Detailed information for compound 590551

Basic information

Technical information
  • TDR Targets ID: 590551
  • Name: hupeheninoside
  • MW: 577.792 | Formula: C33H55NO7
  • H donors: 5 H acceptors: 5 LogP: 3.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: OCC1OC(OC2CCC3C(C2)(C)C2CC4C(C2CC3O)CCC2C4CN3CC(C)CCC3C2C)C(C(C1O)O)O
  • InChi: 1S/C33H55NO7/c1-16-4-9-26-17(2)19-6-7-20-21(23(19)14-34(26)13-16)10-25-22(20)11-27(36)24-8-5-18(12-33(24,25)3)40-32-31(39)30(38)29(37)28(15-35)41-32/h16-32,35-39H,4-15H2,1-3H3
  • InChiKey: YPEOJRRZBDHCLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 98985-22-9
  • 5,14-Cevanine-6-hydroxyl-3-D-glucoside
  • beta-D-Glucopyranoside, (3alpha,5alpha,6alpha)-6-hydroxycevan-3-yl
  • beta-D-Glucopyranoside, (3beta,5alpha,6beta,17beta)-6-hydroxycevan-3-yl

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphofructokinase 0.0224 0.2903 0.5064
Brugia malayi TAR-binding protein 0.0315 0.4167 0.7268
Giardia lamblia Pyruvate kinase 0.0035 0.0284 0.4088
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1846 0.1846
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0222 0.0388
Schistosoma mansoni hypothetical protein 0.0036 0.0293 0.0293
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0284 0.0963
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0049 0.017
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0135 0.0299
Brugia malayi Pre-SET motif family protein 0.0061 0.0643 0.1121
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0285 0.0285
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0022 0.0348
Echinococcus granulosus chromobox protein 1 0.0069 0.0749 0.0749
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0611 0.2104
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0285 0.0363
Loa Loa (eye worm) 6-phosphofructokinase 0.0224 0.2903 0.5064
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0022 0.0348
Leishmania major pyruvate kinase 0.0035 0.0284 0.0979
Loa Loa (eye worm) TAR-binding protein 0.0315 0.4167 0.7268
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0631 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0284 0.0979
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0284 0.0114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0222 0.0388
Trypanosoma brucei cytochrome P450, putative 0.0024 0.013 0.0447
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Brugia malayi Pre-SET motif family protein 0.0427 0.5733 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0284 0.0979
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0285 0.0363
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0323 0.0564
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0282 0.0492
Schistosoma mansoni 6-phosphofructokinase 0.0224 0.2903 0.2903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0467 0.0467
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0049 0.0167
Brugia malayi beta-lactamase 0.0036 0.0285 0.0498
Loa Loa (eye worm) phosphofructokinase 0.0224 0.2903 0.5064
Brugia malayi Cytochrome P450 family protein 0.0024 0.013 0.0226
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0631 0.204
Brugia malayi Blistered cuticle protein 3 0.0038 0.0323 0.0564
Mycobacterium leprae Probable lipase LipE 0.0036 0.0285 0.0983
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0171 0.0187
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0631 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0284 0.0979
Schistosoma mansoni chromobox protein 0.0069 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0498
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0631 0.9821
Brugia malayi hypothetical protein 0.0038 0.0323 0.0564
Trichomonas vaginalis esterase, putative 0.0036 0.0285 0.0363
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0224 0.2903 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0749 0.0749
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0222 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0631 0.0895
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.013 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0315 0.4167 0.4167
Onchocerca volvulus Peroxidasin homolog 0.0038 0.0323 0.0176
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0611 0.0611
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Echinococcus granulosus muscleblind protein 0.0148 0.1846 0.1846
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.0854
Echinococcus multilocularis GPCR, family 2 0.0031 0.0222 0.0222
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0049 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0723 0.1262
Loa Loa (eye worm) beta-lactamase 0.0036 0.0285 0.0498
Echinococcus multilocularis pyruvate kinase 0.0018 0.0044 0.0044
Brugia malayi 6-phosphofructokinase 0.0224 0.2903 0.5064
Loa Loa (eye worm) hypothetical protein 0.0067 0.0723 0.1262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0285 0.0285
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.2903 0.4387
Loa Loa (eye worm) hypothetical protein 0.0061 0.0643 0.1121
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.0854
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0315 0.4167 0.4167
Schistosoma mansoni hypothetical protein 0.0166 0.2101 0.2101
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0135 0.0235
Echinococcus multilocularis pyruvate kinase 0.0035 0.0284 0.0284
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0049 0.0093
Leishmania major cytochrome p450-like protein 0.0024 0.013 0.0447
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0631 0.9821
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0323 0.0564
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0285 0.0285
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1155 0.2015
Leishmania major ATP-dependent phosphofructokinase 0.0224 0.2903 1
Onchocerca volvulus 0.0038 0.0323 0.0176
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0285 0.0967
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0285 0.0967
Echinococcus granulosus pyruvate kinase 0.0018 0.0044 0.0044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0611 0.0611
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0022 0.0077
Entamoeba histolytica phosphofructokinase, putative 0.0224 0.2903 1
Loa Loa (eye worm) CYP4Cod1 0.0024 0.013 0.0226
Echinococcus multilocularis pyruvate kinase 0.0035 0.0284 0.0284
Echinococcus granulosus peroxidasin 0.0038 0.0323 0.0323
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1155 0.2015
Onchocerca volvulus 0.0036 0.0285 0.0116
Schistosoma mansoni pyruvate kinase 0.0018 0.0044 0.0044
Echinococcus granulosus 6 phosphofructokinase 0.0224 0.2903 0.2903
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0044 0.0354
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0611 0.2104
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0285 0.0967
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0284 0.0496
