TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 512.474 | Formula: C27H31Cl2N5O
H donors: 2 H acceptors: 2 LogP: 4.88 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCC(CC1)CN1CCC(CC1)c1c[nH]c2c1nc(N)cc2)/C=C/c1ccc(c(c1)Cl)Cl
InChi: 1S/C27H31Cl2N5O/c28-22-3-1-18(15-23(22)29)2-6-26(35)34-13-7-19(8-14-34)17-33-11-9-20(10-12-33)21-16-31-24-4-5-25(30)32-27(21)24/h1-6,15-16,19-20,31H,7-14,17H2,(H2,30,32)/b6-2+
InChiKey: BSTXWLWHVCACKB-QHHAFSJGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.008	0.0318	1
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0038	0.0012	0.0012
Trypanosoma cruzi	aminopeptidase, putative	0.0074	0.0274	0.8624
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0222	0.0498
Onchocerca volvulus		0.01	0.0469	0.0946
Echinococcus multilocularis	proteasome (prosome, macropain)	0.008	0.0318	0.0318
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0089	0.0388	0.0388
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0057	0.0151	0.0151
Giardia lamblia	Proteasome subunit beta type 1	0.0062	0.0186	0.0444
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0089	0.0388	0.0388
Loa Loa (eye worm)	TATA binding protein associated factor	0.0074	0.0274	0.0274
Onchocerca volvulus		0.0709	0.4963	1
Echinococcus multilocularis	phd:f box containing protein	0.0057	0.0151	0.0151
Leishmania major	hypothetical protein, conserved	0.0057	0.0151	0.4758
Trypanosoma brucei	proteasome beta 6 subunit	0.0062	0.0186	0.5863
Trypanosoma brucei	Aminopeptidase M1, putative	0.0074	0.0274	0.8624
Loa Loa (eye worm)	hypothetical protein	0.0098	0.045	0.045
Brugia malayi	PHD-finger family protein	0.0058	0.0157	0.0352
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0274	0.8624
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0038	0.0012	0.0024
Brugia malayi	Peptidase family M1 containing protein	0.0074	0.0274	0.0616
Trypanosoma cruzi	20S proteasome subunit	0.0038	0.0012	0.0382
Schistosoma mansoni	phd/f-box containing protein	0.0057	0.0151	0.0151
Loa Loa (eye worm)	heterochromatin protein 1	0.0067	0.0225	0.0225
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0057	0.0151	0.4758
Brugia malayi	jmjC domain containing protein	0.0057	0.0151	0.034
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0086	0.0364	0.0364
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.01	0.0469	0.0469
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0089	0.0388	0.0388
Schistosoma mansoni	phosphatidylserine receptor	0.0057	0.0151	0.0151
Echinococcus granulosus	chromobox protein 1	0.0067	0.0225	0.0225
Plasmodium falciparum	phd finger protein, putative	0.0177	0.1038	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Schistosoma mansoni	hypothetical protein	0.0189	0.1123	0.1123
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0062	0.0186	0.1794
Entamoeba histolytica	aminopeptidase, putative	0.0074	0.0274	0.0667
Schistosoma mansoni	chromobox protein	0.0067	0.0225	0.0225
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Plasmodium vivax	JmjC domain containing protein	0.0057	0.0151	0.1456
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0279	0.1785	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0058	0.0157	0.1407
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0053	0.0121	0.0121
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0151	0.0151
Loa Loa (eye worm)	jmjC domain-containing protein	0.0215	0.1314	0.1314
Toxoplasma gondii	aminopeptidase N protein	0.0074	0.0274	0.2639
Echinococcus multilocularis	muscleblind protein 1	0.0154	0.0864	0.0864
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0038	0.0012	0.0012
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0074	0.0274	0.0552
Echinococcus granulosus	phd:f box containing protein	0.0057	0.0151	0.0151
Brugia malayi	F/Y-rich N-terminus family protein	0.0061	0.0181	0.0406
Treponema pallidum	fructose-bisphosphate aldolase	0.057	0.3938	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0244	0.1527	0.1527
Schistosoma mansoni	chromobox protein	0.0067	0.0225	0.0225
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0225	0.0225
Echinococcus granulosus	peregrin	0.0177	0.1038	0.1038
Onchocerca volvulus		0.0074	0.0274	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0304	0.1974	0.1974
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Brugia malayi	chromobox protein homolog 3	0.0038	0.0007	0.0016
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0074	0.0274	0.0274
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0062	0.0186	0.5863
Brugia malayi	Pre-SET motif family protein	0.0089	0.0388	0.0872
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0057	0.0151	0.4758
Schistosoma mansoni	hypothetical protein	0.0067	0.0222	0.0222
Plasmodium vivax	hypothetical protein, conserved	0.0177	0.1038	1
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.008	0.0318	0.1781
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0007	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0151	0.0151
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.057	0.3938	1
Brugia malayi	jmjC domain containing protein	0.0057	0.0151	0.034
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0057	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0222	0.0222
Echinococcus multilocularis	geminin	0.0189	0.1123	0.1123
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Brugia malayi	hypothetical protein	0.0244	0.1527	0.343
Brugia malayi	proteasome subunit beta type 1	0.0062	0.0186	0.0419
Schistosoma mansoni	survival motor neuron protein	0.005	0.0095	0.0095
Echinococcus granulosus	jumonji domain containing protein	0.0247	0.1551	0.1551
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0181	0.0181
Brugia malayi	Proteasome A-type and B-type family protein	0.008	0.0318	0.0714
Leishmania major	proteasome beta 5 subunit, putative	0.008	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0274	0.0274
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0074	0.0274	0.8624
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0057	0.0151	0.1456
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0062	0.0186	0.1697
Brugia malayi	jmjC domain containing protein	0.0057	0.0151	0.034
Schistosoma mansoni	jumonji domain containing protein	0.0462	0.3137	0.3137
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0157	0.1508
Echinococcus granulosus	JmjC domain containing protein 4	0.0057	0.0151	0.0151
