Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0057 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0302 | 0.0466 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0456 | 0.0401 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0057 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0057 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.349 | 0.3453 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0456 | 0.0401 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0459 | 0.0404 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.349 | 0.5382 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0459 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0057 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0057 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0456 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.349 | 0.3453 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.349 | 0.3453 |
Trichomonas vaginalis | set domain proteins, putative | 0.0262 | 0.7457 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.349 | 0.3453 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0302 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.2629 | 0.4055 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0456 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0456 | 0.0621 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0302 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0456 | 0.0401 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0459 | 0.0404 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.349 | 0.5341 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0456 | 0.0401 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0057 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0456 | 0.0401 |
Onchocerca volvulus | 0.0262 | 0.7457 | 1 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0456 | 0.0703 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0456 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0302 | 0.0381 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0422 | 0.0367 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0459 | 0.0404 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0459 | 0.0404 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.349 | 0.3453 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.2629 | 0.4002 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0302 | 0.6093 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0459 | 0.0708 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0456 | 0.0621 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.349 | 0.5382 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.349 | 0.3453 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.349 | 0.5341 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0459 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0459 | 0.0625 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0302 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.6485 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0302 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0459 | 0.0404 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.6485 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.2629 | 0.4055 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0456 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1623 | 0.2437 |
Echinococcus multilocularis | geminin | 0.0346 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0302 | 0.6093 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0459 | 0.0404 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0057 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2629 | 0.4002 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1623 | 0.2503 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0302 | 1 |
Brugia malayi | RNA binding protein | 0.0132 | 0.349 | 0.5382 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0302 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0459 | 0.0404 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1623 | 0.1575 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0456 | 0.0401 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.349 | 0.3453 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0456 | 0.0703 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.349 | 0.5341 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 11 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 91 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 10.79 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 0 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 11 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 91 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.74 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.18086 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.