Detailed information for compound 589685

Basic information

Technical information
  • TDR Targets ID: 589685
  • Name: azanide; cyclohexanamine; platinum(2+); (2S,3 S,4S,5R)-2,3,4,5-tetrahydroxyhexanedioate
  • MW: 828.672 | Formula: C18H38N4O8Pt2
  • H donors: 8 H acceptors: 8 LogP: -5.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 3
  • SMILES: O[C@H]([C@H](C(=O)[O-])O)[C@@H]([C@@H](C(=O)[O-])O)O.NC1CCCCC1.NC1CCCCC1.[Pt+2].[Pt+2].[NH2-].[NH2-]
  • InChi: 1S/2C6H13N.C6H10O8.2H2N.2Pt/c2*7-6-4-2-1-3-5-6;7-1(3(9)5(11)12)2(8)4(10)6(13)14;;;;/h2*6H,1-5,7H2;1-4,7-10H,(H,11,12)(H,13,14);2*1H2;;/q;;;2*-1;2*+2/p-2/t;;1-,2-,3-,4+;;;;/m..0..../s1
  • InChiKey: DGGVCZXQEWWISQ-YFGGKQEOSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • azanide; cyclohexylamine; platinum(2+); (2S,3S,4S,5R)-2,3,4,5-tetrahydroxyadipate
  • platuran
  • azanide; cyclohexanamine; platinum(+2) cation; (2S,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanedioate
  • azanide; cyclohexylamine; platinum(+2) cation; (2S,3S,4S,5R)-2,3,4,5-tetrahydroxyadipate
  • 96081-75-3
  • 1,2-Diaminocyclohexaneplatinum II glucarate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo/keto reductase, putative 0.0248 0.4102 0.4092
Toxoplasma gondii aldose reductase, putative 0.0248 0.4102 1
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Loa Loa (eye worm) oxidoreductase 0.0248 0.4102 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0187 0.0456
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0129 0.0313
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0129 0.0313
Onchocerca volvulus 0.0248 0.4102 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0122 0.197 0.4802
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0654 0.064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0187 0.0456
Onchocerca volvulus 0.0006 0.0016 0.0038
Brugia malayi Muscleblind-like protein 0.0154 0.2512 0.6124
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0129 0.0276
Onchocerca volvulus 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0006 0.0016 0.0016
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0129 0.0113
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0006 0.0016 0.0038
Trypanosoma cruzi aldo/keto reductase, putative 0.0072 0.1126 0.2717
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0006 0.0016 0.0038
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0248 0.4102 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0006 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0016 0.0187 0.0456
Onchocerca volvulus 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo/keto reductase, putative 0.0248 0.4102 0.4092
Entamoeba histolytica aldose reductase, putative 0.0248 0.4102 0.4102
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.2435 0.5936
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Loa Loa (eye worm) oxidoreductase 0.0248 0.4102 1
Schistosoma mansoni protein tyrosine phosphatase 0.0006 0.0016 0.0038
Mycobacterium leprae Conserved hypothetical protein 0.0176 0.2888 0.5922
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0006 0.0016 0.0038
Giardia lamblia Aldose reductase 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus multilocularis muscleblind protein 1 0.0154 0.2512 0.6124
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Trypanosoma cruzi aldo/keto reductase, putative 0.0248 0.4102 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0072 0.1126 1
Schistosoma mansoni aldo-keto reductase 0.0248 0.4102 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0506 0.1233
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0129 0.0313
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Loa Loa (eye worm) oxidoreductase 0.0248 0.4102 1
Schistosoma mansoni hypothetical protein 0.0013 0.0126 0.0307
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0013 0.0129 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.2435 0.5936
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Schistosoma mansoni protein tyrosine phosphatase 0.0006 0.0016 0.0038
Schistosoma mansoni aldo-keto reductase 0.0248 0.4102 1
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0187 0.0456
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.197 0.4802
Echinococcus multilocularis aldehyde reductase 0.0176 0.2888 0.7042
Trichomonas vaginalis dullard protein, putative 0.0013 0.0129 0.0113
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Echinococcus multilocularis hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Schistosoma mansoni hypothetical protein 0.0016 0.0187 0.0456
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0593 0.1412
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Mycobacterium ulcerans oxidoreductase 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.2364 0.5764
Loa Loa (eye worm) hypothetical protein 0.0154 0.2512 0.6124
Onchocerca volvulus 0.0072 0.1126 0.2745
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0006 0.0016 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0187 0.0456
Loa Loa (eye worm) hypothetical protein 0.0013 0.0126 0.0307
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase 1 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Schistosoma mansoni potassium channel beta 0.0072 0.1126 0.2745
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.1126 0.1112
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0006 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase 0.0248 0.4102 1
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0072 0.1126 0.2745
Trypanosoma brucei aldo/keto reductase, putative 0.0072 0.1126 0.2717
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0072 0.1126 0.2745
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Trypanosoma brucei prostaglandin f synthase 0.0248 0.4102 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0129 0.0113
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0013 0.0129 0.0313
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0129 0.0113
Onchocerca volvulus 0.0006 0.0016 0.0038
Leishmania major prostaglandin f synthase, putative 0.0248 0.4102 1
Leishmania major hypothetical protein, conserved 0.0013 0.0129 0.0276
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0129 0.0313
Echinococcus granulosus protein tyrosine phosphatase n9 0.0006 0.0016 0.0038
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.078 0.1902
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0129 0.0129
Loa Loa (eye worm) acetyltransferase 0.0149 0.2435 0.5936
Trichomonas vaginalis dullard protein, putative 0.0013 0.0129 0.0113
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Schistosoma mansoni pcd6 interacting protein-related 0.0006 0.0016 0.0038
Echinococcus granulosus hypothetical protein 0.0248 0.4102 1
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0013 0.0129 0.0276
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.1126 0.1112
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0129 0.0113
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0072 0.1126 0.1112
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) oxidoreductase 0.0248 0.4102 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0248 0.4102 0.4092
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0654 0.1323
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Plasmodium falciparum aldo-keto reductase, putative 0.0072 0.1126 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0072 0.1126 0.1126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.078 0.1902
