Detailed information for compound 594358

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.514 | Formula: C22H32N4O3
  • H donors: 3 H acceptors: 4 LogP: 4.29 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1cc(cc(c1OCCCCC(=O)O)CCC)Cc1cnc(nc1N)N
  • InChi: 1S/C22H32N4O3/c1-3-7-16-11-15(13-18-14-25-22(24)26-21(18)23)12-17(8-4-2)20(16)29-10-6-5-9-19(27)28/h11-12,14H,3-10,13H2,1-2H3,(H,27,28)(H4,23,24,25,26)
  • InChiKey: IFBJOAYSYJLPCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.016 0.1606
Mycobacterium leprae Probable lipase LipE 0.0038 0.0298 0.0925
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0028 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0217 0.0565
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0241 0.0667
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Schistosoma mansoni ap endonuclease 0.002 0.008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Schistosoma mansoni cpg binding protein 0.006 0.0557 0.055
Loa Loa (eye worm) hypothetical protein 0.0258 0.291 0.778
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0298 0.0291
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0092
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Brugia malayi steroid hormone receptor 0.0032 0.0217 0.0565
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.007 0.0064
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0217 0.0211
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0057
Brugia malayi ecdysone receptor 0.0015 0.002 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0298 0.0925
Brugia malayi RNA recognition motif domain containing protein 0.0328 0.3738 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.0298 0.1443
Schistosoma mansoni lamin 0.0054 0.0482 0.0476
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.002 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0241 0.2452
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0152 0.0145
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.016 0.026
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0241 0.0671
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0814 0.0808
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0217 0.0211
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0214 0.2162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1529 0.1524
Brugia malayi hypothetical protein 0.0015 0.002 0.0036
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0217 0.0211
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0021 0.0014
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.002 0.0013
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.002 0.0036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0482 0.1274
Mycobacterium ulcerans lipase LipD 0.0038 0.0298 0.1443
Echinococcus multilocularis dna polymerase eta 0.0044 0.037 0.0364
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0069 0.0062
Loa Loa (eye worm) RNA binding protein 0.0328 0.3738 1
Trichomonas vaginalis heat shock protein, putative 0.0027 0.016 0.0441
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0028 0.0057
Plasmodium vivax JmjC domain containing protein 0.0016 0.0028 0.0734
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0217 0.0211
Brugia malayi hypothetical protein 0.0017 0.0041 0.0092
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.0964 0.2567
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.3531 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.078
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.0964 0.2718
Echinococcus granulosus endoplasmin 0.0027 0.016 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0217 0.0565
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0298 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Loa Loa (eye worm) hypothetical protein 0.0025 0.014 0.0357
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.007 0.0064
Brugia malayi hypothetical protein 0.0017 0.0041 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0217 0.0565
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0028 0.018
Echinococcus granulosus lamin dm0 0.0054 0.0482 0.0476
Leishmania major DNA polymerase kappa, putative 0.0019 0.007 0.0668
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0092
Loa Loa (eye worm) DR-78 0.0015 0.002 0.0036
Echinococcus multilocularis lamin dm0 0.0054 0.0482 0.0476
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0028 0.018
Schistosoma mansoni ap endonuclease 0.002 0.008 0.0073
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.002 0.0013
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0576 0.057
Schistosoma mansoni lamin 0.0054 0.0482 0.0476
Brugia malayi nuclear receptor NHR-67 0.0015 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0856 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.078
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.002 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0217 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Schistosoma mansoni nuclear receptor 0.0015 0.002 0.0013
Brugia malayi beta-lactamase family protein 0.0038 0.0298 0.078
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0241 0.1978
Plasmodium falciparum heat shock protein 90 0.0034 0.0241 1
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Mycobacterium tuberculosis Conserved protein 0.0038 0.0298 0.0849
Onchocerca volvulus 0.006 0.0557 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Onchocerca volvulus 0.0038 0.0298 0.5294
Schistosoma mansoni nuclear hormone receptor 0.0015 0.002 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0241 0.2452
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0241 0.2452
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.0668
Echinococcus granulosus tar DNA binding protein 0.0328 0.3738 0.3734
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0028 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.008 0.2512
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0217 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0328 0.3738 0.3734
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0328 0.3738 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0092
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0028 0.0021
Echinococcus granulosus cpg binding protein 0.0064 0.0597 0.0591
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.008 0.3113
Entamoeba histolytica protein kinase, putative 0.0094 0.0964 0.2718
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0298 0.083
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0964 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0217 0.0211
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0028 0.0021
Toxoplasma gondii exonuclease III APE 0.002 0.008 0.0616
Echinococcus granulosus intermediate filament protein 0.0054 0.0482 0.0476
Brugia malayi CXXC zinc finger family protein 0.006 0.0557 0.1474
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0298 0.0291
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.007 0.0731
Schistosoma mansoni nuclear hormone receptor 0.0015 0.002 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.007 0.0731
Echinococcus granulosus dna polymerase eta 0.0044 0.037 0.0364
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0576 0.1526
