Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.0062 | 0.1074 | 0.2513 |
Schistosoma mansoni | nuclear receptor | 0.0029 | 0.03 | 0.0703 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0383 | 0.0666 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0042 | 0.0602 | 0.1408 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0139 | 0.2918 | 0.5076 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0296 | 0.0296 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.4274 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0296 | 0.0694 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0563 | 0.9413 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Loa Loa (eye worm) | DR-78 | 0.0029 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0542 | 0.0542 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1042 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0062 | 0.1074 | 0.1074 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0717 | 0.1677 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Leishmania major | AUT2/APG4/ATG4 cysteine peptidase, putative | 0.0059 | 0.1012 | 0.9653 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0717 | 0.1247 |
Brugia malayi | glutathione reductase | 0.0041 | 0.0589 | 0.1024 |
Trichomonas vaginalis | Clan CA, family C54, ATG4-like cysteine peptidase | 0.0059 | 0.1012 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0542 | 0.1267 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0062 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0383 | 0.0383 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0542 | 0.0542 |
Brugia malayi | ecdysteroid receptor | 0.0062 | 0.1074 | 0.1868 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0438 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0717 | 0.0717 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.1141 | 0.267 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0062 | 0.1074 | 0.1868 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.3855 | 0.6362 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.1074 | 0.2513 |
Brugia malayi | nuclear receptor NHR-88 | 0.0062 | 0.1074 | 0.1868 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0542 | 0.435 |
Echinococcus granulosus | geminin | 0.0164 | 0.3509 | 0.8211 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0094 | 0.1844 | 0.2592 |
Schistosoma mansoni | family C54 unassigned peptidase (C54 family) | 0.0059 | 0.1012 | 0.2367 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0092 | 0.1797 | 0.1546 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0062 | 0.1074 | 0.2513 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.017 | 0.3638 | 0.3444 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0029 | 0.03 | 0.0703 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0542 | 0.0942 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.4274 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.03 | 0.0522 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.1074 | 0.1868 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.03 | 0.0703 |
Brugia malayi | nuclear receptor RXR | 0.0029 | 0.03 | 0.0522 |
Echinococcus multilocularis | Peptidase C54 | 0.0059 | 0.1012 | 0.2367 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0542 | 0.0542 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0094 | 0.1844 | 0.8393 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0062 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0062 | 0.1074 | 0.1074 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0296 | 0.1583 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0204 | 0.0542 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0717 | 0.1677 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Brugia malayi | Thioredoxin reductase | 0.0041 | 0.0589 | 0.1024 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0542 | 0.0942 |
Echinococcus granulosus | tar DNA binding protein | 0.0196 | 0.4274 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.03 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0296 | 0.0694 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0149 | 0.3148 | 0.5476 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0033 | 0.0383 | 0.0896 |
Entamoeba histolytica | peptidase, C54 family | 0.0059 | 0.1012 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0196 | 0.4274 | 0.4274 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0542 | 0.1267 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0062 | 0.1074 | 0.1868 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0542 | 0.1267 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0041 | 0.0589 | 0.8625 |
Onchocerca volvulus | 0.0039 | 0.0542 | 0.0253 | |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0029 | 0.03 | 0.03 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0717 | 0.1677 |
Onchocerca volvulus | 0.023 | 0.5061 | 0.491 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0105 | 0.2093 | 0.3088 |
Brugia malayi | nuclear hormone receptor | 0.0062 | 0.1074 | 0.1868 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0062 | 0.1074 | 0.2513 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.065 | 0.0208 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0062 | 0.1074 | 0.1868 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0149 | 0.3148 | 0.7367 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0105 | 0.2093 | 0.3088 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0042 | 0.0602 | 0.1408 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.1074 | 0.2513 |
Brugia malayi | RNA binding protein | 0.0196 | 0.4274 | 0.7434 |
Onchocerca volvulus | 0.0039 | 0.0542 | 0.0253 | |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0029 | 0.03 | 0.0522 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0296 | 0.0694 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.1141 | 0.267 |
Onchocerca volvulus | 0.0039 | 0.0542 | 0.0253 | |
Mycobacterium tuberculosis | Probable reductase | 0.0094 | 0.1844 | 0.2592 |
Brugia malayi | tailless protein | 0.0029 | 0.03 | 0.0522 |
Toxoplasma gondii | thioredoxin reductase | 0.0041 | 0.0589 | 0.4883 |
Brugia malayi | nuclear receptor RXR | 0.0033 | 0.0383 | 0.0666 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1042 | 0.2439 |
Echinococcus granulosus | cysteine protease atg4b | 0.0059 | 0.1012 | 0.2367 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.5749 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.5749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0542 | 0.0542 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0029 | 0.03 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0029 | 0.03 | 0.0703 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.065 | 0.1521 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.1074 | 0.2513 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.1074 | 0.2513 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0717 | 0.1677 |
Plasmodium vivax | glutathione reductase, putative | 0.0041 | 0.0589 | 0.8625 |
Plasmodium falciparum | glutathione reductase | 0.0041 | 0.0589 | 1 |
