0.3228
Schistosoma mansoni kinase 0.0053 0.0521 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0716 0.0716
Schistosoma mansoni hypothetical protein 0.0032 0.0272 0.0272
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0095 0.1009 0.2801
Trypanosoma brucei unspecified product 0.002 0.0133 0.037
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0066 0.0505
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0479 0.2591
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.007 0.0716 0.1298
Loa Loa (eye worm) hypothetical protein 0.0093 0.0991 0.1795
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.0165
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0004 0.0007
Trypanosoma brucei unspecified product 0.0014 0.0059 0.0165
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0064 0.0179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0129 0.0129
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0091
Brugia malayi hypothetical protein 0.0009 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0064 0.0217
Onchocerca volvulus 0.0034 0.0296 0.0537
Loa Loa (eye worm) hypothetical protein 0.005 0.0479 0.0867
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0331 0.7958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0296 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0064 0.0491
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0384 1
Brugia malayi N-terminal motif family protein 0.0188 0.211 0.3823
Onchocerca volvulus 0.0009 0.0004 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0019 0.0034
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.014 0.0253
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0066 0.0184
Brugia malayi Muscleblind-like protein 0.0313 0.3572 0.6473
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0716 0.0716
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.049 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0059 0.0165
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0315 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0019 0.0019
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0026 0.0046
Toxoplasma gondii hypothetical protein 0.0051 0.0493 0.3756
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0026 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0187
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0066 0.0359
Schistosoma mansoni dep domain containing protein 0.0009 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Onchocerca volvulus 0.0262 0.2973 0.5387
Plasmodium vivax glutathione reductase, putative 0.0042 0.0384 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0019 0.0019
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0019 0.0035
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0133 0.037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.1122 0.2033
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.014 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0456 0.0456
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0019 0.0034
Echinococcus multilocularis dna polymerase eta 0.002 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Trypanosoma brucei trypanothione reductase 0.0042 0.0384 0.1066
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0026 0.0026
Schistosoma mansoni bromodomain containing protein 0.0136 0.1493 0.1493
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0085 0.0085
Toxoplasma gondii hypothetical protein 0.0009 0.0004 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0133 0.037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0187
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0004 0.0004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0779 0.0779
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.3601 1
Mycobacterium ulcerans hypothetical protein 0.005 0.0479 0.2591
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0056 0.0187
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0479 0.4216
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.014 0.1245
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0133 0.0448
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0066 0.0184
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0319 0.0577
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0066 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0066 0.012
Leishmania major hypothetical protein, conserved 0.0032 0.0272 0.0754
Brugia malayi Fli-1 protein 0.0232 0.2629 0.4763
Schistosoma mansoni elf1 0.0011 0.0026 0.0026
Trypanosoma cruzi ISWI complex protein 0.0032 0.0272 0.0754
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0129 0.0129
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0064 0.1548
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Plasmodium falciparum thioredoxin reductase 0.0042 0.0384 0.9231
Echinococcus multilocularis bloom syndrome protein 0.005 0.0488 0.0488
Schistosoma mansoni myst-related protein 0.0011 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.06
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0307 0.1663
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0026 0.0026
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0066 0.0066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0019 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0019 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0064 0.0349
Treponema pallidum NADH oxidase 0.0014 0.0064 1
Schistosoma mansoni DNA helicase recq5 0.0021 0.014 0.014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0064 0.0064
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0066 0.0359
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0004 0.0004
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0026 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0066 0.0359
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0479 0.2591
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0085 0.0085
Schistosoma mansoni gabp alpha 0.0077 0.0795 0.0795
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0403 0.073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0091 0.0165
Trichomonas vaginalis helicase, putative 0.0014 0.0056 0.0187
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0479 0.4266
Loa Loa (eye worm) hypothetical protein 0.0093 0.0985 0.1785
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0066 0.0359
Schistosoma mansoni hypothetical protein 0.0357 0.4094 0.4094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0019 0.0034
Brugia malayi AMP-binding enzyme family protein 0.005 0.0479 0.0867
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0479 0.2591
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0066 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0019 0.0034
Echinococcus granulosus GPCR family 2 0.0017 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0133 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.1312 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0839 0.1521
Echinococcus granulosus dual specificity 0.0095 0.1009 0.1009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0291 0.222