Echinococcus multilocularis aldo keto reductase 0.0248 0.4102 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0006 0.0016 0.0038
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0654 0.1323
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus granulosus voltage gated potassium channel subunit 0.0072 0.1126 0.2745
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.078 0.1902
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0248 0.4102 0.4092
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0006 0.0016 0.0038
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Plasmodium vivax aldehyde reductase, putative 0.0072 0.1126 1
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0597 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Echinococcus multilocularis muscleblind protein 0.0154 0.2512 0.6124
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0248 0.4102 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Trypanosoma cruzi aldo-keto reductase 0.0248 0.4102 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0593 0.4652
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Onchocerca volvulus 4.1 G protein, putative homolog 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0006 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0016 0.0187 0.0456
Brugia malayi hypothetical protein 0.0006 0.0016 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Giardia lamblia Aldose reductase 0.0248 0.4102 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0654 0.1595
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Brugia malayi NADH-dependent xylose reductase 0.0072 0.1126 0.2745
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Entamoeba histolytica alcohol dehydrogenase, putative 0.0072 0.1126 0.1126
Loa Loa (eye worm) protein tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.4102 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0122 0.197 0.4802
Onchocerca volvulus 0.0248 0.4102 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Onchocerca volvulus 0.0006 0.0016 0.0038
Leishmania major aldo-keto reductase-like protein 0.0248 0.4102 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0248 0.4102 1
Schistosoma mansoni pol-related 0.0248 0.4102 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Brugia malayi hypothetical protein 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.2435 0.5936
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Entamoeba histolytica aldose reductase, putative 0.0248 0.4102 0.4102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0187 0.0456
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0187 0.0456
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0006 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0035 0.0506 0.1233
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Brugia malayi hypothetical protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0006 0.0016 0.0038
Brugia malayi hypothetical protein 0.0006 0.0016 0.0038
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0654 0.064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.197 0.4802
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0006 0.0016 0.0038
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0072 0.1126 0.2511
Echinococcus multilocularis 0.0006 0.0016 0.0038
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0122 0.197 0.4802
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0154 0.2512 0.6124
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0072 0.1126 0.2745
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Plasmodium falciparum aldehyde reductase, putative 0.0072 0.1126 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0248 0.4102 0.4092
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Trypanosoma brucei aldo-keto reductase, putative 0.0248 0.4102 1
Onchocerca volvulus 0.0248 0.4102 1
Echinococcus multilocularis 0.0013 0.0129 0.0313
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus multilocularis voltage gated potassium channel subunit 0.0072 0.1126 0.2745
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Brugia malayi hypothetical protein 0.0006 0.0016 0.0038
Echinococcus granulosus aldehyde reductase 0.0176 0.2888 0.7042
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase 0.0248 0.4102 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0187 0.0456
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Trichomonas vaginalis dullard protein, putative 0.0013 0.0129 0.0113
Schistosoma mansoni protein tyrosine phosphatase 0.0006 0.0016 0.0038
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0006 0.0016 0.0038
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0006 0.0016 0.0016
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase 0.0248 0.4102 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Entamoeba histolytica aldose reductase, putative 0.0248 0.4102 0.4102
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0248 0.4102 0.4092
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Echinococcus granulosus GPCR family 2 0.0016 0.0187 0.0456
Onchocerca volvulus 0.0248 0.4102 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0506 0.1233
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0072 0.1126 0.2511
Onchocerca volvulus 0.0248 0.4102 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0129 0.0313
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0187 0.0456
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0248 0.4102 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0122 0.197 0.4802
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0122 0.197 0.4802
Onchocerca volvulus 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0006 0.0016 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0248 0.4102 0.4092
Echinococcus granulosus muscleblind protein 0.0154 0.2512 0.6124
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.1126 0.1112
Schistosoma mansoni hypothetical protein 0.0016 0.0187 0.0456
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Onchocerca volvulus 0.0006 0.0016 0.0038
Loa Loa (eye worm) oxidoreductase 0.0248 0.4102 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0654 0.5271
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0006 0.0016 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.078 0.1902
Onchocerca volvulus 0.0006 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0038
Echinococcus multilocularis GPCR, family 2 0.0016 0.0187 0.0456
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0248 0.4102 1
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0129 0.0313
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0006 0.0016 0.0038
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0006 0.0016 0.0038
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0072 0.1126 0.1112
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0006 0.0016 0.0038
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0072 0.1126 0.2717
Onchocerca volvulus 0.0006 0.0016 0.0038
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0248 0.4102 1
Toxoplasma gondii aldo-keto reductase 0.0072 0.1126 0.2511
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0006 0.0016 0.0038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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