Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glutamate synthase, putative | 0.0041 | 0.0131 | 0.0014 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0131 | 0.003 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0442 | 0.3031 | 0.3185 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0153 | 0.0942 | 0.2803 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.1298 | 0.1298 |
Brugia malayi | hypothetical protein | 0.0252 | 0.1657 | 0.2575 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0041 | 0.0131 | 0.0014 |
Treponema pallidum | NADH oxidase | 0.0153 | 0.0942 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.078 | 0.1871 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0112 | 0.0649 | 0.1009 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0153 | 0.0942 | 1 |
Echinococcus granulosus | geminin | 0.0202 | 0.1298 | 0.1365 |
Brugia malayi | glutaminase DH11.1 | 0.0912 | 0.6433 | 1 |
Mycobacterium ulcerans | glutamate synthase subunit beta | 0.0041 | 0.0131 | 0.0014 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.0041 | 0.0131 | 0.0049 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0036 | 0.0102 | 0.0107 |
Schistosoma mansoni | disulfide oxidoreductase | 0.0041 | 0.0131 | 0.0131 |
Leishmania major | 2,4-dienoyl-coa reductase fadh1, putative | 0.0041 | 0.0131 | 0.003 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0508 | 0.0534 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0041 | 0.0131 | 0.0138 |
Plasmodium falciparum | thioredoxin reductase | 0.044 | 0.3022 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0313 | 0.0313 |
Schistosoma mansoni | sulfide quinone reductase | 0.0041 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.1657 | 0.2575 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0508 | 0.0508 |
Brugia malayi | Pre-SET motif family protein | 0.0457 | 0.3144 | 0.4888 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0041 | 0.0131 | 0.0138 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0131 | 0.003 |
Schistosoma mansoni | glutamate synthase | 0.0041 | 0.0131 | 0.0131 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh1 | 0.0041 | 0.0131 | 0.0014 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0153 | 0.0942 | 0.0942 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0153 | 0.0942 | 0.2825 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.1211 | 0.1726 |
Trypanosoma cruzi | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0041 | 0.0131 | 0.003 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0014 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0036 | 0.0102 | 0.0107 |
Mycobacterium leprae | PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) | 0.0041 | 0.0131 | 0.0049 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0112 | 0.0649 | 0.1009 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0442 | 0.3031 | 0.3185 |
Echinococcus multilocularis | sulfide:quinone oxidoreductase | 0.0041 | 0.0131 | 0.0138 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.1824 | 0.2696 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0153 | 0.0942 | 1 |
Giardia lamblia | Kinase, PLK | 0.0189 | 0.1205 | 1 |
Mycobacterium ulcerans | monoxygenase | 0.0041 | 0.0131 | 0.0014 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Echinococcus granulosus | NADPH:adrenodoxin oxidoreductase | 0.0041 | 0.0131 | 0.0138 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.1824 | 0.2696 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.078 | 0.1213 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0508 | 0.0534 |
Trypanosoma brucei | trypanothione reductase | 0.044 | 0.3022 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0041 | 0.0131 | 0.0108 |
Brugia malayi | hypothetical protein | 0.013 | 0.078 | 0.1213 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1339 | 0.9514 | 0.9514 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase-like protein, putative | 0.0041 | 0.0131 | 0.003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0508 | 0.0508 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Echinococcus granulosus | sulfide:quinone oxidoreductase | 0.0041 | 0.0131 | 0.0138 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0131 | 0.003 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0153 | 0.0942 | 0.1298 |
Brugia malayi | glutamate synthase | 0.0041 | 0.0131 | 0.0204 |
Trypanosoma brucei | NADPH:adrenodoxin oxidoreductase, mitochondrial, putative | 0.0041 | 0.0131 | 0.003 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0131 | 0.003 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0217 | 0.0338 |
Trypanosoma cruzi | 2,4-dienoyl-coa reductase fadh1, putative | 0.0041 | 0.0131 | 0.003 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0313 | 0.0313 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0041 | 0.0131 | 0.003 |
Echinococcus multilocularis | glutamate synthase | 0.0041 | 0.0131 | 0.0138 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0153 | 0.0942 | 0.099 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Plasmodium vivax | thioredoxin reductase, putative | 0.044 | 0.3022 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0246 | 0.1619 | 0.2517 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0041 | 0.0131 | 0.0082 |
