Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0037 | 0.0037 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1839 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1839 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0037 | 0.0085 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0193 | 0.1 | 0.2315 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.0239 | 0.0221 |
Schistosoma mansoni | microtubule-associated protein tau | 0.08 | 0.432 | 0.432 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0048 | 0.011 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0348 | 0.0348 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1839 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1839 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0718 | 0.3872 | 0.8962 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0348 | 0.0846 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0244 | 0.0986 |
Trypanosoma brucei | aldehyde dehydrogenase family, putative | 0.0014 | 0.0022 | 0.0004 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1322 |
Brugia malayi | TAR-binding protein | 0.0259 | 0.1364 | 0.1364 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1839 | 1 | 1 |
Echinococcus multilocularis | succinate semialdehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0015 | 0.0029 | 0.0066 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0052 | 0.0209 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0081 | 0.0062 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0081 | 0.0059 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1839 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 0.0501 | 0.116 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0208 | 0.0482 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.1364 | 0.1364 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0038 | 0.0155 | 0.0359 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0081 | 0.0053 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0025 | 0.0101 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0017 | 0.0038 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0017 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0022 | 0.0022 |
Schistosoma mansoni | protein phosphatase 2C | 0.0015 | 0.0029 | 0.0029 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.1364 | 0.1364 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.0348 | 0.0805 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0588 | 0.0588 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0718 | 0.3872 | 0.8962 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.0244 | 0.0986 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0029 | 0.0115 |
Echinococcus granulosus | lamin | 0.0027 | 0.0094 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.102 | 0.102 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0037 | 0.0085 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0015 | 0.0029 | 0.0066 |
Echinococcus multilocularis | phd:f box containing protein | 0.0015 | 0.0029 | 0.0066 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.0348 | 0.0805 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0312 | 0.0312 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0052 | 0.0029 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1839 | 1 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0111 | 0.0258 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0015 | 0.0029 | 0.0066 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0052 | 0.0029 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0208 | 0.084 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0064 | 0.0295 | 0.0683 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0029 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0102 | 0.0501 | 0.0501 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0142 | 0.0142 |
Echinococcus multilocularis | betaine aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.0239 | 0.0217 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.0256 | 0.0234 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.0501 | 0.0501 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0094 | 0.0094 |
Brugia malayi | Succinate semialdehyde dehydrogenase, mitochondrial precursor | 0.0014 | 0.0022 | 0.0022 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0094 | 0.0218 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0052 | 0.012 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1839 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1839 | 1 | 1 |
Echinococcus multilocularis | Fatty aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0718 | 0.3872 | 0.8962 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.0155 | 0.0344 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0239 | 0.0563 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0048 | 0.0025 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0588 | 0.2372 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.0257 | 0.0257 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0048 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0208 | 0.084 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0348 | 0.0846 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0094 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0022 | 0.0091 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0052 | 0.0033 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0052 | 0.1355 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0259 | 0.1364 | 0.5505 |
Echinococcus multilocularis | aldehyde dehydrogenase family 3 member B1 | 0.0014 | 0.0022 | 0.0052 |
Schistosoma mansoni | phd/f-box containing protein | 0.0015 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0052 | 0.0029 |
Echinococcus granulosus | phd:f box containing protein | 0.0015 | 0.0029 | 0.0066 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0102 | 0.0501 | 0.2024 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 0.0501 | 0.116 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0015 | 0.0029 | 0.0006 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0038 | 0.0155 | 0.0359 |
Trypanosoma brucei | aldehyde dehydrogenase family, putative | 0.0014 | 0.0022 | 0.0004 |
Echinococcus granulosus | tar DNA binding protein | 0.0259 | 0.1364 | 0.3157 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0048 | 0.0019 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0312 | 0.0312 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0007 | 0.0017 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0266 | 0.0266 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0006 | 0.0015 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0193 | 0.1 | 0.2315 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0348 | 0.0846 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0037 | 0.0085 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0111 | 0.0111 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1839 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.1364 | 0.1364 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0081 | 0.0053 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.0239 | 0.0554 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0155 | 0.0133 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0015 | 0.0029 | 0.0006 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0111 | 0.0111 |
Onchocerca volvulus | 0.0527 | 0.2827 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0029 | 0.0115 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.0239 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0094 | 0.0094 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0029 | 0.0006 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0029 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0037 | 0.0037 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0029 | 0.0029 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0038 | 0.0155 | 0.0155 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.0239 | 0.0239 |
