Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0082 | 0.0353 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0059 | 0.0188 | 0.0188 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0062 | 0.0206 | 0.0206 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0131 | 0.0705 | 0.0705 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0208 | 0.1261 | 0.1262 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0193 | 0.1149 | 0.1149 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0038 | 0.0812 |
Brugia malayi | Smad1 | 0.0059 | 0.0188 | 0.0313 |
Brugia malayi | PHD-finger family protein | 0.0134 | 0.0723 | 0.1205 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0131 | 0.0705 | 0.1174 |
Brugia malayi | AF-10 protein | 0.008 | 0.0341 | 0.0568 |
Brugia malayi | hypothetical protein | 0.0072 | 0.0283 | 0.0472 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0508 | 0.3419 | 0.5692 |
Mycobacterium leprae | conserved hypothetical protein | 0.0074 | 0.0296 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0047 | 0.0102 | 0.2904 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0474 | 0.3173 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0206 | 0.0343 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0038 | 0.0035 | 0.0035 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0283 | 1 |
Brugia malayi | hypothetical protein | 0.0245 | 0.1527 | 0.2543 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0296 | 0.0297 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0047 | 0.0102 | 0.2904 |
Echinococcus granulosus | RUN | 0.0062 | 0.0206 | 0.0206 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0023 | 0.0289 |
Onchocerca volvulus | 0.0084 | 0.0366 | 0.1585 | |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.0334 | 0.9473 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0131 | 0.0705 | 0.1174 |
Onchocerca volvulus | 0.0084 | 0.0366 | 0.1585 | |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0047 | 0.0102 | 0.0103 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0062 | 0.0206 | 0.0206 |
Brugia malayi | hypothetical protein | 0.0329 | 0.2126 | 0.354 |
Mycobacterium ulcerans | beta-lactamase | 0.0074 | 0.0296 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0296 | 0.8403 |
Echinococcus granulosus | lamin dm0 | 0.0084 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.1261 | 0.2099 |
Schistosoma mansoni | tar DNA-binding protein | 0.04 | 0.2637 | 0.2639 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0079 | 0.0334 | 0.2179 |
Schistosoma mansoni | intermediate filament proteins | 0.0084 | 0.0366 | 0.0367 |
Brugia malayi | MH1 domain containing protein | 0.0059 | 0.0188 | 0.0313 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0206 | 0.0206 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0296 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0062 | 0.0206 | 0.1344 |
Echinococcus granulosus | phd:f box containing protein | 0.0079 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0206 | 0.0343 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0304 | 0.1947 | 0.1947 |
Brugia malayi | PHD-finger family protein | 0.0091 | 0.0415 | 0.0691 |
Echinococcus granulosus | neuropeptide s receptor | 0.0968 | 0.6725 | 0.6725 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.04 | 0.2637 | 0.439 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0084 | 0.0366 | 0.061 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0079 | 0.0334 | 0.9473 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0059 | 0.0188 | 0.0313 |
Schistosoma mansoni | smad1 5 8 and | 0.0059 | 0.0188 | 0.0188 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.0131 | 0.0218 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0047 | 0.0102 | 0.017 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0009 | 0.0029 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.008 | 0.0341 | 0.0342 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0091 | 0.042 | 0.0421 |
Schistosoma mansoni | zinc finger protein | 0.0105 | 0.0518 | 0.0518 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0038 | 0.0038 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0038 | 0.0249 |
Schistosoma mansoni | tar DNA-binding protein | 0.04 | 0.2637 | 0.2639 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0047 | 0.0102 | 0.017 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0109 | 0.0109 |
Trypanosoma cruzi | ISWI complex protein | 0.0082 | 0.0353 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0059 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0366 | 0.061 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0296 | 0.0493 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0059 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1533 | 0.2553 |
Schistosoma mansoni | single-minded | 0.0051 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1527 | 0.2543 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0035 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0079 | 0.0334 | 0.0556 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0033 | 0.0624 |
Schistosoma mansoni | loxhd1 | 0.0062 | 0.0206 | 0.0206 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0343 | 0.2227 | 0.2227 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0131 | 0.0705 | 0.1174 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0023 | 0.0664 |
