Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0146 | 0.0203 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2001 | 0.1883 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0378 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0884 | 0.075 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0378 | 0.0236 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0378 | 0.0236 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0884 | 0.261 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0378 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3153 | 0.3052 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0884 | 0.075 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3153 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0378 | 0.0962 |
Echinococcus granulosus | lamin | 0.0027 | 0.0884 | 0.075 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0378 | 0.0236 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3153 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1291 | 0.1162 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0378 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0378 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0378 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2277 | 0.7148 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0378 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0884 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1291 | 0.3934 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0378 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0378 | 0.0236 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0146 | 0.0203 |
Schistosoma mansoni | lamin | 0.0027 | 0.0884 | 0.075 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0884 | 0.075 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0884 | 0.075 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0378 | 0.0962 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2277 | 0.7148 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0378 | 0.0236 |
Onchocerca volvulus | 0.0027 | 0.0884 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0378 | 0.0236 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3153 | 0.3052 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2001 | 0.1883 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3153 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2001 | 0.6248 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2001 | 0.6248 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0378 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2001 | 0.1883 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0378 | 0.0236 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0378 | 0.0962 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0853 | 0.2507 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3153 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0378 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0378 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3153 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3153 | 0.3052 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0884 | 0.261 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0146 | 0.0203 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1291 | 0.3934 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2277 | 0.7148 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0378 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2001 | 0.1883 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2001 | 0.1883 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3153 | 0.3052 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0884 | 0.261 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0884 | 0.261 |
Onchocerca volvulus | 0.0027 | 0.0884 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3153 | 0.3052 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2277 | 0.7148 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0884 | 0.261 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2001 | 0.1883 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0378 | 0.0962 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0378 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0378 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0378 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3153 | 0.3052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3153 | 0.3052 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0378 | 0.0236 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2001 | 0.1883 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0884 | 0.075 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0378 | 0.5 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3153 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0884 | 0.075 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0378 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0146 | 0.0203 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0378 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2.88 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.45 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.94 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 25 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.9 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -3 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -3 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 25 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 102 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.1 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.79557 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.