Echinococcus multilocularis | pyridine nucleotide disulfide oxidoreductase | 0.0041 | 0.0131 | 0.0138 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0153 | 0.0942 | 0.2825 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0189 | 0.1205 | 0.1267 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0131 | 0.003 |
Loa Loa (eye worm) | glutaminase 2 | 0.0912 | 0.6433 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.1298 | 0.1298 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0189 | 0.1205 | 0.3734 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0131 | 0.0204 |
Loa Loa (eye worm) | thioredoxin reductase | 0.044 | 0.3022 | 0.4697 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0081 | 0.0425 | 0.1045 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0014 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0209 | 0.0209 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0081 | 0.0425 | 0.1017 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.0041 | 0.0131 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.078 | 0.1213 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0153 | 0.0942 | 0.7547 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0081 | 0.0425 | 0.1017 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0066 | 0.0313 | 0.0313 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprB | 0.0041 | 0.0131 | 0.0014 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.1824 | 0.2696 |
Toxoplasma gondii | NADH dehydrogenase (NDH2-II) | 0.0041 | 0.0131 | 0.003 |
Echinococcus granulosus | glutamate synthase | 0.0041 | 0.0131 | 0.0138 |
Schistosoma mansoni | sulfide quinone reductase | 0.0041 | 0.0131 | 0.0131 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0252 | 0.1657 | 0.1741 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0066 | 0.0313 | 0.0329 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0122 | 0.019 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0014 |
Brugia malayi | glutathione reductase | 0.044 | 0.3022 | 0.4697 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0246 | 0.1619 | 0.2517 |
Toxoplasma gondii | selenide, water dikinase | 0.0041 | 0.0131 | 0.003 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Echinococcus multilocularis | apoptosis inducing factor 1 mitochondrial | 0.0041 | 0.0131 | 0.0138 |
Echinococcus granulosus | pyridine nucleotide disulfide oxidoreductase | 0.0041 | 0.0131 | 0.0138 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.0508 | 0.079 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.019 | 0.1211 | 0.1726 |
Plasmodium falciparum | glutathione reductase | 0.044 | 0.3022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0425 | 0.0661 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0425 | 0.0661 |
Mycobacterium leprae | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0041 | 0.0131 | 0.0049 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.0508 | 0.0534 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0041 | 0.0131 | 0.0204 |
Onchocerca volvulus | 0.0521 | 0.3601 | 1 | |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0153 | 0.0942 | 0.1298 |
Toxoplasma gondii | non-proton pumping type-II NADH dehydrogenase I | 0.0041 | 0.0131 | 0.003 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0153 | 0.0942 | 0.1086 |
Trypanosoma brucei | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0131 | 0.003 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0041 | 0.0131 | 0.0138 |
Echinococcus multilocularis | NADPH:adrenodoxin oxidoreductase | 0.0041 | 0.0131 | 0.0138 |
Trypanosoma brucei | 2,4-dienoyl-coa reductase-like protein | 0.0041 | 0.0131 | 0.003 |
Plasmodium vivax | SET domain protein, putative | 0.0066 | 0.0313 | 0.0627 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0041 | 0.0131 | 0.0138 |
Mycobacterium tuberculosis | Possible dehydrogenase/reductase | 0.0041 | 0.0131 | 0.0049 |
Wolbachia endosymbiont of Brugia malayi | NADPH-dependent glutamate synthase beta chain | 0.0041 | 0.0131 | 0.0108 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0153 | 0.0942 | 0.2825 |
Trypanosoma cruzi | pyridine nucleotide-disulphide oxidoreductase, putative | 0.0041 | 0.0131 | 0.003 |
Mycobacterium leprae | THIOREDOXIN TRXC (TRX) (MPT46) | 0.0041 | 0.0131 | 0.0049 |
Plasmodium falciparum | thioredoxin reductase | 0.0153 | 0.0942 | 0.2803 |
Schistosoma mansoni | glutamate synthase | 0.0041 | 0.0131 | 0.0131 |
Leishmania major | 2,4-dienoyl-coa reductase-like protein | 0.0041 | 0.0131 | 0.003 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.1117 | 0.7911 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.1117 | 0.7911 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0209 | 0.0325 |
Onchocerca volvulus | 0.0066 | 0.0313 | 0.0523 | |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0041 | 0.0131 | 0.0082 |