Echinococcus granulosus | single minded 2 | 0.0038 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0705 | 0.0706 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0038 | 0.0119 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.1527 | 0.1527 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0246 | 0.1533 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0062 | 0.0206 | 0.0818 | |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0079 | 0.0334 | 0.2179 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1422 | 0.999 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0339 | 0.2204 | 0.2206 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0296 | 0.0493 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0091 | 0.042 | 0.042 |
Plasmodium vivax | JmjC domain containing protein | 0.0079 | 0.0334 | 0.2179 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0109 | 0.0109 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0079 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | ICD-1 protein | 0.0036 | 0.0023 | 0.0039 |
Loa Loa (eye worm) | TAR-binding protein | 0.04 | 0.2637 | 0.439 |
Brugia malayi | Bromodomain containing protein | 0.0402 | 0.2656 | 0.4422 |
Plasmodium vivax | hypothetical protein, conserved | 0.008 | 0.0341 | 0.2226 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.009 | 0.0408 | 0.0408 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0074 | 0.0296 | 0.0296 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0035 | 0.0012 | 0.0012 |
Brugia malayi | PHD-finger family protein | 0.0246 | 0.1533 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0705 | 0.1174 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0074 | 0.0296 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0355 | 0.0592 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0036 | 0.0023 | 0.0664 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.1527 | 0.1527 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0077 | 0.0318 | 0.9023 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0043 | 0.0071 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0038 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0296 | 0.0493 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0038 | 0.0038 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0062 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0414 | 0.2741 | 0.4564 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.231 | 0.2312 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0047 | 0.0102 | 0.3038 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0109 | 0.0181 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0296 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0245 | 0.1527 | 0.2542 |
Brugia malayi | Bromodomain containing protein | 0.0205 | 0.124 | 0.2064 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.0283 | 0.0283 |
Brugia malayi | MH2 domain containing protein | 0.0868 | 0.6006 | 1 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0079 | 0.0334 | 0.0334 |
Brugia malayi | MH1 domain containing protein | 0.0059 | 0.0188 | 0.0313 |
Loa Loa (eye worm) | intermediate filament protein | 0.0084 | 0.0366 | 0.061 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0283 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0036 | 0.0023 | 0.0664 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0705 | 0.0706 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0038 | 0.0033 | 0.094 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0246 | 0.1533 | 0.1533 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0074 | 0.0296 | 0.0934 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0038 | 0.5 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0047 | 0.0102 | 0.3038 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0334 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.042 | 0.07 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2741 | 0.4564 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0131 | 0.0705 | 0.0705 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0296 | 0.8403 |
Giardia lamblia | PHD finger protein 15 | 0.0246 | 0.1533 | 1 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0079 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0045 | 0.0086 | 0.0143 |
Schistosoma mansoni | jumonji domain containing protein | 0.0079 | 0.0334 | 0.0334 |
Brugia malayi | beta-lactamase | 0.0074 | 0.0296 | 0.0493 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0968 | 0.6725 | 0.6725 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0868 | 0.6006 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0047 | 0.0102 | 0.2904 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0074 | 0.0296 | 0.0297 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0296 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0074 | 0.0296 | 0.0493 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0806 | 0.5562 | 0.5562 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0246 | 0.1533 | 0.2553 |
Echinococcus granulosus | geminin | 0.0354 | 0.231 | 0.231 |
Trypanosoma cruzi | ISWI complex protein | 0.0082 | 0.0353 | 1 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.008 | 0.0341 | 0.9677 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0074 | 0.0296 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0059 | 0.0188 | 0.0313 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.0131 | 0.0131 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0033 | 0.0624 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0045 | 0.0086 | 0.0143 |
Echinococcus granulosus | smad | 0.0059 | 0.0188 | 0.0188 |
Mycobacterium leprae | Probable lipase LipE | 0.0074 | 0.0296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.2126 | 0.354 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0245 | 0.1527 | 0.2542 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0246 | 0.1533 | 0.1533 |