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0482 0.1274
Schistosoma mansoni tar DNA-binding protein 0.0328 0.3738 0.3734
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0217 0.0211
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.002 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0217 0.0565
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0092
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0298 0.0849
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.007 0.0186
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0028 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0217 0.0565
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0028 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.008 0.0826
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0217 0.0565
Brugia malayi nuclear receptor NHR-88 0.0015 0.002 0.0036
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1645 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1529 0.1524
Schistosoma mansoni DNA polymerase eta 0.0044 0.037 0.0364
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0814 0.0808
Mycobacterium ulcerans heat shock protein 90 0.0027 0.016 0.0571
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0028 0.0021
Onchocerca volvulus 0.0054 0.0482 0.8641
Leishmania major DNA polymerase eta, putative 0.0044 0.037 0.3796
Schistosoma mansoni nuclear receptor 0.0015 0.002 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Brugia malayi MH2 domain containing protein 0.0126 0.1343 0.3582
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.016 0.1606
Brugia malayi Nuclear hormone receptor E75 0.0015 0.002 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0298 0.3087
Schistosoma mansoni tar DNA-binding protein 0.0328 0.3738 0.3734
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0298 0.083
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Schistosoma mansoni hypothetical protein 0.017 0.1859 0.1854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0092
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0298 0.0849
Plasmodium falciparum endoplasmin, putative 0.0021 0.0088 0.345
Trichomonas vaginalis ap endonuclease, putative 0.002 0.008 0.0212
Loa Loa (eye worm) hypothetical protein 0.0094 0.0959 0.2552
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.016 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1529 0.1524
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.007 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0217 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0964 0.0959
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0298 0.1443
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.007 0.0731
Brugia malayi RNA binding protein 0.0328 0.3738 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.078
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0814 0.2163
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Brugia malayi heat shock protein 90 0.0034 0.0241 0.063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.078
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.002 0.0036
Echinococcus multilocularis geminin 0.017 0.1859 0.1854
Leishmania major DNA polymerase eta, putative 0.0031 0.0214 0.2162
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0041 0.0092
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.002 0.0013
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0028 0.0021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.002 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.037 0.3796
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0217 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0298 0.0849
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.037 0.3838
Loa Loa (eye worm) hypothetical protein 0.0094 0.0959 0.2552
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0298 0.0849
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1645 1
Brugia malayi Nuclear hormone receptor E75 0.0015 0.002 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1529 0.1524
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0021 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0311 0.3531 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0535 0.0529
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0298 0.078
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0814 0.0808
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.002 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0041 0.0092
Echinococcus granulosus heat shock protein 90 0.0034 0.0241 0.0235
Echinococcus multilocularis lamin 0.0054 0.0482 0.0476
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0217 0.0565
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0298 0.0849
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0298 0.1443
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.002 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0007 0.0004
Echinococcus granulosus lamin 0.0054 0.0482 0.0476
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0298 0.083
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.007 0.0181
Schistosoma mansoni intermediate filament proteins 0.0054 0.0482 0.0476
Loa Loa (eye worm) hypothetical protein 0.0026 0.0152 0.0389
Echinococcus granulosus heat shock protein 0.0034 0.0241 0.0235
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0028 0.0021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1529 0.4081
Leishmania major hypothetical protein, conserved 0.0038 0.0298 0.304
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0217 0.0211
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0576 0.057
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.008 0.0196
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0021 0.0014
Brugia malayi nuclear receptor RXR 0.0017 0.0041 0.0092
Echinococcus multilocularis heat shock protein 90 0.0034 0.0241 0.0235
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.002 0.0013
Schistosoma mansoni cpg binding protein 0.0064 0.0597 0.0591
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0217 0.0211
Echinococcus multilocularis dual specificity 0.0094 0.0964 0.0959
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.1939 0.518
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0217 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0298 0.304
Loa Loa (eye worm) hypothetical protein 0.0082 0.0814 0.2163
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.0668
Loa Loa (eye worm) beta-lactamase 0.0038 0.0298 0.078
Brugia malayi jmjC domain containing protein 0.0016 0.0028 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.007 0.0668
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0217 0.0211
Schistosoma mansoni heat shock protein 0.0034 0.0241 0.0235
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0041 0.0035
Echinococcus multilocularis endoplasmin 0.0027 0.016 0.0154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0217 0.3835
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.008 0.0764
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0217 0.0211
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.002 0.0036
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0217 0.3835
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0217 0.0211
