Detailed information for compound 592143

Basic information

Technical information
  • TDR Targets ID: 592143
  • Name: N-[(8-hydroxyquinolin-7-yl)-(4-methylphenyl)m ethyl]butanamide
  • MW: 334.412 | Formula: C21H22N2O2
  • H donors: 2 H acceptors: 3 LogP: 4.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)NC(c1ccc2c(c1O)nccc2)c1ccc(cc1)C
  • InChi: 1S/C21H22N2O2/c1-3-5-18(24)23-19(16-9-7-14(2)8-10-16)17-12-11-15-6-4-13-22-20(15)21(17)25/h4,6-13,19,25H,3,5H2,1-2H3,(H,23,24)
  • InChiKey: YLHAGZFGLRYNET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(8-hydroxy-7-quinolyl)-(4-methylphenyl)methyl]butanamide
  • N-[(8-hydroxy-7-quinolyl)-(4-methylphenyl)methyl]butyramide
  • BAS 01277879
  • N-[(8-Hydroxy-quinolin-7-yl)-p-tolyl-methyl]-butyramide
  • EU-0007127
  • Oprea1_764838
  • Oprea1_445508

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Human herpesvirus 4 (strain B95-8) Latent membrane protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0702769 0.268814 0.659964
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00555969 0.00888928 0.00969085
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma cruzi hypothetical protein, conserved 0.0203282 0.0682042 0.0872864
Entamoeba histolytica fructokinase, putative 0.00563294 0.00918347 0.00890938
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0203282 0.0682042 0.0815849
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00555969 0.00888928 0.00969085
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0815849
Echinococcus granulosus neuropeptide receptor 0.0702769 0.268814 0.345223
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0263601 0.0924303 0.116744
Entamoeba histolytica iron-containing superoxide dismutase 0.0182335 0.0597914 0.0744647
Leishmania major cytochrome P450 reductase, putative 0.0361679 0.131821 0.167769
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0373233 0.136462 0.175518
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis dro:myosuppressin receptor 0.0702769 0.268814 0.345223
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.196134 0.774293 1
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0182335 0.0597914 0.07555
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.00948012 0.024635 0.0300632
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0394227 0.144894 0.186418
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.196134 0.774293 0.772201
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.00644587 0.0124485 0.00426736
Trichomonas vaginalis iron superoxide dismutase A, putative 0.0182335 0.0597914 0.07555
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei adenosine transporter, putative 0.0263601 0.0924303 0.116744
Echinococcus granulosus neuropeptides capa receptor 0.0702769 0.268814 0.345223
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma cruzi nucleoside transporter 1, putative 0.0263601 0.0924303 0.118602
Trypanosoma cruzi hypothetical protein, conserved 0.0203282 0.0682042 0.0872864
Brugia malayi larval opioid receptor 0.0702769 0.268814 0.347173
Trypanosoma cruzi nucleoside transporter 1, putative 0.0263601 0.0924303 0.118602
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0702769 0.268814 0.345223
Onchocerca volvulus Putative pyridoxal kinase 0.00563294 0.00918347 0.0225463
Trichomonas vaginalis conserved hypothetical protein 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0203282 0.0682042 0.125108
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.114691 0.447196 0.576292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Schistosoma mansoni clathrin coat associated protein ap-50 0.00752008 0.0167628 0.0216492
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.00392044 0.00230553 0.00117254
Schistosoma mansoni sumo-1-activating enzyme E1a 0.00471102 0.00548076 0.00707841
Toxoplasma gondii nucleoside transporter protein 0.0263601 0.0924303 0.116744
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Leishmania major nucleoside transporter 1, putative 0.0263601 0.0924303 0.116744
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Echinococcus multilocularis g protein coupled receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Schistosoma mansoni growth hormone secretagogue receptor 0.0702769 0.268814 0.347173
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.196134 0.774293 1
Schistosoma mansoni app binding protein 0.00392044 0.00230553 0.0029776
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0702769 0.268814 0.347173
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Echinococcus granulosus ubiquitin modifier activating enzyme 1 0.0123348 0.0361003 0.0437764
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0702769 0.268814 0.345223
Echinococcus granulosus tachykinin peptides receptor 99D 0.0702769 0.268814 0.345223
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.104762 0.407316 0.525191
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Schistosoma mansoni neuropeptide receptor 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Toxoplasma gondii nucleoside transporter protein 0.0263601 0.0924303 0.116744
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.00606064 0.0109012 0.0140789
Trypanosoma cruzi nucleoside transporter 1, putative 0.0263601 0.0924303 0.118602
Loa Loa (eye worm) hypothetical protein 0.0394227 0.144894 0.26578
Trichomonas vaginalis ribokinase, putative 0.00563294 0.00918347 0.0100715
Loa Loa (eye worm) hypothetical protein 0.104762 0.407316 0.747145
Echinococcus multilocularis G-protein coupled receptor, putative 0.0702769 0.268814 0.345223
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0702769 0.268814 0.345223
Echinococcus granulosus dro:myosuppressin receptor 0.0702769 0.268814 0.345223
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0702769 0.268814 0.345223
Trypanosoma cruzi iron superoxide dismutase, putative 0.0182335 0.0597914 0.0764117
Brugia malayi Dopamine receptor protein 1 0.0702769 0.268814 0.347173
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Loa Loa (eye worm) PDE1B protein 0.0373233 0.136462 0.250313
Schistosoma mansoni amine GPCR 0.0702769 0.268814 0.347173
Echinococcus multilocularis neuropeptide receptor A26 0.0702769 0.268814 0.345223
Onchocerca volvulus 0.0702769 0.268814 0.659964
Brugia malayi ThiF family protein 0.00392044 0.00230553 0.0029776
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0263601 0.0924303 0.116744
Onchocerca volvulus 0.0702769 0.268814 0.659964