Schistosoma mansoni | tar DNA-binding protein | 0.04 | 0.2637 | 0.2639 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0121 | 0.0632 | 0.0633 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0296 | 0.0934 |
Echinococcus multilocularis | geminin | 0.0354 | 0.231 | 0.231 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0109 | 0.0109 |
Echinococcus multilocularis | RUN | 0.0062 | 0.0206 | 0.0206 |
Brugia malayi | Bromodomain containing protein | 0.0259 | 0.1625 | 0.2705 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0079 | 0.0334 | 0.9473 |
Loa Loa (eye worm) | Smad1 | 0.0059 | 0.0188 | 0.0313 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0059 | 0.0188 | 0.0188 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0059 | 0.0188 | 0.0188 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0023 | 0.0289 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0841 | 0.5814 | 0.5814 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0806 | 0.5562 | 0.5562 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0062 | 0.0206 | 0.0206 |
Plasmodium falciparum | phd finger protein, putative | 0.0246 | 0.1533 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0091 | 0.0415 | 0.0691 |
Schistosoma mansoni | jumonji domain containing protein | 0.0641 | 0.437 | 0.4375 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.0296 | 0.8403 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1408 | 0.2344 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0868 | 0.6006 | 1 |
Echinococcus granulosus | transcription factor btf3 | 0.0036 | 0.0023 | 0.0023 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1422 | 0.999 | 0.999 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1334 | 0.2221 |
Brugia malayi | RNA binding protein | 0.04 | 0.2637 | 0.439 |
Echinococcus multilocularis | zinc finger protein | 0.0105 | 0.0518 | 0.0518 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0308 | 0.198 | 0.1982 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0102 | 0.3099 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.231 | 0.2312 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0968 | 0.6725 | 0.6725 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0038 | 0.1082 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0047 | 0.0102 | 0.2904 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0102 | 0.3099 |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0296 | 0.0934 |
Echinococcus granulosus | GPCR family 2 | 0.0131 | 0.0705 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0296 | 0.0493 |
Echinococcus multilocularis | lamin dm0 | 0.0084 | 0.0366 | 0.0366 |
Leishmania major | basic transcription factor 3a, putative | 0.0036 | 0.0023 | 0.0664 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0109 | 0.0109 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0121 | 0.0632 | 0.0632 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0074 | 0.0296 | 0.8403 |
Brugia malayi | hypothetical protein | 0.0172 | 0.0998 | 0.1661 |
Onchocerca volvulus | 0.0074 | 0.0296 | 0.125 | |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0079 | 0.0334 | 0.0334 |
Plasmodium vivax | hypothetical protein, conserved | 0.0246 | 0.1533 | 1 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0079 | 0.0334 | 0.0334 |
Echinococcus granulosus | peregrin | 0.0259 | 0.1625 | 0.1625 |
Toxoplasma gondii | NAC domain-containing protein | 0.0036 | 0.0023 | 0.0153 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0091 | 0.042 | 0.042 |
Onchocerca volvulus | 0.0329 | 0.2126 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0074 | 0.0296 | 0.0934 |
Loa Loa (eye worm) | RNA binding protein | 0.04 | 0.2637 | 0.439 |
Echinococcus multilocularis | lamin | 0.0084 | 0.0366 | 0.0366 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0079 | 0.0334 | 0.0334 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0091 | 0.042 | 0.0421 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0246 | 0.1533 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.1423 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0.0122 | 0.0418 | |
Schistosoma mansoni | smad1 5 8 and | 0.0059 | 0.0188 | 0.0188 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0074 | 0.0296 | 0.0934 |
Brugia malayi | TAR-binding protein | 0.04 | 0.2637 | 0.439 |
Echinococcus multilocularis | smad | 0.0059 | 0.0188 | 0.0188 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0705 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1243 | 0.2069 |
Schistosoma mansoni | Smad4 | 0.0059 | 0.0188 | 0.0188 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0308 | 0.198 | 0.198 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0038 | 0.0033 | 0.094 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0077 | 0.0318 | 0.2075 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0074 | 0.0296 | 0.0296 |
Schistosoma mansoni | smad | 0.0059 | 0.0188 | 0.0188 |
Brugia malayi | hypoxia-induced factor 1 | 0.0158 | 0.0902 | 0.1502 |
Brugia malayi | hypothetical protein | 0.0077 | 0.0318 | 0.053 |
Brugia malayi | jmjC domain containing protein | 0.0079 | 0.0334 | 0.0556 |
Echinococcus multilocularis | phd:f box containing protein | 0.0079 | 0.0334 | 0.0334 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0062 | 0.0206 | 0.0206 |
Schistosoma mansoni | protein phosphatase 2C | 0.0079 | 0.0334 | 0.0334 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0041 | 0.0054 | 0.0054 |
Onchocerca volvulus | 0.0074 | 0.0296 | 0.125 | |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0121 | 0.0632 | 0.0632 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.008 | 0.0341 | 0.2226 |