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.007 0.0171
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0078 0.075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1356 0.135
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.002 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0328 0.3738 0.3734
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Loa Loa (eye worm) hypothetical protein 0.0054 0.0482 0.1274
Loa Loa (eye worm) hypothetical protein 0.0053 0.047 0.1242
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0241 0.063
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0069 0.0062
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0064 0.0154
Schistosoma mansoni hypothetical protein 0.0177 0.1939 0.1934
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.0964 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0557 0.1474
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.007 0.0668
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1529 0.1524
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.002 0.0036
Entamoeba histolytica hypothetical protein 0.0094 0.0964 0.2718
Schistosoma mansoni zinc finger protein 0.0015 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Treponema pallidum heat shock protein 90 0.0027 0.016 0.0234
Brugia malayi nuclear hormone receptor 0.0032 0.0217 0.0565
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0217 0.0211
Schistosoma mansoni endoplasmin 0.0034 0.0241 0.0235
Giardia lamblia Fructose-bisphosphate aldolase 0.0311 0.3531 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0814 0.2163
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0298 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.008 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0217 0.0565
Schistosoma mansoni heat shock protein 0.0034 0.0241 0.0235
Brugia malayi nuclear receptor NHR-88 0.0032 0.0217 0.0565
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0814 0.2163
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.008 0.0027
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0028 0.0289
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0082 0.0814 0.0808
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0241 0.2503
Brugia malayi Protein kinase domain containing protein 0.0094 0.0964 0.2567
Brugia malayi jmjC domain containing protein 0.0016 0.0028 0.0057
Brugia malayi jmjC domain containing protein 0.0016 0.0028 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0217 0.0565
Echinococcus multilocularis GPCR, family 2 0.0082 0.0814 0.0808
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0028 0.091
Trichomonas vaginalis esterase, putative 0.0038 0.0298 0.083
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0535 0.0529
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0028 0.0021
Echinococcus granulosus heat shock protein 90 0.0027 0.016 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Brugia malayi beta-lactamase 0.0038 0.0298 0.078
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.002 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0217 0.0211
Onchocerca volvulus 0.0015 0.002 0.0242
Schistosoma mansoni endoplasmin 0.0034 0.0241 0.0235
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0007 0.0068
Brugia malayi beta-lactamase family protein 0.0038 0.0298 0.078
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1194 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.008 0.0212
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0241 0.1978
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.016 0.0154
Echinococcus granulosus phd:f box containing protein 0.0016 0.0028 0.0021
Brugia malayi intermediate filament protein 0.0054 0.0482 0.1274
Echinococcus multilocularis heat shock protein 90 0.0027 0.016 0.0154
Onchocerca volvulus 0.0015 0.002 0.0242
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0241 0.2452
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0241 0.0494
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0298 0.0849
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1645 0.5885
Trypanosoma brucei unspecified product 0.0019 0.007 0.0731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0217 0.0565
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.291 0.778
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0088 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0217 0.0565
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0217 0.0565
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.002 0.0036
Echinococcus granulosus geminin 0.017 0.1859 0.1854
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Schistosoma mansoni cpg binding protein 0.0064 0.0597 0.0591
Mycobacterium ulcerans hypothetical protein 0.0038 0.0298 0.1443
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0241 0.8068
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.007 0.0064
Schistosoma mansoni coup transcription factor 0.0032 0.0217 0.0211
Onchocerca volvulus 0.0032 0.0217 0.3835
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0298 0.0291
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.002 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0241 0.2452
Loa Loa (eye worm) hypothetical protein 0.0044 0.037 0.0975
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0241 0.2503
Giardia lamblia Grp94/Hsp90 0.0027 0.016 0.026
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.008 0.0058
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0028 0.0223
Loa Loa (eye worm) hypothetical protein 0.0025 0.014 0.0357
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0057
Brugia malayi tailless protein 0.0015 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0565
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.002 0.0036
Echinococcus multilocularis musashi 0.0054 0.0482 0.0476
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0217 0.0211
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0021 0.0014
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0214 0.1743
Echinococcus multilocularis dnaJ subfamily B 0.0856 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0217 0.0211
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0217 0.0211
Onchocerca volvulus 0.0038 0.0298 0.5294
Trichomonas vaginalis endoplasmin, putative 0.0021 0.0088 0.0234
Plasmodium vivax endoplasmin, putative 0.0034 0.0241 0.8068
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0028 0.0057
Brugia malayi conserved hypotetical protein 0.0015 0.002 0.0036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0185 0.0479
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.008 0.0196
Brugia malayi jmjC domain containing protein 0.0016 0.0028 0.0057
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1343 0.3582
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1529 0.4081
Brugia malayi nuclear receptor RXR 0.0015 0.002 0.0036
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0482 0.1274
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0217 0.0565
Mycobacterium tuberculosis Conserved protein 0.0038 0.0298 0.0849
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0185 0.0479
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0217 0.0565