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0373233 0.136462 0.17378
Entamoeba histolytica kinase, PfkB family 0.00563294 0.00918347 0.00890938
Echinococcus multilocularis neuropeptide receptor 0.0702769 0.268814 0.345223
Trypanosoma cruzi iron superoxide dismutase, putative 0.0182335 0.0597914 0.0764117
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0182335 0.0597914 0.0764117
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.196134 0.774293 1
Loa Loa (eye worm) G-protein coupled receptor 0.0702769 0.268814 0.493088
Schistosoma mansoni neuropeptide receptor 0.0702769 0.268814 0.347173
Trypanosoma cruzi superoxide dismutase, putative 0.00462558 0.0051376 0.00576439
Schistosoma mansoni neuropeptide receptor 0.0702769 0.268814 0.347173
Echinococcus granulosus g protein coupled receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0182335 0.0597914 0.07555
Entamoeba histolytica nucleoside transporter, putative 0.0263601 0.0924303 0.116744
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei adenosine transporter 2, putative 0.0263601 0.0924303 0.116744
Schistosoma mansoni biogenic amine (5HT) receptor 0.0702769 0.268814 0.347173
Trypanosoma cruzi superoxide dismutase, putative 0.0104541 0.0285467 0.0360237
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0394227 0.144894 0.184703
Entamoeba histolytica ubiquitin-activating enzyme E1 1, putative 0.00948012 0.024635 0.0289246
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0203282 0.0682042 0.0872864
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Leishmania major adenosine kinase-like protein 0.00563294 0.00918347 0.00890938
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) hypothetical protein 0.0263601 0.0924303 0.169546
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0702769 0.268814 0.345223
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0702769 0.268814 0.347173
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.00563294 0.00918347 0.00890938
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0139559 0.0426112 0.0482959
Trypanosoma cruzi hypothetical protein, conserved 0.0203282 0.0682042 0.0872864
Trypanosoma cruzi nucleobase transporter, putative 0.0263601 0.0924303 0.118602
Loa Loa (eye worm) hypothetical protein 0.0203282 0.0682042 0.125108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Trypanosoma cruzi superoxide dismutase, putative 0.0104541 0.0285467 0.0360237
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei adenosine transporter 2, putative 0.0263601 0.0924303 0.116744
Trichomonas vaginalis conserved hypothetical protein 0.0203282 0.0682042 0.0864348
Echinococcus granulosus 7TM GPCR rhodopsin 0.0702769 0.268814 0.345223
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trichomonas vaginalis sulfite reductase, putative 0.0394227 0.144894 0.185659
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.196134 0.774293 1
Brugia malayi hypothetical protein 0.00563294 0.00918347 0.0118604
Loa Loa (eye worm) hypothetical protein 0.0182335 0.0597914 0.109676
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.196134 0.774293 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0394227 0.144894 0.186418
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Leishmania major hypothetical protein, conserved 0.0203282 0.0682042 0.0853624
Trypanosoma cruzi iron superoxide dismutase, putative 0.0182335 0.0597914 0.0764117
Trypanosoma brucei iron superoxide dismutase C, mitochondrial 0.0104541 0.0285467 0.0339916
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0139559 0.0426112 0.0482959
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.196134 0.774293 1
Plasmodium falciparum nitric oxide synthase, putative 0.0394227 0.144894 0.181335
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.00462558 0.0051376 0.00576439
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Entamoeba histolytica ribokinase, putative 0.00563294 0.00918347 0.00890938
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.135019 0.52884 0.68205
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.00644587 0.0124485 0.0152147
Echinococcus multilocularis methionine synthase reductase 0.0254668 0.0888423 0.112096
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.131036 0.512843 0.661725
Plasmodium vivax superoxide dismutase [Fe], putative 0.0182335 0.0597914 0.0706422
Echinococcus granulosus ribokinase 0.00563294 0.00918347 0.00890938
Schistosoma mansoni adenosine kinase 0.0612059 0.232382 0.300121
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Brugia malayi putative neuropeptide receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis ribokinase, putative 0.00563294 0.00918347 0.0100715
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis conserved hypothetical protein 0.0203282 0.0682042 0.0864348
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis adenosine kinase 0.0612059 0.232382 0.298031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0702769 0.268814 0.345223
Trypanosoma cruzi hypothetical protein, conserved 0.00751243 0.0167321 0.0207518
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.122147 0.47714 0.61589
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0263601 0.0924303 0.116744
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.00606064 0.0109012 0.0199963
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.196134 0.774293 1
Trypanosoma brucei ribokinase, putative 0.00563294 0.00918347 0.00890938
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus granulosus SUMO activating enzyme subunit 1 0.00471102 0.00548076 0.00411305
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0373233 0.136462 0.175518
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0203282 0.0682042 0.0853624
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.131036 0.512843 0.940713
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0203282 0.0682042 0.0853624
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.196134 0.774293 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0394227 0.144894 0.184703
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus granulosus biogenic amine 5HT receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0373233 0.136462 0.176241
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0203282 0.0682042 0.0853624
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Echinococcus granulosus neuropeptide FF receptor 2 0.0702769 0.268814 0.345223
Schistosoma mansoni cytochrome P450 reductase 0.0394227 0.144894 0.18713