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1369 0.2481
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0066 0.012
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.014 0.014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0296 0.0296
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0066 0.0359
Giardia lamblia Kinase, PLK 0.0104 0.1122 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0133 0.037
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0026 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0241
Plasmodium falciparum zinc finger protein, putative 0.0011 0.0026 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0019 0.0034
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0133 0.0241
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0133 0.0133
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0019 0.0019
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0505 0.1699
Onchocerca volvulus 0.0478 0.5519 1
Brugia malayi MH2 domain containing protein 0.0125 0.1369 0.2481
Plasmodium falciparum glutathione reductase 0.0042 0.0384 0.9231
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0479 0.1329
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0019 0.0019
Echinococcus multilocularis dna polymerase kappa 0.002 0.0133 0.0133
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0026 0.0046
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0066 0.0359
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0315 0.0315
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0384 0.0696
Toxoplasma gondii thioredoxin reductase 0.0042 0.0384 0.2927
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0166 0.1847 1
Onchocerca volvulus 0.0015 0.0066 0.012
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0026 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0456 0.0456
Echinococcus granulosus dna polymerase kappa 0.002 0.0133 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0479 0.2591
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0066 0.0359
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0019 0.0034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0315 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0019 0.0034
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.1122 0.2033
Loa Loa (eye worm) glutathione reductase 0.0042 0.0384 0.0696
Schistosoma mansoni ets-related 0.0232 0.2629 0.2629
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0064 0.0179
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0779 0.0779
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0066 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0019 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0515 0.0933
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0034 0.0296 0.7707
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.1135 0.6145
Plasmodium vivax SET domain protein, putative 0.0034 0.0296 0.7718
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Echinococcus granulosus cpg binding protein 0.0068 0.0692 0.0692
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0133 0.0721
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0091 0.0091
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0004 0.0007
Brugia malayi AMP-binding enzyme family protein 0.005 0.0479 0.0867
Schistosoma mansoni SET domain protein 0.001 0.0012 0.0012
Brugia malayi SET domain containing protein 0.001 0.0012 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0479 0.2591
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.049 0.049
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0064 0.0179
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0091 0.0165
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0015 0.0389
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0066 0.1726
Trypanosoma brucei ISWI complex protein 0.0032 0.0272 0.0754
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.0066 0.0584
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0066 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0091
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0795 0.0795
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0267 0.0267
Giardia lamblia DINP protein human, muc B family 0.002 0.0133 0.1187
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0066 0.0184
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.033 0.0598
Schistosoma mansoni hypothetical protein 0.0043 0.0403 0.0403
Entamoeba histolytica hypothetical protein 0.0011 0.0026 0.0228
Brugia malayi steroid hormone receptor 0.0011 0.0019 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1009 0.1009
Mycobacterium tuberculosis Probable reductase 0.0095 0.101 0.5471
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.012
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0026 0.0046
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0488 0.0884
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.0577
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0133 0.037
Schistosoma mansoni cpg binding protein 0.006 0.0604 0.0604
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.1135 0.6145
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.06
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Loa Loa (eye worm) oxidoreductase 0.0015 0.0066 0.012
Brugia malayi Pre-SET motif family protein 0.023 0.2601 0.4713
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.06
Brugia malayi hypothetical protein 0.0093 0.0991 0.1795
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0064 0.1677
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0133 0.037
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0064 0.0179
Onchocerca volvulus 0.0011 0.0019 0.0034
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0066 0.0184
Schistosoma mansoni bromodomain containing protein 0.0012 0.0041 0.0041
Echinococcus multilocularis muscleblind protein 1 0.0313 0.3572 0.3572
Brugia malayi Ets-domain containing protein 0.0077 0.0795 0.1441
Loa Loa (eye worm) hypothetical protein 0.005 0.0479 0.0867
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0331 0.1792
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.1135 0.6145
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0488 0.1641
Brugia malayi AMP-binding enzyme family protein 0.005 0.0479 0.0867
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0133 0.1187
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Echinococcus granulosus geminin 0.0357 0.4094 0.4094
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0064 0.0179
Echinococcus granulosus bloom syndrome protein 0.005 0.0488 0.0488
Entamoeba histolytica hypothetical protein 0.0095 0.1009 0.8991
Leishmania major trypanothione reductase 0.0042 0.0384 0.1066
Loa Loa (eye worm) hypothetical protein 0.0093 0.0991 0.1795
Schistosoma mansoni DNA polymerase eta 0.002 0.0133 0.0133
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.002 0.015
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0019 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0307 0.1663