Loa Loa (eye worm) blistered cuticle protein 3 0.0038 0.0323 0.0564
Schistosoma mansoni chromobox protein 0.0069 0.0749 0.0749
Mycobacterium ulcerans beta-lactamase 0.0036 0.0285 0.0983
Echinococcus granulosus pyruvate kinase 0.0035 0.0284 0.0284
Brugia malayi Peroxidasin 0.0038 0.0323 0.0564
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0631 0.9815
Loa Loa (eye worm) hypothetical protein 0.003 0.0212 0.0369
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0285 0.0363
Onchocerca volvulus Peroxidasin homolog 0.0038 0.0323 0.0176
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0049 0.017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1155 0.2015
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0049 0.0086
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0435
Loa Loa (eye worm) hypothetical protein 0.0035 0.0284 0.0496
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0467 0.0815
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0284 0.0979
Echinococcus granulosus GPCR family 2 0.0031 0.0222 0.0222
Echinococcus multilocularis microtubule associated protein 2 0.0734 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0498
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0044 0.0683
Loa Loa (eye worm) hypothetical protein 0.0039 0.0328 0.0572
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0285 0.0967
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0284 0.0114
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0049
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0323 0.0564
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0022 0.0022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2951 1
Schistosoma mansoni 6-phosphofructokinase 0.0224 0.2903 0.2903
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.013 0.0226
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0235
Brugia malayi beta-lactamase family protein 0.0036 0.0285 0.0498
Mycobacterium ulcerans lipase LipD 0.0036 0.0285 0.0983
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0631 1
Loa Loa (eye worm) RNA binding protein 0.0315 0.4167 0.7268
Loa Loa (eye worm) hypothetical protein 0.0148 0.1846 0.322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0467 0.0467
Brugia malayi beta-lactamase family protein 0.0036 0.0285 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0467 0.0467
Schistosoma mansoni ap endonuclease 0.0019 0.0049 0.0049
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0284 0.0496
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0284 0.0979
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0284 0.0496
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0498
Toxoplasma gondii exonuclease III APE 0.0019 0.0049 0.0767
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0284 0.4218
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0044 0.0347
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0049 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0643 0.0643
Echinococcus multilocularis peroxidasin 0.0038 0.0323 0.0323
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0224 0.2903 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.08 0.08
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0222 0.0388
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0643 0.0643
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0643 0.0643
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0323 0.0564
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0643 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0293 0.0293
Echinococcus granulosus tar DNA binding protein 0.0315 0.4167 0.4167
Mycobacterium ulcerans hypothetical protein 0.0036 0.0285 0.0983
Brugia malayi Cytochrome P450 family protein 0.0024 0.013 0.0226
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0022 0.0039
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0284 0.0361
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0222 0.0222
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0049 0.0049
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0631 0.0895
Brugia malayi Heterochromatin protein 1 0.0069 0.0749 0.1307
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.2903 0.4387
Echinococcus multilocularis chromobox protein 1 0.0069 0.0749 0.0749
Echinococcus granulosus geminin 0.0166 0.2101 0.2101
Toxoplasma gondii ABC1 family protein 0.0036 0.0285 0.4437
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Schistosoma mansoni pyruvate kinase 0.0035 0.0284 0.0284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0467 0.0467
Brugia malayi RNA recognition motif domain containing protein 0.0315 0.4167 0.7268
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0631 0.9821
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0643 0.0643
Onchocerca volvulus Peroxidase homolog 0.0038 0.0323 0.0176
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0284 0.0496
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.2903 0.4387
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0284 0.0361
Schistosoma mansoni hypothetical protein 0.0067 0.0723 0.0723
Schistosoma mansoni peroxidasin 0.0038 0.0323 0.0323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0467 0.0467
Entamoeba histolytica phosphofructokinase, putative 0.0224 0.2903 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1846 0.322
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0328 0.0183
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0224 0.2903 1
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0631 0.9815
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.0022
Brugia malayi hypothetical protein 0.0036 0.0293 0.0511
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.0854
Schistosoma mansoni peroxidasin 0.0038 0.0323 0.0323
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0284 0.4419
Loa Loa (eye worm) 6-phosphofructokinase 0.0224 0.2903 0.5064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0498
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0285 0.0363
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0285 0.0498
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0631 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0611 0.2104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0611 0.207
Onchocerca volvulus 0.0038 0.0323 0.0176
Trichomonas vaginalis phosphofructokinase, putative 0.0224 0.2903 0.4387
Brugia malayi Muscleblind-like protein 0.0148 0.1846 0.322
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0022 0.0077
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0022 0.0077
Echinococcus multilocularis geminin 0.0166 0.2101 0.2101
Mycobacterium ulcerans 6-phosphofructokinase 0.0224 0.2903 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0643 0.0643
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0369 0.0491
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0369 0.0491
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0612 0.0612