Trypanosoma brucei | AUT2/APG4/ATG4 cysteine peptidase, putative | 0.0059 | 0.1012 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0204 | 0.111 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0204 | 0.111 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0041 | 0.0589 | 0.0094 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0563 | 0.4761 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0029 | 0.03 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | glutathione reductase | 0.0041 | 0.0589 | 0.0589 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0062 | 0.1074 | 0.2513 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.1074 | 0.2513 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0029 | 0.03 | 0.0703 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0196 | 0.4274 | 0.7434 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0029 | 0.03 | 0.0703 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0094 | 0.1844 | 0.2592 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0062 | 0.1074 | 0.1074 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0029 | 0.03 | 0.0522 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0062 | 0.1074 | 0.1868 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0062 | 0.1074 | 0.2513 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0062 | 0.1074 | 0.0801 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0196 | 0.4274 | 0.4274 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0105 | 0.2093 | 0.3088 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0062 | 0.1074 | 0.1074 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0033 | 0.0383 | 0.0896 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0542 | 0.0542 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.1074 | 0.1868 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0062 | 0.1074 | 0.2513 |
Brugia malayi | ecdysone receptor | 0.0029 | 0.03 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.2918 | 0.2918 |
Onchocerca volvulus | 0.0029 | 0.03 | 0.0004 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0029 | 0.03 | 0.0703 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0145 | 0.3049 | 0.7134 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1042 | 0.2439 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0296 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0542 | 0.1267 |
Brugia malayi | conserved hypotetical protein | 0.0029 | 0.03 | 0.0522 |
Loa Loa (eye worm) | acetyltransferase | 0.0149 | 0.3148 | 0.3148 |
Trypanosoma cruzi | AUT2/APG4/ATG4 cysteine peptidase, putative | 0.0059 | 0.1012 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0717 | 0.1677 |
Schistosoma mansoni | nuclear hormone receptor | 0.0062 | 0.1074 | 0.2513 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0062 | 0.1074 | 0.2513 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0542 | 0.0542 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1042 | 1 |
Trichomonas vaginalis | Clan CA, family C54, ATG4-like cysteine peptidase | 0.0059 | 0.1012 | 0.0902 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0542 | 0.0942 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0062 | 0.1074 | 0.1868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.4274 | 1 |
Schistosoma mansoni | family C54 unassigned peptidase (C54 family) | 0.0059 | 0.1012 | 0.2367 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0105 | 0.2093 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.1141 | 0.267 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.445 | 0.445 |
Brugia malayi | Peptidase family C54 containing protein | 0.0059 | 0.1012 | 0.1759 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.1141 | 0.267 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0062 | 0.1074 | 0.1074 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.0383 | 0.0896 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.1074 | 0.1868 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3509 | 0.8211 |
Schistosoma mansoni | nuclear receptor | 0.0029 | 0.03 | 0.0703 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0542 | 0.435 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.1074 | 0.1868 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0062 | 0.1074 | 0.1868 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0029 | 0.03 | 0.0004 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.1074 | 0.2513 |
Trichomonas vaginalis | Clan CA, family C54, ATG4-like cysteine peptidase | 0.0059 | 0.1012 | 0.0902 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0204 | 0.0562 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0383 | 0.0383 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.1074 | 0.2513 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.5749 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0029 | 0.03 | 0.0703 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.2918 | 0.6828 |
Trichomonas vaginalis | Clan CA, family C54, ATG4-like cysteine peptidase | 0.0059 | 0.1012 | 0.0902 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0029 | 0.03 | 0.0004 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0029 | 0.03 | 0.0703 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0041 | 0.0589 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0062 | 0.1074 | 0.0801 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.065 | 0.0208 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0062 | 0.1074 | 0.1074 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0062 | 0.1074 | 0.2513 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.1074 | 0.2513 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0029 | 0.03 | 0.0703 |
Onchocerca volvulus | 0.0062 | 0.1074 | 0.0801 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0064 | 0.1141 | 0.267 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.03 | 0.0522 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0204 | 0.445 | 0.774 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.03 | 0.0522 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0383 | 0.0666 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0204 | 0.445 | 0.774 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1042 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0029 | 0.03 | 0.0522 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.1074 | 0.2513 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0296 | 0.0516 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0029 | 0.03 | 0.0703 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.1141 | 0.267 |
Trichomonas vaginalis | Clan CA, family C54, ATG4-like cysteine peptidase | 0.0059 | 0.1012 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0064 | 0.1141 | 0.267 |
Schistosoma mansoni | autophagin-1 (C54 family) | 0.0059 | 0.1012 | 0.2367 |
Echinococcus granulosus | Peptidase C54 | 0.0059 | 0.1012 | 0.2367 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0296 | 0.2068 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3509 | 0.8211 |
Leishmania major | trypanothione reductase | 0.0041 | 0.0589 | 0.4883 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.1074 | 0.1868 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0717 | 0.1677 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.5749 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0029 | 0.03 | 0.0522 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0094 | 0.1844 | 0.2592 |
