Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0075 | 0.0807 | 0.2723 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0028 | 0.0214 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 0.1982 | 0.1964 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0028 | 0.0214 | 0.0664 |
Brugia malayi | TATA binding protein associated factor | 0.0013 | 0.0022 | 0.0114 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0166 | 0.1963 | 0.1945 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0026 | 0.0194 | 0.0347 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0026 | 0.0194 | 0.0172 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0224 | 0.0773 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0286 | 0.1459 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0013 | 0.0022 | 0.0413 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0013 | 0.0022 | 0.0023 |
Onchocerca volvulus | Alhambra homolog | 0.0033 | 0.028 | 0.4707 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0028 | 0.0215 | 0.0388 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0026 | 0.0194 | 0.0172 |
Schistosoma mansoni | ran | 0.0021 | 0.0129 | 0.0259 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0013 | 0.0022 | 0.0045 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0286 | 0.0575 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.1199 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0022 | 0.0005 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0166 | 0.1963 | 0.3917 |
Schistosoma mansoni | protein phosphatase 2C | 0.0026 | 0.0194 | 0.0391 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0129 | 0.0294 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.3712 | 0.7458 |
Echinococcus granulosus | snurportin 1 | 0.0304 | 0.3712 | 0.7447 |
Echinococcus multilocularis | tumor protein p63 | 0.0382 | 0.4691 | 0.4679 |
Echinococcus multilocularis | snurportin 1 | 0.0304 | 0.3712 | 0.3697 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0013 | 0.0022 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0022 | 0.0005 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0243 | 0.0489 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0286 | 0.0264 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0028 | 0.0214 | 1 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0028 | 0.0214 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.1982 | 0.3983 |
Echinococcus granulosus | phd:f box containing protein | 0.0026 | 0.0194 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0194 | 0.0471 |
Brugia malayi | Peptidase family M1 containing protein | 0.0013 | 0.0022 | 0.0114 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0013 | 0.0022 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0224 | 0.0552 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.028 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0286 | 0.0533 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.024 | 0.2903 | 1 |
Plasmodium vivax | JmjC domain containing protein | 0.0026 | 0.0194 | 0.6672 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0013 | 0.0022 | 0.0023 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0033 | 0.028 | 0.0563 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.028 | 0.0563 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0.028 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0129 | 0.415 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0156 | 0.6984 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0156 | 0.1704 |
Loa Loa (eye worm) | aminopeptidase N | 0.0013 | 0.0022 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0286 | 0.072 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0129 | 0.136 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0075 | 0.0807 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1199 | 0.3193 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.1199 | 0.6109 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0022 | 0.0114 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0033 | 0.028 | 0.0521 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.1982 | 0.3983 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0223 | 0.0448 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0544 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0777 | 0.3956 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.028 | 0.1428 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0286 | 0.0575 |
Brugia malayi | Peptidase family M1 containing protein | 0.0013 | 0.0022 | 0.0114 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0286 | 0.1459 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0013 | 0.0022 | 0.0045 |
Schistosoma mansoni | ran | 0.0021 | 0.0129 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0777 | 0.2049 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0194 | 0.0597 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.028 | 0.0258 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0243 | 0.0446 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0129 | 0.415 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0026 | 0.0194 | 0.0347 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0075 | 0.0807 | 0.411 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0156 | 0.0464 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0156 | 0.0464 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.024 | 0.2903 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0075 | 0.0807 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.057 | 0.149 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0625 | 0.1257 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0156 | 0.6984 |
Echinococcus granulosus | tumor protein p63 | 0.0382 | 0.4691 | 0.9423 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.0724 | 0.1906 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0224 | 0.7831 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0075 | 0.0807 | 0.0786 |
Trypanosoma brucei | hypothetical protein, conserved | 0.024 | 0.2903 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.1199 | 0.6109 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0286 | 0.0264 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0404 | 0.4977 | 0.4965 |
Brugia malayi | jmjC domain containing protein | 0.0026 | 0.0194 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.028 | 0.0704 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0043 | 0.041 | 0.0782 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.01 | 0.1124 | 0.2989 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0033 | 0.028 | 0.0704 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0214 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0236 | 0.2849 | 0.5725 |
Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.0026 | 0.0194 | 0.3573 |
Leishmania major | hypothetical protein, conserved | 0.024 | 0.2903 | 1 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0028 | 0.0215 | 0.0193 |
Mycobacterium tuberculosis | Conserved protein | 0.0028 | 0.0214 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0236 | 0.2849 | 0.2833 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.028 | 1 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0013 | 0.0022 | 0.0045 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0026 | 0.0194 | 0.0597 |
Echinococcus granulosus | peregrin | 0.0033 | 0.028 | 0.0521 |
Echinococcus granulosus | dnaJ subfamily B | 0.0404 | 0.4977 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0075 | 0.0807 | 0.1621 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0026 | 0.0194 | 0.0471 |
