Detailed information for compound 589715

Basic information

Technical information
  • TDR Targets ID: 589715
  • Name: 5-bromo-1-[(4S,5R)-4-hydroxy-5-(hydroxymethyl )tetrahydrofuran-2-yl]pyrimidin-2-one
  • MW: 291.099 | Formula: C9H11BrN2O4
  • H donors: 2 H acceptors: 3 LogP: -0.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC(C[C@@H]1O)n1cc(Br)cnc1=O
  • InChi: 1S/C9H11BrN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2/t6-,7+,8?/m0/s1
  • InChiKey: ZVJGRUIFYOSAMF-KJFJCRTCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromo-1-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-2-pyrimidinone
  • 5-bromo-1-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 5-bromo-1-[(4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one
  • 1-(2-deoxy-beta-ribofuranosyl)-5-bromo-2-pyrimidinone
  • 96245-87-3
  • 2(1H)-Pyrimidinone, 5-bromo-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-
  • BrPdR

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0511 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0324 0.0319
Schistosoma mansoni hypothetical protein 0.0033 0.0177 0.0077
Echinococcus granulosus pyruvate kinase 0.0035 0.0226 0.0149
Echinococcus granulosus netrin receptor unc 5 0.0033 0.017 0.0093
Schistosoma mansoni hypothetical protein 0.0303 0.8402 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0103 0.2315 0.332
Echinococcus granulosus Ankyrin 0.0033 0.0174 0.0097
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0324 0.0324
Schistosoma mansoni hypothetical protein 0.0043 0.0462 0.0421
Loa Loa (eye worm) hypothetical protein 0.0033 0.0177 0.0096
Brugia malayi Pre-SET motif family protein 0.0219 0.5835 0.8628
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.017 0.017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.1398 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0831 0.1082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.2385 0.3426
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.1398 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.017 0.017
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0324 0.0318
Brugia malayi PAS domain containing protein 0.0061 0.1004 0.1343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0324 0.0319
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0324 0.0249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0226 0.0169
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0113 0.0113
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0177 0.0177
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.258 0.2522
Loa Loa (eye worm) hypothetical protein 0.0052 0.0742 0.0949
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0324 0.0319
Brugia malayi ecdysteroid receptor 0.0038 0.0324 0.0319
Echinococcus multilocularis Ankyrin 0.0033 0.0174 0.0174
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0226 0.0169
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1363 0.1885
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.1398 1
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0324 0.0319
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0324 0.0319
Echinococcus granulosus aryl hydrocarbon receptor 0.0131 0.3149 0.3095
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0324 0.0255
Onchocerca volvulus 0.0038 0.0324 0.0318
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0831 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0511 0.06
Schistosoma mansoni single-minded 0.0061 0.1004 0.1075
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0511 0.06
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.1398 1
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.2315 0.2255
Brugia malayi nuclear receptor NHR-88 0.0038 0.0324 0.0319
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0324 0.0324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0324 0.0255
Brugia malayi hypothetical protein 0.0112 0.258 0.372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0739 0.4382
Brugia malayi AMP-binding enzyme family protein 0.0073 0.1398 0.1937
Schistosoma mansoni patched 1 0.0044 0.0511 0.048
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0324 0.0249
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0226 0.017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.1398 1
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.3671 0.3621
Brugia malayi hypothetical protein 0.0249 0.6745 1
Brugia malayi Uncoordinated protein 44 0.0033 0.017 0.0086
Onchocerca volvulus Netrin receptor homolog 0.0033 0.017 0.0086
Echinococcus granulosus pyruvate kinase 0.0035 0.0226 0.0149
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.017 0.0093
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0226 0.017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0177 0.01
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0324 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.1398 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0177 0.0177
Brugia malayi steroid hormone receptor 0.0038 0.0324 0.0319
Entamoeba histolytica hypothetical protein 0.0112 0.258 1
Entamoeba histolytica hypothetical protein 0.0112 0.258 1
Schistosoma mansoni pyruvate kinase 0.0035 0.0226 0.0136
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0226 0.017
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0511 0.0437
Trichomonas vaginalis set domain proteins, putative 0.0249 0.6758 1
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0324 0.0255
Loa Loa (eye worm) hypothetical protein 0.0104 0.2337 0.3354
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0324 0.0249
Loa Loa (eye worm) hypothetical protein 0.0115 0.2668 0.3853
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0324 0.0319
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0055 0.0831 0.1082
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0073 0.1398 0.1937
Echinococcus granulosus nuclear factor of activated T cells 5 0.0325 0.9082 0.9075
Mycobacterium ulcerans putative regulatory protein 0.0045 0.0523 0.2541
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0226 0.5
Onchocerca volvulus 0.0052 0.0742 0.0946
Brugia malayi Protein kinase domain containing protein 0.0033 0.017 0.0086
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0324 0.0255
Onchocerca volvulus 0.0051 0.0703 0.0887
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0324 0.0249
Giardia lamblia Pyruvate kinase 0.0035 0.0226 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0324 0.0319
Brugia malayi bHLH-PAS transcription factor 0.0045 0.0523 0.0619
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.017 0.0086
Echinococcus multilocularis pyruvate kinase 0.0035 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.013 0.3133 0.4553
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0324 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0324 0.0319
Echinococcus multilocularis tumor protein p63 0.0355 1 1
Schistosoma mansoni hypothetical protein 0.0043 0.0462 0.0421
Schistosoma mansoni hypothetical protein 0.0033 0.0177 0.0077
Echinococcus multilocularis protein dispatched 1 0.0051 0.0703 0.0703
Echinococcus multilocularis pyruvate kinase 0.0035 0.0226 0.0226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0739 0.4382
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0325 0.9082 0.9082
Schistosoma mansoni hypothetical protein 0.0043 0.0462 0.0421
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.1398 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0177 0.01
Loa Loa (eye worm) hypothetical protein 0.0073 0.1398 0.1937
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0324 0.0255
Loa Loa (eye worm) hypothetical protein 0.0055 0.0831 0.1082
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0226 0.1568
Loa Loa (eye worm) hypothetical protein 0.0033 0.017 0.0086
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0249 0.6745 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0176 0.4517 0.5313
