Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.1109 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.079 | 0.079 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.2939 | 0.6633 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1499 | 0.1425 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0032 | 0.079 | 0.0854 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1499 | 0.1425 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1499 | 0.1499 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0117 | 0.003 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.1109 | 0.1032 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0086 | 0.0086 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.3495 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0263 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.079 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1136 | 0.1058 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1499 | 0.1499 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.1109 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.1134 | 0.1057 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.3495 | 0.8342 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1499 | 0.1499 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.1505 | 0.2775 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.1109 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2186 | 0.2118 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.7588 | 0.7588 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0211 | 0.0125 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.1132 | 0.1773 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.1109 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1016 | 0.0937 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1252 | 0.1176 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.1109 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0357 | 0.0273 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.1109 | 0.171 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0226 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.3495 | 0.8342 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0211 | 0.0211 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.3495 | 0.8342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1499 | 0.1425 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.3969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1505 | 0.1431 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0226 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.3969 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.1109 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0357 | 0.0357 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1499 | 0.2758 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.1109 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.3495 | 0.8342 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2186 | 0.2118 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0211 | 0.0125 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.3495 | 0.8342 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0263 | 0.0178 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0226 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1499 | 0.1425 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.2362 | 0.2362 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.1134 | 0.1057 |
Brugia malayi | glutathione reductase | 0.0039 | 0.1109 | 0.171 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0047 | 0.1505 | 0.1431 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.1505 | 0.2775 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2728 | 0.2665 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1346 | 0.1271 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.3969 | 1 |
Echinococcus granulosus | geminin | 0.0175 | 0.7588 | 0.7567 |
Brugia malayi | hypothetical protein | 0.0104 | 0.4191 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.7588 | 0.7588 |
Echinococcus multilocularis | geminin | 0.0175 | 0.7588 | 0.7567 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1016 | 0.0937 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1499 | 0.1425 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0086 | 0.0086 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0357 | 0.0273 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.1109 | 0.1032 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.3969 | 1 |
Leishmania major | trypanothione reductase | 0.0039 | 0.1109 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 10 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 10 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.602 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.602 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 0.794 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.794 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 4.28 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 7.89 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 8.78 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 56 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 6.38 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -5 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 56 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 100 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 7.39 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.04088 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.