Detailed information for compound 591396

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 390.235 | Formula: C20H14Cl2FNO2
  • H donors: 2 H acceptors: 2 LogP: 5.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)CNC(=O)c1ccc(c(c1)c1cc(Cl)cc(c1)Cl)O
  • InChi: 1S/C20H14Cl2FNO2/c21-15-7-14(8-16(22)10-15)18-9-13(4-5-19(18)25)20(26)24-11-12-2-1-3-17(23)6-12/h1-10,25H,11H2,(H,24,26)
  • InChiKey: XSLREBBIUJADEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0221 0.4333 0.8832
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0188 0.3652 1
Schistosoma mansoni chromobox protein 0.0074 0.1266 0.1977
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2518 0.4
Onchocerca volvulus 0.0032 0.0401 0.007
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Trichomonas vaginalis chromobox protein, putative 0.0074 0.1266 0.2333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0736 0.1121
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0234 0.045
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0043 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0622 0.0581
Brugia malayi hypothetical protein 0.0024 0.0234 0.0477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0736 0.1121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.014 0.0382
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0188 0.3652 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.083 0.1619
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.078 0.1191
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.1057 0.2749
Plasmodium falciparum phd finger protein, putative 0.0031 0.0369 0.0826
Echinococcus multilocularis neuropeptide s receptor 0.0492 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0734 0.1421
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0736 0.0696
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1057 0.1639
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.014 0.0097
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.078 0.1191
Echinococcus multilocularis neuropeptide receptor A26 0.0492 1 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.1815 1
Echinococcus granulosus neuropeptide receptor A26 0.0492 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1057 0.2612
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0926 0.0887
Leishmania major hypothetical protein, conserved 0.0024 0.0234 0.0925
Echinococcus granulosus geminin 0.018 0.3476 0.3448
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0369 0.0826
Echinococcus granulosus chromobox protein 1 0.0074 0.1266 0.1229
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0622 0.0581
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0637 0.096
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0926 0.0887
Brugia malayi hypothetical protein 0.0016 0.0053 0.0108
Schistosoma mansoni ap endonuclease 0.002 0.014 0.0156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.014 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0736 0.1121
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0188 0.3652 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0384 0.0702
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.1057 0.1018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0369 0.067
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0384 0.0343
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0073 0.003
Brugia malayi chromobox protein homolog 3 0.0041 0.0588 0.1199
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.014 0.0382
Toxoplasma gondii exonuclease III APE 0.002 0.014 0.0186
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.014 0.0285
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.014 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.397 0.3944
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.014 0.0382
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0926 0.1427
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0505 0.0464
Onchocerca volvulus Huntingtin homolog 0.013 0.2436 0.4494
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.036 0.0318
Echinococcus multilocularis geminin 0.018 0.3476 0.3448
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2518 0.4
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2518 0.4
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1056 0.2084
Schistosoma mansoni jumonji domain containing protein 0.008 0.1403 0.2199
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.078 0.074
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.1815 1
Brugia malayi jmjC domain containing protein 0.0101 0.1838 0.3747
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0234 0.0925
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0736 0.1426
Brugia malayi Pre-SET motif family protein 0.0032 0.0384 0.0783
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.4333 0.8822
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0073 0.0149
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0073 0.0049
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.014 0.0199
Schistosoma mansoni hypothetical protein 0.0076 0.1313 0.2053
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0336 0.0406
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0188 0.3652 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.1815 0.178
Brugia malayi hypothetical protein 0.0076 0.1313 0.2677
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0188 0.3652 0.5
Plasmodium vivax SET domain protein, putative 0.0032 0.0384 0.087
Echinococcus granulosus peregrin 0.0031 0.0369 0.0327
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0505 0.0746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0734 0.1496
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0234 0.045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1313 0.1276
Brugia malayi mbt repeat family protein 0.0051 0.078 0.1589
Echinococcus multilocularis chromobox protein 1 0.0074 0.1266 0.1229
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.078 0.074
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0505 0.0464
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0369 0.0327
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2518 0.4
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1815 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0734 0.1421
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1313 0.1276
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0384 0.0343
Echinococcus granulosus tar DNA binding protein 0.0134 0.2518 0.2485
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.1057 0.1639
Schistosoma mansoni hypothetical protein 0.0033 0.0414 0.06
Schistosoma mansoni hypothetical protein 0.0031 0.0369 0.0527
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.014 0.0097
Trichomonas vaginalis set domain proteins, putative 0.0251 0.4969 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0369 0.067
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.078 0.074
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0384 0.0343
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.014 0.0186
Trichomonas vaginalis hypothetical protein 0.0188 0.3652 0.7272
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1815 0.2865
Echinococcus granulosus chromobox protein 1 0.0074 0.1266 0.1229
Schistosoma mansoni kinase 0.0051 0.0786 0.1202
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2144 0.4321
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0073 0.0062
