Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.3602 | 1 |
Echinococcus granulosus | geminin | 0.0173 | 0.5037 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.005 | 0.1226 | 0.3404 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0171 | 0.0339 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0784 | 0.2177 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0171 | 0.0339 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0045 | 0.1082 | 0.3005 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0784 | 0.2177 |
Onchocerca volvulus | 0.0035 | 0.0784 | 1 | |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0171 | 0.0339 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0784 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.3602 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.3602 | 0.7151 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3602 | 0.7151 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.1436 | 0.2851 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0171 | 0.0339 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0784 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0784 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.6652 | 0.6367 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0784 | 0.2177 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0784 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0784 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0784 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5037 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0171 | 0.0474 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0784 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0784 | 0.2177 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0061 | 0.158 | 0.3137 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0784 | 0.2177 |
Loa Loa (eye worm) | glutamate receptor | 0.0019 | 0.0298 | 0.0826 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0784 | 0.1557 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0784 | 0.2177 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0013 | 0.0088 | 0.0244 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1198 | 0.3327 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0042 | 0.0978 | 0.1941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3602 | 0.7151 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0784 | 0.1557 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3602 | 0.7151 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0171 | 0.0474 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0784 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.005 | 0.1226 | 0.3404 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0784 | 0.2177 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0784 | 0.2177 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1198 | 0.3327 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0784 | 0.2177 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0042 | 0.0978 | 0.1941 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.3602 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0784 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0171 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0723 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0784 | 0.2177 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0171 | 0.0339 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0723 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.158 | 0.4386 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0171 | 0.0474 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0723 | 0.1435 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0171 | 0.0339 |
Onchocerca volvulus | 0.0035 | 0.0784 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3602 | 0.7151 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0784 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0784 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1198 | 0.3327 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0013 | 0.0088 | 0.0244 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0088 | 0.0244 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0171 | 0.0474 |
Echinococcus multilocularis | geminin | 0.0173 | 0.5037 | 1 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.3602 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.3602 | 0.7151 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.5037 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.3602 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0784 | 0.2177 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0024 | 0.0441 | 0.0876 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0784 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.3306 | 0.9179 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0171 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0171 | 0.0339 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0013 | 0.0088 | 0.0244 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0784 | 0.1557 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1198 | 0.3327 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0061 | 0.158 | 0.3137 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0171 | 0.0339 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0024 | 0.0441 | 0.1226 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0784 | 0.2177 |
Onchocerca volvulus | 0.0035 | 0.0784 | 1 | |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.3306 | 0.9179 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0042 | 0.0978 | 0.1941 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0784 | 0.1557 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.3306 | 0.9179 |
Brugia malayi | RNA binding protein | 0.0126 | 0.3602 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0784 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0784 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.3602 | 0.7151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.