TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 402.463 | Formula: C17H26N2O7S
H donors: 2 H acceptors: 6 LogP: -0.96 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)O.O[C@H]1[C@H](N2CCCCC2)c2cc(ccc2OC1(C)C)[N+](=O)[O-]
InChi: 1S/C16H22N2O4.CH4O3S/c1-16(2)15(19)14(17-8-4-3-5-9-17)12-10-11(18(20)21)6-7-13(12)22-16;1-5(2,3)4/h6-7,10,14-15,19H,3-5,8-9H2,1-2H3;1H3,(H,2,3,4)/t14-,15+;/m1./s1
InChiKey: VHFKTOUDMGCKNS-LIOBNPLQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0035	0.028	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0057	0.5
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0173	0.3093	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0424	0.0312
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.2486	0.2486
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0035	0.028	0.028
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0057	0.0354
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0035	0.028	0.028
Schistosoma mansoni	protein tyrosine phosphatase	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0035	0.028	0.028
Brugia malayi	putative malonyl-CoA decarboxylase	0.044	0.8544	0.8544
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0878	0.0878
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0035	0.028	0.028
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0035	0.028	0.028
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.2404	0.2404
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.1606	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0035	0.028	0.028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0599	0.0599
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.028	0.028
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0311	0.0311
Onchocerca volvulus		0.0035	0.028	0.0909
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.4917	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Leishmania major	malonyl-coa decarboxylase-like protein	0.0173	0.3093	1
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.044	0.8544	0.5
Schistosoma mansoni	hypothetical protein	0.0037	0.0311	0.0311
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0173	0.3093	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0057	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Brugia malayi	hypothetical protein	0.0035	0.028	0.028
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0441	0.0441
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0057	0.0057
Brugia malayi	RNA binding protein	0.0064	0.0878	0.0878
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.1606	0.1606
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0415	0.8023	0.8023
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0441	0.0441
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0878	0.0878
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.4917	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0424	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0512	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0057	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Leishmania major	tyrosine specific protein phosphatase, putative	0.0035	0.028	0.0734
Schistosoma mansoni	hypothetical protein	0.0172	0.3077	0.3077
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0035	0.028	0.1742
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.044	0.8544	0.8544
Brugia malayi	TAR-binding protein	0.0064	0.0878	0.0878
Entamoeba histolytica	hypothetical protein	0.0037	0.0311	0.1937
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0035	0.028	0.028
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0424	0.0312
Onchocerca volvulus		0.0035	0.028	0.0909
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0415	0.8023	0.8023
Onchocerca volvulus		0.0035	0.028	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0057	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0599	0.0599
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0441	0.0348
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0512	1	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0424	0.5
Schistosoma mansoni	hypothetical protein	0.0041	0.041	0.041
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.3266	0.6439
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0353	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0599	0.0599
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0057	0.5
Brugia malayi	Protein-tyrosine phosphatase	0.0035	0.028	0.028
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.4917	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0878	0.0878
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.4917	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0272	0.0272
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase 1	0.0035	0.028	0.028
Schistosoma mansoni	protein tyrosine phosphatase	0.0035	0.028	0.028
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0353	0.2197
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Onchocerca volvulus	4.1 G protein, putative homolog	0.0035	0.028	0.0909
Schistosoma mansoni	hypothetical protein	0.0041	0.041	0.041
Onchocerca volvulus		0.0035	0.028	0.0909
Onchocerca volvulus		0.0035	0.028	0.0909
Echinococcus multilocularis	hypothetical protein	0.0035	0.028	0.028
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0057	0.5
Onchocerca volvulus		0.0035	0.028	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0272	0.0272
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0415	0.8023	0.8023
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0415	0.8023	0.8023
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0565	0.0565
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0424	0.5
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0057	0.5
Onchocerca volvulus		0.0035	0.028	0.0909
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.4917	1
Echinococcus multilocularis	expressed conserved protein	0.0094	0.1482	0.1482
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0512	1	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0057	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0878	0.0878
Onchocerca volvulus		0.0035	0.028	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0262	0.4917	0.4917
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0057	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.3266	0.6439
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0441	0.0441
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0057	0.0057
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0035	0.028	0.028
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0035	0.028	0.028
Brugia malayi	hypothetical protein	0.0035	0.028	0.028
Schistosoma mansoni	protein tyrosine phosphatase	0.0035	0.028	0.028
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0035	0.028	0.0734