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0702769 0.268814 0.493088
Echinococcus multilocularis manganese superoxide dismutase 0.0182335 0.0597914 0.0744647
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.00392044 0.00230553 0.00117254
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Plasmodium falciparum superoxide dismutase [Fe] 0.0182335 0.0597914 0.0706422
Echinococcus granulosus ubiquitin modifier activating enzyme 6 0.0123348 0.0361003 0.0437764
Trypanosoma cruzi hypothetical protein, conserved 0.00751243 0.0167321 0.0207518
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0203282 0.0682042 0.0880858
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Brugia malayi follicle stimulating hormone receptor 0.0702769 0.268814 0.347173
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.00563294 0.00918347 0.00890938
Trypanosoma brucei ribokinase, putative 0.00563294 0.00918347 0.00890938
Echinococcus granulosus manganese superoxide dismutase 0.0182335 0.0597914 0.0744647
Echinococcus granulosus allatostatin A receptor 0.0702769 0.268814 0.345223
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) hypothetical protein 0.00520154 0.00745084 0.0136672
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Echinococcus granulosus fmrfamide receptor 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0702769 0.268814 0.493088
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.135019 0.52884 0.68205
Toxoplasma gondii superoxide dismutase SOD2 0.0182335 0.0597914 0.0744647
Trypanosoma cruzi nucleoside transporter-like, putative 0.0263601 0.0924303 0.118602
Schistosoma mansoni biogenic amine receptor 0.0702769 0.268814 0.347173
Brugia malayi G-protein coupled receptor 0.0702769 0.268814 0.347173
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0702769 0.268814 0.345223
Plasmodium vivax hypothetical protein, conserved 0.0139559 0.0426112 0.0482959
Loa Loa (eye worm) hypothetical protein 0.00563294 0.00918347 0.0168453
Schistosoma mansoni biogenic amine receptor 0.0702769 0.268814 0.347173
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0263601 0.0924303 0.116744
Echinococcus granulosus g-protein coupled receptor 0.0702769 0.268814 0.345223
Echinococcus granulosus sex peptide receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni superoxide dismutase [mn] 0.0182335 0.0597914 0.0772206
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0702769 0.268814 0.347173
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0394227 0.144894 0.184703
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Schistosoma mansoni adenosine kinase 0.0612059 0.232382 0.300121
Plasmodium falciparum ubiquitin-activating enzyme E1 0.0123348 0.0361003 0.0398271
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.122147 0.47714 0.61508
Trichomonas vaginalis ribokinase, putative 0.00563294 0.00918347 0.0100715
Trypanosoma brucei hypothetical protein, conserved 0.0203282 0.0682042 0.0853624
Leishmania major iron superoxide dismutase 0.0182335 0.0597914 0.0744647
Echinococcus granulosus serotonin receptor 0.0702769 0.268814 0.345223
Echinococcus multilocularis neuropeptides capa receptor 0.0702769 0.268814 0.345223
Echinococcus granulosus tm gpcr rhodopsin 0.0702769 0.268814 0.345223
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.139084 0.545164 1
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0182335 0.0597914 0.0764117
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0203282 0.0682042 0.0880858
Plasmodium vivax phosphodiesterase gamma, putative 0.0203282 0.0682042 0.0815849
Brugia malayi ORL1-like opioid receptor 0.0702769 0.268814 0.347173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0394227 0.144894 0.184703
Echinococcus multilocularis ribokinase 0.00563294 0.00918347 0.00890938
Schistosoma mansoni ribokinase 0.00563294 0.00918347 0.0118604
Brugia malayi Adenosine kinase-like 0.0612059 0.232382 0.300121
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.131036 0.512843 0.661725
Schistosoma mansoni neuropeptide F-like receptor 0.0702769 0.268814 0.347173
Leishmania major ubiquitin-activating enzyme e1, putative 0.00448583 0.00457633 0.00294149
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0139559 0.0426112 0.0533216
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Schistosoma mansoni voltage-gated potassium channel 0.00668196 0.0133967 0.0173018
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) neuropeptide F receptor 0.0702769 0.268814 0.493088
Leishmania major iron superoxide dismutase, putative 0.0182335 0.0597914 0.0744647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Echinococcus granulosus neuropeptide Y receptor 0.0702769 0.268814 0.345223
Brugia malayi ube1-prov protein 0.0123348 0.0361003 0.0466236
Loa Loa (eye worm) hypothetical protein 0.0612059 0.232382 0.426261
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.131036 0.512843 0.661328
Trypanosoma brucei nucleoside 2-deoxyribosyltransferase 0.00751243 0.0167321 0.0186876
Giardia lamblia hypothetical protein 0.0203282 0.0682042 0.0771403
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0203282 0.0682042 0.0853624
Trypanosoma brucei adenosine transporter 2 0.0263601 0.0924303 0.116744
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.196134 0.774293 1
Echinococcus multilocularis g protein coupled receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni hypothetical protein 0.0702769 0.268814 0.347173
Giardia lamblia Hypothetical protein 0.0203282 0.0682042 0.0771403
Echinococcus granulosus adenosine kinase 0.0612059 0.232382 0.298031
Echinococcus multilocularis neuropeptide Y receptor 0.0702769 0.268814 0.345223
Loa Loa (eye worm) flavodoxin family protein 0.0139559 0.0426112 0.0781623
Echinococcus multilocularis somatostatin receptor 0.0702769 0.268814 0.345223
Trypanosoma brucei iron superoxide dismutase 0.0182335 0.0597914 0.0744647
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.196134 0.774293 1
Brugia malayi Serotonin receptor 0.0702769 0.268814 0.347173
Schistosoma mansoni amine GPCR 0.0702769 0.268814 0.347173
Loa Loa (eye worm) FAD binding domain-containing protein 0.0254668 0.0888423 0.162964
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei nucleoside transporter 1, putative 0.0263601 0.0924303 0.116744
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei adenosine kinase, putative 0.0612059 0.232382 0.298031
Trypanosoma brucei iron superoxide dismutase 0.0182335 0.0597914 0.0744647