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0225	0.0454
Brugia malayi	jmjC domain containing protein	0.0215	0.1314	0.2952
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0151	0.0151
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0864	0.0864
Brugia malayi	hypothetical protein	0.064	0.4451	1
Echinococcus granulosus	aminopeptidase N	0.0074	0.0274	0.0274
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0074	0.0274	0.2552
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0062	0.0186	0.0444
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.057	0.3938	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0038	0.0012	0.0012
Brugia malayi	jmjC domain containing protein	0.0057	0.0151	0.034
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0629	0.0629
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0007	0.0014
Brugia malayi	Dopamine receptor protein 1	0.0435	0.2938	0.6601
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.008	0.0318	0.0779
Trypanosoma cruzi	aminopeptidase, putative	0.0074	0.0274	0.8624
Brugia malayi	Muscleblind-like protein	0.0154	0.0864	0.1942
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0062	0.0186	0.0186
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0157	0.1508
Echinococcus granulosus	muscleblind protein	0.0154	0.0864	0.0864
Trichomonas vaginalis	set domain proteins, putative	0.0709	0.4963	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Echinococcus granulosus	geminin	0.0189	0.1123	0.1123
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0074	0.0274	0.0274
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0057	0.0151	0.0151
Mycobacterium ulcerans	proteasome PrcB	0.008	0.0318	0.1781
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0038	0.0012	0.0012
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0074	0.0274	0.2639
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0062	0.0186	0.0186
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1391	1	1
Schistosoma mansoni	protein phosphatase 2C	0.0057	0.0151	0.0151
Echinococcus multilocularis	jumonji domain containing protein	0.0247	0.1551	0.1551
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Plasmodium falciparum	proteasome subunit beta type-5	0.008	0.0318	0.2979
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0623	0.4327	0.4327
Brugia malayi	AF-10 protein	0.0058	0.0157	0.0352
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0225	0.0454
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0629	0.0629
Schistosoma mansoni	hypothetical protein	0.0058	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0074	0.0274	0.0616
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Echinococcus granulosus	lysine specific demethylase 5A	0.0215	0.1314	0.1314
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0057	0.015	0.0838
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0057	0.015	0.0838
Plasmodium vivax	proteasome subunit beta type-5, putative	0.008	0.0318	0.3061
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.045	0.045
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0274	0.8624
Onchocerca volvulus		0.0074	0.0274	0.0552
Brugia malayi	Peptidase family M1 containing protein	0.0074	0.0274	0.0616
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0038	0.0012	0.0382
Echinococcus multilocularis	peregrin	0.0177	0.1038	0.1038
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0057	0.015	0.0336
Loa Loa (eye worm)	aminopeptidase N	0.0074	0.0274	0.0274
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0028	0.0057
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0215	0.1314	0.1314
Loa Loa (eye worm)	jmjC domain-containing protein	0.0366	0.2433	0.2433
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0028	0.0057
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.057	0.3938	0.7935
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0279	0.1785	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0274	0.8624
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0581	0.4019	0.4019
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0062	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0274	0.0274
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0074	0.0274	0.8624
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0057	0.015	0.0838
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0089	0.0388	0.3737
Echinococcus granulosus	histone lysine methyltransferase setb	0.0089	0.0388	0.0388
Toxoplasma gondii	aminopeptidase N, putative	0.0074	0.0274	0.2639
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0074	0.0274	0.0274
Echinococcus granulosus	jumonji domain containing 1A	0.0057	0.0151	0.0151
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0058	0.0157	0.4926
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0157	0.0157
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0062	0.0186	0.1794
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0074	0.0274	0.2639
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0089	0.0388	0.0388
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0057	0.0151	0.4758
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0058	0.0157	0.4926
Giardia lamblia	Fructose-bisphosphate aldolase	0.057	0.3938	1
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0057	0.0151	0.1355
Echinococcus granulosus	survival motor neuron protein 1	0.0244	0.1527	0.1527
Toxoplasma gondii	proteasome subunit beta type, putative	0.008	0.0318	0.3061
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1038	0.1038
Brugia malayi	hypothetical protein	0.0074	0.0274	0.0616
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0074	0.0274	0.0552
Brugia malayi	jmjC domain containing protein	0.0581	0.4019	0.903
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.008	0.0318	0.064
Brugia malayi	Peptidase family M1 containing protein	0.0074	0.0274	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0435	0.2938	0.2938
Mycobacterium ulcerans	aminopeptidase N PepN	0.0074	0.0274	0.1536
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0581	0.4019	0.4019
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0151	0.0151
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0057	0.015	0.4707
Loa Loa (eye worm)	PHD-finger family protein	0.0177	0.1038	0.1038
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0074	0.0274	0.0552
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0215	0.1314	0.1314
