Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.0582 | 0.0465 |
Brugia malayi | Serotonin receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | neuropeptide F receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | G-protein coupled receptor | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0034 | 0.0124 | 0.0463 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | RE15519p | 0.0034 | 0.0124 | 0.0463 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0258 | 0.3492 | 0.3411 |
Brugia malayi | G-protein coupled receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | neuropeptide F receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | putative neuropeptide receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Dopamine receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.1412 | 0.5285 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.1412 | 0.5285 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0034 | 0.0124 | 0.0463 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0691 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.0582 | 0.218 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | follicle stimulating hormone receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | ORL1-like opioid receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0691 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.0582 | 0.218 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.0582 | 0.0465 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Dopamine receptor protein 2 | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.0582 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0034 | 0.0124 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | AKH receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1705 | 0.638 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | sulfakinin receptor protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2672 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Dopamine receptor protein 1 | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0034 | 0.0124 | 0.0463 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.0582 | 0.0465 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | larval opioid receptor | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0203 | 0.2672 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0279 | 0.3803 | 0.3726 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0258 | 0.3492 | 0.3411 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.3492 | 0.3411 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.0582 | 0.0465 |
Brugia malayi | Melatonin receptor type 1A | 0.0034 | 0.0124 | 0.0463 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0582 | 0.0465 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | Serotonin receptor | 0.0034 | 0.0124 | 0.0463 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0582 | 0.218 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.0582 | 0.218 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.1705 | 0.1601 |
Brugia malayi | G protein-coupled receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0203 | 0.2672 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.1412 | 0.5285 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0279 | 0.3803 | 0.3726 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0582 | 0.0465 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0034 | 0.0124 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0203 | 0.2672 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Schistosoma mansoni | thyroid hormone receptor | 0.0279 | 0.3803 | 0.3726 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0139 | 0.1705 | 0.638 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0034 | 0.0124 | 0.0463 |
Brugia malayi | GnHR receptor homolog | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0582 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.0582 | 0.0465 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0582 | 0.0465 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0124 | 0.0463 |
Onchocerca volvulus | 0.0034 | 0.0124 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -2.56 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0.52 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.6 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 9 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 23 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 57 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 1.98 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 9 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 23 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 57 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.1 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.79634 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.