Trypanosoma brucei | aldehyde dehydrogenase, putative | 0.0014 | 0.0022 | 0.0004 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.0244 | 0.0566 |
Brugia malayi | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Echinococcus granulosus | dnaJ subfamily B | 0.0408 | 0.2177 | 0.5039 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0029 | 0.0115 |
Onchocerca volvulus | Aldehyde dehydrogenase homolog | 0.0014 | 0.0022 | 0.0079 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0208 | 0.0736 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0029 | 0.0029 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.0239 | 0.0239 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0052 | 0.012 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Echinococcus multilocularis | succinate semialdehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0052 | 0.012 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.0239 | 0.0217 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0038 | 0.0155 | 0.0359 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.0266 | 0.0615 |
Schistosoma mansoni | succinate semialdehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0239 | 0.0217 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0259 | 0.1364 | 0.5505 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0048 | 0.0048 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0029 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0048 | 0.0025 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0239 | 0.0563 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0348 | 0.0348 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0408 | 0.2177 | 0.5039 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0094 | 0.0379 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0015 | 0.0029 | 0.001 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0037 | 0.0037 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0081 | 0.0059 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0048 | 0.011 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0038 | 0.0155 | 0.6108 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0048 | 0.0192 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1341 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.0239 | 0.0554 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1839 | 1 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0208 | 0.0208 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0037 | 0.0085 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0052 | 0.0076 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0348 | 0.0846 |
Onchocerca volvulus | 0.0067 | 0.0312 | 0.1103 | |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.0257 | 0.0594 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0017 | 0.004 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0037 | 0.0148 |
Brugia malayi | Pre-SET motif family protein | 0.0067 | 0.0312 | 0.0312 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0266 | 0.1072 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0038 | 0.0155 | 0.0133 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0052 | 0.0052 |
Echinococcus granulosus | microtubule associated protein 2 | 0.08 | 0.432 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0029 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Trypanosoma brucei | aldehyde dehydrogenase, putative | 0.0014 | 0.0022 | 0.0004 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0052 | 0.0052 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0048 | 0.0065 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.0348 | 0.0348 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.0239 | 0.0554 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.0244 | 0.0566 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0048 | 0.0025 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0208 | 0.0482 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Brugia malayi | Pre-SET motif family protein | 0.0463 | 0.2477 | 0.2477 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1322 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0208 | 0.0208 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0029 | 0.0115 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0038 | 0.0155 | 0.0155 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1341 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0048 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0296 | 0.1561 | 0.1561 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0048 | 0.0065 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0007 | 0.0007 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0255 | 0.1341 | 0.3104 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0208 | 0.0208 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0052 | 0.0076 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.0239 | 0.0217 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0208 | 0.0482 |
Plasmodium vivax | SET domain protein, putative | 0.0067 | 0.0312 | 0.0284 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0094 | 0.0218 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0038 | 0.0155 | 0.0359 |
Brugia malayi | RNA binding protein | 0.0259 | 0.1364 | 0.1364 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0007 | 0.0017 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0052 | 0.0029 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0048 | 0.0025 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.0501 | 0.0501 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0142 | 0.0573 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 0.0501 | 0.116 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0718 | 0.3872 | 0.3872 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1322 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0208 | 0.0208 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0038 | 0.0155 | 0.0344 |
Loa Loa (eye worm) | aldehyde dehydrogenase 4 | 0.0014 | 0.0022 | 0.0091 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0208 | 0.0482 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0155 | 0.0136 |
Brugia malayi | Aldehyde dehydrogenase protein 4 | 0.0014 | 0.0022 | 0.0022 |
Echinococcus granulosus | aldehyde dehydrogenase family 3 member B1 | 0.0014 | 0.0022 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0081 | 0.0328 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0052 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.102 | 0.102 |
Schistosoma mansoni | jumonji domain containing protein | 0.0015 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0015 | 0.0059 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0048 | 0.0025 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0037 | 0.0037 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 0.0501 | 0.116 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.0239 | 0.0221 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0006 | 0.0006 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.0257 | 0.0257 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0094 | 0.0218 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0312 | 0.0312 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0052 | 0.012 |
Brugia malayi | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor | 0.0014 | 0.0022 | 0.0022 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0048 | 0.1159 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | delta-1-pyrroline-5-carboxylate dehydrogenase | 0.0014 | 0.0022 | 0.0091 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1839 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1839 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0081 | 0.0059 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0015 | 0.0029 | 0.0006 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0094 | 0.0094 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0038 | 0.0155 | 0.0344 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0015 | 0.0029 | 0.0029 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0015 | 0.0029 | 0.0066 |
Onchocerca volvulus | 0.0027 | 0.0094 | 0.0333 | |
