Detailed information for compound 589947

Basic information

Technical information
  • TDR Targets ID: 589947
  • Name: 2-[(3-amino-2-methyl-propanoyl)amino]ethyl di hydrogen phosphate
  • MW: 226.167 | Formula: C6H15N2O5P
  • H donors: 4 H acceptors: 4 LogP: -4.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(C(=O)NCCOP(=O)(O)O)C
  • InChi: 1S/C6H15N2O5P/c1-5(4-7)6(9)8-2-3-13-14(10,11)12/h5H,2-4,7H2,1H3,(H,8,9)(H2,10,11,12)
  • InChiKey: WSQUYBNOQAUBKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3-amino-2-methyl-1-oxopropyl)amino]ethyl dihydrogen phosphate
  • 2-[(3-azanyl-2-methyl-propanoyl)amino]ethyl dihydrogen phosphate
  • 2-[(3-amino-2-methylpropanoyl)amino]ethyl dihydrogen phosphate
  • SZJ 3361
  • 96923-17-0
  • 3-Amino-2-methyl-N-(2-(phosphonooxy)ethyl)propanamide
  • Propanamide, 3-amino-2-methyl-N-(2-(phosphonooxy)ethyl)-
  • Szj-3361

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.008 0.008
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0107 0.0122
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0008 0.008 0.0057
Trypanosoma brucei UDP-galactose 4-epimerase 0.011 0.3192 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0144 0.0144
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0325 0.0325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0325 0.0971
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.5462 0.5462
Brugia malayi hypothetical protein 0.0009 0.0107 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0107 0.0122
Brugia malayi hypothetical protein 0.0008 0.008 0.0091
Echinococcus multilocularis geminin 0.0333 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0325 0.037
Onchocerca volvulus 0.0008 0.008 0.0094
Brugia malayi N-terminal motif family protein 0.0006 0.003 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.5462 0.5462
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.005 0.005
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0144 0.0144
Brugia malayi RasGEF domain containing protein 0.0006 0.003 0.0034
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0325 0.5
Brugia malayi nuclear hormone receptor 0.001 0.0144 0.0165
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.003 0.003
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.008 0.0091
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0144 0.0165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0325 0.0971
Echinococcus multilocularis UDP glucose 4 epimerase 0.0106 0.3061 0.3061
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0144 0.0217
Schistosoma mansoni dishevelled 0.0009 0.0107 0.0107
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.008 0.0091
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.003 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0144 0.0144
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3396 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.008 0.008
Schistosoma mansoni thyroid hormone receptor 0.001 0.0144 0.0144
Schistosoma mansoni nuclear hormone receptor 0.001 0.0144 0.0144
Schistosoma mansoni rab6-interacting 0.0042 0.1127 0.1127
Brugia malayi N-terminal motif family protein 0.0006 0.003 0.0034
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1241 0.2985
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.008 0.008
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0325 0.0337
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0008 0.008 0.0057
Echinococcus multilocularis RUN 0.0042 0.1127 0.1127
Leishmania major trypanothione reductase 0.0046 0.1241 0.3197
Brugia malayi Doublecortin family protein 0.0042 0.1127 0.1285
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0008 0.008 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0144 0.0165
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0195 0.0223
Echinococcus granulosus Protein son of sevenless 0.0006 0.003 0.003
Leishmania major udp-glc 4-epimerase, putative 0.011 0.3192 1
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0325 0.0971
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.008 0.0091
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0106 0.3061 0.3468
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0144 0.0144
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0106 0.3061 0.3468
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.008 0.0091
Echinococcus granulosus ras GTP exchange factor 0.0006 0.003 0.003
Onchocerca volvulus 0.0042 0.1127 0.2078
Echinococcus granulosus cpg binding protein 0.003 0.0739 0.0739
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0333 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0144 0.0144
Brugia malayi ecdysteroid receptor 0.001 0.0144 0.0165
Schistosoma mansoni rab6-interacting 0.0042 0.1127 0.1127
Onchocerca volvulus 0.001 0.0144 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0144 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0144 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0144 0.0165
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0144 0.0144
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0144 0.0144
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.005 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0144 0.0144
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.003 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.5462 0.5462
Brugia malayi RasGEF domain containing protein 0.0006 0.003 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1646 0.1646
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0107 0.0122
Echinococcus granulosus RUN 0.0042 0.1127 0.1127
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0107 0.0107
Mycobacterium ulcerans glutaminase 0.0293 0.8771 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0144 0.0165
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Loa Loa (eye worm) hypothetical protein 0.0179 0.5307 0.6051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0144 0.0144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3396 1
Schistosoma mansoni lipoxygenase 0.0186 0.5496 0.5496
Schistosoma mansoni thyroid hormone receptor 0.001 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0107 0.0122
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.1127 0.1127
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0144 0.0165
Echinococcus multilocularis expressed protein 0.0008 0.008 0.008
Echinococcus multilocularis son of sevenless 1 0.0006 0.003 0.003
Onchocerca volvulus 0.0028 0.0691 0.1251
Echinococcus multilocularis cpg binding protein 0.003 0.0739 0.0739
