Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.3511 | 0.8136 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.152 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0166 | 0.2921 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.2257 | 0.2257 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.044 | 1 |
Leishmania major | trypanothione reductase | 0.0047 | 0.044 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0018 | 0 | 0.5 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0053 | 0.015 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0166 | 0.2921 |
Brugia malayi | glutathione reductase | 0.0047 | 0.044 | 0.1254 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.1341 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.044 | 0.044 |
Echinococcus granulosus | snurportin 1 | 0.0307 | 0.4315 | 0.4315 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.152 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0053 | 0.0053 |
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0274 | 0.3835 | 0.3835 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.2257 | 0.2257 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.044 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0085 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0053 | 0.0053 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.044 | 0.102 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0085 | 0.0829 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.1341 | 0.8342 |
Echinococcus multilocularis | geminin | 0.0169 | 0.2257 | 0.2257 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0085 | 0.0829 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0307 | 0.4315 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0166 | 0.0472 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0166 | 0.2921 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.044 | 0.102 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0166 | 0.2921 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.044 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.1341 | 0.8342 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0166 | 0.0166 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.044 | 0.1254 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0253 | 0.3511 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.152 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0053 | 0.0053 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0085 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.4315 | 0.4315 |
Echinococcus multilocularis | snurportin 1 | 0.0307 | 0.4315 | 0.4315 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0688 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.1341 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.044 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.044 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0053 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0688 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.044 | 0.044 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0274 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0166 | 0.0384 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.1341 | 0.8342 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0085 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0166 | 0.2921 |
Echinococcus granulosus | geminin | 0.0169 | 0.2257 | 0.2257 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.044 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0956 | 0.2724 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.044 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.152 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0053 | 0.0122 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.1341 | 0.8342 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0085 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1.65 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.28 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 3 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 95 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 0 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -3 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 3 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 95 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.89 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.1279 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.