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0831 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.2364 0.2715
Onchocerca volvulus 0.013 0.3133 0.4542
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0511 0.0437
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.1398 1
Schistosoma mansoni netrin receptor unc5 0.0033 0.017 0.0069
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0324 0.0318
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0226 0.0169
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0226 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0739 0.4382
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.258 0.258
Onchocerca volvulus 0.0045 0.0539 0.0641
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0831 0.5163
Onchocerca volvulus 0.0073 0.1398 0.1932
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0324 0.0249
Echinococcus granulosus death domain containing protein 0.0033 0.017 0.0093
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.2315 0.332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0324 0.0324
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.2337 0.7946
Loa Loa (eye worm) hypothetical protein 0.0055 0.0831 0.1082
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0324 0.0318
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.1398 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0324 0.0319
Schistosoma mansoni survival motor neuron protein 0.0051 0.0703 0.0712
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.1398 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0703 0.089
Loa Loa (eye worm) hypothetical protein 0.0115 0.2652 0.3829
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0324 0.0249
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0226 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0174 0.0092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Brugia malayi CHE-14 protein 0.0044 0.0511 0.06
Echinococcus multilocularis expressed conserved protein 0.0097 0.2123 0.2123
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0324 0.0255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.017 0.0086
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.5835 0.8628
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0324 0.0249
Brugia malayi nuclear hormone receptor 0.0038 0.0324 0.0319
Onchocerca volvulus 0.0249 0.6762 1
Schistosoma mansoni coup transcription factor 0.0038 0.0324 0.0255
Schistosoma mansoni hypothetical protein 0.0033 0.0177 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0324 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0324 0.0249
Echinococcus multilocularis X box binding protein 1 0.0303 0.8402 0.8402
Loa Loa (eye worm) hypothetical protein 0.0072 0.1363 0.1885
Schistosoma mansoni hypothetical protein 0.0072 0.1363 0.1508
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0324 0.0255
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.1398 1
Entamoeba histolytica hypothetical protein 0.0112 0.258 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0324 0.0319
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0115 0.2652 0.3829
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0324 0.0324
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.2385 0.3426
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.1398 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0324 0.0319
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0324 0.0319
Mycobacterium ulcerans hypothetical protein 0.0073 0.1398 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.1398 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0177 0.0096
Schistosoma mansoni hypothetical protein 0.0051 0.0703 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0324 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0106 0.2385 0.3426
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0324 0.0255
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0226 1
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.6745 0.6745
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0226 0.017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0324 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0073 0.1398 0.1937
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.2315 0.2315
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.017 0.0069
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.2315 0.7757
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0831 0.5163
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0324 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0324 0.0324
Brugia malayi AMP-binding enzyme family protein 0.0073 0.1398 0.1937
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0324 0.0319
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0831 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0113 0.0036
Echinococcus multilocularis aryl hydrocarbon receptor 0.0131 0.3149 0.3149
Echinococcus granulosus single minded 2 0.0045 0.0523 0.0449
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0043 0.0462 0.0421
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.3671 0.3671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.2385 0.3426
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0324 0.0255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0324 0.0319
Schistosoma mansoni pyruvate kinase 0.0035 0.0226 0.0136
Echinococcus granulosus expressed conserved protein 0.0097 0.2123 0.2061
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0104 0.2337 0.3345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0054 0.0816 0.106
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.6745 0.6719
Schistosoma mansoni hypothetical protein 0.0033 0.0177 0.0077
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.258 0.2976
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0226 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0324 0.0255
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0324 0.0324
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.1398 1
Schistosoma mansoni hypothetical protein 0.0112 0.258 0.2976
Loa Loa (eye worm) hypothetical protein 0.0073 0.1398 0.1937
Echinococcus multilocularis transfer RNA-Lys 0.0045 0.0523 0.0523
Entamoeba histolytica hypothetical protein 0.0112 0.258 1
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0226 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0324 0.0319
Echinococcus granulosus GPCR family 2 0.0033 0.0177 0.01
Brugia malayi Death domain containing protein 0.0033 0.017 0.0086
Echinococcus granulosus X box binding protein 1 0.0303 0.8402 0.8389
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0324 0.0255
Loa Loa (eye worm) hypothetical protein 0.0055 0.0831 0.1082
Schistosoma mansoni hypothetical protein 0.0033 0.017 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0324 0.0319
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0511 0.0511
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0739 0.4382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0324 0.0319
Echinococcus multilocularis protein patched 0.0044 0.0511 0.0511
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.2337 0.7946
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.017
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0742 0.0759
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0177 0.0096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0177 0.0096
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0324 0.0249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0319
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0174 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0324 0.0319
Entamoeba histolytica heat shock transcription factor, putative 0.0104 0.2337 0.7946
Brugia malayi HSF-type DNA-binding domain containing protein 0.0104 0.2337 0.3354

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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