TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 469.661 | Formula: C31H39N3O
H donors: 0 H acceptors: 1 LogP: 5.59 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N(c1ccccc1)Cc1ccccc1)CCCCN1CCN(CC1)CCCc1ccccc1
InChi: 1S/C31H39N3O/c35-31(34(30-18-8-3-9-19-30)27-29-15-6-2-7-16-29)20-10-11-21-32-23-25-33(26-24-32)22-12-17-28-13-4-1-5-14-28/h1-9,13-16,18-19H,10-12,17,20-27H2
InChiKey: LWDROUBWOBOGMV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0253	0.1737	0.173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Loa Loa (eye worm)	cysteine protease	0.1371	1	1
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0145	0.0145
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0253	0.1737	1
Echinococcus granulosus	cathepsin l1	0.0918	0.665	0.665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0706	0.5087	0.5083
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Entamoeba histolytica	cysteine proteinase, putative	0.0918	0.665	0.6647
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0253	0.1737	0.173
Plasmodium vivax	serine-repeat antigen (SERA)	0.0253	0.1737	0.173
Entamoeba histolytica	cysteine proteinase, putative	0.0706	0.5087	0.5083
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0145	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0453	0.3217	0.3217
Trypanosoma cruzi	cysteine peptidase, putative	0.0453	0.3217	0.3211
Loa Loa (eye worm)	inositol-1	0.0038	0.0145	0.0145
Brugia malayi	Cathepsin L-like precursor	0.0918	0.665	0.6647
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0706	0.5087	0.5087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0253	0.1737	0.173
Echinococcus granulosus	cathepsin L	0.0253	0.1737	0.1737
Giardia lamblia	Cathepsin L precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0185	0.0185
Schistosoma mansoni	cathepsin B (C01 family)	0.0253	0.1737	0.1737
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0253	0.1737	0.173
Leishmania major	cathepsin L-like protease	0.1371	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1371	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0918	0.665	0.6647
Trypanosoma cruzi	cysteine peptidase, putative	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Onchocerca volvulus		0.1371	1	1
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0253	0.1737	0.173
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0918	0.665	0.6647
Entamoeba histolytica	cysteine protease, putative	0.1371	1	1
Giardia lamblia	Cysteine protease	0.0253	0.1737	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0706	0.5087	0.5083
Echinococcus multilocularis	geminin	0.0179	0.1192	0.1192
Echinococcus granulosus	geminin	0.0179	0.1192	0.1192
Leishmania major	cathepsin L-like protease	0.1371	1	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0145	0.0137
Onchocerca volvulus		0.1371	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1371	1	1
Echinococcus granulosus	cathepsin b	0.0253	0.1737	0.1737
Echinococcus multilocularis	zinc finger protein	0.0021	0.002	0.002
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Giardia lamblia	Cathepsin L precursor	0.0253	0.1737	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0453	0.3217	0.3211
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0115	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0253	0.1737	0.173
Plasmodium falciparum	serine repeat antigen 3	0.0253	0.1737	0.173
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0706	0.5087	0.5083
Plasmodium falciparum	serine repeat antigen 2	0.0253	0.1737	0.173
Loa Loa (eye worm)	ctsf protein	0.1371	1	1
Leishmania major	cathepsin L-like protease	0.1371	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0361	0.0361
Brugia malayi	Cathepsin L-like precursor	0.1371	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0253	0.1737	0.1737
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1371	1	1
Plasmodium falciparum	serine repeat antigen 9	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1371	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0253	0.1737	0.1737
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Brugia malayi	PHD-finger family protein	0.0026	0.0061	0.0053
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Echinococcus multilocularis	cathepsin L cysteine protease	0.1371	1	1
Brugia malayi	cathepsin L precursor	0.0253	0.1737	0.173
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0045	0.02	0.02
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Loa Loa (eye worm)	hypothetical protein	0.0453	0.3217	0.3217
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0253	0.1737	0.173
Onchocerca volvulus		0.1371	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0145	0.0137
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0148	0.0148
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0706	0.5087	0.5083
Plasmodium vivax	vivapain-3	0.0706	0.5087	0.5083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0253	0.1737	0.173
Brugia malayi	Papain family cysteine protease containing protein	0.0253	0.1737	0.173
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0145	0.0145
Onchocerca volvulus	Cathepsin F homolog	0.1371	1	1
Echinococcus multilocularis	cathepsin b	0.0253	0.1737	0.1737
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0253	0.1737	0.173
Brugia malayi	Papain family cysteine protease containing protein	0.0253	0.1737	0.173
Brugia malayi	Cathepsin L-like precursor	0.0918	0.665	0.6647
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0253	0.1737	0.173
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0145	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1371	1	1
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0022	0.0028	0.0028
Schistosoma mansoni	hypothetical protein	0.0179	0.1192	0.1192
Entamoeba histolytica	cysteine proteinase, putative	0.1371	1	1
Giardia lamblia	Cathepsin L precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0253	0.1737	0.173
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0253	0.1737	1
Onchocerca volvulus		0.1371	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0453	0.3217	0.3211
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0918	0.665	0.665
