Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0 | 0.5 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.002 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Plasmodium vivax | replication factor C subunit 1, putative | 0.002 | 0 | 0.5 |
Chlamydia trachomatis | DNA ligase | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.002 | 0 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.002 | 0 | 0.5 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0 | 0.5 |
Giardia lamblia | Replication factor C, subunit 1 | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0 | 0.5 |
Treponema pallidum | DNA ligase (lig) | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Toxoplasma gondii | ATPase, AAA family protein | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.002 | 0 | 0.5 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.