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0085 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0019 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0019 0.0034
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0066 0.0359
Brugia malayi Protein kinase domain containing protein 0.0095 0.1009 0.1828
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0019 0.0034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0056 0.0187
Schistosoma mansoni DNA helicase recq1 0.0021 0.014 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0011 0.0011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0085 0.0085
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0066 0.0184
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0515 0.0933
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0064 0.0349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0064 0.5
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0315 0.0315
Trypanosoma cruzi ISWI complex protein 0.0032 0.0272 0.0754
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0091 0.0165
Loa Loa (eye worm) hypothetical protein 0.0094 0.0999 0.181
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0133 0.0241
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0095 0.101 0.8903
Loa Loa (eye worm) hypothetical protein 0.0085 0.0898 0.1627
Echinococcus granulosus dna polymerase eta 0.002 0.0133 0.0133
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1369 0.2481
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0066 0.012
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.1122 0.1122
Brugia malayi DIX domain containing protein 0.0009 0.0004 0.0007
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0064 0.0491
Schistosoma mansoni eyes absent homolog 0.0093 0.0991 0.0991
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0019 0.0019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0456 0.0456
Schistosoma mansoni ets-related 0.0011 0.0026 0.0026
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0066 0.0359
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0456 0.0827
Loa Loa (eye worm) hypothetical protein 0.0478 0.5519 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0133 0.037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0416 0.1155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0019 0.0034
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0064 0.1945
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0515 0.0933
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.101 0.5471
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.101 0.5471
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.002 0.3058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0307 0.1663
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0064 0.5
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Onchocerca volvulus 0.005 0.0479 0.0867
Brugia malayi Bromodomain containing protein 0.008 0.0838 0.1518
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Echinococcus granulosus muscleblind protein 0.0313 0.3572 0.3572
Brugia malayi glutathione reductase 0.0042 0.0384 0.0696
Echinococcus multilocularis geminin 0.0357 0.4094 0.4094
Entamoeba histolytica protein kinase, putative 0.0095 0.1009 0.8991
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0384 0.2079
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.1122 0.1122
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0479 0.2591
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0026
Loa Loa (eye worm) fli-1 protein 0.0232 0.2629 0.4763
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0019 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0479 0.1329
Echinococcus multilocularis dual specificity 0.0095 0.1009 0.1009
Leishmania major mitochondrial DNA polymerase beta 0.0315 0.3601 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0066 0.012
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0212 0.0588
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0019 0.0034
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0331 0.8621
Echinococcus multilocularis dnaJ subfamily B 0.0859 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0665 0.1205
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0064 0.1548
Echinococcus granulosus protein C ets 2 0.0011 0.0026 0.0026
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0173 0.0313
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Echinococcus multilocularis GPCR, family 2 0.0017 0.0091 0.0091
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.039 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0479 0.2591
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.014 0.014
Entamoeba histolytica recQ family helicase, putative 0.0027 0.0212 0.1887
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Brugia malayi CXXC zinc finger family protein 0.006 0.0604 0.1095
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.0716 0.0716
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1847 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0064 0.0349
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0019 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0133 0.0721
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0488 0.1641
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0066 0.0359
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0066 0.012
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.101 0.5471
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Echinococcus multilocularis cpg binding protein 0.0068 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1649 0.4579
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0019 0.0019
Schistosoma mansoni zinc finger protein 0.0044 0.0417 0.0417
Brugia malayi Pre-SET motif family protein 0.0034 0.0296 0.0537
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0133 0.037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0416 0.1155
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0019 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0019 0.0019
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0066 0.0184
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.2601 0.4713
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.014 0.014
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0095 0.1009 0.1828
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0064 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0133 0.037
Loa Loa (eye worm) hypothetical protein 0.0254 0.288 0.5219
Onchocerca volvulus 0.006 0.0604 0.1095
Brugia malayi nuclear hormone receptor 0.0011 0.0019 0.0034
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0363 0.0363
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0064 0.0117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0296 0.2259
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0019 0.0034
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0064 0.0064
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0004 0.0004
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0133 0.0133
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0026 0.0026