Echinococcus granulosus | betaine aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0017 | 0.004 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0081 | 0.0059 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0102 | 0.0413 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0052 | 0.012 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.0239 | 0.0966 |
Onchocerca volvulus | 0.0048 | 0.0208 | 0.0736 | |
Echinococcus multilocularis | geminin | 0.0196 | 0.102 | 0.2361 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.0257 | 0.0594 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0048 | 0.0048 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.0244 | 0.0244 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.0239 | 0.0554 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0052 | 0.0076 |
Onchocerca volvulus | 0.0027 | 0.0094 | 0.0333 | |
Echinococcus granulosus | Fatty aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0052 | 0.0033 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0048 | 0.0065 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0037 | 0.0085 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0718 | 0.3872 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.0239 | 0.0217 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0029 | 0.0029 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0052 | 0.0033 |
Schistosoma mansoni | delta 1-pyrroline-5-carboxylate synthetase | 0.0014 | 0.0022 | 0.0022 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0037 | 0.0037 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.0291 | 0.0291 |
Loa Loa (eye worm) | TAR-binding protein | 0.0259 | 0.1364 | 0.5505 |
Schistosoma mansoni | lamin | 0.0027 | 0.0094 | 0.0094 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0048 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0025 | 0.0025 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0022 | 0.0091 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0111 | 0.0258 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0067 | 0.0312 | 0.0722 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1322 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0266 | 0.0266 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0038 | 0.0155 | 0.0155 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0048 | 0.0025 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0029 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0463 | 0.2477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0233 | 0.094 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0048 | 0.0019 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0038 | 0.0155 | 0.0133 |
Echinococcus multilocularis | tar DNA binding protein | 0.0259 | 0.1364 | 0.3157 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0052 | 0.012 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0007 | 0.003 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0015 | 0.0029 | 0.0066 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0015 | 0.0029 | 0.0066 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0718 | 0.3872 | 0.8962 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0015 | 0.0059 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0052 | 0.0033 |
Trypanosoma brucei | delta-1-pyrroline-5-carboxylate dehydrogenase, putative | 0.0014 | 0.0022 | 0.0004 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0029 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0718 | 0.3872 | 0.3858 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0094 | 0.0218 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0067 | 0.0312 | 0.0312 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0255 | 0.1341 | 0.1322 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.1364 | 0.1364 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0022 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.0244 | 0.0244 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0239 | 0.0563 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0067 | 0.0312 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0091 | 0.0368 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.0239 | 0.0563 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0255 | 0.1341 | 0.3104 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0094 | 0.0218 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.08 | 0.432 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0081 | 0.0053 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0052 | 0.0033 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0037 | 0.0085 |
Echinococcus granulosus | succinate semialdehyde dehydrogenase | 0.0014 | 0.0022 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0029 | 0.0115 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0081 | 0.0081 |
Trichomonas vaginalis | set domain proteins, putative | 0.0527 | 0.2827 | 0.7285 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0033 | 0.0033 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0067 | 0.0312 | 0.0722 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.0257 | 0.0594 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0017 | 0.0038 | 0.0087 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0006 | 0.0015 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0255 | 0.1341 | 0.1322 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0052 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0094 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0312 | 0.1258 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0015 | 0.0029 | 0.0029 |
Schistosoma mansoni | lamin | 0.0027 | 0.0094 | 0.0094 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0038 | 0.0155 | 0.0359 |
Onchocerca volvulus | 0.0029 | 0.0102 | 0.0362 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0037 | 0.0148 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | aldehyde dehydrogenase | 0.0014 | 0.0022 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0052 | 0.0209 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.0244 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0155 | 0.0625 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0266 | 0.0266 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0233 | 0.094 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0015 | 0.0029 | 0.0006 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.0244 | 0.0566 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0052 | 0.0029 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0067 | 0.0312 | 0.029 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0052 | 0.0033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0155 | 0.0344 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0588 | 0.2372 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0038 | 0.0155 | 0.0359 |
Echinococcus granulosus | geminin | 0.0196 | 0.102 | 0.2361 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.0239 | 0.0217 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0048 | 0.0029 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0259 | 0.1364 | 0.1364 |
Schistosoma mansoni | hypothetical protein | 0.0408 | 0.2177 | 0.2177 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0233 | 0.0233 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.0239 | 0.0217 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0102 | 0.0102 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.0501 | 0.0501 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1839 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -5.26 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -3.35 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -2.57 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 15 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 46 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 2.9 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 15 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 46 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.87 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.3433 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.