Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0563 | 0.0555 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0171 | 0.1312 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.3839 | 0.9534 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1834 | 0.2351 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0425 | 0.0259 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.0782 | 0.137 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1303 | 0.0797 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0425 | 0.0259 |
Echinococcus multilocularis | geminin | 0.0183 | 0.7242 | 0.7195 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.3839 | 0.5187 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1303 | 0.1303 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.1303 | 0.0797 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0574 | 0.078 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0574 | 0.078 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0171 | 0.0171 |
Onchocerca volvulus | 0.0038 | 0.1303 | 0.2577 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1904 | 0.1904 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0574 | 0.4402 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1303 | 0.1303 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.1303 | 0.2839 |
Brugia malayi | hypothetical protein | 0.0129 | 0.5056 | 0.5056 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.1574 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0425 | 0.0425 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.5056 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.1574 | 0.1427 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.3839 | 0.3732 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0574 | 0.041 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.0782 | 0.0622 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.025 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1303 | 0.2839 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.0782 | 0.137 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1508 | 0.1891 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0425 | 0.036 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.1303 | 0.1601 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0574 | 0.078 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.1303 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1303 | 0.1303 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.1303 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1303 | 0.1303 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.1303 | 0.2839 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.1303 | 0.0797 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1303 | 0.2839 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0171 | 0.1312 |
Onchocerca volvulus | 0.0038 | 0.1303 | 0.2577 | |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.1303 | 1 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.1574 | 0.1427 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.3839 | 0.3732 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.177 | 0.4157 |
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.0782 | 0.0622 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.1303 | 0.0797 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.1303 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 1 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0171 | 0.0171 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0104 | 0.4012 | 0.4012 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0574 | 0.0569 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.1303 | 0.2839 |
Brugia malayi | beta-lactamase | 0.0038 | 0.1303 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0171 | 0.0171 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.1303 | 0.0797 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.3839 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.3839 | 0.7593 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.1303 | 0.2839 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.4012 | 0.4012 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.1303 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.1303 | 0.1152 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1904 | 0.1904 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.3839 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.1833 | 0.1691 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1834 | 0.2351 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0574 | 0.0574 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0574 | 0.4402 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1303 | 0.0797 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0425 | 0.0259 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.0782 | 0.0782 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.1303 | 0.1303 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0149 | 0.5845 | 0.5773 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0574 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0574 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1986 | 0.1986 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0425 | 0.036 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0106 | 0.4078 | 0.5526 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0574 | 0.1098 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0425 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1219 | 0.1219 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0656 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1219 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.5056 | 0.5056 |
Onchocerca volvulus | 0.0038 | 0.1303 | 0.2577 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.1303 | 0.1601 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1508 | 0.1891 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.1303 | 0.1303 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0158 | 0.6222 | 0.6156 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0243 | 0.972 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.7242 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0183 | 0.7242 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0425 | 0.0259 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0171 | 0.0171 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.1303 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1303 | 0.1303 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0049 | 0.177 | 0.4157 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0574 | 0.078 |
Brugia malayi | Muscleblind-like protein | 0.0158 | 0.6222 | 0.6222 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.1303 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1508 | 0.1891 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1303 | 0.2839 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.1574 | 0.1427 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.1303 | 0.0797 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0574 | 0.078 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0574 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.4983 | 0.4983 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.1303 | 0.0797 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.3839 | 0.3839 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.1303 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.5056 | 0.5056 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0104 | 0.4012 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0574 | 0.0743 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0425 | 0.0425 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1574 | 0.1574 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0425 | 0.0425 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0574 | 0.0574 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.1303 | 0.1152 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.1303 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.3839 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.1303 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1904 | 0.1904 |
Echinococcus granulosus | geminin | 0.0183 | 0.7242 | 0.7195 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1904 | 0.1904 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0445 | 0.3417 |
Schistosoma mansoni | kinase | 0.0051 | 0.1824 | 0.2337 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.3839 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6222 | 0.6222 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.1303 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.1303 | 0.0797 |
Echinococcus granulosus | muscleblind protein | 0.0158 | 0.6222 | 0.6156 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0149 | 0.5845 | 0.5773 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0574 | 0.8744 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1219 | 0.1219 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.1574 | 0.3604 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1834 | 0.1834 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1303 | 0.2839 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.025 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0574 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.1303 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0104 | 0.4012 | 0.3908 |
Echinococcus multilocularis | muscleblind protein | 0.0158 | 0.6222 | 0.6156 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.1303 | 1 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.1574 | 0.1984 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.1574 | 0.1574 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.3753 | 0.3645 |
Onchocerca volvulus | Huntingtin homolog | 0.0129 | 0.5056 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.1303 | 0.2839 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.1303 | 0.2839 |
Onchocerca volvulus | 0.0051 | 0.1834 | 0.3626 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.3839 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0104 | 0.4012 | 0.3908 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.3839 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.0171 | 0.2605 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.1574 | 0.1574 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0425 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6222 | 0.6222 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0425 | 0.0259 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0425 | 0.036 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0574 | 0.0569 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.3839 | 0.3839 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1303 | 0.1303 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0437 | 0.3353 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1508 | 0.1891 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.0782 | 0.0782 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.3753 | 0.3645 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0425 | 0.0259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.