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0878	0.0878
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0878	0.0878
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0035	0.028	0.028
Schistosoma mansoni	patched 1	0.0043	0.0441	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0035	0.028	0.028
Brugia malayi	hypothetical protein	0.0037	0.0311	0.0311
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0057	0.0057
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.1637	0.1637
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0035	0.028	0.028
Schistosoma mansoni	hypothetical protein	0.0172	0.3077	0.3077
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0035	0.028	0.028
Onchocerca volvulus		0.0024	0.0057	0.0185
Brugia malayi	CHE-14 protein	0.0043	0.0441	0.0441
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0512	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0599	0.0599
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0035	0.028	0.1742
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0035	0.028	0.028
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0035	0.028	0.028
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.028	0.028
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0415	0.8023	0.8023
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0057	0.5
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0057	0.5
Onchocerca volvulus		0.0035	0.028	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0035	0.028	0.028
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0057	0.0057
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Echinococcus multilocularis	geminin	0.0172	0.3077	0.3077
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0035	0.028	0.028
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.2486	0.2486
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Entamoeba histolytica	hypothetical protein	0.0037	0.0311	0.1937
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0512	1	1
Onchocerca volvulus		0.0035	0.028	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.1606	0.1606
Onchocerca volvulus		0.0035	0.028	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0512	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0878	0.0878
Onchocerca volvulus		0.0035	0.028	0.0909
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0272	0.0272
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.3077	0.6032
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.2481	0.2481
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0638	0.0638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Schistosoma mansoni	hypothetical protein	0.0041	0.041	0.041
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0035	0.028	0.028
Entamoeba histolytica	hypothetical protein	0.0037	0.0311	0.1937
Schistosoma mansoni	hypothetical protein	0.0041	0.041	0.041
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Schistosoma mansoni	pcd6 interacting protein-related	0.0035	0.028	0.028
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0441	0.0441
Trichomonas vaginalis	glucosylceramidase, putative	0.0262	0.4917	1
Echinococcus granulosus	geminin	0.0172	0.3077	0.3077
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Echinococcus multilocularis	protein patched	0.0043	0.0441	0.0441
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.2481	0.2481
Echinococcus granulosus	expressed conserved protein	0.0094	0.1482	0.1482
Loa Loa (eye worm)	hypothetical protein	0.01	0.1606	0.1606
Onchocerca volvulus		0.0035	0.028	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0878	0.0878
Onchocerca volvulus	Glucosylceramidase homolog	0.0172	0.3077	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0424	0.0424
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.028	0.028
Onchocerca volvulus		0.0035	0.028	0.0909
Brugia malayi	hypothetical protein	0.0035	0.028	0.028
Entamoeba histolytica	hypothetical protein	0.0037	0.0311	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.1606	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0057	0.0057
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.028	0.028
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0035	0.028	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0353	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0311	0.0311
Brugia malayi	hypothetical protein	0.0035	0.028	0.028
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.028	0.028
Echinococcus multilocularis		0.0035	0.028	0.028
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0057	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0057	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0441	0.0441
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.2486	0.2486
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0035	0.028	0.028
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.028	0.028
Brugia malayi	Protein-tyrosine phosphatase	0.0035	0.028	0.028
Brugia malayi	hypothetical protein	0.0035	0.028	0.028
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0035	0.028	0.028
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Loa Loa (eye worm)	acetyltransferase	0.0143	0.2486	0.2486
Loa Loa (eye worm)	hypothetical protein	0.0035	0.028	0.028
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.028	0.028
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0262	0.4917	0.4917
Onchocerca volvulus		0.0035	0.028	0.0909
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0878	0.0878
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.028	0.028
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0057	0.0354
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0173	0.3093	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0035	0.028	0.028
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0035	0.028	0.028
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0035	0.028	0.028
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0878	0.0878
Onchocerca volvulus		0.0035	0.028	0.0909
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0878	0.0878

Activities

Activity type	Activity value	Assay description	Source	Reference
Max fall in blood pressure (functional)	= 28 mmHg	Maximum fall in systolic blood pressure at interval from 1 to 6 hours at a dose of 1 mg/kg when administered per orally in rats	ChEMBL.	6631915
Max fall in blood pressure (functional)	= 73 mmHg	Maximum fall in systolic blood pressure at interval from 1 to 6 hours at a dose of 3 mg/kg when administered per orally in rats	ChEMBL.	6631915
Max fall in blood pressure (functional)	= 105 mmHg	Maximum fall in systolic blood pressure, intervals from 1 to 6 hours at a dose of 10 mg/kg administered per orally	ChEMBL.	6631915

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL40495

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 59115