Mycobacterium ulcerans | lipase LipD | 0.0074 | 0.0296 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.04 | 0.2637 | 0.2639 |
Echinococcus granulosus | intermediate filament protein | 0.0084 | 0.0366 | 0.0366 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0074 | 0.0296 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.008 | 0.0341 | 0.2226 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0038 | 0.0064 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.032 | 0.2066 | 0.2066 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0074 | 0.0296 | 0.0934 |
Echinococcus granulosus | lamin | 0.0084 | 0.0366 | 0.0366 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0059 | 0.0188 | 0.0313 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0038 | 0.1082 |
Echinococcus multilocularis | Smad4 | 0.0059 | 0.0188 | 0.0188 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0414 | 0.2741 | 0.4564 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0038 | 0.0812 |
Onchocerca volvulus | 0.0074 | 0.0296 | 0.125 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.0102 | 0.3099 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0074 | 0.0296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0998 | 0.1661 |
Schistosoma mansoni | tar DNA-binding protein | 0.04 | 0.2637 | 0.2639 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0077 | 0.0318 | 0.2075 |
Schistosoma mansoni | lipoxygenase | 0.0304 | 0.1947 | 0.1949 |
Brugia malayi | bHLH-PAS transcription factor | 0.0038 | 0.0035 | 0.0058 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0047 | 0.0102 | 0.0102 |
Brugia malayi | jmjC domain containing protein | 0.0308 | 0.198 | 0.3296 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.009 | 0.0408 | 0.0408 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0558 | 0.0559 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0091 | 0.042 | 0.0421 |
Schistosoma mansoni | phd/f-box containing protein | 0.0079 | 0.0334 | 0.0334 |
Onchocerca volvulus | 0.0208 | 0.1261 | 0.5862 | |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0298 | 0.1906 | 0.1906 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0023 | 0.0289 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0079 | 0.0334 | 0.0334 |
Brugia malayi | jmjC domain containing protein | 0.0806 | 0.5562 | 0.9261 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0036 | 0.0023 | 0.0153 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0062 | 0.0206 | 0.1344 |
Toxoplasma gondii | ABC1 family protein | 0.0074 | 0.0296 | 0.1933 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0318 | 0.9023 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0033 | 0.0624 |
Onchocerca volvulus | 0.0062 | 0.0206 | 0.0818 | |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0283 | 0.0284 |
Echinococcus multilocularis | tar DNA binding protein | 0.04 | 0.2637 | 0.2637 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0122 | 0.0123 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0091 | 0.042 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0296 | 0.0493 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0047 | 0.0102 | 0.2904 |
Echinococcus granulosus | Smad4 | 0.0059 | 0.0188 | 0.0188 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0131 | 0.0705 | 0.0705 |
Echinococcus granulosus | jumonji domain containing protein | 0.0343 | 0.2227 | 0.2227 |
Schistosoma mansoni | polycystin 1-related | 0.0062 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0318 | 0.053 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0109 | 0.0109 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0122 | 0.0204 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0043 | 0.0071 |
Brugia malayi | jmjC domain containing protein | 0.0079 | 0.0334 | 0.0556 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0158 | 0.0902 | 0.1502 |
Schistosoma mansoni | transcription factor btf3 | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.1799 | 0.2995 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0035 | 0.0015 | 0.01 |
Echinococcus multilocularis | GPCR, family 2 | 0.0131 | 0.0705 | 0.0705 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0079 | 0.0334 | 0.9473 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0296 | 0.0493 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0296 | 0.0493 |
Brugia malayi | MH2 domain containing protein | 0.0059 | 0.0188 | 0.0313 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0077 | 0.0318 | 0.2075 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.008 | 0.0341 | 0.9677 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0109 | 0.0181 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0077 | 0.0318 | 0.9023 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0038 | 0.0033 | 0.094 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0033 | 0.0624 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0077 | 0.0318 | 0.9023 |
Brugia malayi | jmjC domain containing protein | 0.0079 | 0.0334 | 0.0556 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.0283 | 0.0283 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0084 | 0.0366 | 0.061 |
Echinococcus multilocularis | musashi | 0.0084 | 0.0366 | 0.0366 |
Echinococcus multilocularis | peregrin | 0.0259 | 0.1625 | 0.1625 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0131 | 0.0705 | 0.0705 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0047 | 0.0102 | 0.0102 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0414 | 0.2741 | 0.4564 |
Schistosoma mansoni | rab6-interacting | 0.0062 | 0.0206 | 0.0206 |
Echinococcus granulosus | zinc finger protein | 0.0105 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0095 | 0.0444 | 0.0739 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0206 | 0.0343 |
