Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0103 | 0.0354 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0282 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.006 | 0.1101 | 0.3775 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0065 | 0.0065 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0103 | 0.0103 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0103 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0526 | 0.0526 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0641 | 0.0641 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0282 | 0.0968 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0011 | 0.0038 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0065 | 0.0223 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0011 | 0.0038 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0065 | 0.0065 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0792 | 0.0792 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0065 | 0.0223 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0526 | 0.0526 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0089 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.2916 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0103 | 0.0103 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0103 | 0.0354 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0282 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0103 | 0.0354 |
Echinococcus granulosus | smad | 0.0008 | 0.0065 | 0.0065 |
Schistosoma mansoni | smad | 0.0008 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.2215 | 0.7595 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0103 | 0.0103 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.2215 | 0.7595 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0525 | 0.0525 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0103 | 0.0103 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0792 | 0.0792 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0641 | 0.0641 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | hypothetical protein | 0.051 | 1 | 1 |
Onchocerca volvulus | 0.003 | 0.0492 | 0.1687 | |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0065 | 0.0223 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0282 | 0.0282 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0282 | 0.0968 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.1244 | 0.4265 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0065 | 0.0223 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0282 | 0.0282 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0641 | 0.0641 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0792 | 0.2715 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0011 | 0.0011 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0065 | 0.0065 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0282 | 0.2283 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0526 | 0.0526 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0641 | 0.2197 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0526 | 0.0526 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0065 | 0.0065 |
Schistosoma mansoni | hypothetical protein | 0.051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0065 | 0.0223 |
Brugia malayi | Smad1 | 0.0008 | 0.0065 | 0.0223 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0065 | 0.0065 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0103 | 0.0103 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.1014 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0053 | 0.0053 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0103 | 0.0103 |
Brugia malayi | DnaJ domain containing protein | 0.006 | 0.1101 | 0.3775 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0641 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0065 | 0.0065 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.1862 | 0.6386 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0103 | 0.0103 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0103 | 0.0103 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1244 | 0.4265 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0103 | 0.0354 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0792 | 0.2715 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0641 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0526 | 0.1805 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0526 | 0.1805 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0103 | 0.0103 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0103 | 0.0103 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0282 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0053 | 0.0053 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0103 | 0.0103 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0103 | 0.0103 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2794 | 0.9582 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0053 | 0.0053 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0282 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0065 | 0.0065 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0103 | 0.0103 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0282 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0065 | 0.0223 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0525 | 0.0525 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.2794 | 0.2794 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0282 | 0.2283 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0492 | 0.1687 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.1862 | 0.6386 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0103 | 0.0103 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0103 | 0.0354 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0492 | 0.1687 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0011 | 0.0038 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0053 | 0.0053 |
Brugia malayi | hypothetical protein | 0.0152 | 0.2916 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0386 | 0.7535 | 0.7535 |
Schistosoma mansoni | hypothetical protein | 0.042 | 0.8226 | 0.8226 |
Echinococcus granulosus | dnaJ subfamily B | 0.042 | 0.8226 | 0.8226 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0103 | 0.0103 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1244 | 0.1244 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.1101 | 0.1101 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0526 | 0.1805 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0089 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0103 | 0.0354 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0103 | 0.0354 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0282 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0011 | 0.0038 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0065 | 0.0065 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0103 | 0.0354 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0526 | 0.0526 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1862 | 0.6386 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.1862 | 0.6386 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0792 | 0.0792 |
Onchocerca volvulus | 0.001 | 0.0103 | 0.0354 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0103 | 0.0103 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2794 | 0.9582 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.2794 | 0.9582 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.2794 | 0.2794 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0103 | 0.0103 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0526 | 0.0526 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0103 | 0.0354 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0526 | 0.0526 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.006 | 0.1101 | 0.1101 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0282 | 0.5 |
Trichomonas vaginalis | protein kinase inhibitor, putative | 0.006 | 0.1101 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0282 | 0.0282 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0103 | 0.0103 |
Echinococcus multilocularis | geminin | 0.051 | 1 | 1 |
Onchocerca volvulus | 0.0152 | 0.2916 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0792 | 0.0792 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0641 | 0.0641 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0103 | 0.0103 |
Echinococcus multilocularis | dnaJ subfamily B | 0.042 | 0.8226 | 0.8226 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0103 | 0.0354 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0526 | 0.1805 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0526 | 0.0526 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0792 | 0.0792 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.2794 | 0.2794 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0103 | 0.0354 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0011 | 0.0011 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0089 | 0.0089 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0282 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0792 | 0.0792 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0103 | 0.0354 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0103 | 0.0103 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0103 | 0.0354 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0282 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0641 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0053 | 0.0053 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0086 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0526 | 0.0526 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0282 | 0.0282 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0065 | 0.0065 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0641 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0492 | 0.0492 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0065 | 0.0223 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0103 | 0.0103 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.2215 | 0.7595 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0282 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0525 | 0.0525 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.006 | 0.1101 | 0.1101 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0792 | 0.0792 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.1147 | 0.1147 |
Echinococcus multilocularis | smad | 0.0008 | 0.0065 | 0.0065 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0103 | 0.0103 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0525 | 0.0525 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0011 | 0.0038 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 3.75 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3.79 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.82 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 88 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0.72 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 8 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 88 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.91 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.22211 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.