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0394227 0.144894 0.136968
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus granulosus g protein coupled receptor 0.0702769 0.268814 0.345223
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0139559 0.0426112 0.0533216
Echinococcus granulosus neuropeptide Y receptor 0.0702769 0.268814 0.345223
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0815849
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0203282 0.0682042 0.0880858
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma brucei unspecified product 0.0263601 0.0924303 0.116744
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.131036 0.512843 0.940713
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0263601 0.0924303 0.11778
Trypanosoma cruzi hypothetical protein, conserved 0.00751243 0.0167321 0.0207518
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0702769 0.268814 0.493088
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.135019 0.52884 0.679192
Loa Loa (eye worm) ube1-prov protein 0.0123348 0.0361003 0.0662193
Loa Loa (eye worm) hypothetical protein 0.104762 0.407316 0.747145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0570497 0.215689 0.278563
Echinococcus multilocularis neuropeptide receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.135019 0.52884 0.682997
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0702769 0.268814 0.345223
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0263601 0.0924303 0.11778
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Brugia malayi neuropeptide F receptor 0.0702769 0.268814 0.347173
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0702769 0.268814 0.345223
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Brugia malayi neuropeptide F receptor 0.0702769 0.268814 0.347173
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Echinococcus granulosus G protein coupled receptor 139 0.0702769 0.268814 0.345223
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.012405 0.0363823 0.0893221
Schistosoma mansoni myosin xvIII 0.0702769 0.268814 0.347173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Echinococcus granulosus neuropeptides capa receptor 0.0702769 0.268814 0.345223
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0203282 0.0682042 0.0880858
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0208292 0.0702162 0.0879686
Brugia malayi sulfakinin receptor protein 0.0702769 0.268814 0.347173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Echinococcus granulosus tm gpcr rhodopsin 0.0702769 0.268814 0.345223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Onchocerca volvulus 0.0702769 0.268814 0.659964
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0394227 0.144894 0.184703
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0702769 0.268814 0.347173
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.0203282 0.0682042 0.125108
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Trichomonas vaginalis conserved hypothetical protein 0.00751243 0.0167321 0.0198382
Chlamydia trachomatis sulfite reductase 0.0254668 0.0888423 0.040659
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Schistosoma mansoni amine GPCR 0.0702769 0.268814 0.347173
Trypanosoma cruzi superoxide dismutase, putative 0.0104541 0.0285467 0.0360237
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0702769 0.268814 0.347173
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0203282 0.0682042 0.0853624
Trypanosoma cruzi NEDD8-activating enzyme E1 regulatory subunit, putative 0.00392044 0.00230553 0.00210357
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.0182335 0.0597914 0.051077
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0702769 0.268814 0.347173
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Leishmania major nucleobase transporter 0.0263601 0.0924303 0.116744
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0702769 0.268814 0.347173
Schistosoma mansoni histamine h1 receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0263601 0.0924303 0.11778
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.196134 0.774293 1
Plasmodium falciparum superoxide dismutase [Fe] 0.0104541 0.0285467 0.030002
Echinococcus multilocularis neuropeptide Y receptor 0.0702769 0.268814 0.345223
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.122147 0.47714 0.61589
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0203282 0.0682042 0.0853624
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0254668 0.0888423 0.11474
Onchocerca volvulus 0.055573 0.209758 0.514977
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Brugia malayi Melatonin receptor type 1A 0.0702769 0.268814 0.347173
Giardia lamblia Hypothetical protein 0.0361679 0.131821 0.160288
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0203282 0.0682042 0.0815849
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0702769 0.268814 0.659964
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Echinococcus multilocularis fmrfamide receptor 0.0702769 0.268814 0.345223
Trypanosoma cruzi hypothetical protein 0.00751243 0.0167321 0.0207518
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0139559 0.0426112 0.054204
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0702769 0.268814 0.347173
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0702769 0.268814 0.347173
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0139559 0.0426112 0.0533216
Schistosoma mansoni opsin-like receptor 0.0702769 0.268814 0.347173
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0263601 0.0924303 0.116744
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0139559 0.0426112 0.054204
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.252331 1 1
Onchocerca volvulus 0.0702769 0.268814 0.659964
Brugia malayi Dopamine receptor 0.0702769 0.268814 0.347173
Loa Loa (eye worm) G-protein coupled receptor 0.0702769 0.268814 0.493088
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0373233 0.136462 0.17378
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trichomonas vaginalis ubiquitin-activating enzyme E1 X, putative 0.00410304 0.00303891 0.0021214
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0702769 0.268814 0.345223
Brugia malayi GnHR receptor homolog 0.0702769 0.268814 0.347173
Trichomonas vaginalis conserved hypothetical protein 0.00563294 0.00918347 0.0100715
Echinococcus multilocularis allatostatin A receptor 0.0702769 0.268814 0.345223
