Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0166 | 0.1007 |
Leishmania major | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Echinococcus multilocularis | dna polymerase eta | 0.0067 | 0.0167 | 0.1014 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0048 | 0.007 | 0.9835 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0008 | 0.0047 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0048 | 0.007 | 0.9835 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0227 | 0.0986 | 0.1383 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0039 | 0.0024 | 0.0091 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0166 | 0.1436 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0166 | 0.1007 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1991 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0031 | 0.0185 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0048 | 0.007 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0093 | 0.0839 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0039 | 0.0024 | 0.0734 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0227 | 0.0986 | 0.1383 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0166 | 0.1436 |
Plasmodium falciparum | glutathione reductase | 0.01 | 0.0333 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.01 | 0.0333 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0253 | 0.1116 | 0.1565 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0166 | 0.1496 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0041 | 0.0031 | 0.0207 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0018 | 0.0109 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0031 | 0.0185 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0067 | 0.0167 | 0.5024 |
Brugia malayi | Thioredoxin reductase | 0.01 | 0.0333 | 0.3 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0166 | 0.1436 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0031 | 0.0043 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0227 | 0.0986 | 0.1383 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0041 | 0.0031 | 0.2392 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0048 | 0.007 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0041 | 0.0031 | 0.4267 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0167 | 0.1447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0166 | 0.1007 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0031 | 0.0031 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Brugia malayi | glutathione reductase | 0.01 | 0.0333 | 0.3 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0561 | 0.2692 | 0.2777 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0018 | 0.0109 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0067 | 0.0167 | 0.1507 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.01 | 0.0333 | 0.2019 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0048 | 0.007 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1991 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0018 | 0.0109 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0048 | 0.007 | 0.9835 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0048 | 0.007 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.01 | 0.0333 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0067 | 0.0167 | 0.1014 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0018 | 0.0162 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0252 | 0.111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0093 | 0.0774 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0253 | 0.1116 | 0.1565 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0048 | 0.007 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.01 | 0.0333 | 0.2019 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1991 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.165 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0067 | 0.0167 | 0.5024 |
Loa Loa (eye worm) | glutathione reductase | 0.01 | 0.0333 | 0.2951 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0048 | 0.007 | 0.9835 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0253 | 0.1116 | 0.0211 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0041 | 0.0031 | 0.0185 |
Trichomonas vaginalis | MYB, putative | 0.0049 | 0.0072 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0031 | 0.0185 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0041 | 0.0031 | 0.4267 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0253 | 0.1116 | 0.1565 |
Echinococcus granulosus | geminin | 0.0357 | 0.165 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0166 | 0.1496 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.01 | 0.0333 | 0.0467 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0166 | 0.1007 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.1429 | 0.7131 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.01 | 0.0333 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0067 | 0.0167 | 0.1014 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0041 | 0.0031 | 0.0185 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0166 | 0.1007 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0031 | 0.0918 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0166 | 0.1007 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0018 | 0.0109 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0048 | 0.007 | 0.9835 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.165 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0093 | 0.0774 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.01 | 0.0333 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.01 | 0.0333 | 0.1237 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0067 | 0.0167 | 0.5024 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0041 | 0.0031 | 0.0043 |
Brugia malayi | MH2 domain containing protein | 0.0252 | 0.111 | 1 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0048 | 0.007 | 0.9835 |
Plasmodium vivax | thioredoxin reductase, putative | 0.01 | 0.0333 | 1 |
Giardia lamblia | Myb 1-like protein | 0.0049 | 0.0072 | 1 |
Trichomonas vaginalis | C-MYB, putative | 0.0048 | 0.007 | 0.9835 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0166 | 0.1007 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.0049 | 0.0072 | 0.0266 |
Trichomonas vaginalis | C-MYB, putative | 0.0048 | 0.007 | 0.9835 |
Trichomonas vaginalis | MYB72, putative | 0.0048 | 0.007 | 0.9835 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0166 | 0.1496 |
Echinococcus multilocularis | geminin | 0.0357 | 0.165 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0031 | 0.0185 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0048 | 0.007 | 0.9835 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0561 | 0.2692 | 0.2692 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0561 | 0.2692 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0561 | 0.2692 | 0.2692 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.1429 | 0.7131 | 1 |
Trichomonas vaginalis | MYB3r3, putative | 0.0048 | 0.007 | 0.9835 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0252 | 0.111 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Leishmania major | DNA polymerase eta, putative | 0.0039 | 0.0024 | 0.0734 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0008 | 0.007 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0048 | 0.007 | 0.9835 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0031 | 0.0918 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0049 | 0.0072 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0227 | 0.0986 | 0.1383 |
Loa Loa (eye worm) | thioredoxin reductase | 0.01 | 0.0333 | 0.2951 |
Giardia lamblia | DINP protein human, muc B family | 0.0041 | 0.0031 | 0.427 |
Leishmania major | trypanothione reductase | 0.01 | 0.0333 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0227 | 0.0986 | 0.1383 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0031 | 0.0275 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0227 | 0.0986 | 0.1383 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0031 | 0.0918 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0093 | 0.0839 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.71 uM | Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reached | ChEMBL. | 10229631 |
IC50 (functional) | 0 uM | Concentration of the compound needed to inhibit 50% of the PLC elicited by 10 nM 2-MeSADP at P2Y1 receptor in the turkey erythrocyte membranes; 'c' means cannot be accurately estimated under these assay conditions | ChEMBL. | 10229631 |
Increase (functional) | = 53 % | Agonist activity for stimulation of PLC at P2Y purinoceptor 1 in the turkey erythrocyte membranes. | ChEMBL. | 10229631 |
Inhibition (functional) | = 46 % | Antagonist activity for inhibition of PLC elicited by 10 nM 2-MeSADP at P2Y purinoceptor 1 in turkey erythrocyte membranes | ChEMBL. | 10229631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.