Echinococcus granulosus | GPCR family 2 | 0.0064 | 0.1141 | 0.267 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0062 | 0.1074 | 0.2513 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1042 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0062 | 0.1074 | 0.1868 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0204 | 0.0542 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0029 | 0.03 | 0.0522 |
Brugia malayi | hypothetical protein | 0.0029 | 0.03 | 0.0522 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0717 | 0.1677 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Brugia malayi | TAR-binding protein | 0.0196 | 0.4274 | 0.7434 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0033 | 0.0383 | 0.0383 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0029 | 0.03 | 0.0703 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0062 | 0.1074 | 0.1868 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1042 | 0.2439 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.3855 | 0.6362 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0029 | 0.03 | 0.03 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0204 | 0.0562 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0062 | 0.1074 | 0.2513 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0033 | 0.0383 | 0.0896 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0064 | 0.1141 | 0.1141 |
Schistosoma mansoni | coup transcription factor | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1012 | 0.1012 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0062 | 0.1074 | 0.0801 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0296 | 0.0694 |
Brugia malayi | nuclear receptor NHR-67 | 0.0029 | 0.03 | 0.0522 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0241 | 0.5342 | 0.5342 |
Onchocerca volvulus | 0.0029 | 0.03 | 0.0004 | |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0064 | 0.1141 | 0.1985 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0259 | 0.5749 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0204 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0259 | 0.5749 | 0.5749 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.065 | 0.5575 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.065 | 0.5575 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1141 | 0.1141 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0542 | 0.4506 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0062 | 0.1074 | 0.1868 |
Echinococcus multilocularis | cysteine protease atg4b | 0.0059 | 0.1012 | 0.2367 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0204 | 0.0204 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.4399 | 0.7652 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0064 | 0.1141 | 0.267 |
Plasmodium falciparum | thioredoxin reductase | 0.0041 | 0.0589 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Echinococcus granulosus | FTZ F1 alpha | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1797 | 0.1797 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0542 | 0.7567 |
Echinococcus multilocularis | tar DNA binding protein | 0.0196 | 0.4274 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1042 | 0.2439 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.1074 | 0.1868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.4274 | 1 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0383 | 0.0666 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.03 | 0.0703 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.4399 | 0.4399 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0542 | 0.0542 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.5749 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1074 | 0.1074 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.4274 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0251 | 0.5565 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.1074 | 0.2513 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0542 | 0.4506 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0204 | 0.445 | 0.445 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0094 | 0.1844 | 0.2592 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.1074 | 0.1868 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.5061 | 0.8679 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0029 | 0.03 | 0.0522 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0241 | 0.5342 | 0.5342 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0029 | 0.03 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0542 | 0.0542 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0204 | 0.0562 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.5749 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Brugia malayi | steroid hormone receptor | 0.0062 | 0.1074 | 0.1868 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0149 | 0.3148 | 0.7367 |
Schistosoma mansoni | nuclear hormone receptor | 0.0029 | 0.03 | 0.0703 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0041 | 0.0589 | 0.5058 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0296 | 0.0694 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0296 | 0.0694 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1042 | 0.0997 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1042 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.1141 | 0.267 |
Brugia malayi | MH2 domain containing protein | 0.0241 | 0.5342 | 0.9291 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0383 | 0.0666 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0563 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0041 | 0.0589 | 0.5058 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.03 | 0.03 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0094 | 0.1844 | 0.2592 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0029 | 0.03 | 0.0703 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.065 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0029 | 0.03 | 0.0703 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.017 | 0.3638 | 0.5946 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0271 | 0.0635 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0542 | 0.0942 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0062 | 0.1074 | 0.2513 |
Loa Loa (eye worm) | RNA binding protein | 0.0196 | 0.4274 | 0.4274 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0064 | 0.1141 | 0.1985 |
Brugia malayi | Phospholipase A2 family protein | 0.0092 | 0.1797 | 0.3126 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3509 | 0.8211 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0542 | 0.4506 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -1.1 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 0.25 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.21 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 40 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 83 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 9 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -4 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 40 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 83 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.63 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.2365 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.