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0325 0.0971
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.008 0.0091
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.008 0.008
Echinococcus granulosus expressed protein 0.0008 0.008 0.008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0144 0.0144
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0144 0.0144
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.003 0.003
Trypanosoma brucei trypanothione reductase 0.0046 0.1241 0.3197
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0144 0.0217
Schistosoma mansoni polycystin 1-related 0.0042 0.1127 0.1127
Brugia malayi steroid hormone receptor 0.001 0.0144 0.0165
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.003 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.1127 0.1127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0325 0.0971
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0144 0.0165
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0107 0.0107
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0144 0.0165
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0106 0.3061 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.008 0.008
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0106 0.3061 1
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0107 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0691 0.0787
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.008 0.008
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.003 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.1127 0.1127
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0107 0.0107
Schistosoma mansoni glutaminase 0.0293 0.8771 0.8771
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.008 0.008
Brugia malayi hypothetical protein 0.0042 0.1127 0.1285
Brugia malayi UDP galactose 4'-epimerase 0.0106 0.3061 0.349
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1241 0.1241
Schistosoma mansoni cpg binding protein 0.0028 0.0691 0.0691
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.008 0.008
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Giardia lamblia UDP-glucose 4-epimerase 0.011 0.3192 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.003 0.0034
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.3039 0.8837
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0031 0.0001
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.008 0.0057
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0107 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1453 0.4555
Loa Loa (eye worm) hypothetical protein 0.0009 0.0107 0.0122
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.008 0.008
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.3039 0.8837
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0325 0.0337
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0144 0.0165
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.008 0.0057
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3396 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0107 0.0122
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1241 0.3997
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.1127 0.1127
Trichomonas vaginalis glutaminase, putative 0.0293 0.8771 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0144 0.0144
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.008 0.008
Brugia malayi hypothetical protein 0.0042 0.1127 0.1285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0144 0.0165
Loa Loa (eye worm) hypothetical protein 0.0009 0.0107 0.0122
Trichomonas vaginalis helicase, putative 0.0006 0.0031 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0144 0.0165
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.005 0.005
Mycobacterium tuberculosis Probable reductase 0.0105 0.3039 0.8837
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0144 0.0165
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1241 0.1415
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0008 0.008 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.5462 0.5462
Loa Loa (eye worm) glutaminase 0.0293 0.8771 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0107 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0144 0.0144
Schistosoma mansoni cpg binding protein 0.003 0.0739 0.0739
Loa Loa (eye worm) hypothetical protein 0.0008 0.008 0.0091
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0144 0.0144
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0325 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.5462 0.5462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0144 0.0144
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.008 0.0091
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0144 0.0165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0144 0.0144
Schistosoma mansoni UDP-glucose 4-epimerase 0.0106 0.3061 0.3061
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.008 0.0091
Brugia malayi RasGEF domain containing protein 0.0006 0.003 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0144 0.0165
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0106 0.3061 0.3468
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.008 0.0091
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0325 0.0735
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.3039 0.8837
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.008 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0325 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.1127 0.875
Echinococcus granulosus son of sevenless 1 0.0006 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.1127 0.1285
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.005 0.005
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0325 0.0325
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.008 0.0091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0144 0.0144
Onchocerca volvulus 0.0008 0.008 0.0094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0144 0.0165
Plasmodium vivax glutathione reductase, putative 0.0046 0.1241 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0102 0.0116
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0325 0.0971
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Onchocerca volvulus 0.0009 0.0107 0.0146
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.008 0.0057
Plasmodium falciparum glutathione reductase 0.0046 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0144 0.0165