Brugia malayi | beta-NAC-like protein | 0.0036 | 0.0023 | 0.0039 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0077 | 0.0318 | 0.2075 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0038 | 0.0812 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0074 | 0.0296 | 0.0493 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0334 | 0.0556 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0053 | 0.1331 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0047 | 0.0102 | 0.2904 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0074 | 0.0296 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0074 | 0.0296 | 0.0493 |
Schistosoma mansoni | hypothetical protein | 0.0283 | 0.1799 | 0.1801 |
Brugia malayi | hypothetical protein | 0.005 | 0.0121 | 0.0202 |
Schistosoma mansoni | rab6-interacting | 0.0062 | 0.0206 | 0.0206 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0074 | 0.0296 | 0.0934 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0059 | 0.0188 | 0.0188 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0246 | 0.1533 | 0.1535 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0091 | 0.042 | 0.042 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0705 | 0.0706 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0033 | 0.0624 |
Brugia malayi | jmjC domain containing protein | 0.0079 | 0.0334 | 0.0556 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0193 | 0.1149 | 0.1149 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0283 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0041 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | doublecortin family protein | 0.0062 | 0.0206 | 0.0343 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0074 | 0.0296 | 0.0934 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0038 | 0.1082 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1422 | 0.999 | 0.999 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0968 | 0.6725 | 0.6725 |
Trypanosoma brucei | ISWI complex protein | 0.0082 | 0.0353 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0074 | 0.0296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0415 | 0.0691 |
Schistosoma mansoni | lamin | 0.0084 | 0.0366 | 0.0367 |
Schistosoma mansoni | lipoxygenase | 0.0193 | 0.1149 | 0.115 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0341 | 0.0342 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0079 | 0.0334 | 0.0556 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0038 | 0.0064 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.032 | 0.2066 | 0.2066 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.0283 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0074 | 0.0296 | 0.0493 |
Onchocerca volvulus | Alhambra homolog | 0.0246 | 0.1533 | 0.7165 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0079 | 0.0334 | 0.0334 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0304 | 0.1947 | 0.1947 |
Schistosoma mansoni | hypothetical protein | 0.0246 | 0.1533 | 0.1535 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0079 | 0.0334 | 0.2179 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.2798 | 0.4659 |
Brugia malayi | RNA recognition motif domain containing protein | 0.04 | 0.2637 | 0.439 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0074 | 0.0296 | 0.0934 |
Schistosoma mansoni | zinc finger protein | 0.0082 | 0.0353 | 0.0353 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0079 | 0.0334 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0054 | 0.009 |
Echinococcus multilocularis | transcription factor btf3 | 0.0036 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0111 | 0.0558 | 0.093 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0091 | 0.042 | 0.0421 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.0296 | 1 |
Schistosoma mansoni | lamin | 0.0084 | 0.0366 | 0.0367 |
Plasmodium vivax | hypothetical protein, conserved | 0.0074 | 0.0296 | 0.1933 |
Echinococcus granulosus | tar DNA binding protein | 0.04 | 0.2637 | 0.2637 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0283 | 0.1799 | 0.2995 |
Brugia malayi | intermediate filament protein | 0.0084 | 0.0366 | 0.061 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0206 | 0.0343 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0036 | 0.0023 | 0.0153 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0122 | 0.0123 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0308 | 0.198 | 0.1982 |
Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.008 | 0.0341 | 0.2226 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0062 | 0.0206 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.2491 | 0.4147 |
Brugia malayi | Doublecortin family protein | 0.0062 | 0.0206 | 0.0343 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0038 | 0.1082 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0308 | 0.198 | 0.3296 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.0283 | 0.0284 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.52 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.85 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.76 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 26 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 86 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 15.97 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 26 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 86 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.04 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.91648 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.