Schistosoma mansoni | jumonji domain containing protein | 0.0026 | 0.0194 | 0.0391 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0098 | 0.1103 | 0.1083 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0033 | 0.028 | 0.0258 |
Echinococcus granulosus | geminin | 0.0167 | 0.1982 | 0.3955 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0286 | 0.0575 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0129 | 0.0107 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0236 | 0.2849 | 0.7663 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0018 | 0.0089 | 0.0179 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0224 | 0.4123 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0019 | 0.011 | 0.0559 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0028 | 0.0214 | 0.0386 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0223 | 0.0548 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0286 | 0.0533 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0243 | 0.0221 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0224 | 0.7831 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0243 | 0.0489 |
Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.0026 | 0.0194 | 0.3573 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0028 | 0.0214 | 0.0664 |
Brugia malayi | jmjC domain containing protein | 0.0026 | 0.0194 | 0.099 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0304 | 0.3712 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0129 | 0.5574 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0224 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0194 | 0.0471 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0129 | 0.0215 |
Onchocerca volvulus | 0.0056 | 0.057 | 1 | |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0013 | 0.0022 | 0.0023 |
Brugia malayi | RNA, U transporter 1 | 0.0081 | 0.0889 | 0.4528 |
Brugia malayi | PHD-finger family protein | 0.0012 | 0.002 | 0.0104 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0013 | 0.0022 | 0.0413 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0129 | 0.037 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0026 | 0.0194 | 0.0347 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0013 | 0.0022 | 0.0077 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0013 | 0.0022 | 0.0045 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.028 | 0.5154 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0224 | 0.0407 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0075 | 0.0807 | 0.278 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0026 | 0.0194 | 0.0597 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.057 | 0.1146 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0028 | 0.0214 | 0.0664 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0129 | 0.037 |
Plasmodium falciparum | JmjC domain-containing protein, putative | 0.0026 | 0.0194 | 0.6672 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0026 | 0.0194 | 0.0391 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0224 | 0.0451 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.028 | 0.5154 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.1124 | 0.5724 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0236 | 0.2849 | 0.5705 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0013 | 0.0022 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0022 | 0.0005 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0026 | 0.0194 | 0.0471 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0286 | 0.072 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0156 | 0.6984 |
Echinococcus multilocularis | phd:f box containing protein | 0.0026 | 0.0194 | 0.0172 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0223 | 0.1135 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.0443 | 0.085 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0026 | 0.0194 | 0.0391 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.0443 | 0.0422 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.01 | 0.1124 | 0.2258 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0777 | 0.1561 |
Schistosoma mansoni | jumonji domain containing protein | 0.0144 | 0.1683 | 0.3381 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0028 | 0.0214 | 0.0192 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0214 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0013 | 0.0022 | 0.0114 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0026 | 0.0194 | 0.0471 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0129 | 0.0445 |
Brugia malayi | jmjC domain containing protein | 0.0026 | 0.0194 | 0.099 |
Brugia malayi | jmjC domain containing protein | 0.0166 | 0.1963 | 1 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0129 | 0.0658 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0774 | 0.2041 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0026 | 0.0194 | 0.0172 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.01 | 0.1124 | 0.2223 |
Brugia malayi | jmjC domain containing protein | 0.0026 | 0.0194 | 0.099 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.01 | 0.1124 | 0.2258 |
Trypanosoma brucei | aminopeptidase, putative | 0.0013 | 0.0022 | 0.0077 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0129 | 0.037 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0022 | 0.0114 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0013 | 0.0022 | 0.0077 |
Schistosoma mansoni | hypothetical protein | 0.0404 | 0.4977 | 1 |
Toxoplasma gondii | aminopeptidase N protein | 0.0013 | 0.0022 | 0.0413 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0224 | 0.0773 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0026 | 0.0194 | 0.0669 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0028 | 0.0214 | 1 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0043 | 0.041 | 0.0388 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0075 | 0.0807 | 0.2723 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0013 | 0.0022 | 0.0023 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0286 | 0.0533 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0286 | 0.0575 |
Onchocerca volvulus | 0.0028 | 0.0223 | 0.3657 | |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0028 | 0.0214 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0075 | 0.0807 | 0.2723 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0075 | 0.0807 | 0.2131 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0224 | 0.0202 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0129 | 0.2374 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.028 | 0.1428 |
Schistosoma mansoni | phd/f-box containing protein | 0.0026 | 0.0194 | 0.0391 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0286 | 0.0264 |
Brugia malayi | hypothetical protein | 0.0108 | 0.1236 | 0.6298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -0.4 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = -0.22 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.4 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 21 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 24 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 93 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 15.52 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 21 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 24 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 93 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 5.97 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 1.06704 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.