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0107 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.5462 0.6228
Brugia malayi glutaminase DH11.1 0.0293 0.8771 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0144 0.0165
Brugia malayi hypothetical protein 0.0009 0.0107 0.0122
Toxoplasma gondii UDP-glucose 4-epimerase 0.0106 0.3061 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0186 0.5496 0.5496
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0107 0.0107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0325 0.5
Toxoplasma gondii thioredoxin reductase 0.0046 0.1241 0.384
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.1127 0.1127
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.008 0.008
Echinococcus granulosus UDP glucose 4 epimerase 0.0106 0.3061 0.3061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.5462 0.5462
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0144 0.0144
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.008 0.0091
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.008 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0144 0.0165
Schistosoma mansoni dishevelled 0.0009 0.0107 0.0107
Loa Loa (eye worm) glutathione reductase 0.0046 0.1241 0.1415
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.1127 0.1127
Onchocerca volvulus 0.0008 0.008 0.0094
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3396 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0107 0.0107
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0325 0.0325
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.008 0.008
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.003 0.0034
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0144 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0144 0.0144
Schistosoma mansoni lipoxygenase 0.011 0.3177 0.3177
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.008 0.008
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.008 0.008
Entamoeba histolytica G protein alpha subunit, putative 0.0008 0.008 0.0164
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0144 0.0144
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.008 0.008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0325 0.0971
Loa Loa (eye worm) hypothetical protein 0.0042 0.1127 0.1285
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.008 0.0091
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0107 0.0146
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0325 0.0971
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0144 0.0165
Echinococcus multilocularis Protein son of sevenless 0.0006 0.003 0.003
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0107 0.0107
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0325 0.0735
Echinococcus granulosus FTZ F1 alpha 0.001 0.0144 0.0144
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1241 0.1241
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0144 0.0217
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1241 1
Schistosoma mansoni hypothetical protein 0.0042 0.1127 0.1127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.008 0.0091
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.008 0.0057
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0186 0.5496 0.5496
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.3039 0.8837
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0106 0.3061 1
Brugia malayi glutathione reductase 0.0046 0.1241 0.1415
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0107 0.0107
Brugia malayi CXXC zinc finger family protein 0.0028 0.0691 0.0787
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.1127 0.875
Loa Loa (eye worm) hypothetical protein 0.0008 0.008 0.0091
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.008 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0144 0.0144
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0144 0.0165
Schistosoma mansoni coup transcription factor 0.001 0.0144 0.0144
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0008 0.008 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0144 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0144 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Schistosoma mansoni cpg binding protein 0.003 0.0739 0.0739
Loa Loa (eye worm) glutaminase 2 0.0293 0.8771 1
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.003 0.003
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0008 0.008 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0144 0.0165
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.008 0.008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0031 0.0001
Brugia malayi G-protein alpha subunit 0.0008 0.008 0.0091
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.003 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0099 0.0112
Brugia malayi N-terminal motif family protein 0.0179 0.5307 0.6051
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.008 0.008
Loa Loa (eye worm) doublecortin family protein 0.0042 0.1127 0.1285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0001
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0106 0.3061 0.349
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0031 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0031 0.0001
Treponema pallidum NADH oxidase 0.0016 0.0325 0.5
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.5307 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0195 0.0223
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.003 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.5462 0.5462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0144 0.0144
Brugia malayi Thioredoxin reductase 0.0046 0.1241 0.1415
Schistosoma mansoni hypothetical protein 0.0333 1 1
Schistosoma mansoni dep domain containing protein 0.0009 0.0107 0.0107
Onchocerca volvulus 0.0042 0.1127 0.2078
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0107 0.0107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.5462 0.6228
Loa Loa (eye worm) hypothetical protein 0.0008 0.008 0.0091
Schistosoma mansoni loxhd1 0.0042 0.1127 0.1127
Schistosoma mansoni ras GTP exchange factor 0.0006 0.003 0.003
Brugia malayi nuclear receptor NHR-88 0.001 0.0144 0.0165
Brugia malayi DIX domain containing protein 0.0009 0.0107 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0144 0.0165
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.3039 0.8837
Plasmodium falciparum thioredoxin reductase 0.0046 0.1241 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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