Trypanosoma brucei | NADH dehydrogenase | 0.0041 | 0.0131 | 0.003 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0041 | 0.0131 | 0.0014 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0189 | 0.1205 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase family protein | 0.0041 | 0.0131 | 0.0204 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0153 | 0.0942 | 0.1464 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.044 | 0.3022 | 0.3747 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0081 | 0.0425 | 0.1017 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0515 | 0.0622 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0041 | 0.0131 | 0.0014 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.0508 | 0.079 |
Toxoplasma gondii | thioredoxin reductase | 0.044 | 0.3022 | 1 |
Mycobacterium ulcerans | NADPH dependent 2,4-dienoyl-CoA reductase FadH | 0.0041 | 0.0131 | 0.0014 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0153 | 0.0942 | 0.2825 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0066 | 0.0313 | 0.0329 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0189 | 0.1205 | 0.1873 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0122 | 0.0122 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0131 | 0.0014 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1339 | 0.9514 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0153 | 0.0942 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0275 | 0.1824 | 0.2835 |
Mycobacterium tuberculosis | Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) | 0.0041 | 0.0131 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0209 | 0.0209 |
Mycobacterium ulcerans | dehydrogenase | 0.0041 | 0.0131 | 0.0014 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0189 | 0.1205 | 0.3734 |
Onchocerca volvulus | 0.0051 | 0.0209 | 0.0225 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0189 | 0.1205 | 0.1205 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.1824 | 0.2696 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0041 | 0.0131 | 0.003 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0153 | 0.0942 | 0.2803 |
Loa Loa (eye worm) | pyridine nucleotide-disufhide oxidoreductase | 0.0041 | 0.0131 | 0.0204 |
Brugia malayi | Pre-SET motif family protein | 0.0066 | 0.0313 | 0.0486 |
Mycobacterium ulcerans | glutaminase | 0.0912 | 0.6433 | 1 |
Entamoeba histolytica | glutamate synthase beta subunit, putative | 0.0041 | 0.0131 | 0.0082 |
Loa Loa (eye worm) | programmed cell death 8 | 0.0041 | 0.0131 | 0.0204 |
Schistosoma mansoni | glutaminase | 0.0912 | 0.6433 | 0.6433 |
Mycobacterium leprae | Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) | 0.0041 | 0.0131 | 0.0049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Leishmania major | hypothetical protein, conserved | 0.0081 | 0.0425 | 0.1045 |
Plasmodium falciparum | glutathione reductase | 0.0153 | 0.0942 | 0.2803 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0153 | 0.0942 | 0.2825 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0131 | 0.0131 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0153 | 0.0942 | 0.1298 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0153 | 0.0942 | 0.2825 |
Brugia malayi | Thioredoxin reductase | 0.044 | 0.3022 | 0.4697 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0081 | 0.0425 | 0.1045 |
Mycobacterium ulcerans | NADPH:adrenodoxin oxidoreductase FprA | 0.0041 | 0.0131 | 0.0014 |
Mycobacterium tuberculosis | Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) | 0.0041 | 0.0131 | 0.0049 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0122 | 0.019 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0066 | 0.0313 | 0.0313 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0122 | 0.0122 |
Echinococcus multilocularis | geminin | 0.0202 | 0.1298 | 0.1365 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.1005 | 0.7101 | 0.8963 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0153 | 0.0942 | 0.2825 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0041 | 0.0131 | 0.0082 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0153 | 0.0942 | 0.2825 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0063 | 0.0295 | 0.031 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0122 | 0.0129 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0515 | 0.0622 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.0508 | 0.0508 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0131 | 0.003 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0275 | 0.1824 | 0.2835 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0122 | 0.0129 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.0508 | 0.0534 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0041 | 0.0131 | 0.0082 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.1824 | 0.2696 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0041 | 0.0131 | 0.0014 |
Trypanosoma brucei | polo-like protein kinase | 0.0189 | 0.1205 | 0.3734 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Plasmodium vivax | glutathione reductase, putative | 0.044 | 0.3022 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0153 | 0.0942 | 0.099 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0014 |
Echinococcus multilocularis | expressed protein | 0.0423 | 0.2898 | 0.3046 |
