Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0421 | 0.3128 | 0.2786 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | acetylcholinesterase | 0.0618 | 0.4777 | 0.7826 |
Loa Loa (eye worm) | carboxylesterase | 0.0618 | 0.4777 | 0.7826 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0203 | 0.1299 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1049 | 0.0603 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | coup transcription factor | 0.0421 | 0.3128 | 0.2786 |
Brugia malayi | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | neuroligin | 0.0104 | 0.0474 | 0.0493 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0108 | 0.0503 | 0.1185 |
Brugia malayi | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0421 | 0.3128 | 0.5017 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.024 | 0.1608 | 0.3788 |
Schistosoma mansoni | glycogen phosphorylase | 0.0554 | 0.4245 | 0.3959 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0421 | 0.3128 | 0.2786 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.077 | 0.6052 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0095 | 0.0395 | 0.0359 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0222 | 0.1463 | 0.2179 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0199 | 0.1264 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.077 | 0.6052 | 0.5855 |
Schistosoma mansoni | nuclear hormone receptor | 0.0421 | 0.3128 | 0.2786 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0108 | 0.0503 | 0.0543 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.0543 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.077 | 0.6052 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | glycogen phosphorylase | 0.0554 | 0.4245 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0104 | 0.0474 | 0.0493 |
Brugia malayi | carbohydrate phosphorylase | 0.0554 | 0.4245 | 0.6921 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Schistosoma mansoni | nuclear receptor | 0.0199 | 0.1264 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0421 | 0.3128 | 0.5017 |
Onchocerca volvulus | 0.0199 | 0.1264 | 0.2094 | |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0421 | 0.3128 | 0.2786 |
Brugia malayi | nuclear receptor NHR-67 | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0199 | 0.1264 | 0.1839 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0086 | 0.0318 | 0.075 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0421 | 0.3128 | 0.5017 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0104 | 0.0474 | 0.0631 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | Carboxylesterase family protein | 0.0104 | 0.0474 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Brugia malayi | Carboxylesterase family protein | 0.0104 | 0.0474 | 0.0493 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | nuclear hormone receptor | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | glycogen phosphorylase | 0.024 | 0.1608 | 0.119 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0618 | 0.4777 | 0.7826 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0108 | 0.0503 | 0.0703 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0105 | 0.0476 | 0.1122 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0554 | 0.4245 | 0.6921 |
Giardia lamblia | Glycogen phosphorylase | 0.0554 | 0.4245 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.024 | 0.1608 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0421 | 0.3128 | 0.2786 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0554 | 0.4245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | geminin | 0.0173 | 0.1049 | 0.1473 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0222 | 0.1463 | 0.1039 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0104 | 0.0474 | 0.0493 |
Brugia malayi | Carboxylesterase family protein | 0.0618 | 0.4777 | 0.7826 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.4777 | 0.7826 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0104 | 0.0474 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | tailless protein | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | acetylcholinesterase | 0.0618 | 0.4777 | 0.7826 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0421 | 0.3128 | 0.5017 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0421 | 0.3128 | 0.5017 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0108 | 0.0503 | 0.0703 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.024 | 0.1608 | 0.3788 |
Brugia malayi | nuclear receptor NHR-88 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0199 | 0.1264 | 0.0829 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | ecdysteroid receptor | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | nuclear hormone receptor | 0.0199 | 0.1264 | 0.0829 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0421 | 0.3128 | 0.5017 |
Echinococcus granulosus | glycogen phosphorylase | 0.0554 | 0.4245 | 0.6921 |
Brugia malayi | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0554 | 0.4245 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0199 | 0.1264 | 0.1839 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0108 | 0.0503 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.077 | 0.6052 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0104 | 0.0474 | 0.0493 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0618 | 0.4777 | 0.4517 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0222 | 0.1463 | 0.2179 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0222 | 0.1463 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Schistosoma mansoni | thyroid hormone receptor | 0.0421 | 0.3128 | 0.2786 |
Schistosoma mansoni | thyroid hormone receptor | 0.0421 | 0.3128 | 0.2786 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.024 | 0.1608 | 0.3788 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.024 | 0.1608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0421 | 0.3128 | 0.2786 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0222 | 0.1463 | 0.2179 |
Schistosoma mansoni | zinc finger protein | 0.0199 | 0.1264 | 0.0829 |
Loa Loa (eye worm) | carboxylesterase | 0.0104 | 0.0474 | 0.0493 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0104 | 0.0474 | 0.0631 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0421 | 0.3128 | 0.7038 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Echinococcus granulosus | carboxylesterase 5A | 0.0618 | 0.4777 | 0.7826 |