Echinococcus granulosus neuropeptide s receptor 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Loa Loa (eye worm) hypothetical protein 0.00563294 0.00918347 0.0168453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Schistosoma mansoni biogenic amine (5HT) receptor 0.0702769 0.268814 0.347173
Trypanosoma cruzi superoxide dismutase, putative 0.0104541 0.0285467 0.0360237
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.00448583 0.00457633 0.00294149
Echinococcus multilocularis neuropeptide s receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni NADPH flavin oxidoreductase 0.022212 0.07577 0.0978571
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.196134 0.774293 1
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus multilocularis neuropeptide FF receptor 2 0.0702769 0.268814 0.345223
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0394227 0.144894 0.181335
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0123348 0.0361003 0.0437764
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0702769 0.268814 0.345223
Brugia malayi flavodoxin family protein 0.0394227 0.144894 0.18713
Loa Loa (eye worm) hypothetical protein 0.104762 0.407316 0.747145
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0394227 0.144894 0.184703
Schistosoma mansoni neuropeptide receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Leishmania major nucleoside transporter 1, putative 0.0263601 0.0924303 0.116744
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00606064 0.0109012 0.0111345
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.104762 0.407316 0.525191
Echinococcus multilocularis fmrfamide receptor 0.0702769 0.268814 0.345223
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.122147 0.47714 0.61162
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.104762 0.407316 0.525191
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0203282 0.0682042 0.0880858
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0263601 0.0924303 0.11778
Echinococcus multilocularis orexin receptor type 2 0.0702769 0.268814 0.345223
Leishmania major iron superoxide dismutase, putative 0.0182335 0.0597914 0.0744647
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0373233 0.136462 0.176241
Trichomonas vaginalis superoxide dismutase, putative 0.0182335 0.0597914 0.07555
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Echinococcus multilocularis serotonin receptor 0.0702769 0.268814 0.345223
Plasmodium falciparum phosphodiesterase gamma, putative 0.0203282 0.0682042 0.0815849
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.196134 0.774293 1
Echinococcus multilocularis G protein coupled receptor 139 0.0702769 0.268814 0.345223
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0203282 0.0682042 0.0872864
Schistosoma mansoni neuropeptide f receptor 76f 0.0702769 0.268814 0.347173
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus multilocularis g protein coupled receptor 0.0702769 0.268814 0.345223
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0373233 0.136462 0.17378
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.196134 0.774293 1
Leishmania major tagatose-6-phosphate kinase-like protein 0.00563294 0.00918347 0.00890938
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0702769 0.268814 0.345223
Onchocerca volvulus Neuropeptide F receptor homolog 0.0702769 0.268814 0.659964
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.104762 0.407316 0.524634
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.196134 0.774293 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.131036 0.512843 0.661328
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.196134 0.774293 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0203282 0.0682042 0.0872864
Echinococcus granulosus peptide allatostatin:somatostatin 0.0702769 0.268814 0.345223
Plasmodium falciparum phosphodiesterase delta, putative 0.0203282 0.0682042 0.0815849
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.104762 0.407316 1
Leishmania major adenosine kinase-like protein 0.00563294 0.00918347 0.00890938
Echinococcus granulosus orexin receptor type 2 0.0702769 0.268814 0.345223
Trypanosoma cruzi hypothetical protein 0.00751243 0.0167321 0.0207518
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.196134 0.774293 1
Toxoplasma gondii nucleoside transporter protein 0.0263601 0.0924303 0.116744
Trypanosoma cruzi nucleobase transporter, putative 0.0263601 0.0924303 0.118602
Echinococcus granulosus biogenic amine 5HT receptor 0.0702769 0.268814 0.345223
Entamoeba histolytica type A flavoprotein, putative 0.0139559 0.0426112 0.0522103
Brugia malayi ThiF family protein 0.00471102 0.00548076 0.00707841
Schistosoma mansoni biogenic amine receptor 0.0702769 0.268814 0.347173
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0139559 0.0426112 0.0522103
Trypanosoma brucei adenosine transporter 2, putative 0.0263601 0.0924303 0.116744
Brugia malayi Ribokinase 0.00563294 0.00918347 0.0118604
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.114691 0.447196 0.820296
Schistosoma mansoni amine GPCR 0.0702769 0.268814 0.347173
Trypanosoma cruzi hypothetical protein, conserved 0.0203282 0.0682042 0.0872864
Schistosoma mansoni ubiquitin-activating enzyme E1 0.00986292 0.0261724 0.0338016
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0394227 0.144894 0.184703
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Brugia malayi Nucleoside transporter family protein 0.104762 0.407316 0.526049
Schistosoma mansoni hypothetical protein 0.0702769 0.268814 0.347173
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0762318 0.29273 0.377516
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0702769 0.268814 0.345223
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0182335 0.0597914 0.07555
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0203282 0.0682042 0.0872864
Echinococcus granulosus neuropeptide receptor A26 0.0702769 0.268814 0.345223
Schistosoma mansoni opsin-like receptor 0.0702769 0.268814 0.347173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Schistosoma mansoni protein kinase 0.0263601 0.0924303 0.119374
Schistosoma mansoni sumo-1-activating enzyme E1a 0.00405048 0.00282781 0.00365212
Leishmania major hypothetical protein, conserved 0.0203282 0.0682042 0.0853624
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0263601 0.0924303 0.116744
Trypanosoma brucei adenosine transporter 2, putative 0.0263601 0.0924303 0.116744