Mycobacterium ulcerans | NADH dehydrogenase Ndh | 0.0041 | 0.0131 | 0.0014 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Mycobacterium tuberculosis | Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate | 0.0041 | 0.0131 | 0.0049 |
Mycobacterium ulcerans | NADH dehydrogenase | 0.0041 | 0.0131 | 0.0014 |
Entamoeba histolytica | disulphide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0082 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.1005 | 0.7101 | 0.8963 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0189 | 0.1205 | 0.3095 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0066 | 0.0313 | 0.0656 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0275 | 0.1824 | 0.2696 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0313 | 0.0486 |
Mycobacterium tuberculosis | NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) | 0.0041 | 0.0131 | 0.0049 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0252 | 0.1657 | 0.1741 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0153 | 0.0942 | 0.2803 |
Echinococcus granulosus | expressed protein | 0.0423 | 0.2898 | 0.3046 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.1117 | 0.7911 | 1 |
Leishmania major | NADH dehydrogenase, putative | 0.0041 | 0.0131 | 0.003 |
Mycobacterium tuberculosis | Probable reductase | 0.1005 | 0.7101 | 0.8963 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.1005 | 0.7101 | 0.8963 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0102 | 0.0102 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0153 | 0.0942 | 0.2825 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0189 | 0.1205 | 0.1873 |
Trichomonas vaginalis | glutaminase, putative | 0.0912 | 0.6433 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0041 | 0.0131 | 0.0014 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.1005 | 0.7101 | 0.8963 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.018 | 0.1141 | 0.2911 |
Leishmania major | trypanothione reductase | 0.044 | 0.3022 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1339 | 0.9514 | 1 |
Schistosoma mansoni | glutamate synthase | 0.0041 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | glutathione reductase | 0.044 | 0.3022 | 0.4697 |
Trichomonas vaginalis | set domain proteins, putative | 0.0521 | 0.3601 | 0.5512 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0041 | 0.0131 | 0.003 |
Entamoeba histolytica | pyridine nucleotide-disulfide oxidoreductase family protein | 0.0041 | 0.0131 | 0.0082 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.044 | 0.3022 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0066 | 0.0313 | 0.0329 |
Schistosoma mansoni | kinase | 0.0096 | 0.0533 | 0.0533 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0457 | 0.3144 | 0.4888 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0131 | 0.003 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0041 | 0.0131 | 0.003 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0153 | 0.0942 | 0.1298 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0081 | 0.0425 | 0.1045 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0131 | 0.003 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.018 | 0.1141 | 0.1614 |
Loa Loa (eye worm) | glutaminase | 0.0912 | 0.6433 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.078 | 0.1871 |
Trypanosoma cruzi | NADH dehydrogenase, putative | 0.0041 | 0.0131 | 0.003 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0189 | 0.1205 | 0.1267 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0014 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0153 | 0.0942 | 0.1298 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0041 | 0.0131 | 0.0108 |
Mycobacterium ulcerans | ferredoxin reductase | 0.0041 | 0.0131 | 0.0014 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.1117 | 0.7911 | 1 |
Echinococcus granulosus | apoptosis inducing factor 1 mitochondrial | 0.0041 | 0.0131 | 0.0138 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.1005 | 0.7101 | 0.8963 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0189 | 0.1205 | 0.1715 |
Trichomonas vaginalis | glutamate synthase, putative | 0.0041 | 0.0131 | 0.0014 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0153 | 0.0942 | 0.2825 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.1005 | 0.7101 | 0.8963 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0081 | 0.0425 | 0.1045 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0041 | 0.0131 | 0.0014 |
Brugia malayi | NADPH:adrenodoxin oxidoreductase, mitochondrial precursor | 0.0041 | 0.0131 | 0.0204 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0153 | 0.0942 | 0.2803 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0189 | 0.1205 | 0.3734 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0041 | 0.0131 | 0.0014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -3.47 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.35 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 4.3 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 57 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 57 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.1 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.79421 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.