Loa Loa (eye worm) | carboxylesterase | 0.0104 | 0.0474 | 0.0493 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0104 | 0.0474 | 0.0493 |
Schistosoma mansoni | nuclear receptor | 0.0199 | 0.1264 | 0.0829 |
Echinococcus granulosus | neuroligin | 0.0104 | 0.0474 | 0.0493 |
Brugia malayi | nuclear hormone receptor | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | DR-78 | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0554 | 0.4245 | 0.6921 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0474 | 0.0493 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0199 | 0.1264 | 0.2094 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0554 | 0.4245 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0421 | 0.3128 | 0.5017 |
Echinococcus granulosus | acetylcholinesterase | 0.0618 | 0.4777 | 0.7826 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0203 | 0.1299 | 0.19 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0554 | 0.4245 | 0.6921 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0554 | 0.4245 | 0.6921 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0421 | 0.3128 | 0.7038 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0199 | 0.1264 | 0.1839 |
Onchocerca volvulus | 0.0421 | 0.3128 | 0.7038 | |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1049 | 0.0603 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0199 | 0.1264 | 0.1839 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0554 | 0.4245 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.1463 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0618 | 0.4777 | 0.7826 |
Brugia malayi | Carboxylesterase family protein | 0.0618 | 0.4777 | 0.7826 |
Onchocerca volvulus | 0.0199 | 0.1264 | 0.2094 | |
Trypanosoma brucei | RNA helicase, putative | 0.0113 | 0.0543 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0421 | 0.3128 | 0.2786 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0199 | 0.1264 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0203 | 0.1299 | 0.0867 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0421 | 0.3128 | 0.7038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0421 | 0.3128 | 0.5017 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0104 | 0.0474 | 0.0493 |
Brugia malayi | nuclear receptor RXR | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0421 | 0.3128 | 0.2786 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | conserved hypotetical protein | 0.0199 | 0.1264 | 0.1839 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0108 | 0.0503 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0421 | 0.3128 | 0.5017 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.077 | 0.6052 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1049 | 0.1473 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0199 | 0.1264 | 0.1839 |
Entamoeba histolytica | hypothetical protein | 0.0086 | 0.0318 | 0.075 |
Brugia malayi | ecdysone receptor | 0.0199 | 0.1264 | 0.1839 |
Echinococcus multilocularis | acetylcholinesterase | 0.0618 | 0.4777 | 0.7826 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0199 | 0.1264 | 0.1839 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0181 | 0.1115 | 0.1585 |
Brugia malayi | nuclear receptor NHR-88 | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0421 | 0.3128 | 0.2786 |
Brugia malayi | nuclear receptor RXR | 0.0222 | 0.1463 | 0.2179 |
Schistosoma mansoni | glycogen phosphorylase | 0.0554 | 0.4245 | 0.3959 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0199 | 0.1264 | 0.0829 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0554 | 0.4245 | 0.6921 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | FTZ F1 alpha | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0226 | 0.149 | 0.1067 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0108 | 0.0503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0104 | 0.0474 | 0.0493 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0618 | 0.4777 | 0.7826 |
Schistosoma mansoni | nuclear hormone receptor | 0.0199 | 0.1264 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0421 | 0.3128 | 0.5017 |
Brugia malayi | Carboxylesterase family protein | 0.0104 | 0.0474 | 0.0493 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0222 | 0.1463 | 0.1039 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0421 | 0.3128 | 0.5017 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0199 | 0.1264 | 0.1839 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0421 | 0.3128 | 0.5017 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0554 | 0.4245 | 1 |
Brugia malayi | steroid hormone receptor | 0.0421 | 0.3128 | 0.5017 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0222 | 0.1463 | 0.2179 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0554 | 0.4245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0421 | 0.3128 | 0.2786 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.3128 | 0.5017 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1264 | 0.1839 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 118 uM | Cytotoxic concentration of the compound in Wild Type CEM cells | ChEMBL. | 10229630 |
EC50 (functional) | = 2.83 uM | Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts | ChEMBL. | 10229630 |
EC50 (functional) | = 11.7 uM | Antiviral activity evaluated as the ability to inhibit the replication of HIV-1 in human T-lymphocytic cells (CEM) | ChEMBL. | 10229630 |
EC50 (functional) | = 12.5 uM | Antiviral activity evaluated as the ability to inhibit the replication of HIV-2 in human T-lymphocytic cells (CEM) | ChEMBL. | 10229630 |
logP (ADMET) | = 0.93 | Partition coefficient (logP) | ChEMBL. | 10229630 |
MCC (functional) | > 50 uM | Minimal cytotoxic concentration required to cause morphological alteration of C3H/3T3 fibroblast culture cells | ChEMBL. | 10229630 |
SI (functional) | = 10 | Selectivity index of the compound was determined by CC50 of CEM cells/EC50 of CEM cells against HIV-1 | ChEMBL. | 10229630 |
T1/2 (ADMET) | = 23.4 hr | Hydrolysis half life of the compound in phosphate buffer. | ChEMBL. | 10229630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.