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Loa Loa (eye worm) TAR-binding protein 0.0328 0.3738 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0057
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.002 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0064 0.0058
Brugia malayi Endoplasmin precursor 0.0034 0.0241 0.063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0064 0.0058
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0298 0.083
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0576 0.057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0217 0.0211
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0217 0.0565
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0814 0.0808
Echinococcus granulosus dual specificity 0.0094 0.0964 0.0959
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0298 0.083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.291 0.778
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0028 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0217 0.0211
Brugia malayi jmjC domain containing protein 0.0058 0.0535 0.1417
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0217 0.0565
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0535 0.0529
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0241 0.0667
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.002 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0041 0.0092
Entamoeba histolytica protein kinase, putative 0.0094 0.0964 0.2718
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0298 0.078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0041 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0535 0.0529
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0217 0.0211
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.0964 1
Loa Loa (eye worm) endoplasmin 0.0034 0.0241 0.063
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0028 0.0021
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.002 0.0242
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.007 0.0186
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0217 0.0211
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0217 0.0565
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0041 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1529 0.1524
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0217 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Brugia malayi nuclear hormone receptor 0.0015 0.002 0.0036
Schistosoma mansoni hypothetical protein 0.0082 0.0814 0.0808
Echinococcus multilocularis tar DNA binding protein 0.0328 0.3738 0.3734
Trichomonas vaginalis heat shock protein, putative 0.0027 0.016 0.0441
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.007 0.0171
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Onchocerca volvulus 0.0038 0.0298 0.5294
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0021 0.0014
Trichomonas vaginalis heat shock protein, putative 0.0027 0.016 0.0441
Trypanosoma brucei heat shock protein, putative 0.0034 0.0241 0.2503
Schistosoma mansoni hypothetical protein 0.0082 0.0814 0.0808
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.008 0.0208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.2746 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0298 0.0291
Schistosoma mansoni hypothetical protein 0.0082 0.0814 0.0808
Leishmania major hypothetical protein, conserved 0.0016 0.0028 0.0223
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.008 0.0764
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0311 0.3531 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.016 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.291 0.778
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0061 0.0147
Leishmania major heat shock protein 83-1 0.0034 0.0241 0.2452
Brugia malayi TAR-binding protein 0.0328 0.3738 1
Echinococcus multilocularis cpg binding protein 0.0064 0.0597 0.0591
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0028 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0217 0.0565
Brugia malayi hypothetical protein 0.0015 0.002 0.0036
Onchocerca volvulus 0.0054 0.0482 0.8641
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.0964 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0217 0.0211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.007 0.0731
Echinococcus granulosus GPCR family 2 0.0082 0.0814 0.0808
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0152 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0217 0.0565
Brugia malayi ecdysteroid receptor 0.0032 0.0217 0.0565
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0217 0.0211
Echinococcus granulosus dna polymerase kappa 0.0019 0.007 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1343 0.3582
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0298 0.304
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0217 0.0211
Treponema pallidum fructose-bisphosphate aldolase 0.0311 0.3531 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.002 0.0242
Loa Loa (eye worm) hypothetical protein 0.0177 0.1939 0.518
Brugia malayi jmjC domain containing protein 0.0062 0.0576 0.1526
Toxoplasma gondii ABC1 family protein 0.0038 0.0298 0.2451
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0041 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1529 0.1524
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0217 0.0211
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.016 0.1606
Schistosoma mansoni hypothetical protein 0.017 0.1859 0.1854
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.037 0.0975
Echinococcus multilocularis heat shock protein 0.0034 0.0241 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0328 0.3738 0.3734
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0217 0.0565
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0217 0.0211
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.008 0.0764
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0241 0.2503
Mycobacterium tuberculosis Conserved protein 0.0038 0.0298 0.0849
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0036
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0217 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0217 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0217 0.0565
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0028 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0217 0.3835
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0298 0.078

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0.16 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.12 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.3 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 18 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 23 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 95 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -2 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 18 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 23 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 95 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.71 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.19502 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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