Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0415 | 0.1158 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0366 | 0.0357 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0033 | 0.0025 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0335 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0415 | 0.178 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0056 | 0.0073 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0081 | 0.1083 | 0.1075 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0335 | 0.0327 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0056 | 0.0048 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0056 | 0.0048 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0033 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.175 | 0.1742 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0181 | 0.0447 |
Echinococcus granulosus | dnaJ subfamily B | 0.0397 | 0.5658 | 0.5654 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0366 | 0.0357 |
Toxoplasma gondii | hypothetical protein | 0.0016 | 0.0137 | 0.1125 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0762 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.0181 | 0.0447 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0415 | 0.115 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.1151 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0415 | 0.5078 |
Onchocerca volvulus | 0.0035 | 0.0415 | 0.644 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0056 | 0.0048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.2635 | 0.2629 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0056 | 0.0048 |
Onchocerca volvulus | 0.0016 | 0.0137 | 0.1447 | |
Loa Loa (eye worm) | RNA binding protein | 0.0188 | 0.2635 | 0.7807 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0415 | 0.178 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.0316 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0415 | 0.0407 |
Brugia malayi | Cytochrome P450 family protein | 0.0047 | 0.0594 | 0.1686 |
Onchocerca volvulus | 0.0035 | 0.0415 | 0.644 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1083 | 0.3151 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0056 | 0.0074 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0762 | 0.0754 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0415 | 0.178 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0415 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0137 | 0.0315 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0698 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0366 | 0.0357 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0081 | 0.1083 | 0.1075 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0056 | 0.0048 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0335 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.2402 | 0.7106 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0366 | 0.1001 |
Onchocerca volvulus | 0.0016 | 0.0137 | 0.1447 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0137 | 0.1897 | 0.189 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0415 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0056 | 0.0074 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.0181 | 0.0447 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0366 | 0.1001 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.1151 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0415 | 0.1151 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0415 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0415 | 0.5078 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Echinococcus multilocularis | tumor protein p63 | 0.0329 | 0.4665 | 0.466 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.0181 | 0.3444 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Onchocerca volvulus | 0.0048 | 0.0605 | 0.9836 | |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0056 | 0.0048 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0415 | 0.0407 |
Brugia malayi | RNA binding protein | 0.0188 | 0.2635 | 0.7807 |
Echinococcus granulosus | serotonin transporter | 0.0016 | 0.0137 | 0.0128 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0366 | 0.0357 |
Schistosoma mansoni | hypothetical protein | 0.0397 | 0.5658 | 0.5654 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0056 | 0.0074 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0397 | 0.5658 | 0.5654 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.1125 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0056 | 0.0073 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0614 | 0.1745 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0172 | 0.2402 | 0.7106 |
Loa Loa (eye worm) | serotonin transporter b | 0.0016 | 0.0137 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0366 | 0.0357 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0188 | 0.2635 | 0.7807 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0016 | 0.0137 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.1151 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0056 | 0.0074 |
Onchocerca volvulus | 0.0035 | 0.0415 | 0.644 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.0181 | 0.0447 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0056 | 0.0074 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.1354 | 0.3964 |
Echinococcus granulosus | tar DNA binding protein | 0.0188 | 0.2635 | 0.2629 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.0058 | 0.0049 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.0673 | 0.8741 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0415 | 0.1158 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.3147 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0239 | 0.3367 | 0.3361 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.3367 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0329 | 0.4665 | 0.466 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.2635 | 0.2629 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0415 | 0.0407 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0449 | 0.6408 | 0.6405 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.1151 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0056 | 0.0048 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0449 | 0.6408 | 0.6405 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0081 | 0.1083 | 0.1075 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0415 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.1354 | 0.3964 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0047 | 0.0594 | 0.1687 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0016 | 0.0137 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1354 | 0.3964 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0056 | 0.0073 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0056 | 0.0073 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0056 | 0.0048 |
Brugia malayi | hypothetical protein | 0.0239 | 0.3367 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0056 | 0.0073 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.2635 | 0.2629 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0415 | 0.5078 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0056 | 0.0048 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0081 | 0.1083 | 0.1075 |
Onchocerca volvulus | 0.0049 | 0.0614 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0415 | 0.5078 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.0765 | 0.0757 |
Plasmodium falciparum | transporter, putative | 0.0016 | 0.0137 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.1354 | 0.3964 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.1151 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0415 | 0.0407 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0168 | 0.2333 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | cytochrome P450 | 0.001 | 0.0058 | 0.0078 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0415 | 0.115 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0896 | 0.0888 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.0315 |
Onchocerca volvulus | 0.0016 | 0.0137 | 0.1447 | |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0415 | 0.5078 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0056 | 0.0073 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0312 | 0.0841 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0415 | 0.115 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0415 | 0.1158 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0056 | 0.0048 |