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0066 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0019 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0064 0.1677
Brugia malayi ecdysteroid receptor 0.0011 0.0019 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0066 0.012
Loa Loa (eye worm) hypothetical protein 0.0313 0.3572 0.6473
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0066 0.0359
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.101 0.5471
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.1135 1
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0066 0.0066
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.1122 0.2033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0859 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0999 0.181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.06
Echinococcus multilocularis ets variant gene 4 0.0011 0.0026 0.0026
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0042 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Brugia malayi transcription factor E74 isoform 0.0011 0.0026 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0064 0.0179
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0064 0.0179
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.1122 0.3116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0456 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0053 0.0515 0.0933
Leishmania major DNA polymerase eta, putative 0.002 0.0133 0.037
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.101 0.5471
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0026 0.0046
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0064 0.0217
Schistosoma mansoni cpg binding protein 0.0068 0.0692 0.0692
Loa Loa (eye worm) histone methyltransferase 0.002 0.0129 0.0233
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0064 0.0179
Entamoeba histolytica protein kinase domain containing protein 0.0095 0.1009 0.8991
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.053 0.1472
Schistosoma mansoni dishevelled 0.0009 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0036 0.0319 0.0319
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0795 0.0795
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0019 0.0019
Entamoeba histolytica recQ family helicase, putative 0.001 0.0015 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0307 0.1663
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0133 0.037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0133 0.0448
Brugia malayi Thioredoxin reductase 0.0042 0.0384 0.0696
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0331 1
Trypanosoma brucei unspecified product 0.0014 0.0059 0.0165
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0059 0.0165
Entamoeba histolytica recQ family DNA helicase 0.0011 0.002 0.0175
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.3601 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0026 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0066 0.0359
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0066 0.0184
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0019 0.0019
Brugia malayi Ets-domain containing protein 0.0077 0.0795 0.1441
Brugia malayi hypothetical protein 0.0009 0.0004 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0187
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0479 0.4266
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0004 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0212 0.0588
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.1009 0.2801
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0026 0.0026
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0064 0.0349
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0128 0.1405 0.1405
Loa Loa (eye worm) hypothetical protein 0.0313 0.3572 0.6473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0456 0.0456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0187
Loa Loa (eye worm) RecQ helicase 0.005 0.0488 0.0884
Echinococcus multilocularis muscleblind protein 0.0313 0.3572 0.3572
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 0.3601 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0331 0.1792
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0046
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0066 0.0359
Brugia malayi nuclear receptor NHR-88 0.0011 0.0019 0.0034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.014 0.1065
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0133 0.0721
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0034
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0066 0.0505
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0133 0.0241
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.014 0.0253
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0064 0.0179
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.1009 0.2801
Schistosoma mansoni zinc finger protein 0.0032 0.0272 0.0272
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0085 0.0085
Onchocerca volvulus 0.0019 0.0116 0.0211
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.0026
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0066 0.0359
Loa Loa (eye worm) hypothetical protein 0.0148 0.1636 0.2964
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0026 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0604 0.1095
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0066 0.0359
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0066 0.0591
Schistosoma mansoni hypothetical protein 0.0017 0.0091 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0019 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0019 0.0034
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0296 0.0296
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0004 0.0004
Echinococcus multilocularis zinc finger protein 0.0044 0.0417 0.0417
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1414 0.1414
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.012
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0212 0.0588
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0331 0.06
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0019 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.1122 0.3774
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0019 0.0035
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0384 0.1066
Schistosoma mansoni cpg binding protein 0.0068 0.0692 0.0692
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0479 0.4216
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0133 0.0721
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0026 0.0026
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0066 0.0223
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0066 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0019 0.0034
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0095 0.1009 0.2801
Entamoeba histolytica protein kinase, putative 0.0095 0.1009 0.8991
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0019 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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