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1371	1	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0075	0.042	0.042
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0008	0.0008
Plasmodium falciparum	serine repeat antigen 1	0.0253	0.1737	0.173
Brugia malayi	Papain family cysteine protease containing protein	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0253	0.1737	0.173
Plasmodium vivax	unspecified product	0.0453	0.3217	0.3211
Onchocerca volvulus	Cathepsin L homolog	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0706	0.5087	0.5083
Trypanosoma cruzi	cysteine proteinase, putative	0.0706	0.5087	0.5083
Loa Loa (eye worm)	hypothetical protein	0.1371	1	1
Entamoeba histolytica	cysteine protease, putative	0.0253	0.1737	0.173
Entamoeba histolytica	cysteine protease, putative	0.0253	0.1737	0.173
Brugia malayi	fibroinase precursor	0.0253	0.1737	0.173
Plasmodium falciparum	serine repeat antigen 5	0.0253	0.1737	0.173
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0008	0.5
Toxoplasma gondii	cathepsin B	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0253	0.1737	0.1737
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0253	0.1737	0.1737
Schistosoma mansoni	cathepsin C	0.0253	0.1737	0.1737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0918	0.665	0.6647
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0145	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0253	0.1737	0.173
Echinococcus granulosus	cathepsin l1	0.1371	1	1
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0253	0.1737	0.173
Brugia malayi	Cathepsin L-like precursor	0.1371	1	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0334	0.0334
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0453	0.3217	0.3217
Echinococcus multilocularis	cysteine protease	0.1371	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0253	0.1737	0.173
Giardia lamblia	Cathepsin L precursor	0.0253	0.1737	1
Brugia malayi	cathepsin L-like precursor	0.0918	0.665	0.6647
Onchocerca volvulus		0.1371	1	1
Echinococcus multilocularis	cathepsin L	0.0706	0.5087	0.5087
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0253	0.1737	0.173
Toxoplasma gondii	cathepsin CPC1	0.0253	0.1737	0.173
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0115	1
Onchocerca volvulus		0.0918	0.665	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Brugia malayi	Cathepsin L-like precursor	0.0453	0.3217	0.3211
Trypanosoma cruzi	cysteine peptidase, putative	0.1371	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0706	0.5087	0.5083
Giardia lamblia	Cathepsin L-like protease	0.0253	0.1737	1
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0145	0.0137
Trypanosoma cruzi	cysteine peptidase, putative	0.1371	1	1
Toxoplasma gondii	cathepsin CPC2	0.0253	0.1737	0.173
Trypanosoma cruzi	major cysteine proteinase, putative	0.0253	0.1737	0.173
Echinococcus granulosus	cathepsin b	0.0253	0.1737	0.1737
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0145	0.0137
Brugia malayi	Papain family cysteine protease containing protein	0.0253	0.1737	0.173
Entamoeba histolytica	cysteine proteinase, putative	0.0706	0.5087	0.5083
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0145	0.0145
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0253	0.1737	0.173
Onchocerca volvulus		0.1371	1	1
Leishmania major	cathepsin L-like protease	0.1371	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0918	0.665	0.665
Entamoeba histolytica	cysteine protease, putative	0.0253	0.1737	0.173
Brugia malayi	cathepsin B-like cysteine proteinase	0.0253	0.1737	0.173
Leishmania major	cathepsin L-like protease	0.1371	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0167	0.0167
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	cathepsin s	0.0453	0.3217	0.3217
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0043	0.0043
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0253	0.1737	0.173
Trypanosoma cruzi	cruzipain precursor, putative	0.1371	1	1
Leishmania major	cathepsin L-like protease	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Giardia lamblia	Cysteine protease	0.0253	0.1737	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0253	0.1737	0.1737
Loa Loa (eye worm)	fibroinase	0.1371	1	1
Giardia lamblia	Cysteine protease	0.0253	0.1737	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1371	1	1
Plasmodium falciparum	serine repeat antigen 4	0.0253	0.1737	0.173
Echinococcus granulosus	zinc finger protein	0.0021	0.002	0.002
Echinococcus multilocularis	cathepsin L	0.0253	0.1737	0.1737
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0253	0.1737	0.173
Schistosoma mansoni	ap endonuclease	0.0019	0.0008	0.0008
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Echinococcus multilocularis	cathepsin L cysteine protease	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0918	0.665	0.6647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0706	0.5087	0.5087
Brugia malayi	Cathepsin L-like precursor	0.1371	1	1
Giardia lamblia	Hypothetical protein	0.0253	0.1737	1
Plasmodium falciparum	serine repeat antigen 6	0.0253	0.1737	0.173
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0253	0.1737	0.173
Plasmodium vivax	vivapain-2	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Giardia lamblia	Cysteine protease	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0253	0.1737	0.173
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0253	0.1737	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Plasmodium vivax	vivapain-1	0.0706	0.5087	0.5083
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0253	0.1737	0.173
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0043	0.0043
Entamoeba histolytica	cysteine protease, putative	0.0253	0.1737	0.173
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0253	0.1737	0.173
Brugia malayi	Papain family cysteine protease containing protein	0.0706	0.5087	0.5083
Trypanosoma cruzi	cysteine protease, putative	0.0706	0.5087	0.5083
Entamoeba histolytica	cysteine protease, putative	0.0253	0.1737	0.173
Brugia malayi	Inositol-1	0.0038	0.0145	0.0137
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0826	0.5969	0.5969