Onchocerca volvulus 0.0702769 0.268814 0.659964
Brugia malayi Tachykinin-like peptides receptor 99D 0.0702769 0.268814 0.347173
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0739867 0.283713 0.277074
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.0182335 0.0597914 0.0772206
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0784017 0.301446 0.387493
Loa Loa (eye worm) hypothetical protein 0.00392044 0.00230553 0.00422907
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Schistosoma mansoni voltage-gated potassium channel 0.00668196 0.0133967 0.0173018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0702769 0.268814 0.493088
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.114691 0.447196 0.577553
Trypanosoma cruzi p450 reductase, putative 0.0394227 0.144894 0.186418
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.13552 0.530852 0.684657
Loa Loa (eye worm) hypothetical protein 0.0203282 0.0682042 0.125108
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0263601 0.0924303 0.116744
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0570497 0.215689 0.27793
Schistosoma mansoni alpha-1 adrenergic receptor 0.0702769 0.268814 0.347173
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0702769 0.268814 0.345223
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.0182335 0.0597914 0.0744647
Toxoplasma gondii superoxide dismutase SOD3 0.0182335 0.0597914 0.0744647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0373233 0.136462 0.17378
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis sex peptide receptor 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.135019 0.52884 0.68205
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Brugia malayi FAD binding domain containing protein 0.0254668 0.0888423 0.11474
Onchocerca volvulus 0.0702769 0.268814 0.659964
Brugia malayi Serotonin receptor 0.0702769 0.268814 0.347173
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.00644587 0.0124485 0.0131387
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.196134 0.774293 1
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.00644587 0.0124485 0.0152147
Leishmania major superoxide dismutase, putative 0.0104541 0.0285467 0.0339916
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0182335 0.0597914 0.146794
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0394227 0.144894 0.184703
Onchocerca volvulus 0.0702769 0.268814 0.659964
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0702769 0.268814 0.345223
Entamoeba histolytica nucleoside transporter, putative 0.104762 0.407316 0.524634
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0203282 0.0682042 0.0880858
Entamoeba histolytica type A flavoprotein, putative 0.0139559 0.0426112 0.0522103
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.104762 0.407316 1
Brugia malayi RE15519p 0.0702769 0.268814 0.347173
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Entamoeba histolytica type A flavoprotein, putative 0.0139559 0.0426112 0.0522103
Onchocerca volvulus 0.0702769 0.268814 0.659964
Echinococcus granulosus neuropeptide receptor 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.135019 0.52884 0.970057
Loa Loa (eye worm) TYRA-2 protein 0.0702769 0.268814 0.493088
Schistosoma mansoni adenoreceptor 0.0702769 0.268814 0.347173
Loa Loa (eye worm) neuropeptide F receptor 0.0702769 0.268814 0.493088
Toxoplasma gondii flavodoxin domain-containing protein 0.0172107 0.0556835 0.0691435
Toxoplasma gondii flavodoxin domain-containing protein 0.0172107 0.0556835 0.0691435
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.196134 0.774293 1
Trypanosoma brucei adenosine transporter 2, putative 0.0263601 0.0924303 0.116744
Onchocerca volvulus 0.0702769 0.268814 0.659964
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Entamoeba histolytica nucleoside transporter, putative 0.0263601 0.0924303 0.116744
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0361679 0.131821 0.168745
Echinococcus granulosus hypothetical protein 0.0702769 0.268814 0.345223
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0394227 0.144894 0.186418
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.196134 0.774293 1
Schistosoma mansoni amine GPCR 0.0702769 0.268814 0.347173
Schistosoma mansoni equilibrative nucleoside transporter 0.0263601 0.0924303 0.119374
Echinococcus granulosus 7tm_1 domain containing protein 0.0702769 0.268814 0.345223
Schistosoma mansoni diflavin oxidoreductase 0.0172107 0.0556835 0.0719152
Entamoeba histolytica type A flavoprotein, putative 0.0139559 0.0426112 0.0522103
Brugia malayi G protein-coupled receptor 0.0702769 0.268814 0.347173
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0203282 0.0682042 0.0872864
Trypanosoma cruzi hypothetical protein, conserved 0.0203282 0.0682042 0.0872864
Trichomonas vaginalis superoxide dismutase [mn], putative 0.0182335 0.0597914 0.07555
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Onchocerca volvulus 0.0702769 0.268814 0.659964
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Echinococcus multilocularis serotonin receptor 0.0702769 0.268814 0.345223
Brugia malayi AKH receptor 0.0702769 0.268814 0.347173
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0650972 0.24801 0.320305
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0853624
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0570497 0.215689 0.27793
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.196134 0.774293 1
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.00563294 0.00918347 0.00890938
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Schistosoma mansoni hypothetical protein 0.0702769 0.268814 0.347173
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0702769 0.268814 0.347173
Leishmania major p450 reductase, putative 0.0394227 0.144894 0.184703
Brugia malayi G-protein coupled receptor 0.0702769 0.268814 0.347173
Echinococcus granulosus methionine synthase reductase 0.0254668 0.0888423 0.112096
Trypanosoma brucei adenosine kinase, putative 0.0612059 0.232382 0.298031
Onchocerca volvulus Ribokinase homolog 0.00563294 0.00918347 0.0225463
Brugia malayi putative neuropeptide receptor NPR1 0.0702769 0.268814 0.347173
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0739867 0.283713 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0203282 0.0682042 0.0880858
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.104762 0.407316 0.524634
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Loa Loa (eye worm) FAD binding domain-containing protein 0.0394227 0.144894 0.26578
