Detailed information for compound 590395

Basic information

Technical information
  • TDR Targets ID: 590395
  • Name: 5-methyl-6-(3-pyridyl)thiomorpholin-3-one hyd rochloride
  • MW: 244.741 | Formula: C10H13ClN2OS
  • H donors: 1 H acceptors: 2 LogP: 1.69 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(C(N1)C)c1cccnc1.Cl
  • InChi: 1S/C10H12N2OS.ClH/c1-7-10(14-6-9(13)12-7)8-3-2-4-11-5-8;/h2-5,7,10H,6H2,1H3,(H,12,13);1H
  • InChiKey: YRFKLKSSPJBUQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-6-(3-pyridyl)-3-thiomorpholinone hydrochloride
  • 5-methyl-6-pyridin-3-yl-thiomorpholin-3-one hydrochloride
  • 5-methyl-6-pyridin-3-ylthiomorpholin-3-one hydrochloride
  • ZSY 27
  • 98320-12-8
  • 5-Methyl-6-(4-pyridinyl)-2H-1,4-thiazine-3(4H)one hcl
  • Zsy-27
  • 2H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-, monohydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.7034 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.099 0.099
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1867 0.205
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0217
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.5859 0.5859
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.3425 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0653 0.0653
Schistosoma mansoni tar DNA-binding protein 0.0061 0.099 0.0954
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.1641
Loa Loa (eye worm) hypothetical protein 0.0411 1 1
Echinococcus multilocularis protein patched 0.0041 0.0463 0.0206
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0463 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.3868 0.6311
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3017 0.3871
Loa Loa (eye worm) hypothetical protein 0.005 0.0701 0.0701
Schistosoma mansoni tar DNA-binding protein 0.0061 0.099 0.0954
Echinococcus multilocularis expressed conserved protein 0.009 0.1718 0.1854
Brugia malayi TAR-binding protein 0.0061 0.099 0.099
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0161 0.357 0.4714
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0463 0.0463
Echinococcus granulosus expressed conserved protein 0.009 0.1718 0.1854
Leishmania major malonyl-coa decarboxylase-like protein 0.0161 0.357 0.5074
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0217
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0062
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.1641
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5859 1
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Schistosoma mansoni tar DNA-binding protein 0.0061 0.099 0.0954
Loa Loa (eye worm) RNA binding protein 0.0061 0.099 0.099
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5859 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5859 1
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.3868 0.6311
Mycobacterium ulcerans hypothetical protein 0.0156 0.3425 1
Brugia malayi hypothetical protein 0.0035 0.0306 0.0306
Brugia malayi RNA binding protein 0.0061 0.099 0.099
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.364 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.7034 1
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.099 0.099
Loa Loa (eye worm) hypothetical protein 0.0095 0.1867 0.1867
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.2922 0.3436
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.3017 0.4289
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1867 0.1867
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1905 0.2149
Loa Loa (eye worm) hypothetical protein 0.0048 0.0653 0.0653
Schistosoma mansoni patched 1 0.0041 0.0463 0.0266
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.7034 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0463 0.0206
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.1641
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0259 0.0259
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0161 0.357 0.4714
Schistosoma mansoni tar DNA-binding protein 0.0061 0.099 0.0954
Schistosoma mansoni hypothetical protein 0.0039 0.0425 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5859 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Echinococcus multilocularis geminin 0.033 0.792 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.5859 0.5859
Schistosoma mansoni hypothetical protein 0.033 0.792 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.099 0.0898
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0161 0.357 0.4714
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Echinococcus granulosus tar DNA binding protein 0.0061 0.099 0.0898
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.3017 0.3871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0653 0.0653
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5859 1
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.0411 1 0.5
Toxoplasma gondii hypothetical protein 0.0048 0.0638 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0463 0.0463
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.1641
Schistosoma mansoni tar DNA-binding protein 0.0061 0.099 0.0954
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0 0.5
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0463 0.0206
Brugia malayi CHE-14 protein 0.0041 0.0463 0.0463
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0715 0.0358
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1867 0.205
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.2922 0.3436
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.7034 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0653 0.0653
Schistosoma mansoni hypothetical protein 0.033 0.792 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.364 0.5889
Echinococcus granulosus geminin 0.033 0.792 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0306 0.0062
Loa Loa (eye worm) TAR-binding protein 0.0061 0.099 0.099
Echinococcus multilocularis protein dispatched 1 0.0047 0.0612 0.0402
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1867 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5859 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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