Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Giardia lamblia | Aldose reductase | 0.0126 | 0.8519 | 0.5 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0126 | 0.8519 | 0.8519 |
Schistosoma mansoni | tyrosine kinase | 0.0057 | 0.3116 | 0.2228 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0126 | 0.8519 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0126 | 0.8519 | 0.9929 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Leishmania major | aldo-keto reductase-like protein | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2169 | 0.0878 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2169 | 0.2169 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Loa Loa (eye worm) | oxidoreductase | 0.0126 | 0.8519 | 0.8247 |
Onchocerca volvulus | 0.0126 | 0.8519 | 1 | |
Schistosoma mansoni | aldo-keto reductase | 0.0126 | 0.8519 | 0.9929 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0058 | 0.3196 | 0.3196 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0126 | 0.8519 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0058 | 0.3196 | 0.1945 |
Echinococcus granulosus | hypothetical protein | 0.0126 | 0.8519 | 0.8247 |
Brugia malayi | Protein kinase domain containing protein | 0.007 | 0.4165 | 0.3092 |
Echinococcus granulosus | aldo keto reductase | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | aldo keto reductase | 0.0126 | 0.8519 | 0.8247 |
Schistosoma mansoni | tyrosine kinase | 0.0057 | 0.3116 | 0.2228 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.3196 | 0.2342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2169 | 0.0878 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0058 | 0.3196 | 0.1945 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0126 | 0.8519 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0126 | 0.8519 | 0.8247 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0037 | 0.1553 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.3196 | 0.2342 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.8569 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0127 | 0.8569 | 0.8305 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0127 | 0.8569 | 0.8305 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0127 | 0.8569 | 0.8569 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2169 | 0.0729 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0126 | 0.8519 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0057 | 0.3116 | 0.2228 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0058 | 0.3196 | 0.1945 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | aldehyde reductase | 0.009 | 0.5679 | 0.4884 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0126 | 0.8519 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0058 | 0.3196 | 0.1945 |
Echinococcus multilocularis | aldo keto reductase | 0.0126 | 0.8519 | 0.8519 |
Trypanosoma brucei | prostaglandin f synthase | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.8569 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2169 | 0.0878 |
Loa Loa (eye worm) | oxidoreductase | 0.0126 | 0.8519 | 0.8247 |
Loa Loa (eye worm) | oxidoreductase | 0.0126 | 0.8519 | 0.8247 |
Loa Loa (eye worm) | oxidoreductase | 0.0126 | 0.8519 | 0.8247 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2169 | 0.0729 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.009 | 0.5679 | 0.5922 |
Schistosoma mansoni | pol-related | 0.0126 | 0.8519 | 0.9929 |
Echinococcus multilocularis | aldo keto reductase | 0.0126 | 0.8519 | 0.8519 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0126 | 0.8519 | 0.8247 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Echinococcus multilocularis | aldo keto reductase | 0.0126 | 0.8519 | 0.8519 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2169 | 0.0729 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Onchocerca volvulus | 0.0126 | 0.8519 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Leishmania major | prostaglandin f synthase, putative | 0.0126 | 0.8519 | 1 |
Giardia lamblia | Aldose reductase | 0.0126 | 0.8519 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0127 | 0.8569 | 0.8305 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0126 | 0.8519 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0037 | 0.1553 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0126 | 0.8519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.8519 | 0.8247 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0126 | 0.8519 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0126 | 0.8519 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0058 | 0.3196 | 0.1945 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2169 | 0.0729 |
Loa Loa (eye worm) | oxidoreductase | 0.0126 | 0.8519 | 0.8247 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0126 | 0.8519 | 0.8519 |
Entamoeba histolytica | aldose reductase, putative | 0.0126 | 0.8519 | 1 |
Onchocerca volvulus | 0.0126 | 0.8519 | 1 | |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0037 | 0.1553 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0058 | 0.3196 | 0.3196 |
Mycobacterium ulcerans | oxidoreductase | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.009 | 0.5679 | 0.5679 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0126 | 0.8519 | 0.8247 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0037 | 0.1553 | 0.1553 |
Trypanosoma cruzi | aldo-keto reductase | 0.0126 | 0.8519 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0126 | 0.8519 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0037 | 0.1553 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2169 | 0.2169 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0126 | 0.8519 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0127 | 0.8569 | 0.8569 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0126 | 0.8519 | 0.8247 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0126 | 0.8519 | 1 |
Echinococcus granulosus | insulin receptor | 0.0127 | 0.8569 | 0.8305 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4085 | 0.2998 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.3196 | 0.2342 |
Onchocerca volvulus | 0.0126 | 0.8519 | 1 | |
Onchocerca volvulus | 0.0126 | 0.8519 | 1 | |
Onchocerca volvulus | 0.0126 | 0.8519 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0126 | 0.8519 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.15 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.07 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.03 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 94 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 98 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 3.7 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 94 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 98 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.95 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.11783 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.