Trypanosoma cruzi nucleoside transporter-like, putative 0.0263601 0.0924303 0.118602
Plasmodium vivax superoxide dismutase [Fe], putative 0.0104541 0.0285467 0.030002
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Onchocerca volvulus 0.0702769 0.268814 0.659964
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.122147 0.47714 0.61508
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0815849
Trypanosoma cruzi hypothetical protein, conserved 0.0203282 0.0682042 0.0872864
Echinococcus multilocularis neuropeptides capa receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni opsin-like receptor 0.0702769 0.268814 0.347173
Trypanosoma brucei Mitochondrial SSU ribosomal protein, putative 0.00462558 0.0051376 0.00366854
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0702769 0.268814 0.347173
Leishmania major ribokinase, putative 0.00563294 0.00918347 0.00890938
Trypanosoma brucei purine nucleoside transporter 0.0263601 0.0924303 0.116744
Echinococcus granulosus somatostatin receptor 0.0702769 0.268814 0.345223
Entamoeba histolytica type A flavoprotein, putative 0.0139559 0.0426112 0.0522103
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0815849
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Onchocerca volvulus 0.0702769 0.268814 0.659964
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0650972 0.24801 0.319075
Trypanosoma brucei adenosine transporter 2 0.0263601 0.0924303 0.116744
Leishmania major superoxide dismutase, putative 0.0104541 0.0285467 0.0339916
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0203282 0.0682042 0.0853624
Toxoplasma gondii superoxide dismutase 0.0182335 0.0597914 0.0744647
Brugia malayi hypothetical protein 0.0263601 0.0924303 0.119374
Schistosoma mansoni neuropeptide F-like receptor 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trichomonas vaginalis superoxide dismutase, putative 0.0182335 0.0597914 0.07555
Echinococcus granulosus rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Giardia lamblia Hypothetical protein 0.104762 0.407316 0.52036
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0373233 0.136462 0.170368
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.139084 0.545164 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0139559 0.0426112 0.054204
Toxoplasma gondii kinase, pfkB family protein 0.00563294 0.00918347 0.00890938
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0702769 0.268814 0.345223
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.196134 0.774293 1
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.00471102 0.00548076 0.00411305
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00606064 0.0109012 0.0111345
Toxoplasma gondii kinase, pfkB family protein 0.0612059 0.232382 0.298031
Toxoplasma gondii hypothetical protein 0.00471102 0.00548076 0.00411305
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0139559 0.0426112 0.0533216
Leishmania major hypothetical protein, conserved 0.0139559 0.0426112 0.0522103
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0702769 0.268814 0.493088
Leishmania major cAMP-specific phosphodiesterase, putative 0.0762318 0.29273 0.376204
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0373233 0.136462 0.17378
Schistosoma mansoni hypothetical protein 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.00948012 0.024635 0.0300632
Trypanosoma cruzi adenosine kinase, putative 0.0612059 0.232382 0.299508
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) melatonin receptor type 1A 0.0702769 0.268814 0.493088
Onchocerca volvulus 0.00563294 0.00918347 0.0225463
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0702769 0.268814 0.347173
Leishmania major putative PfkB family sugar kinase 0.00563294 0.00918347 0.00890938
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Trypanosoma brucei unspecified product 0.0263601 0.0924303 0.116744
Schistosoma mansoni clathrin coat associated protein ap-50 0.00752008 0.0167628 0.0216492
Loa Loa (eye worm) hypothetical protein 0.00471102 0.00548076 0.0100534
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0762318 0.29273 0.376204
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0182335 0.0597914 0.146794
Echinococcus granulosus g protein coupled receptor 0.0702769 0.268814 0.345223
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0702769 0.268814 0.347173
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Onchocerca volvulus 0.0702769 0.268814 0.659964
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0702769 0.268814 0.345223
Loa Loa (eye worm) hypothetical protein 0.131036 0.512843 0.940713
Trypanosoma cruzi iron superoxide dismutase, putative 0.012405 0.0363823 0.0461523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0702769 0.268814 0.345223
Echinococcus granulosus tm gpcr rhodopsin 0.0702769 0.268814 0.345223
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Trypanosoma brucei purine nucleoside transporter 0.0263601 0.0924303 0.116744
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.104762 0.407316 0.525191
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0853624
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Giardia lamblia Nitric oxide synthase, inducible 0.0361679 0.131821 0.160288
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.196134 0.774293 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0570497 0.215689 0.27793
Echinococcus granulosus equilibrative nucleoside transporter 0.104762 0.407316 0.524634
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0394227 0.144894 0.184703
Trypanosoma brucei adenosine transporter, putative 0.0263601 0.0924303 0.116744
Trypanosoma brucei superoxide dismutase, putative 0.0104541 0.0285467 0.0339916
Trypanosoma cruzi adenosine kinase, putative 0.00563294 0.00918347 0.0109942
Brugia malayi Dopamine receptor protein 2 0.0702769 0.268814 0.347173
Loa Loa (eye worm) hypothetical protein 0.0702769 0.268814 0.493088
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0702769 0.268814 0.345223
Trypanosoma cruzi ribokinase, putative 0.00563294 0.00918347 0.0109942
Brugia malayi flavodoxin family protein 0.0139559 0.0426112 0.0550324
Onchocerca volvulus 0.0702769 0.268814 0.659964
Leishmania major nucleobase transporter 0.0263601 0.0924303 0.116744
Onchocerca volvulus 0.0702769 0.268814 0.659964
Plasmodium vivax flavodoxin domain containing protein 0.0361679 0.131821 0.164332