Brugia malayi | cytochrome P450 | 0.001 | 0.0058 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0415 | 0.1151 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0762 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0614 | 0.0606 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0366 | 0.1002 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0016 | 0.0137 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0605 | 0.1718 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0698 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1083 | 0.3151 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0056 | 0.0074 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0366 | 0.0357 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0312 | 0.0841 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.175 | 0.1742 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0366 | 0.1002 |
Brugia malayi | TAR-binding protein | 0.0188 | 0.2635 | 0.7807 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0081 | 0.1083 | 0.3151 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0415 | 0.1158 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.1125 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0056 | 0.0048 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0016 | 0.0137 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0056 | 0.0073 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0016 | 0.0137 | 0.0128 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0415 | 0.5078 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0415 | 0.115 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0762 | 1 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0016 | 0.0137 | 0.0128 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0056 | 0.0074 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0081 | 0.1083 | 0.1075 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0056 | 0.0073 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0056 | 0.0048 |
Onchocerca volvulus | 0.0028 | 0.0312 | 0.4589 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.1897 | 0.189 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0056 | 0.0073 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0312 | 0.0304 |
Loa Loa (eye worm) | TAR-binding protein | 0.0188 | 0.2635 | 0.7807 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0762 | 0.228 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0081 | 0.1083 | 0.1075 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0056 | 0.0073 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0016 | 0.0137 | 0.0315 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0415 | 0.1158 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0188 | 0.2635 | 0.7807 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0239 | 0.3367 | 0.3361 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.0315 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.001 | 0.0058 | 0.0049 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0415 | 0.1151 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0366 | 0.0357 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0016 | 0.0137 | 0.0128 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0415 | 0.5078 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0366 | 0.0357 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0762 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Onchocerca volvulus | 0.0016 | 0.0137 | 0.1447 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0605 | 0.0596 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 0.0058 | 0.0078 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0056 | 0.0048 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0762 | 0.0754 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0056 | 0.0048 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0415 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0415 | 0.1158 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0366 | 0.0357 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0016 | 0.0137 | 0.0128 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0449 | 0.6408 | 0.6405 |
Echinococcus granulosus | neuropeptide s receptor | 0.0449 | 0.6408 | 0.6405 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0056 | 0.0073 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.1125 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Echinococcus multilocularis | 0.001 | 0.0058 | 0.0049 | |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0056 | 0.0048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.2635 | 0.2629 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.0181 | 0.3444 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0056 | 0.0048 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0335 | 0.0327 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0415 | 0.1158 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0762 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0056 | 0.0074 |
Schistosoma mansoni | cytochrome P450 | 0.001 | 0.0058 | 0.0049 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0415 | 0.1158 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0415 | 0.1158 |
Toxoplasma gondii | hypothetical protein | 0.0016 | 0.0137 | 0.1125 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0056 | 0.0073 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0056 | 0.0074 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.0181 | 0.3444 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0415 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0415 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.0181 | 0.1749 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0762 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.1897 | 0.189 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0056 | 0.0048 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.175 | 0.1742 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0056 | 0.0048 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0033 | 0.0005 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0056 | 0.0048 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0896 | 0.2593 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0137 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0896 | 0.2593 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0366 | 0.0357 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0415 | 0.178 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0181 | 0.1749 |
Echinococcus multilocularis | serotonin transporter | 0.0016 | 0.0137 | 0.0128 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0056 | 0.0073 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0056 | 0.0048 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0056 | 0.0048 |
Plasmodium falciparum | amino acid transporter, putative | 0.0016 | 0.0137 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0016 | 0.0137 | 0.0316 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0081 | 0.1083 | 0.3151 |
Echinococcus multilocularis | tar DNA binding protein | 0.0188 | 0.2635 | 0.2629 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0016 | 0.0137 | 0.0128 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0762 | 0.0754 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0415 | 0.178 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0614 | 0.0606 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0016 | 0.0137 | 0.0315 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0181 | 0.0447 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0056 | 0.0048 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0016 | 0.0137 | 0.0128 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.2635 | 0.2629 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.85 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.19 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.19 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 5 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 15 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 86 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.44 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 15 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 86 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.94 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.1514 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.