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.078 0.074
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0654 0.1064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1057 0.2612
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.078 0.0893
Onchocerca volvulus Huntingtin homolog 0.013 0.2436 0.4494
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0736 0.0696
Onchocerca volvulus 0.0051 0.078 0.0893
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0369 0.0527
Loa Loa (eye worm) hypothetical protein 0.013 0.2436 0.4922
Loa Loa (eye worm) hypothetical protein 0.0051 0.078 0.1515
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0384 0.0552
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2144 0.4321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.1057 0.2612
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.014 0.0186
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0073 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0073 0.003
Brugia malayi isocitrate dehydrogenase 0.0017 0.0073 0.0149
Onchocerca volvulus 0.0251 0.4969 1
Schistosoma mansoni ap endonuclease 0.002 0.014 0.0156
Onchocerca volvulus 0.0044 0.0637 0.0583
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0073 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0414 0.0763
Trichomonas vaginalis chromobox protein, putative 0.0074 0.1266 0.2333
Brugia malayi TAR-binding protein 0.0134 0.2518 0.5132
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.078 0.1191
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0384 0.087
Entamoeba histolytica hypothetical protein 0.0076 0.1313 0.7003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.014 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0134 0.2518 0.4
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.1815 0.3144
Brugia malayi follicle stimulating hormone receptor 0.0248 0.4905 1
Loa Loa (eye worm) hypothetical protein 0.013 0.2436 0.4922
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0736 0.1501
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.1057 0.1018
Loa Loa (eye worm) TAR-binding protein 0.0134 0.2518 0.5089
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0926 0.0887
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0188 0.3652 1
Loa Loa (eye worm) MBCTL1 0.0058 0.0926 0.1816
Brugia malayi Heterochromatin protein 1 0.0074 0.1266 0.2581
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0654 0.1064
Echinococcus multilocularis peregrin 0.0031 0.0369 0.0327
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0369 0.0826
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.1815 0.178
Schistosoma mansoni chromobox protein 0.0074 0.1266 0.1977
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0234 0.0925
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.078 0.1515
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0188 0.3652 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0401 0.0737
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.2518 0.5089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0588 0.1121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0734 0.1496
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0926 0.1887
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0384 0.0552
Brugia malayi RNA binding protein 0.0134 0.2518 0.5132
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0234 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0588 0.0928
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.397 0.3944
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0588 0.0928
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0043 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.1815 0.3645
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.1838 0.1803
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0234 0.0925
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1815 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0384 0.0552
Brugia malayi MH2 domain containing protein 0.0116 0.2144 0.437
Schistosoma mansoni hypothetical protein 0.0311 0.6229 1
Entamoeba histolytica hypothetical protein 0.0076 0.1313 0.7003
Entamoeba histolytica hypothetical protein 0.0076 0.1313 0.7003
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0414 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0336 0.0406
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.4905 1
Brugia malayi Bromodomain containing protein 0.0031 0.0369 0.0752
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0505 0.0746
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0505 0.095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0234 0.0393
Loa Loa (eye worm) RNA binding protein 0.0134 0.2518 0.5089
Entamoeba histolytica hypothetical protein 0.0076 0.1313 0.7003
Brugia malayi PHD-finger family protein 0.0031 0.0369 0.0752
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1313 0.2053
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0369 0.0327
Echinococcus multilocularis tar DNA binding protein 0.0134 0.2518 0.2485
Schistosoma mansoni hypothetical protein 0.018 0.3476 0.5549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0736 0.0696
Brugia malayi mbt repeat family protein 0.0051 0.078 0.1589
Trypanosoma brucei polo-like protein kinase 0.01 0.1815 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0588 0.0477
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0654 0.0619
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0073 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0234 0.045
Plasmodium falciparum enoyl-acyl carrier reductase 0.0188 0.3652 1
Brugia malayi hypothetical protein 0.013 0.2436 0.4967
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.1838 0.1803
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.1266 0.2516
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0073 0.003
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0759 0.1282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0736 0.0696
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.1057 0.2749
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0759 0.1282
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.2518 0.5132
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0926 0.0887
Giardia lamblia Kinase, PLK 0.01 0.1815 1
Brugia malayi jmjC domain containing protein 0.0037 0.0505 0.1029
Echinococcus multilocularis chromobox protein 1 0.0074 0.1266 0.1229
Loa Loa (eye worm) hypothetical protein 0.0058 0.0926 0.1816
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0369 0.0826
Schistosoma mansoni hypothetical protein 0.018 0.3476 0.5549
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1815 0.3469
Giardia lamblia PHD finger protein 15 0.0031 0.0369 0.1368
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.1057 0.5648
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.1815 0.37

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 1 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 3.75 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.04 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.34 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.19 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 0 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.25 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.55938 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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