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0074	0.0274	0.0274
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Onchocerca volvulus	Alhambra homolog	0.0177	0.1038	0.2092
Echinococcus multilocularis	JmjC domain containing protein 4	0.0057	0.0151	0.0151
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0074	0.0274	0.8624
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0177	0.1038	0.1038
Toxoplasma gondii	PHD-finger domain-containing protein	0.0177	0.1038	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.1464	0.8202
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0062	0.0186	0.0186
Mycobacterium ulcerans	aminopeptidase N PepN	0.0074	0.0274	0.1536
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0038	0.0012	0.0117
Trypanosoma brucei	aminopeptidase, putative	0.0074	0.0274	0.8624
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Echinococcus multilocularis	lysine specific demethylase 5A	0.0215	0.1314	0.1314
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.045	0.1012
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0062	0.0186	0.5863
Echinococcus multilocularis	jumonji domain containing 1A	0.0057	0.0151	0.0151
Brugia malayi	MH2 domain containing protein	0.0122	0.0629	0.1413
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0279	0.1785	1
Onchocerca volvulus		0.005	0.0095	0.0192
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.015	0.015
Schistosoma mansoni	hypothetical protein	0.0177	0.1038	0.1038
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0095	0.0214
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0062	0.0186	0.5863
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0074	0.0274	0.2552
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0089	0.0388	0.0388
Brugia malayi	Bromodomain containing protein	0.0177	0.1038	0.2333
Plasmodium vivax	SET domain protein, putative	0.0089	0.0388	0.3737
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0057	0.0151	0.1456
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0007	0.0014
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.0151	0.0151
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0244	0.1527	0.1527
Echinococcus multilocularis	muscleblind protein	0.0154	0.0864	0.0864
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.008	0.0318	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0038	0.0012	0.0024
Echinococcus granulosus	chromobox protein 1	0.0067	0.0225	0.0225
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.008	0.0318	0.0318
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0074	0.0274	0.8624
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0074	0.0274	0.0274
Trypanosoma brucei	Aminopeptidase M1, putative	0.0074	0.0274	0.8624
Echinococcus granulosus	PHD finger protein rhinoceros	0.0177	0.1038	0.1038
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0074	0.0274	0.8624
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1391	1	1
Schistosoma mansoni	hypothetical protein	0.005	0.0095	0.0095
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.008	0.0318	0.1781
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0038	0.0012	0.0012
Brugia malayi	PHD-finger family protein	0.0177	0.1038	0.2333
Toxoplasma gondii	PHD-finger domain-containing protein	0.0177	0.1038	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0274	0.0274
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0062	0.0186	0.0375
Toxoplasma gondii	aminopeptidase n, putative	0.0074	0.0274	0.2639
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0038	0.0012	0.0117
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0074	0.0274	0.8624
Giardia lamblia	PHD finger protein 15	0.0177	0.1038	0.2614
Brugia malayi	Heterochromatin protein 1	0.0067	0.0225	0.0506
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0074	0.0274	0.8624
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0038	0.0012	0.0382
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0177	0.1038	0.1038
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0074	0.0274	0.0274
Schistosoma mansoni	hypothetical protein	0.0189	0.1123	0.1123
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.008	0.0318	0.0779
Leishmania major	proteasome beta 2 subunit, putative	0.0038	0.0012	0.0382
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1391	1	1
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.008	0.0318	1
Echinococcus granulosus	proteasome prosome macropain	0.008	0.0318	0.0318
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0057	0.015	0.015
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0057	0.015	0.015
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.045	0.1012
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.008	0.0318	0.0318
Brugia malayi	TATA binding protein associated factor	0.0074	0.0274	0.0616
Onchocerca volvulus		0.0074	0.0274	0.0552
Echinococcus multilocularis	aminopeptidase N	0.0074	0.0274	0.0274
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0074	0.0274	0.0274
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0058	0.0157	0.1508
Brugia malayi	Pre-SET motif family protein	0.0623	0.4327	0.9723
Echinococcus multilocularis	lysine specific demethylase 6a	0.0057	0.0151	0.0151
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0028	0.0057
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0074	0.0274	0.8624
Brugia malayi	proteasome subunit beta type 2	0.0038	0.0012	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0388	0.0388
Echinococcus granulosus	lysine specific demethylase 6a	0.0057	0.0151	0.0151

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -0.49 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 1.93 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 2.32 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 53 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 97 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 99 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 6.62	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -2 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 53 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 97 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 99 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.15	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.70149 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL528287
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 594651