Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0107 | 0.3612 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0009 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0233 | 0.312 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0077 | 0.0124 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0085 | 0.6071 |
Brugia malayi | CHE-14 protein | 0.0083 | 0.0281 | 0.0279 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0047 | 0.0138 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0009 | 0.0008 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0226 | 0.2179 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0119 | 0.8604 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.0713 | 0.0712 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0085 | 0.6071 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0107 | 0.7771 |
Onchocerca volvulus | 0.0014 | 0.0009 | 0.0672 | |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0014 | 0.0009 | 0.0546 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0009 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0092 | 0.009 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0035 | 0.0092 | 0.6421 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0119 | 0.4036 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0077 | 0.0742 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0.0092 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0047 | 0.0138 | 0.183 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Echinococcus multilocularis | expressed conserved protein | 0.0182 | 0.0667 | 0.1077 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0308 | 0.2963 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0107 | 0.3612 |
Onchocerca volvulus | 0.0014 | 0.0009 | 0.0672 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0077 | 0.0075 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0138 | 0.0331 |
Echinococcus multilocularis | protein dispatched 1 | 0.0095 | 0.0327 | 0.0527 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0138 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0119 | 0.4036 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0138 | 0.0331 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0014 | 0.0009 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0075 | 0.0073 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0339 | 0.0338 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0233 | 0.0375 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0014 | 0.0009 | 0.0546 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0233 | 0.3171 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0138 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0269 | 0.363 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0083 | 0.0281 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0182 | 0.0667 | 0.6427 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0226 | 0.799 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0269 | 0.363 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0014 | 0.0009 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0077 | 0.0947 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0063 | 0.1981 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0138 | 0.0136 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0308 | 0.4169 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0218 | 0.2915 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0226 | 0.0365 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0077 | 0.0124 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0014 | 0.0009 | 0.0844 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0226 | 0.3031 |
Onchocerca volvulus | Protein patched homolog | 0.0012 | 0.0002 | 0.012 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0014 | 0.0009 | 0.0089 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0308 | 0.2963 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.0226 | 0.3031 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0281 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0354 | 0.0352 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0077 | 0.0075 |
Onchocerca volvulus | 0.003 | 0.0075 | 0.54 | |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.0226 | 0.0225 |
Trypanosoma brucei | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.1008 | 0.3902 | 1 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0014 | 0.0009 | 0.0546 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.0226 | 0.0365 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0193 | 0.0713 | 0.6869 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0009 | 0.0008 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0196 | 0.0725 | 1 |
Onchocerca volvulus | 0.0014 | 0.0009 | 0.0672 | |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0047 | 0.0138 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0138 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0035 | 0.0092 | 1 |
Echinococcus multilocularis | protein patched | 0.0083 | 0.0281 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0077 | 0.0075 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0339 | 0.0338 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0083 | 0.0281 | 0.2704 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0218 | 0.0216 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0047 | 0.0138 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0077 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0009 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0077 | 0.0947 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0014 | 0.0009 | 0.0546 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0308 | 0.0306 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0276 | 0.1038 | 0.1676 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0339 | 0.0338 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0035 | 0.0092 | 1 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.0226 | 0.0225 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0233 | 0.3171 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0193 | 0.0713 | 0.0712 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0085 | 0.6071 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0014 | 0.0009 | 0.0015 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0077 | 0.0124 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0014 | 0.0009 | 0.0546 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0047 | 0.0138 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0308 | 0.4169 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0107 | 0.0106 |
Loa Loa (eye worm) | oxidoreductase | 0.0014 | 0.0009 | 0.0008 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0077 | 0.0742 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0063 | 0.1981 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0308 | 0.0497 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0233 | 0.224 |
Mycobacterium ulcerans | hypothetical protein | 0.0047 | 0.0138 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0138 | 0.0136 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0308 | 0.0497 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0077 | 0.0947 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0138 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0077 | 0.0947 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0233 | 0.3171 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0047 | 0.0138 | 0.183 |
Onchocerca volvulus | 0.0047 | 0.0138 | 1 | |
Wolbachia endosymbiont of Brugia malayi | malonyl-CoA decarboxylase | 0.2565 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0083 | 0.0281 | 0.0453 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0014 | 0.0009 | 0.0008 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0233 | 0.312 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.0226 | 0.799 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.1008 | 0.3902 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0233 | 0.3171 |
Onchocerca volvulus | 0.0014 | 0.0009 | 0.0672 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0107 | 0.0106 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0047 | 0.0138 | 0.0331 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0138 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0014 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0077 | 0.0075 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0193 | 0.0713 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0033 | 0.0085 | 0.6071 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0009 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0092 | 0.009 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0276 | 0.1038 | 1 |
Leishmania major | malonyl-coa decarboxylase-like protein | 0.1008 | 0.3902 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0218 | 0.0216 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0014 | 0.0009 | 0.0008 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1593 | 0.6194 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0035 | 0.0092 | 0.6617 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0233 | 0.0231 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0009 | 0.0546 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0047 | 0.0138 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2565 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0047 | 0.0138 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0138 | 0.0136 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0047 | 0.0138 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0083 | 0.0281 | 0.2704 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0269 | 0.363 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0047 | 0.0138 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0009 | 0.0546 |
Toxoplasma gondii | propionate-CoA ligase | 0.0014 | 0.0009 | 1 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0092 | 0.009 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0014 | 0.0009 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0092 | 0.009 |
Onchocerca volvulus | Protein patched homolog | 0.0012 | 0.0002 | 0.012 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0014 | 0.0009 | 0.0844 |
Trypanosoma cruzi | malonyl-CoA decarboxylase, mitochondrial precursor, putative | 0.1008 | 0.3902 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0014 | 0.0009 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0308 | 0.0306 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.0009 | 0.0008 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0138 | 0.0136 |
Onchocerca volvulus | 0.0012 | 0.0002 | 0.012 | |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0339 | 0.0338 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0193 | 0.0713 | 0.1151 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0047 | 0.0138 | 0.183 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0308 | 0.4169 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.0226 | 0.2179 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0014 | 0.0009 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0269 | 0.363 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0092 | 0.009 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0083 | 0.0281 | 0.0279 |
Schistosoma mansoni | patched 1 | 0.0083 | 0.0281 | 0.3794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.