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0373233 0.136462 0.17378
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.00948012 0.024635 0.0300632
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Trypanosoma cruzi adenosine kinase, putative 0.00563294 0.00918347 0.0109942
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.0182335 0.0597914 0.051077
Brugia malayi hypothetical protein 0.0702769 0.268814 0.347173
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Leishmania major tagatose-6-phosphate kinase-like protein 0.00563294 0.00918347 0.00890938
Leishmania major adenosine kinase, putative 0.0612059 0.232382 0.298031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0373233 0.136462 0.17378
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0203282 0.0682042 0.0880858
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.00462558 0.0051376 0.00576439
Brugia malayi hypothetical protein 0.104762 0.407316 0.526049
Brugia malayi G protein-coupled receptor F59B2.13 0.0702769 0.268814 0.347173
Trypanosoma brucei nucleoside transporter 1, putative 0.0263601 0.0924303 0.116744
Leishmania major ubiquitin-activating enzyme e1, putative 0.00644587 0.0124485 0.0131387
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0702769 0.268814 0.347173
Leishmania major hypothetical protein, conserved 0.00751243 0.0167321 0.0186876
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.196134 0.774293 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus multilocularis g-protein coupled receptor 0.0702769 0.268814 0.345223
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.252331 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0203282 0.0682042 0.0864348
Echinococcus granulosus alpha 1A adrenergic receptor 0.0702769 0.268814 0.345223
Onchocerca volvulus 0.0702769 0.268814 0.659964
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Trypanosoma cruzi nucleobase transporter, putative 0.0263601 0.0924303 0.118602
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0570497 0.215689 0.27793
Mycobacterium leprae Probable superoxide dismutase SodA 0.0182335 0.0597914 0.184344
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0373233 0.136462 0.17378
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.00563294 0.00918347 0.00890938
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0263601 0.0924303 0.116744
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0263601 0.0924303 0.11778
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0570497 0.215689 0.27793
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.196134 0.774293 1
Echinococcus granulosus equilibrative nucleoside transporter 3 0.104762 0.407316 0.524634
Echinococcus multilocularis ubiquitin modifier activating enzyme 6 0.0123348 0.0361003 0.0437764
Trypanosoma cruzi adenosine kinase, putative 0.0612059 0.232382 0.299508
Brugia malayi FAD binding domain containing protein 0.0394227 0.144894 0.18713
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.114691 0.447196 0.576292
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.135019 0.52884 0.68205
Echinococcus multilocularis ubiquitin modifier activating enzyme 1 0.0123348 0.0361003 0.0437764
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0203282 0.0682042 0.0853624

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.349 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 3.398 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 4.454 uM PUBCHEM_BIOASSAY: Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
AC50 (functional) = 4.94 uM PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
EC50 (functional) = 0.715 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) = 4.162 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 4.21 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 4.2103 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 15 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) > 15 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Measure Toxicity of Compounds Not in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007, AID434946] ChEMBL. No reference
EC50 (functional) > 150 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Secondary Assay to Identify Inhibitors of Hsp90. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007, AID434938] ChEMBL. No reference
EC50 (functional) > 180 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
IC50 (functional) = 2.52 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID465] ChEMBL. No reference
IC50 (functional) = 3.79 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID465] ChEMBL. No reference
IC50 (functional) = 5.93 uM PUBCHEM_BIOASSAY: SAR analysis of small molecule cytotoxicity in HEK293 cells for activators of NF-kappaB using a luminescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID435022, AID435025] ChEMBL. No reference
IC50 (functional) = 6.36 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID489026] ChEMBL. No reference
IC50 (functional) = 6.94 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID489026] ChEMBL. No reference
IC50 (functional) = 8.08 uM PUBCHEM_BIOASSAY: SAR analysis of small molecule cytotoxicity in HEK293 cells for activators of NF-kappaB using a luminescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435003, AID435012, AID435022, AID435025] ChEMBL. No reference
IC50 (functional) > 118.648 uM PUBCHEM_BIOASSAY: Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID435030, AID449728, AID449731, AID488942, AID488955, AID488956] ChEMBL. No reference
Inhibition (functional) = -1.36 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 3.47 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.55 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 45 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 52 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 88 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 5.07 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 45 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 52 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 88 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 89.2 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 95.5 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.609 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
XC50 (functional) = 6.02 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.95681 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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