Giardia lamblia	Encystation-specific protease	0.0253	0.1737	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0253	0.1737	0.173
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0145	0.0137
Toxoplasma gondii	cathepsin CPL	0.1371	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0253	0.1737	0.173
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0145	0.0137
Brugia malayi	Cathepsin L-like precursor	0.1371	1	1
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Loa Loa (eye worm)	cathepsin B	0.0253	0.1737	0.1737
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0253	0.1737	0.1737
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0253	0.1737	0.173
Plasmodium vivax	vivapain-2	0.1371	1	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0706	0.5087	0.5087
Entamoeba histolytica	cysteine proteinase, putative	0.0706	0.5087	0.5083
Trypanosoma cruzi	cysteine proteinase, putative	0.0706	0.5087	0.5083
Plasmodium vivax	unspecified product	0.0253	0.1737	0.173
Schistosoma mansoni	zinc finger protein	0.0021	0.002	0.002
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0253	0.1737	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0253	0.1737	0.173
Brugia malayi	Bromodomain containing protein	0.0079	0.0453	0.0445
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0253	0.1737	0.1737
Echinococcus granulosus	cysteine protease	0.0706	0.5087	0.5087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Entamoeba histolytica	hypothetical protein	0.0253	0.1737	0.173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0253	0.1737	0.173
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0253	0.1737	0.173
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0253	0.1737	0.1737
Entamoeba histolytica	cysteine protease, putative	0.0253	0.1737	0.173
Brugia malayi	Bromodomain containing protein	0.0041	0.0166	0.0158
Echinococcus multilocularis	cysteine protease	0.1371	1	1
Giardia lamblia	Cathepsin L precursor	0.0253	0.1737	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0706	0.5087	0.5087
Plasmodium falciparum	serine repeat antigen 8	0.0253	0.1737	0.173
Echinococcus multilocularis	cathepsin b	0.0253	0.1737	0.1737
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0253	0.1737	0.173
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0145	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0706	0.5087	0.5083
Giardia lamblia	Cathepsin L-like protease	0.0253	0.1737	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0253	0.1737	0.173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0918	0.665	0.665
Giardia lamblia	Cathepsin L precursor	0.0253	0.1737	1
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0005	0.0005
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0043	0.0043
Leishmania major	cathepsin L-like protease	0.1371	1	1
Plasmodium vivax	unspecified product	0.0706	0.5087	0.5083
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0253	0.1737	0.173
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1371	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1371	1	1
Entamoeba histolytica	cysteine protease, putative	0.0706	0.5087	0.5083
Echinococcus granulosus	cathepsin L	0.0706	0.5087	0.5087
Entamoeba histolytica	cysteine proteinase, putative	0.0706	0.5087	0.5083
Schistosoma mansoni	ap endonuclease	0.0019	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0179	0.1192	0.1192
Onchocerca volvulus		0.1371	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Giardia lamblia	Hypothetical protein	0.0253	0.1737	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1371	1	1
Leishmania major	cathepsin L-like protease	0.1371	1	1
Giardia lamblia	Cathepsin B precursor	0.0253	0.1737	1
Entamoeba histolytica	cysteine proteinase 2	0.0706	0.5087	0.5083
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0253	0.1737	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0145	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0918	0.665	0.665
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0706	0.5087	0.5083
Brugia malayi	Cathepsin L-like precursor	0.1371	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0453	0.3217	0.3217
Brugia malayi	cathepsin L-like cysteine proteinase	0.0253	0.1737	0.173
Entamoeba histolytica	cysteine proteinase, putative	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Plasmodium falciparum	serine repeat antigen 7	0.0253	0.1737	0.173
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0253	0.1737	0.173
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1371	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Schistosoma mansoni	cathepsin F (C01 family)	0.1371	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0453	0.3217	0.3211
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1371	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0253	0.1737	0.173
Leishmania major	cysteine peptidase A (CPA)	0.1371	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.1737	0.1737
Brugia malayi	Papain family cysteine protease containing protein	0.0706	0.5087	0.5083
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0253	0.1737	0.173
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1737	0.1737
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0148	0.0148
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0145	0.0145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1371	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Log 1/C (binding)	= 6.92	Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter	ChEMBL.	11931612
Log 1/C (binding)	= 6.92	Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter	ChEMBL.	11931612
pKD (binding)	= 6.69	Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells	ChEMBL.	11931612
pKD (binding)	= 7.24	Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells	ChEMBL.	11931612
pKD (binding)	= 6.69	Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells	ChEMBL.	11931612
pKD (binding)	= 7.24	Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells	ChEMBL.	11931612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL41027

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 59240