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Echinococcus granulosus pyruvate kinase 0.0035 0.0284 0.0284
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.013 0.0226
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0285 0.0983
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0323 0.0564
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0171 0.0187
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0049 0.0049
Echinococcus multilocularis 6 phosphofructokinase 0.0224 0.2903 0.2903
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0049 0.0443
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0369 0.0247
Plasmodium vivax SET domain protein, putative 0.0061 0.0643 1
Onchocerca volvulus Peroxidase homolog 0.0038 0.0323 0.0176
Trichomonas vaginalis set domain proteins, putative 0.0486 0.6554 1
Leishmania major hypothetical protein, conserved 0.0036 0.0285 0.0983
Onchocerca volvulus Chorion peroxidase homolog 0.0038 0.0323 0.0176
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0284 0.0979
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0285 0.0285
Echinococcus multilocularis muscleblind protein 0.0148 0.1846 0.1846
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0498
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0749 0.1076
Echinococcus multilocularis pyruvate kinase 0.0028 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0224 0.2903 0.9837
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0285 0.0983
Schistosoma mansoni tar DNA-binding protein 0.0315 0.4167 0.4167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Onchocerca volvulus 0.0038 0.0323 0.0176
Echinococcus multilocularis pyruvate kinase 0.0018 0.0044 0.0044
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0749 0.1076
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Brugia malayi RNA binding protein 0.0315 0.4167 0.7268
Loa Loa (eye worm) hypothetical protein 0.0036 0.0285 0.0498
Brugia malayi 6-phosphofructokinase 0.0224 0.2903 0.5064
Onchocerca volvulus Dual oxidase homolog 0.0038 0.0323 0.0176
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0293 0.0293
Mycobacterium tuberculosis Conserved protein 0.0036 0.0285 0.0967
Entamoeba histolytica hypothetical protein 0.0036 0.0293 0.0854
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0323 0.0564
Onchocerca volvulus 0.0036 0.0285 0.0116
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0323 0.0564
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0285 0.0983
Onchocerca volvulus 0.0036 0.0285 0.0116
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0631 0.0895
Schistosoma mansoni microtubule-associated protein tau 0.0734 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0631 0.0895
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0611 0.95
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0224 0.2903 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0222 0.0388
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0285 0.0967
Brugia malayi chromobox protein homolog 3 0.0039 0.0328 0.0572
Onchocerca volvulus 0.0486 0.6554 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0467 0.0467
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0631 0.0895
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0285 0.0983
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0631 0.0895
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0285 0.0983
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0049 0.017
Loa Loa (eye worm) hypothetical protein 0.0098 0.1155 0.2015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0611 0.0611
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0022 0.0077
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0631 0.204
Schistosoma mansoni tar DNA-binding protein 0.0315 0.4167 0.4167
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0315 0.4167 0.7268
Schistosoma mansoni hypothetical protein 0.0031 0.0222 0.0222
Brugia malayi isocitrate dehydrogenase 0.0017 0.0022 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0328 0.0428
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0022 0.0077
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0749 0.1307
Leishmania major pyruvate kinase 0.0035 0.0284 0.0979
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0049 0.017
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0631 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0022 0.0039
Schistosoma mansoni pyruvate kinase 0.0035 0.0284 0.0284
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0022 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0166 0.2101 0.2101
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0427 0.5733 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0285 0.0967
Mycobacterium tuberculosis Conserved protein 0.0036 0.0285 0.0967
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0631 0.0895
Entamoeba histolytica phosphofructokinase, putative 0.0224 0.2903 1
Plasmodium falciparum pyruvate kinase 0.0035 0.0284 0.4297
Mycobacterium tuberculosis Conserved protein 0.0036 0.0285 0.0967
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.013 0.0447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0222 0.0222
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0293 0.0293
Echinococcus granulosus pyruvate kinase 0.0018 0.0044 0.0044
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0323 0.0564
Brugia malayi Cytochrome P450 family protein 0.0035 0.0282 0.0492
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0611 0.2104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0467 0.0815
Echinococcus granulosus pyruvate kinase 0.0018 0.0044 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.013 0.0447
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Onchocerca volvulus 0.0073 0.08 0.0927
Loa Loa (eye worm) hypothetical protein 0.0038 0.0323 0.0564
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0284 0.0496
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0022 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0285 0.0363
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0284 0.0114
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0285 0.0967
Echinococcus multilocularis pyruvate kinase 0.0018 0.0044 0.0044
Echinococcus multilocularis tar DNA binding protein 0.0315 0.4167 0.4167
Schistosoma mansoni tar DNA-binding protein 0.0315 0.4167 0.4167
Echinococcus granulosus chromobox protein 1 0.0069 0.0749 0.0749
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0285 0.0498
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0285 0.4237
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0611 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0328 0.0428
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0285 0.0983
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0323 0.0564

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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